Protein Wnt

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein Wnt

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

O97210_LEIMA

TriTrypDb:

LmjF.04.0800 , LMJLV39_040013400 , LMJSD75_040013700

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

O97210

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97210

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.590
CLV_NRD_NRD_1	135	137	PF00675	0.558
CLV_NRD_NRD_1	248	250	PF00675	0.500
CLV_NRD_NRD_1	75	77	PF00675	0.545
CLV_NRD_NRD_1	95	97	PF00675	0.633
CLV_PCSK_FUR_1	133	137	PF00082	0.540
CLV_PCSK_KEX2_1	132	134	PF00082	0.640
CLV_PCSK_KEX2_1	135	137	PF00082	0.627
CLV_PCSK_KEX2_1	248	250	PF00082	0.502
CLV_PCSK_KEX2_1	95	97	PF00082	0.557
CLV_PCSK_SKI1_1	135	139	PF00082	0.557
CLV_PCSK_SKI1_1	150	154	PF00082	0.541
CLV_PCSK_SKI1_1	341	345	PF00082	0.494
DEG_SPOP_SBC_1	353	357	PF00917	0.629
DOC_MAPK_gen_1	248	254	PF00069	0.485
DOC_MAPK_gen_1	74	82	PF00069	0.498
DOC_MAPK_MEF2A_6	60	67	PF00069	0.557
DOC_MAPK_MEF2A_6	74	82	PF00069	0.494
DOC_PP1_RVXF_1	232	238	PF00149	0.546
DOC_PP2B_LxvP_1	63	66	PF13499	0.556
DOC_USP7_MATH_1	114	118	PF00917	0.711
DOC_USP7_MATH_1	298	302	PF00917	0.655
DOC_USP7_MATH_1	353	357	PF00917	0.593
DOC_WW_Pin1_4	118	123	PF00397	0.587
DOC_WW_Pin1_4	12	17	PF00397	0.405
DOC_WW_Pin1_4	211	216	PF00397	0.501
DOC_WW_Pin1_4	346	351	PF00397	0.519
DOC_WW_Pin1_4	83	88	PF00397	0.514
LIG_14-3-3_CanoR_1	3	12	PF00244	0.446
LIG_14-3-3_CanoR_1	304	308	PF00244	0.522
LIG_BRCT_BRCA1_1	355	359	PF00533	0.603
LIG_BRCT_BRCA1_2	355	361	PF00533	0.596
LIG_EVH1_2	16	20	PF00568	0.390
LIG_FHA_1	16	22	PF00498	0.514
LIG_FHA_1	193	199	PF00498	0.529
LIG_FHA_1	212	218	PF00498	0.371
LIG_FHA_1	230	236	PF00498	0.489
LIG_FHA_1	340	346	PF00498	0.558
LIG_FHA_2	126	132	PF00498	0.573
LIG_FHA_2	304	310	PF00498	0.608
LIG_FHA_2	347	353	PF00498	0.512
LIG_FHA_2	88	94	PF00498	0.501
LIG_LIR_Gen_1	363	372	PF02991	0.487
LIG_LIR_Gen_1	94	104	PF02991	0.576
LIG_LIR_Nem_3	18	23	PF02991	0.426
LIG_LIR_Nem_3	363	368	PF02991	0.480
LIG_LIR_Nem_3	94	100	PF02991	0.563
LIG_NRBOX	23	29	PF00104	0.381
LIG_SH2_CRK	97	101	PF00017	0.558
LIG_SH2_PTP2	79	82	PF00017	0.508
LIG_SH2_SRC	79	82	PF00017	0.508
LIG_SH2_STAT5	207	210	PF00017	0.469
LIG_SH2_STAT5	216	219	PF00017	0.469
LIG_SH2_STAT5	324	327	PF00017	0.469
LIG_SH2_STAT5	333	336	PF00017	0.427
LIG_SH2_STAT5	79	82	PF00017	0.508
LIG_SH3_3	347	353	PF00018	0.512
LIG_SH3_3	46	52	PF00018	0.566
LIG_SH3_3	75	81	PF00018	0.546
LIG_SUMO_SIM_par_1	151	157	PF11976	0.514
LIG_SUMO_SIM_par_1	326	334	PF11976	0.462
LIG_TRAF2_1	154	157	PF00917	0.628
LIG_TRAF2_1	277	280	PF00917	0.571
LIG_TRAF2_1	8	11	PF00917	0.455
LIG_WRC_WIRS_1	182	187	PF05994	0.552
MOD_CK1_1	117	123	PF00069	0.748
MOD_CK1_1	15	21	PF00069	0.425
MOD_CK1_1	228	234	PF00069	0.559
MOD_CK1_1	239	245	PF00069	0.454
MOD_CK1_1	5	11	PF00069	0.585
MOD_CK2_1	4	10	PF00069	0.448
MOD_CK2_1	87	93	PF00069	0.469
MOD_GlcNHglycan	116	119	PF01048	0.667
MOD_GlcNHglycan	167	170	PF01048	0.699
MOD_GlcNHglycan	175	178	PF01048	0.680
MOD_GlcNHglycan	187	190	PF01048	0.449
MOD_GlcNHglycan	44	47	PF01048	0.532
MOD_GSK3_1	11	18	PF00069	0.403
MOD_GSK3_1	114	121	PF00069	0.735
MOD_GSK3_1	181	188	PF00069	0.614
MOD_GSK3_1	2	9	PF00069	0.447
MOD_GSK3_1	205	212	PF00069	0.558
MOD_GSK3_1	218	225	PF00069	0.515
MOD_GSK3_1	238	245	PF00069	0.408
MOD_GSK3_1	47	54	PF00069	0.449
MOD_GSK3_1	83	90	PF00069	0.481
MOD_N-GLC_1	237	242	PF02516	0.558
MOD_N-GLC_1	298	303	PF02516	0.684
MOD_NEK2_1	171	176	PF00069	0.667
MOD_NEK2_1	185	190	PF00069	0.451
MOD_NEK2_1	229	234	PF00069	0.490
MOD_NEK2_1	237	242	PF00069	0.479
MOD_NEK2_1	28	33	PF00069	0.502
MOD_NEK2_1	292	297	PF00069	0.645
MOD_PIKK_1	253	259	PF00454	0.607
MOD_PIKK_1	318	324	PF00454	0.514
MOD_PKA_2	100	106	PF00069	0.681
MOD_PKA_2	2	8	PF00069	0.446
MOD_PKA_2	303	309	PF00069	0.544
MOD_Plk_1	229	235	PF00069	0.614
MOD_Plk_1	242	248	PF00069	0.618
MOD_Plk_1	285	291	PF00069	0.509
MOD_Plk_2-3	323	329	PF00069	0.474
MOD_Plk_4	181	187	PF00069	0.658
MOD_Plk_4	87	93	PF00069	0.500
MOD_ProDKin_1	118	124	PF00069	0.585
MOD_ProDKin_1	12	18	PF00069	0.404
MOD_ProDKin_1	211	217	PF00069	0.503
MOD_ProDKin_1	346	352	PF00069	0.518
MOD_ProDKin_1	83	89	PF00069	0.508
MOD_SUMO_rev_2	366	371	PF00179	0.448
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.451
TRG_ENDOCYTIC_2	79	82	PF00928	0.557
TRG_ENDOCYTIC_2	97	100	PF00928	0.547
TRG_ER_diArg_1	132	135	PF00400	0.565
TRG_ER_diArg_1	247	249	PF00400	0.511
TRG_ER_diArg_1	275	278	PF00400	0.469
TRG_ER_diArg_1	52	55	PF00400	0.447
TRG_ER_diArg_1	95	97	PF00400	0.542
TRG_ER_diArg_1	99	102	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTL4	Leptomonas seymouri	47%	100%
A0A1X0NLR1	Trypanosomatidae	47%	100%
A0A3R7K5C5	Trypanosoma rangeli	46%	100%
A0A3S5H5C8	Leishmania donovani	96%	100%
A4HS77	Leishmania infantum	91%	100%
C9ZY71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AK63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DEH0	Trypanosoma cruzi	45%	100%