Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

O97197_LEIMA

TriTrypDb:

LmjF.04.1120 , LMJLV39_040016800 , LMJSD75_040017100

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97197

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97197

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	464	468	PF00656	0.459
CLV_C14_Caspase3-7	556	560	PF00656	0.577
CLV_C14_Caspase3-7	619	623	PF00656	0.715
CLV_C14_Caspase3-7	705	709	PF00656	0.668
CLV_C14_Caspase3-7	723	727	PF00656	0.675
CLV_NRD_NRD_1	132	134	PF00675	0.475
CLV_NRD_NRD_1	168	170	PF00675	0.591
CLV_NRD_NRD_1	234	236	PF00675	0.714
CLV_NRD_NRD_1	308	310	PF00675	0.653
CLV_NRD_NRD_1	427	429	PF00675	0.470
CLV_NRD_NRD_1	508	510	PF00675	0.468
CLV_NRD_NRD_1	523	525	PF00675	0.458
CLV_NRD_NRD_1	60	62	PF00675	0.527
CLV_NRD_NRD_1	64	66	PF00675	0.538
CLV_NRD_NRD_1	677	679	PF00675	0.705
CLV_NRD_NRD_1	729	731	PF00675	0.669
CLV_NRD_NRD_1	782	784	PF00675	0.564
CLV_NRD_NRD_1	798	800	PF00675	0.472
CLV_NRD_NRD_1	839	841	PF00675	0.718
CLV_PCSK_FUR_1	129	133	PF00082	0.478
CLV_PCSK_KEX2_1	131	133	PF00082	0.480
CLV_PCSK_KEX2_1	168	170	PF00082	0.587
CLV_PCSK_KEX2_1	308	310	PF00082	0.653
CLV_PCSK_KEX2_1	381	383	PF00082	0.450
CLV_PCSK_KEX2_1	388	390	PF00082	0.447
CLV_PCSK_KEX2_1	512	514	PF00082	0.489
CLV_PCSK_KEX2_1	523	525	PF00082	0.506
CLV_PCSK_KEX2_1	60	62	PF00082	0.527
CLV_PCSK_KEX2_1	64	66	PF00082	0.538
CLV_PCSK_KEX2_1	677	679	PF00082	0.799
CLV_PCSK_KEX2_1	729	731	PF00082	0.669
CLV_PCSK_KEX2_1	744	746	PF00082	0.555
CLV_PCSK_KEX2_1	781	783	PF00082	0.590
CLV_PCSK_KEX2_1	796	798	PF00082	0.476
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.450
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.447
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.475
CLV_PCSK_PC1ET2_1	744	746	PF00082	0.673
CLV_PCSK_PC1ET2_1	796	798	PF00082	0.476
CLV_PCSK_PC7_1	304	310	PF00082	0.653
CLV_PCSK_PC7_1	60	66	PF00082	0.523
CLV_PCSK_SKI1_1	100	104	PF00082	0.430
CLV_PCSK_SKI1_1	133	137	PF00082	0.478
CLV_PCSK_SKI1_1	28	32	PF00082	0.457
CLV_PCSK_SKI1_1	385	389	PF00082	0.472
CLV_PCSK_SKI1_1	413	417	PF00082	0.438
CLV_PCSK_SKI1_1	449	453	PF00082	0.465
CLV_PCSK_SKI1_1	498	502	PF00082	0.439
CLV_PCSK_SKI1_1	548	552	PF00082	0.452
CLV_PCSK_SKI1_1	648	652	PF00082	0.588
CLV_PCSK_SKI1_1	677	681	PF00082	0.702
CLV_PCSK_SKI1_1	75	79	PF00082	0.468
CLV_PCSK_SKI1_1	82	86	PF00082	0.434
CLV_PCSK_SKI1_1	841	845	PF00082	0.685
CLV_PCSK_SKI1_1	869	873	PF00082	0.641
DEG_APCC_DBOX_1	132	140	PF00400	0.474
