Zinc_finger_-_C3HC4_type_(RING_finger )_containing_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

O97201_LEIMA

TriTrypDb:

LmjF.04.0540 , LMJLV39_040010500 , LMJSD75_040010900

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

O97201

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97201

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	13
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.460
CLV_C14_Caspase3-7	347	351	PF00656	0.393
CLV_NRD_NRD_1	170	172	PF00675	0.570
CLV_NRD_NRD_1	259	261	PF00675	0.407
CLV_NRD_NRD_1	397	399	PF00675	0.345
CLV_NRD_NRD_1	460	462	PF00675	0.613
CLV_PCSK_KEX2_1	170	172	PF00082	0.570
CLV_PCSK_KEX2_1	259	261	PF00082	0.407
CLV_PCSK_KEX2_1	397	399	PF00082	0.575
CLV_PCSK_KEX2_1	46	48	PF00082	0.268
CLV_PCSK_KEX2_1	460	462	PF00082	0.602
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.254
CLV_PCSK_SKI1_1	405	409	PF00082	0.424
CLV_PCSK_SKI1_1	412	416	PF00082	0.432
CLV_PCSK_SKI1_1	8	12	PF00082	0.357
CLV_PCSK_SKI1_1	83	87	PF00082	0.463
DEG_APCC_DBOX_1	259	267	PF00400	0.390
DEG_APCC_DBOX_1	286	294	PF00400	0.328
DEG_APCC_DBOX_1	404	412	PF00400	0.326
DEG_APCC_DBOX_1	82	90	PF00400	0.398
DEG_Nend_UBRbox_2	1	3	PF02207	0.473
DEG_SPOP_SBC_1	450	454	PF00917	0.525
DOC_CKS1_1	228	233	PF01111	0.541
DOC_CYCLIN_RxL_1	79	88	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.511
DOC_MAPK_gen_1	287	295	PF00069	0.282
DOC_MAPK_gen_1	397	404	PF00069	0.339
DOC_MAPK_gen_1	79	86	PF00069	0.368
DOC_MAPK_MEF2A_6	302	310	PF00069	0.339
DOC_PP1_RVXF_1	289	296	PF00149	0.396
DOC_PP2B_LxvP_1	422	425	PF13499	0.471
DOC_PP2B_LxvP_1	525	528	PF13499	0.588
DOC_PP2B_PxIxI_1	426	432	PF00149	0.531
DOC_PP4_FxxP_1	22	25	PF00568	0.337
DOC_PP4_FxxP_1	66	69	PF00568	0.296
DOC_USP7_MATH_1	120	124	PF00917	0.621
DOC_USP7_MATH_1	218	222	PF00917	0.692
DOC_USP7_MATH_1	249	253	PF00917	0.649
DOC_USP7_MATH_1	335	339	PF00917	0.406
DOC_USP7_MATH_1	4	8	PF00917	0.373
DOC_USP7_MATH_1	450	454	PF00917	0.591
DOC_USP7_MATH_1	498	502	PF00917	0.576
DOC_USP7_MATH_2	212	218	PF00917	0.532
DOC_WW_Pin1_4	136	141	PF00397	0.623
DOC_WW_Pin1_4	152	157	PF00397	0.701
DOC_WW_Pin1_4	195	200	PF00397	0.578
DOC_WW_Pin1_4	227	232	PF00397	0.629
DOC_WW_Pin1_4	247	252	PF00397	0.592
DOC_WW_Pin1_4	380	385	PF00397	0.340
DOC_WW_Pin1_4	451	456	PF00397	0.652
DOC_WW_Pin1_4	494	499	PF00397	0.557
DOC_WW_Pin1_4	520	525	PF00397	0.797
DOC_WW_Pin1_4	557	562	PF00397	0.585
LIG_14-3-3_CanoR_1	193	200	PF00244	0.586
LIG_14-3-3_CanoR_1	260	268	PF00244	0.446
LIG_14-3-3_CanoR_1	328	337	PF00244	0.400
LIG_14-3-3_CanoR_1	451	455	PF00244	0.528
LIG_14-3-3_CanoR_1	8	13	PF00244	0.366
LIG_BRCT_BRCA1_1	337	341	PF00533	0.398
LIG_BRCT_BRCA1_1	485	489	PF00533	0.554
LIG_BRCT_BRCA1_1	6	10	PF00533	0.338
LIG_CtBP_PxDLS_1	34	38	PF00389	0.274
