Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

O97206_LEIMA

TriTrypDb:

LmjF.04.0490 , LMJLV39_040010000 , LMJSD75_040010400

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

O97206

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97206

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.591
CLV_C14_Caspase3-7	119	123	PF00656	0.559
CLV_C14_Caspase3-7	165	169	PF00656	0.740
CLV_NRD_NRD_1	14	16	PF00675	0.507
CLV_NRD_NRD_1	142	144	PF00675	0.594
CLV_NRD_NRD_1	187	189	PF00675	0.708
CLV_NRD_NRD_1	267	269	PF00675	0.675
CLV_NRD_NRD_1	305	307	PF00675	0.650
CLV_NRD_NRD_1	70	72	PF00675	0.658
CLV_PCSK_KEX2_1	14	16	PF00082	0.478
CLV_PCSK_KEX2_1	142	144	PF00082	0.594
CLV_PCSK_KEX2_1	187	189	PF00082	0.708
CLV_PCSK_KEX2_1	27	29	PF00082	0.440
CLV_PCSK_KEX2_1	54	56	PF00082	0.630
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.461
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.630
CLV_PCSK_SKI1_1	206	210	PF00082	0.780
CLV_PCSK_SKI1_1	34	38	PF00082	0.377
CLV_PCSK_SKI1_1	91	95	PF00082	0.595
DEG_APCC_DBOX_1	78	86	PF00400	0.636
DOC_CYCLIN_RxL_1	28	39	PF00134	0.534
DOC_MAPK_gen_1	34	40	PF00069	0.553
DOC_PP2B_LxvP_1	95	98	PF13499	0.532
DOC_PP4_FxxP_1	58	61	PF00568	0.543
DOC_USP7_MATH_1	2	6	PF00917	0.516
DOC_USP7_MATH_1	212	216	PF00917	0.707
DOC_USP7_MATH_1	218	222	PF00917	0.719
DOC_USP7_UBL2_3	160	164	PF12436	0.526
DOC_USP7_UBL2_3	194	198	PF12436	0.729
DOC_USP7_UBL2_3	303	307	PF12436	0.646
DOC_USP7_UBL2_3	313	317	PF12436	0.670
DOC_USP7_UBL2_3	37	41	PF12436	0.411
DOC_WW_Pin1_4	122	127	PF00397	0.433
LIG_14-3-3_CanoR_1	296	304	PF00244	0.729
LIG_Actin_WH2_2	22	39	PF00022	0.432
LIG_Actin_WH2_2	78	96	PF00022	0.616
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BIR_III_2	183	187	PF00653	0.670
LIG_FHA_1	21	27	PF00498	0.552
LIG_FHA_1	293	299	PF00498	0.603
LIG_FHA_1	88	94	PF00498	0.552
LIG_FHA_2	104	110	PF00498	0.601
LIG_FHA_2	131	137	PF00498	0.536
LIG_FHA_2	238	244	PF00498	0.666
LIG_LIR_Apic_2	86	92	PF02991	0.504
LIG_LIR_Gen_1	115	126	PF02991	0.519
LIG_LIR_Gen_1	53	63	PF02991	0.545
LIG_LIR_Nem_3	115	121	PF02991	0.531
LIG_LIR_Nem_3	53	59	PF02991	0.548
LIG_NRP_CendR_1	317	318	PF00754	0.676
LIG_SH2_CRK	89	93	PF00017	0.594
LIG_SH2_NCK_1	118	122	PF00017	0.618
LIG_SH2_STAT5	177	180	PF00017	0.695
LIG_SH2_STAT5	89	92	PF00017	0.604
LIG_SH3_2	49	54	PF14604	0.627
LIG_SH3_3	105	111	PF00018	0.597
LIG_SH3_3	46	52	PF00018	0.602
LIG_TRAF2_1	145	148	PF00917	0.606
LIG_TRAF2_1	240	243	PF00917	0.679
LIG_TRAF2_1	48	51	PF00917	0.620
LIG_TYR_ITIM	116	121	PF00017	0.626
MOD_CK1_1	149	155	PF00069	0.557
MOD_CK1_1	220	226	PF00069	0.725
MOD_CK1_1	263	269	PF00069	0.707
MOD_CK1_1	292	298	PF00069	0.729
MOD_CK1_1	4	10	PF00069	0.492
MOD_CK2_1	218	224	PF00069	0.538
MOD_CK2_1	237	243	PF00069	0.662
MOD_GlcNHglycan	150	154	PF01048	0.694
MOD_GlcNHglycan	195	198	PF01048	0.757
MOD_GlcNHglycan	212	215	PF01048	0.763
MOD_GlcNHglycan	275	278	PF01048	0.621
MOD_GlcNHglycan	292	295	PF01048	0.575
MOD_GlcNHglycan	299	302	PF01048	0.573
MOD_GlcNHglycan	313	316	PF01048	0.616
MOD_GlcNHglycan	44	47	PF01048	0.596
MOD_GSK3_1	212	219	PF00069	0.803
MOD_GSK3_1	220	227	PF00069	0.714
MOD_GSK3_1	292	299	PF00069	0.624
MOD_N-GLC_1	270	275	PF02516	0.593
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	289	294	PF00069	0.705
MOD_NEK2_1	36	41	PF00069	0.584
MOD_NEK2_2	22	27	PF00069	0.536
MOD_PK_1	199	205	PF00069	0.652
MOD_PKA_1	199	205	PF00069	0.683
MOD_Plk_4	112	118	PF00069	0.582
MOD_Plk_4	270	276	PF00069	0.594
MOD_ProDKin_1	122	128	PF00069	0.438
TRG_ENDOCYTIC_2	118	121	PF00928	0.624
TRG_ER_diArg_1	14	17	PF00400	0.499
TRG_ER_diArg_1	186	188	PF00400	0.686
TRG_NLS_Bipartite_1	187	202	PF00514	0.790

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II41	Leptomonas seymouri	62%	98%
A0A1X0NL53	Trypanosomatidae	37%	100%
A0A3S7WNR7	Leishmania donovani	89%	98%
A4H3W9	Leishmania braziliensis	77%	98%
A4HS44	Leishmania infantum	89%	98%
E9AK31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
V5B9E1	Trypanosoma cruzi	37%	100%