DEG_APCC_DBOX_1	22	30	PF00400	0.455
DEG_APCC_KENBOX_2	814	818	PF00400	0.689
DEG_Nend_Nbox_1	1	3	PF02207	0.446
DEG_SIAH_1	694	702	PF03145	0.611
DEG_SPOP_SBC_1	770	774	PF00917	0.552
DOC_CKS1_1	163	168	PF01111	0.667
DOC_CKS1_1	871	876	PF01111	0.630
DOC_CKS1_1	96	101	PF01111	0.439
DOC_CYCLIN_RxL_1	23	33	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.451
DOC_MAPK_DCC_7	23	31	PF00069	0.456
DOC_MAPK_DCC_7	694	704	PF00069	0.682
DOC_MAPK_gen_1	801	809	PF00069	0.586
DOC_MAPK_MEF2A_6	23	31	PF00069	0.456
DOC_PP1_RVXF_1	780	787	PF00149	0.550
DOC_PP2B_LxvP_1	93	96	PF13499	0.437
DOC_PP4_FxxP_1	85	88	PF00568	0.430
DOC_USP7_MATH_1	161	165	PF00917	0.621
DOC_USP7_MATH_1	196	200	PF00917	0.479
DOC_USP7_MATH_1	210	214	PF00917	0.587
DOC_USP7_MATH_1	272	276	PF00917	0.687
DOC_USP7_MATH_1	283	287	PF00917	0.802
DOC_USP7_MATH_1	307	311	PF00917	0.610
DOC_USP7_MATH_1	316	320	PF00917	0.630
DOC_USP7_MATH_1	633	637	PF00917	0.644
DOC_USP7_MATH_1	656	660	PF00917	0.601
DOC_USP7_MATH_1	667	671	PF00917	0.578
DOC_USP7_MATH_1	703	707	PF00917	0.809
DOC_USP7_MATH_1	753	757	PF00917	0.683
DOC_USP7_MATH_1	761	765	PF00917	0.594
DOC_USP7_MATH_1	769	773	PF00917	0.562
DOC_USP7_MATH_1	832	836	PF00917	0.637
DOC_USP7_UBL2_3	815	819	PF12436	0.696
DOC_WW_Pin1_4	162	167	PF00397	0.593
DOC_WW_Pin1_4	194	199	PF00397	0.474
DOC_WW_Pin1_4	202	207	PF00397	0.544
DOC_WW_Pin1_4	274	279	PF00397	0.616
DOC_WW_Pin1_4	303	308	PF00397	0.650
DOC_WW_Pin1_4	312	317	PF00397	0.673
DOC_WW_Pin1_4	590	595	PF00397	0.633
DOC_WW_Pin1_4	640	645	PF00397	0.695
DOC_WW_Pin1_4	759	764	PF00397	0.565
DOC_WW_Pin1_4	870	875	PF00397	0.631
DOC_WW_Pin1_4	95	100	PF00397	0.483
LIG_14-3-3_CanoR_1	100	106	PF00244	0.448
LIG_14-3-3_CanoR_1	107	113	PF00244	0.430
LIG_14-3-3_CanoR_1	188	194	PF00244	0.637
LIG_14-3-3_CanoR_1	23	27	PF00244	0.430
LIG_14-3-3_CanoR_1	285	293	PF00244	0.628
LIG_14-3-3_CanoR_1	308	316	PF00244	0.626
LIG_14-3-3_CanoR_1	36	46	PF00244	0.430
LIG_14-3-3_CanoR_1	4	12	PF00244	0.451
LIG_14-3-3_CanoR_1	524	534	PF00244	0.437
LIG_14-3-3_CanoR_1	648	658	PF00244	0.656
LIG_14-3-3_CanoR_1	70	78	PF00244	0.487
LIG_Actin_RPEL_3	126	145	PF02755	0.476
LIG_Actin_WH2_2	123	139	PF00022	0.471
LIG_AP2alpha_2	44	46	PF02296	0.445
LIG_BIR_III_2	195	199	PF00653	0.481
LIG_BRCT_BRCA1_1	379	383	PF00533	0.419
LIG_FHA_1	652	658	PF00498	0.675
LIG_FHA_1	773	779	PF00498	0.611
LIG_FHA_1	785	791	PF00498	0.414
LIG_FHA_2	171	177	PF00498	0.554
LIG_FHA_2	218	224	PF00498	0.572
LIG_FHA_2	373	379	PF00498	0.429
LIG_FHA_2	516	522	PF00498	0.515
