LeishMANIAdb
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NADH-ubiquinone oxidoreductase subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
NADH-ubiquinone oxidoreductase subunit
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
O97194_LEIMA
TriTrypDb:
LmjF.04.1150 , LMJLV39_040017100 , LMJSD75_040017400
Length:
168

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97194
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97194

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 74 78 PF00656 0.591
CLV_NRD_NRD_1 160 162 PF00675 0.675
CLV_PCSK_KEX2_1 160 162 PF00082 0.603
CLV_PCSK_SKI1_1 139 143 PF00082 0.557
CLV_PCSK_SKI1_1 154 158 PF00082 0.449
CLV_PCSK_SKI1_1 89 93 PF00082 0.539
DEG_COP1_1 90 99 PF00400 0.510
DOC_CYCLIN_RxL_1 151 159 PF00134 0.510
DOC_MAPK_gen_1 19 27 PF00069 0.409
DOC_PP4_FxxP_1 5 8 PF00568 0.541
DOC_WW_Pin1_4 143 148 PF00397 0.478
DOC_WW_Pin1_4 162 167 PF00397 0.545
DOC_WW_Pin1_4 89 94 PF00397 0.578
LIG_14-3-3_CanoR_1 108 113 PF00244 0.526
LIG_14-3-3_CanoR_1 139 149 PF00244 0.567
LIG_FHA_1 42 48 PF00498 0.625
LIG_FHA_1 50 56 PF00498 0.496
LIG_LIR_Gen_1 15 25 PF02991 0.442
LIG_LIR_Nem_3 101 107 PF02991 0.615
LIG_LIR_Nem_3 15 20 PF02991 0.448
LIG_SH2_CRK 104 108 PF00017 0.540
LIG_SH2_STAT5 95 98 PF00017 0.519
LIG_SH3_3 94 100 PF00018 0.646
LIG_UBA3_1 16 21 PF00899 0.386
MOD_CK1_1 129 135 PF00069 0.540
MOD_CK1_1 15 21 PF00069 0.443
MOD_CMANNOS 46 49 PF00535 0.429
MOD_GlcNHglycan 100 103 PF01048 0.615
MOD_GlcNHglycan 114 119 PF01048 0.430
MOD_NEK2_1 156 161 PF00069 0.515
MOD_PKA_2 49 55 PF00069 0.506
MOD_Plk_4 12 18 PF00069 0.515
MOD_ProDKin_1 143 149 PF00069 0.476
MOD_ProDKin_1 162 168 PF00069 0.556
MOD_ProDKin_1 89 95 PF00069 0.581
MOD_SUMO_for_1 141 144 PF00179 0.564
TRG_DiLeu_BaEn_1 115 120 PF01217 0.474
TRG_ENDOCYTIC_2 104 107 PF00928 0.592
TRG_ER_diArg_1 160 162 PF00400 0.634
TRG_ER_diArg_1 83 86 PF00400 0.522

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P452 Leptomonas seymouri 78% 100%
A0A1X0NLB3 Trypanosomatidae 56% 100%
A0A3S7WNX8 Leishmania donovani 97% 100%
A4H429 Leishmania braziliensis 89% 100%
A4HSB3 Leishmania infantum 97% 100%
E9AK96 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5DEI9 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS