Putative heat shock protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein, putative

Species:

Leishmania major

UniProt:

O97211_LEIMA

TriTrypDb:

LmjF.04.0780 , LMJLV39_040013200 , LMJSD75_040013500

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0020016	ciliary pocket	2	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

O97211

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97211

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.208
CLV_C14_Caspase3-7	372	376	PF00656	0.414
CLV_NRD_NRD_1	158	160	PF00675	0.324
CLV_NRD_NRD_1	30	32	PF00675	0.314
CLV_NRD_NRD_1	314	316	PF00675	0.457
CLV_NRD_NRD_1	412	414	PF00675	0.454
CLV_PCSK_KEX2_1	158	160	PF00082	0.280
CLV_PCSK_KEX2_1	30	32	PF00082	0.277
CLV_PCSK_KEX2_1	314	316	PF00082	0.457
CLV_PCSK_KEX2_1	411	413	PF00082	0.477
CLV_PCSK_KEX2_1	450	452	PF00082	0.639
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.639
CLV_PCSK_SKI1_1	170	174	PF00082	0.386
CLV_PCSK_SKI1_1	31	35	PF00082	0.261
DEG_APCC_DBOX_1	169	177	PF00400	0.385
DEG_APCC_DBOX_1	72	80	PF00400	0.611
DEG_ODPH_VHL_1	353	366	PF01847	0.363
DEG_SPOP_SBC_1	391	395	PF00917	0.684
DEG_SPOP_SBC_1	400	404	PF00917	0.625
DOC_CDC14_PxL_1	461	469	PF14671	0.385
DOC_MAPK_gen_1	158	166	PF00069	0.481
DOC_MAPK_gen_1	290	300	PF00069	0.520
DOC_MAPK_gen_1	417	425	PF00069	0.509
DOC_MAPK_MEF2A_6	158	165	PF00069	0.501
DOC_MAPK_MEF2A_6	170	177	PF00069	0.279
DOC_MAPK_MEF2A_6	419	427	PF00069	0.405
DOC_PP2B_LxvP_1	164	167	PF13499	0.385
DOC_PP4_FxxP_1	248	251	PF00568	0.509
DOC_USP7_MATH_1	266	270	PF00917	0.556
DOC_USP7_MATH_1	336	340	PF00917	0.210
DOC_USP7_MATH_1	399	403	PF00917	0.781
DOC_USP7_MATH_1	455	459	PF00917	0.467
DOC_USP7_MATH_1	493	497	PF00917	0.653
DOC_USP7_MATH_1	542	546	PF00917	0.682
DOC_USP7_MATH_2	125	131	PF00917	0.308
DOC_WW_Pin1_4	220	225	PF00397	0.552
DOC_WW_Pin1_4	378	383	PF00397	0.756
DOC_WW_Pin1_4	385	390	PF00397	0.789
DOC_WW_Pin1_4	392	397	PF00397	0.672
DOC_WW_Pin1_4	401	406	PF00397	0.575
DOC_WW_Pin1_4	528	533	PF00397	0.735
LIG_14-3-3_CanoR_1	411	420	PF00244	0.664
LIG_14-3-3_CanoR_1	524	528	PF00244	0.744
LIG_14-3-3_CanoR_1	537	544	PF00244	0.754
LIG_AP2alpha_2	246	248	PF02296	0.509
LIG_BRCT_BRCA1_1	222	226	PF00533	0.547
LIG_BRCT_BRCA1_1	488	492	PF00533	0.640
LIG_deltaCOP1_diTrp_1	127	131	PF00928	0.326
LIG_EH1_1	359	367	PF00400	0.319
LIG_FHA_1	106	112	PF00498	0.410
LIG_FHA_1	191	197	PF00498	0.309
LIG_FHA_1	20	26	PF00498	0.546
LIG_FHA_2	19	25	PF00498	0.468
LIG_FHA_2	204	210	PF00498	0.385
LIG_FHA_2	240	246	PF00498	0.538
LIG_FHA_2	333	339	PF00498	0.242
LIG_IRF3_LxIS_1	111	118	PF10401	0.367
LIG_LIR_Apic_2	245	251	PF02991	0.509
