Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

O97202_LEIMA

TriTrypDb:

LmjF.04.0530 , LMJLV39_040010400 , LMJSD75_040010800

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97202

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97202

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.594
CLV_C14_Caspase3-7	280	284	PF00656	0.631
CLV_MEL_PAP_1	132	138	PF00089	0.535
CLV_NRD_NRD_1	241	243	PF00675	0.597
CLV_NRD_NRD_1	3	5	PF00675	0.539
CLV_NRD_NRD_1	389	391	PF00675	0.555
CLV_NRD_NRD_1	441	443	PF00675	0.667
CLV_PCSK_KEX2_1	3	5	PF00082	0.539
CLV_PCSK_KEX2_1	389	391	PF00082	0.555
CLV_PCSK_KEX2_1	443	445	PF00082	0.673
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.673
CLV_PCSK_SKI1_1	242	246	PF00082	0.521
CLV_PCSK_SKI1_1	363	367	PF00082	0.651
CLV_PCSK_SKI1_1	389	393	PF00082	0.607
CLV_PCSK_SKI1_1	92	96	PF00082	0.607
DEG_APCC_DBOX_1	362	370	PF00400	0.554
DEG_Nend_UBRbox_4	1	3	PF02207	0.541
DEG_SCF_FBW7_1	63	70	PF00400	0.553
DEG_SPOP_SBC_1	113	117	PF00917	0.577
DEG_SPOP_SBC_1	187	191	PF00917	0.575
DEG_SPOP_SBC_1	285	289	PF00917	0.626
DEG_SPOP_SBC_1	77	81	PF00917	0.574
DOC_CDC14_PxL_1	206	214	PF14671	0.601
DOC_CKS1_1	224	229	PF01111	0.389
DOC_CKS1_1	322	327	PF01111	0.564
DOC_CYCLIN_RxL_1	357	367	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.633
DOC_MAPK_gen_1	92	101	PF00069	0.587
DOC_MAPK_MEF2A_6	95	103	PF00069	0.555
DOC_PP2B_LxvP_1	150	153	PF13499	0.680
DOC_PP2B_LxvP_1	391	394	PF13499	0.548
DOC_USP7_MATH_1	102	106	PF00917	0.657
DOC_USP7_MATH_1	124	128	PF00917	0.626
DOC_USP7_MATH_1	179	183	PF00917	0.581
DOC_USP7_MATH_1	187	191	PF00917	0.556
DOC_USP7_MATH_1	25	29	PF00917	0.524
DOC_USP7_MATH_1	277	281	PF00917	0.695
DOC_USP7_MATH_1	285	289	PF00917	0.630
DOC_USP7_MATH_1	400	404	PF00917	0.678
DOC_WW_Pin1_4	143	148	PF00397	0.749
DOC_WW_Pin1_4	16	21	PF00397	0.525
DOC_WW_Pin1_4	188	193	PF00397	0.574
DOC_WW_Pin1_4	223	228	PF00397	0.388
DOC_WW_Pin1_4	298	303	PF00397	0.684
DOC_WW_Pin1_4	321	326	PF00397	0.589
DOC_WW_Pin1_4	4	9	PF00397	0.525
DOC_WW_Pin1_4	63	68	PF00397	0.555
LIG_14-3-3_CanoR_1	11	15	PF00244	0.542
LIG_14-3-3_CanoR_1	3	8	PF00244	0.533
LIG_14-3-3_CanoR_1	49	59	PF00244	0.522
LIG_BIR_III_2	373	377	PF00653	0.610
LIG_CSL_BTD_1	224	227	PF09270	0.385
LIG_CtBP_PxDLS_1	325	329	PF00389	0.526
LIG_deltaCOP1_diTrp_1	222	228	PF00928	0.509
LIG_EH_1	138	142	PF12763	0.551
LIG_FHA_1	197	203	PF00498	0.515
LIG_FHA_1	224	230	PF00498	0.466
LIG_FHA_2	322	328	PF00498	0.555
LIG_LIR_Nem_3	125	131	PF02991	0.598
LIG_LIR_Nem_3	222	228	PF02991	0.532
LIG_NRBOX	361	367	PF00104	0.500
LIG_PCNA_PIPBox_1	385	394	PF02747	0.551
LIG_SH2_CRK	372	376	PF00017	0.603
LIG_SH2_NCK_1	372	376	PF00017	0.603
LIG_SH2_STAT5	131	134	PF00017	0.510
LIG_SH3_1	151	157	PF00018	0.713
LIG_SH3_3	11	17	PF00018	0.554
LIG_SH3_3	151	157	PF00018	0.707
LIG_SH3_3	161	167	PF00018	0.592
LIG_SH3_3	19	25	PF00018	0.506