LIG_FHA_1	223	229	PF00498	0.565
LIG_FHA_1	280	286	PF00498	0.343
LIG_FHA_1	347	353	PF00498	0.356
LIG_FHA_1	397	403	PF00498	0.382
LIG_FHA_1	546	552	PF00498	0.523
LIG_FHA_2	113	119	PF00498	0.507
LIG_FHA_2	414	420	PF00498	0.396
LIG_Integrin_isoDGR_2	575	577	PF01839	0.571
LIG_LIR_Apic_2	19	25	PF02991	0.370
LIG_LIR_Apic_2	29	34	PF02991	0.314
LIG_LIR_Gen_1	267	276	PF02991	0.415
LIG_LIR_Gen_1	370	381	PF02991	0.348
LIG_LIR_Gen_1	399	408	PF02991	0.440
LIG_LIR_Gen_1	512	522	PF02991	0.558
LIG_LIR_Gen_1	7	18	PF02991	0.322
LIG_LIR_Nem_3	177	183	PF02991	0.620
LIG_LIR_Nem_3	256	261	PF02991	0.440
LIG_LIR_Nem_3	267	271	PF02991	0.467
LIG_LIR_Nem_3	359	365	PF02991	0.437
LIG_LIR_Nem_3	369	374	PF02991	0.370
LIG_LIR_Nem_3	399	404	PF02991	0.444
LIG_LIR_Nem_3	512	517	PF02991	0.563
LIG_LIR_Nem_3	7	13	PF02991	0.320
LIG_Pex14_2	295	299	PF04695	0.377
LIG_Rb_pABgroove_1	272	280	PF01858	0.369
LIG_SH2_CRK	268	272	PF00017	0.369
LIG_SH2_CRK	362	366	PF00017	0.518
LIG_SH2_CRK	514	518	PF00017	0.525
LIG_SH2_PTP2	180	183	PF00017	0.574
LIG_SH2_PTP2	401	404	PF00017	0.350
LIG_SH2_SRC	180	183	PF00017	0.574
LIG_SH2_STAP1	268	272	PF00017	0.388
LIG_SH2_STAP1	348	352	PF00017	0.394
LIG_SH2_STAP1	514	518	PF00017	0.563
LIG_SH2_STAT3	320	323	PF00017	0.335
LIG_SH2_STAT5	180	183	PF00017	0.574
LIG_SH2_STAT5	320	323	PF00017	0.335
LIG_SH2_STAT5	348	351	PF00017	0.348
LIG_SH2_STAT5	373	376	PF00017	0.345
LIG_SH2_STAT5	401	404	PF00017	0.350
LIG_SH2_STAT5	98	101	PF00017	0.432
LIG_SH3_2	521	526	PF14604	0.576
LIG_SH3_3	153	159	PF00018	0.610
LIG_SH3_3	221	227	PF00018	0.540
LIG_SH3_3	248	254	PF00018	0.632
LIG_SH3_3	515	521	PF00018	0.624
LIG_SH3_CIN85_PxpxPR_1	446	451	PF14604	0.512
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.293
LIG_SUMO_SIM_par_1	88	93	PF11976	0.331
LIG_TRAF2_2	14	19	PF00917	0.393
LIG_TYR_ITIM	266	271	PF00017	0.371
LIG_UBA3_1	309	318	PF00899	0.362
MOD_CAAXbox	585	588	PF01239	0.583
MOD_CDC14_SPxK_1	198	201	PF00782	0.565
MOD_CDC14_SPxK_1	523	526	PF00782	0.569
MOD_CDK_SPxK_1	195	201	PF00069	0.575
MOD_CDK_SPxK_1	520	526	PF00069	0.560
MOD_CDK_SPxxK_3	557	564	PF00069	0.564
MOD_CK1_1	136	142	PF00069	0.630
MOD_CK1_1	188	194	PF00069	0.607
MOD_CK1_1	195	201	PF00069	0.590
MOD_CK1_1	217	223	PF00069	0.736
MOD_CK1_1	434	440	PF00069	0.761
MOD_CK1_1	459	465	PF00069	0.630
MOD_CK1_1	472	478	PF00069	0.556
MOD_CK2_1	261	267	PF00069	0.368
MOD_CK2_1	341	347	PF00069	0.379
MOD_DYRK1A_RPxSP_1	451	455	PF00069	0.521
MOD_GlcNHglycan	188	191	PF01048	0.630
MOD_GlcNHglycan	216	219	PF01048	0.762
MOD_GlcNHglycan	238	241	PF01048	0.622
MOD_GlcNHglycan	247	250	PF01048	0.498
MOD_GlcNHglycan	336	340	PF01048	0.402
MOD_GlcNHglycan	433	436	PF01048	0.714
MOD_GlcNHglycan	438	441	PF01048	0.666
MOD_GlcNHglycan	474	477	PF01048	0.560
MOD_GlcNHglycan	479	482	PF01048	0.516
MOD_GSK3_1	101	108	PF00069	0.411
MOD_GSK3_1	120	127	PF00069	0.594
MOD_GSK3_1	154	161	PF00069	0.583
MOD_GSK3_1	188	195	PF00069	0.663
MOD_GSK3_1	200	207	PF00069	0.673
MOD_GSK3_1	214	221	PF00069	0.475
MOD_GSK3_1	236	243	PF00069	0.636
MOD_GSK3_1	245	252	PF00069	0.608
MOD_GSK3_1	279	286	PF00069	0.311
MOD_GSK3_1	396	403	PF00069	0.391
MOD_GSK3_1	4	11	PF00069	0.407
MOD_GSK3_1	427	434	PF00069	0.594
MOD_GSK3_1	470	477	PF00069	0.567
MOD_GSK3_1	479	486	PF00069	0.501
MOD_GSK3_1	490	497	PF00069	0.521
MOD_GSK3_1	509	516	PF00069	0.686
MOD_GSK3_1	70	77	PF00069	0.456
MOD_N-GLC_1	218	223	PF02516	0.598
MOD_N-GLC_1	236	241	PF02516	0.622
MOD_NEK2_1	341	346	PF00069	0.453
MOD_NEK2_1	407	412	PF00069	0.370
MOD_NEK2_1	413	418	PF00069	0.440
MOD_NEK2_1	490	495	PF00069	0.565
MOD_NEK2_1	70	75	PF00069	0.391
MOD_NEK2_1	85	90	PF00069	0.484
MOD_NEK2_2	400	405	PF00069	0.453
MOD_PIKK_1	158	164	PF00454	0.546
MOD_PIKK_1	204	210	PF00454	0.686
MOD_PIKK_1	261	267	PF00454	0.391
MOD_PIKK_1	319	325	PF00454	0.320
MOD_PIKK_1	526	532	PF00454	0.572
MOD_PKA_2	101	107	PF00069	0.427
MOD_PKA_2	192	198	PF00069	0.587
MOD_PKA_2	200	206	PF00069	0.506
MOD_PKA_2	283	289	PF00069	0.340
MOD_PKA_2	396	402	PF00069	0.584
MOD_PKA_2	450	456	PF00069	0.517
MOD_PKA_2	459	465	PF00069	0.505
MOD_PKA_2	576	582	PF00069	0.673
MOD_Plk_1	218	224	PF00069	0.681
MOD_Plk_1	366	372	PF00069	0.388
MOD_Plk_4	513	519	PF00069	0.590
MOD_Plk_4	70	76	PF00069	0.393
MOD_Plk_4	85	91	PF00069	0.443
MOD_ProDKin_1	136	142	PF00069	0.637
MOD_ProDKin_1	152	158	PF00069	0.696
MOD_ProDKin_1	195	201	PF00069	0.575
MOD_ProDKin_1	227	233	PF00069	0.629
MOD_ProDKin_1	247	253	PF00069	0.586
MOD_ProDKin_1	380	386	PF00069	0.338
MOD_ProDKin_1	451	457	PF00069	0.653
MOD_ProDKin_1	494	500	PF00069	0.558
MOD_ProDKin_1	520	526	PF00069	0.801
MOD_ProDKin_1	557	563	PF00069	0.586
MOD_SUMO_rev_2	77	81	PF00179	0.394
TRG_DiLeu_BaEn_1	267	272	PF01217	0.406
TRG_ENDOCYTIC_2	180	183	PF00928	0.589
TRG_ENDOCYTIC_2	268	271	PF00928	0.405
TRG_ENDOCYTIC_2	362	365	PF00928	0.545
TRG_ENDOCYTIC_2	373	376	PF00928	0.237
TRG_ENDOCYTIC_2	401	404	PF00928	0.350
TRG_ENDOCYTIC_2	514	517	PF00928	0.525
TRG_ER_diArg_1	169	171	PF00400	0.586
TRG_ER_diArg_1	258	260	PF00400	0.408
TRG_ER_diArg_1	287	290	PF00400	0.298
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV78	Leptomonas seymouri	50%	94%
A0A3Q8IMS6	Leishmania donovani	30%	94%
A0A3R7KFH5	Trypanosoma rangeli	28%	100%
A0A3S5H5B1	Leishmania donovani	90%	99%
A4HDK3	Leishmania braziliensis	29%	100%
A4HDK4	Leishmania braziliensis	29%	100%
A4HS49	Leishmania infantum	90%	99%
A4I0X7	Leishmania infantum	30%	100%
E9AK36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	97%
Q4QAJ3	Leishmania major	32%	95%
Q4QBX6	Leishmania major	23%	100%