LIG_LIR_Gen_1	110	120	PF02991	0.275
LIG_LIR_Gen_1	297	308	PF02991	0.461
LIG_LIR_Gen_1	348	357	PF02991	0.291
LIG_LIR_Gen_1	458	468	PF02991	0.321
LIG_LIR_Gen_1	47	55	PF02991	0.432
LIG_LIR_Gen_1	9	18	PF02991	0.471
LIG_LIR_Nem_3	110	115	PF02991	0.260
LIG_LIR_Nem_3	130	134	PF02991	0.249
LIG_LIR_Nem_3	26	32	PF02991	0.404
LIG_LIR_Nem_3	297	303	PF02991	0.434
LIG_LIR_Nem_3	307	311	PF02991	0.265
LIG_LIR_Nem_3	348	353	PF02991	0.291
LIG_LIR_Nem_3	358	362	PF02991	0.291
LIG_LIR_Nem_3	458	463	PF02991	0.321
LIG_LIR_Nem_3	47	52	PF02991	0.432
LIG_LIR_Nem_3	9	14	PF02991	0.506
LIG_MYND_1	247	251	PF01753	0.509
LIG_Pex14_1	198	202	PF04695	0.385
LIG_PTB_Apo_2	275	282	PF02174	0.457
LIG_SH2_CRK	29	33	PF00017	0.471
LIG_SH2_CRK	306	310	PF00017	0.367
LIG_SH2_CRK	68	72	PF00017	0.563
LIG_SH2_NCK_1	68	72	PF00017	0.584
LIG_SH2_PTP2	162	165	PF00017	0.509
LIG_SH2_STAP1	306	310	PF00017	0.367
LIG_SH2_STAT5	162	165	PF00017	0.509
LIG_SH2_STAT5	202	205	PF00017	0.385
LIG_SH2_STAT5	306	309	PF00017	0.329
LIG_SH2_STAT5	322	325	PF00017	0.295
LIG_SH2_STAT5	359	362	PF00017	0.420
LIG_SH3_3	131	137	PF00018	0.279
LIG_SH3_3	241	247	PF00018	0.592
LIG_SH3_3	379	385	PF00018	0.719
LIG_SUMO_SIM_anti_2	149	156	PF11976	0.385
LIG_SUMO_SIM_par_1	12	17	PF11976	0.452
LIG_SUMO_SIM_par_1	143	149	PF11976	0.412
LIG_SUMO_SIM_par_1	162	168	PF11976	0.378
LIG_SUMO_SIM_par_1	364	370	PF11976	0.295
LIG_TRAF2_1	384	387	PF00917	0.726
LIG_WRC_WIRS_1	305	310	PF05994	0.362
LIG_WRC_WIRS_1	346	351	PF05994	0.356
LIG_WRC_WIRS_1	556	561	PF05994	0.497
MOD_CK1_1	264	270	PF00069	0.449
MOD_CK1_1	280	286	PF00069	0.340
MOD_CK1_1	325	331	PF00069	0.392
MOD_CK1_1	332	338	PF00069	0.378
MOD_CK1_1	507	513	PF00069	0.671
MOD_CK1_1	525	531	PF00069	0.778
MOD_CK2_1	18	24	PF00069	0.310
MOD_CK2_1	239	245	PF00069	0.415
MOD_CK2_1	257	263	PF00069	0.199
MOD_CK2_1	267	273	PF00069	0.281
MOD_CK2_1	364	370	PF00069	0.373
MOD_CK2_1	381	387	PF00069	0.530
MOD_CK2_1	412	418	PF00069	0.612
MOD_CMANNOS	128	131	PF00535	0.385
MOD_CMANNOS	198	201	PF00535	0.385
MOD_GlcNHglycan	252	255	PF01048	0.387
MOD_GlcNHglycan	269	272	PF01048	0.364
MOD_GlcNHglycan	429	432	PF01048	0.415
MOD_GlcNHglycan	452	455	PF01048	0.525
MOD_GlcNHglycan	456	460	PF01048	0.450
MOD_GlcNHglycan	488	491	PF01048	0.452
MOD_GlcNHglycan	495	498	PF01048	0.532
MOD_GlcNHglycan	506	509	PF01048	0.613
MOD_GlcNHglycan	512	515	PF01048	0.589
MOD_GlcNHglycan	533	536	PF01048	0.641
MOD_GlcNHglycan	562	565	PF01048	0.568
MOD_GlcNHglycan	6	9	PF01048	0.415
MOD_GlcNHglycan	83	86	PF01048	0.524
MOD_GSK3_1	148	155	PF00069	0.319
MOD_GSK3_1	19	26	PF00069	0.472
MOD_GSK3_1	216	223	PF00069	0.349
MOD_GSK3_1	257	264	PF00069	0.426
MOD_GSK3_1	325	332	PF00069	0.355
MOD_GSK3_1	369	376	PF00069	0.450
MOD_GSK3_1	377	384	PF00069	0.628
MOD_GSK3_1	523	530	PF00069	0.684
MOD_GSK3_1	531	538	PF00069	0.676
MOD_GSK3_1	548	555	PF00069	0.649
MOD_LATS_1	410	416	PF00433	0.496
MOD_N-GLC_1	240	245	PF02516	0.319
MOD_N-GLC_1	277	282	PF02516	0.363
MOD_N-GLC_1	535	540	PF02516	0.625
MOD_NEK2_1	107	112	PF00069	0.324
MOD_NEK2_1	115	120	PF00069	0.411
MOD_NEK2_1	146	151	PF00069	0.366
MOD_NEK2_1	153	158	PF00069	0.291
MOD_NEK2_1	369	374	PF00069	0.338
MOD_NEK2_1	434	439	PF00069	0.375
MOD_NEK2_1	501	506	PF00069	0.693
MOD_NEK2_1	67	72	PF00069	0.474
MOD_NEK2_1	86	91	PF00069	0.629
MOD_NEK2_2	322	327	PF00069	0.222
MOD_OFUCOSY	432	438	PF10250	0.319
MOD_PIKK_1	23	29	PF00454	0.414
MOD_PIKK_1	280	286	PF00454	0.319
MOD_PIKK_1	542	548	PF00454	0.680
MOD_PKA_1	412	418	PF00069	0.473
MOD_PKA_1	450	456	PF00069	0.483
MOD_PKA_2	332	338	PF00069	0.481
MOD_PKA_2	412	418	PF00069	0.604
MOD_PKA_2	450	456	PF00069	0.574
MOD_PKA_2	515	521	PF00069	0.712
MOD_PKA_2	523	529	PF00069	0.772
MOD_PKA_2	542	548	PF00069	0.680
MOD_Plk_1	240	246	PF00069	0.319
MOD_Plk_1	256	262	PF00069	0.193
MOD_Plk_1	277	283	PF00069	0.305
MOD_Plk_1	374	380	PF00069	0.282
MOD_Plk_2-3	257	263	PF00069	0.319
MOD_Plk_4	107	113	PF00069	0.303
MOD_Plk_4	148	154	PF00069	0.321
MOD_Plk_4	213	219	PF00069	0.351
MOD_Plk_4	277	283	PF00069	0.348
MOD_Plk_4	304	310	PF00069	0.298
MOD_Plk_4	345	351	PF00069	0.325
MOD_Plk_4	355	361	PF00069	0.325
MOD_Plk_4	369	375	PF00069	0.256
MOD_Plk_4	86	92	PF00069	0.554
MOD_ProDKin_1	220	226	PF00069	0.429
MOD_ProDKin_1	378	384	PF00069	0.715
MOD_ProDKin_1	385	391	PF00069	0.759
MOD_ProDKin_1	392	398	PF00069	0.595
MOD_ProDKin_1	401	407	PF00069	0.460
MOD_ProDKin_1	528	534	PF00069	0.685
MOD_SUMO_for_1	442	445	PF00179	0.430
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.385
TRG_ENDOCYTIC_2	11	14	PF00928	0.281
TRG_ENDOCYTIC_2	162	165	PF00928	0.385
TRG_ENDOCYTIC_2	29	32	PF00928	0.281
TRG_ENDOCYTIC_2	306	309	PF00928	0.351
TRG_ENDOCYTIC_2	359	362	PF00928	0.319
TRG_ENDOCYTIC_2	68	71	PF00928	0.401
TRG_ER_diArg_1	157	159	PF00400	0.367
TRG_ER_diArg_1	29	31	PF00400	0.375
TRG_ER_diArg_1	313	315	PF00400	0.295
TRG_ER_diArg_1	330	333	PF00400	0.175
TRG_ER_diArg_1	411	413	PF00400	0.548
TRG_ER_diArg_1	62	65	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R3	Leptomonas seymouri	52%	100%
A0A3R7M9P3	Trypanosoma rangeli	26%	100%
A0A3S7WNV0	Leishmania donovani	90%	99%
A4H3Z0	Leishmania braziliensis	72%	96%
A4HS75	Leishmania infantum	90%	99%
C9ZY69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AK61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%