LIG_SH3_3	204	210	PF00018	0.628
LIG_SH3_3	221	227	PF00018	0.481
LIG_SH3_3	256	262	PF00018	0.664
LIG_Sin3_3	429	436	PF02671	0.650
LIG_TRAF2_1	324	327	PF00917	0.539
LIG_TRAF2_1	351	354	PF00917	0.533
LIG_TRAF2_1	376	379	PF00917	0.620
LIG_TRAF2_1	381	384	PF00917	0.568
MOD_CDK_SPK_2	143	148	PF00069	0.586
MOD_CDK_SPxxK_3	4	11	PF00069	0.533
MOD_CK1_1	105	111	PF00069	0.660
MOD_CK1_1	127	133	PF00069	0.571
MOD_CK1_1	165	171	PF00069	0.708
MOD_CK1_1	18	24	PF00069	0.529
MOD_CK1_1	191	197	PF00069	0.599
MOD_CK1_1	28	34	PF00069	0.506
MOD_CK1_1	403	409	PF00069	0.655
MOD_CK1_1	52	58	PF00069	0.542
MOD_CK1_1	79	85	PF00069	0.600
MOD_CK2_1	119	125	PF00069	0.645
MOD_CK2_1	270	276	PF00069	0.585
MOD_CK2_1	321	327	PF00069	0.577
MOD_CK2_1	348	354	PF00069	0.566
MOD_DYRK1A_RPxSP_1	4	8	PF00069	0.531
MOD_GlcNHglycan	108	111	PF01048	0.668
MOD_GlcNHglycan	121	124	PF01048	0.582
MOD_GlcNHglycan	167	170	PF01048	0.617
MOD_GlcNHglycan	183	186	PF01048	0.450
MOD_GlcNHglycan	193	196	PF01048	0.456
MOD_GlcNHglycan	230	233	PF01048	0.525
MOD_GlcNHglycan	254	257	PF01048	0.494
MOD_GlcNHglycan	279	282	PF01048	0.577
MOD_GlcNHglycan	401	405	PF01048	0.693
MOD_GlcNHglycan	412	415	PF01048	0.573
MOD_GlcNHglycan	55	58	PF01048	0.626
MOD_GSK3_1	102	109	PF00069	0.674
MOD_GSK3_1	12	19	PF00069	0.553
MOD_GSK3_1	187	194	PF00069	0.632
MOD_GSK3_1	298	305	PF00069	0.682
MOD_GSK3_1	326	333	PF00069	0.571
MOD_GSK3_1	403	410	PF00069	0.649
MOD_GSK3_1	48	55	PF00069	0.556
MOD_GSK3_1	63	70	PF00069	0.535
MOD_GSK3_1	76	83	PF00069	0.562
MOD_N-GLC_1	408	413	PF02516	0.557
MOD_NEK2_1	10	15	PF00069	0.556
MOD_NEK2_1	103	108	PF00069	0.630
MOD_NEK2_1	196	201	PF00069	0.542
MOD_NEK2_1	286	291	PF00069	0.649
MOD_NEK2_1	50	55	PF00069	0.653
MOD_NEK2_1	78	83	PF00069	0.608
MOD_NEK2_2	90	95	PF00069	0.600
MOD_PIKK_1	152	158	PF00454	0.648
MOD_PKA_1	3	9	PF00069	0.528
MOD_PKA_1	442	448	PF00069	0.612
MOD_PKA_2	10	16	PF00069	0.541
MOD_PKA_2	134	140	PF00069	0.521
MOD_PKA_2	2	8	PF00069	0.533
MOD_PKA_2	48	54	PF00069	0.521
MOD_PKB_1	47	55	PF00069	0.521
MOD_Plk_1	326	332	PF00069	0.652
MOD_Plk_4	127	133	PF00069	0.566
MOD_Plk_4	55	61	PF00069	0.546
MOD_ProDKin_1	143	149	PF00069	0.748
MOD_ProDKin_1	16	22	PF00069	0.521
MOD_ProDKin_1	188	194	PF00069	0.564
MOD_ProDKin_1	223	229	PF00069	0.389
MOD_ProDKin_1	298	304	PF00069	0.688
MOD_ProDKin_1	321	327	PF00069	0.585
MOD_ProDKin_1	4	10	PF00069	0.529
MOD_ProDKin_1	63	69	PF00069	0.553
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.671
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.598
TRG_ENDOCYTIC_2	372	375	PF00928	0.602
TRG_ER_diArg_1	388	390	PF00400	0.545
TRG_ER_diArg_1	47	50	PF00400	0.524
TRG_NLS_MonoExtC_3	441	446	PF00514	0.533
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNR0	Leishmania donovani	88%	100%
A4H3X3	Leishmania braziliensis	62%	100%
A4HS48	Leishmania infantum	88%	100%
E9AK35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%