LIG_FHA_2	617	623	PF00498	0.684
LIG_FHA_2	650	656	PF00498	0.629
LIG_FHA_2	703	709	PF00498	0.664
LIG_FHA_2	732	738	PF00498	0.650
LIG_GSK3_LRP6_1	594	599	PF00069	0.629
LIG_Integrin_isoDGR_2	245	247	PF01839	0.575
LIG_LIR_Apic_2	622	628	PF02991	0.706
LIG_LIR_Apic_2	661	667	PF02991	0.639
LIG_LIR_Gen_1	156	167	PF02991	0.625
LIG_LIR_Gen_1	327	334	PF02991	0.453
LIG_LIR_Gen_1	427	434	PF02991	0.489
LIG_LIR_Gen_1	44	51	PF02991	0.460
LIG_LIR_Gen_1	478	485	PF02991	0.432
LIG_LIR_Nem_3	156	162	PF02991	0.629
LIG_LIR_Nem_3	327	331	PF02991	0.459
LIG_LIR_Nem_3	427	433	PF02991	0.488
LIG_LIR_Nem_3	44	49	PF02991	0.457
LIG_LIR_Nem_3	478	484	PF02991	0.433
LIG_MYND_1	864	868	PF01753	0.614
LIG_NRBOX	465	471	PF00104	0.455
LIG_PCNA_yPIPBox_3	364	376	PF02747	0.431
LIG_Pex14_2	102	106	PF04695	0.450
LIG_SH2_CRK	360	364	PF00017	0.428
LIG_SH2_CRK	625	629	PF00017	0.700
LIG_SH2_NCK_1	625	629	PF00017	0.700
LIG_SH2_PTP2	664	667	PF00017	0.631
LIG_SH2_STAP1	222	226	PF00017	0.644
LIG_SH2_STAP1	338	342	PF00017	0.519
LIG_SH2_STAP1	349	353	PF00017	0.391
LIG_SH2_STAP1	419	423	PF00017	0.437
LIG_SH2_STAP1	430	434	PF00017	0.445
LIG_SH2_STAT3	342	345	PF00017	0.447
LIG_SH2_STAT5	105	108	PF00017	0.448
LIG_SH2_STAT5	226	229	PF00017	0.669
LIG_SH2_STAT5	664	667	PF00017	0.631
LIG_SH3_2	163	168	PF14604	0.667
LIG_SH3_2	820	825	PF14604	0.692
LIG_SH3_3	160	166	PF00018	0.671
LIG_SH3_3	318	324	PF00018	0.642
LIG_SH3_3	592	598	PF00018	0.679
LIG_SH3_3	670	676	PF00018	0.653
LIG_SH3_3	695	701	PF00018	0.611
LIG_SH3_3	817	823	PF00018	0.693
LIG_SH3_3	868	874	PF00018	0.683
LIG_SH3_3	93	99	PF00018	0.463
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.560
LIG_SUMO_SIM_par_1	28	33	PF11976	0.459
LIG_SUMO_SIM_par_1	369	375	PF11976	0.430
LIG_TRAF2_1	405	408	PF00917	0.449
LIG_TYR_ITIM	326	331	PF00017	0.396
LIG_UBA3_1	480	489	PF00899	0.500
LIG_WW_2	700	703	PF00397	0.583
MOD_CDC14_SPxK_1	643	646	PF00782	0.694
MOD_CDK_SPK_2	303	308	PF00069	0.606
MOD_CDK_SPK_2	870	875	PF00069	0.583
MOD_CDK_SPK_2	95	100	PF00069	0.430
MOD_CDK_SPxK_1	162	168	PF00069	0.592
MOD_CDK_SPxK_1	303	309	PF00069	0.655
MOD_CDK_SPxK_1	640	646	PF00069	0.697
MOD_CDK_SPxxK_3	162	169	PF00069	0.591
MOD_CDK_SPxxK_3	274	281	PF00069	0.616
MOD_CK1_1	108	114	PF00069	0.431
MOD_CK1_1	147	153	PF00069	0.629
MOD_CK1_1	270	276	PF00069	0.634
MOD_CK1_1	297	303	PF00069	0.620
MOD_CK1_1	475	481	PF00069	0.436
MOD_CK1_1	585	591	PF00069	0.635
MOD_CK1_1	593	599	PF00069	0.628
MOD_CK1_1	659	665	PF00069	0.814
MOD_CK1_1	669	675	PF00069	0.608
MOD_CK1_1	684	690	PF00069	0.600
MOD_CK1_1	772	778	PF00069	0.573
MOD_CK1_1	835	841	PF00069	0.588
MOD_CK2_1	372	378	PF00069	0.438
MOD_CK2_1	47	53	PF00069	0.471
MOD_CK2_1	515	521	PF00069	0.588
MOD_CK2_1	525	531	PF00069	0.421
MOD_CK2_1	578	584	PF00069	0.543
MOD_CK2_1	60	66	PF00069	0.506
MOD_CK2_1	649	655	PF00069	0.635
MOD_CK2_1	810	816	PF00069	0.616
MOD_CK2_1	870	876	PF00069	0.632
MOD_GlcNHglycan	107	110	PF01048	0.443
MOD_GlcNHglycan	139	142	PF01048	0.678
MOD_GlcNHglycan	149	152	PF01048	0.602
MOD_GlcNHglycan	198	201	PF01048	0.489
MOD_GlcNHglycan	212	215	PF01048	0.604
MOD_GlcNHglycan	230	233	PF01048	0.550
MOD_GlcNHglycan	236	239	PF01048	0.708
MOD_GlcNHglycan	242	245	PF01048	0.642
MOD_GlcNHglycan	270	273	PF01048	0.784
MOD_GlcNHglycan	412	416	PF01048	0.508
MOD_GlcNHglycan	49	52	PF01048	0.484
MOD_GlcNHglycan	577	583	PF01048	0.561
MOD_GlcNHglycan	635	638	PF01048	0.756
MOD_GlcNHglycan	658	661	PF01048	0.740
MOD_GlcNHglycan	681	684	PF01048	0.719
MOD_GlcNHglycan	722	725	PF01048	0.758
MOD_GlcNHglycan	751	754	PF01048	0.699
MOD_GlcNHglycan	763	766	PF01048	0.725
MOD_GSK3_1	101	108	PF00069	0.447
MOD_GSK3_1	145	152	PF00069	0.612
MOD_GSK3_1	222	229	PF00069	0.567
MOD_GSK3_1	230	237	PF00069	0.614
MOD_GSK3_1	268	275	PF00069	0.708
MOD_GSK3_1	292	299	PF00069	0.752
MOD_GSK3_1	303	310	PF00069	0.610
MOD_GSK3_1	312	319	PF00069	0.518
MOD_GSK3_1	389	396	PF00069	0.446
MOD_GSK3_1	457	464	PF00069	0.514
MOD_GSK3_1	56	63	PF00069	0.514
MOD_GSK3_1	578	585	PF00069	0.650
MOD_GSK3_1	586	593	PF00069	0.597
MOD_GSK3_1	677	684	PF00069	0.658
MOD_GSK3_1	703	710	PF00069	0.691
MOD_GSK3_1	745	752	PF00069	0.701
MOD_GSK3_1	769	776	PF00069	0.627
MOD_LATS_1	58	64	PF00433	0.514
MOD_N-GLC_1	257	262	PF02516	0.611
MOD_N-GLC_1	267	272	PF02516	0.609
MOD_N-GLC_1	37	42	PF02516	0.444
MOD_N-GLC_1	582	587	PF02516	0.642
MOD_NEK2_1	144	149	PF00069	0.543
MOD_NEK2_1	19	24	PF00069	0.465
MOD_NEK2_1	230	235	PF00069	0.596
MOD_NEK2_1	267	272	PF00069	0.602
MOD_NEK2_1	302	307	PF00069	0.629
MOD_NEK2_1	37	42	PF00069	0.422
MOD_NEK2_1	391	396	PF00069	0.448
MOD_NEK2_1	411	416	PF00069	0.306
MOD_NEK2_1	562	567	PF00069	0.687
MOD_NEK2_1	679	684	PF00069	0.589
MOD_NEK2_1	784	789	PF00069	0.663
MOD_NEK2_2	709	714	PF00069	0.624
MOD_NEK2_2	89	94	PF00069	0.451
MOD_PIKK_1	461	467	PF00454	0.470
MOD_PIKK_1	681	687	PF00454	0.662
MOD_PIKK_1	70	76	PF00454	0.485
MOD_PKA_1	308	314	PF00069	0.651
MOD_PKA_1	60	66	PF00069	0.523
MOD_PKA_1	677	683	PF00069	0.659
MOD_PKA_1	744	750	PF00069	0.593
MOD_PKA_2	13	19	PF00069	0.462
MOD_PKA_2	187	193	PF00069	0.475
MOD_PKA_2	22	28	PF00069	0.444
MOD_PKA_2	234	240	PF00069	0.712
MOD_PKA_2	246	252	PF00069	0.548
MOD_PKA_2	307	313	PF00069	0.628
MOD_PKA_2	60	66	PF00069	0.528
MOD_PKA_2	677	683	PF00069	0.705
MOD_PKA_2	728	734	PF00069	0.579
MOD_PKA_2	744	750	PF00069	0.583
MOD_PKB_1	34	42	PF00069	0.447
MOD_PKB_1	646	654	PF00069	0.660
MOD_PKB_1	68	76	PF00069	0.487
MOD_Plk_1	182	188	PF00069	0.491
MOD_Plk_1	222	228	PF00069	0.552
MOD_Plk_1	260	266	PF00069	0.624
MOD_Plk_1	37	43	PF00069	0.445
MOD_Plk_1	449	455	PF00069	0.548
MOD_Plk_1	515	521	PF00069	0.548
MOD_Plk_2-3	810	816	PF00069	0.520
MOD_Plk_4	101	107	PF00069	0.448
MOD_Plk_4	222	228	PF00069	0.601
MOD_Plk_4	38	44	PF00069	0.445
MOD_Plk_4	443	449	PF00069	0.456
MOD_Plk_4	465	471	PF00069	0.455
MOD_Plk_4	540	546	PF00069	0.441
MOD_Plk_4	669	675	PF00069	0.613
MOD_ProDKin_1	162	168	PF00069	0.592
MOD_ProDKin_1	194	200	PF00069	0.472
MOD_ProDKin_1	202	208	PF00069	0.550
MOD_ProDKin_1	274	280	PF00069	0.615
MOD_ProDKin_1	303	309	PF00069	0.650
MOD_ProDKin_1	312	318	PF00069	0.671
MOD_ProDKin_1	590	596	PF00069	0.633
MOD_ProDKin_1	640	646	PF00069	0.697
MOD_ProDKin_1	759	765	PF00069	0.565
MOD_ProDKin_1	870	876	PF00069	0.632
MOD_ProDKin_1	95	101	PF00069	0.485
MOD_SUMO_for_1	387	390	PF00179	0.448
MOD_SUMO_for_1	409	412	PF00179	0.437
MOD_SUMO_rev_2	374	383	PF00179	0.433
MOD_SUMO_rev_2	407	411	PF00179	0.440
MOD_SUMO_rev_2	435	442	PF00179	0.444
MOD_SUMO_rev_2	492	500	PF00179	0.509
TRG_DiLeu_BaEn_3	378	384	PF01217	0.439
TRG_ENDOCYTIC_2	159	162	PF00928	0.678
TRG_ENDOCYTIC_2	328	331	PF00928	0.454
TRG_ENDOCYTIC_2	338	341	PF00928	0.449
TRG_ENDOCYTIC_2	349	352	PF00928	0.422
TRG_ENDOCYTIC_2	360	363	PF00928	0.500
TRG_ENDOCYTIC_2	419	422	PF00928	0.437
TRG_ENDOCYTIC_2	430	433	PF00928	0.446
TRG_ER_diArg_1	128	131	PF00400	0.473
TRG_ER_diArg_1	167	169	PF00400	0.588
TRG_ER_diArg_1	307	309	PF00400	0.651
TRG_ER_diArg_1	34	37	PF00400	0.454
TRG_ER_diArg_1	395	398	PF00400	0.457
TRG_ER_diArg_1	645	648	PF00400	0.661
TRG_ER_diArg_1	67	70	PF00400	0.508
TRG_ER_diArg_1	676	678	PF00400	0.696
TRG_ER_diArg_1	781	783	PF00400	0.590
TRG_ER_diArg_1	797	799	PF00400	0.479
TRG_NES_CRM1_1	542	556	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	801	805	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I386	Leptomonas seymouri	51%	100%
A0A3S5H5E8	Leishmania donovani	92%	100%
A4H426	Leishmania braziliensis	78%	100%
A4HSB0	Leishmania infantum	92%	100%
E9AK93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%