Fructose-bisphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fructose-1,6-bisphosphatase

Species:

Leishmania major

UniProt:

O97193_LEIMA

TriTrypDb:

LmjF.04.1160 , LMJLV39_040017200 , LMJSD75_040017500

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

O97193

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97193

PDB structure(s): 5oey_A , 5oey_B , 5oey_C , 5oey_D , 5oez_A , 5oez_B , 5oez_C , 5oez_D , 5ofu_A , 5ofu_B , 5ofu_C , 5ofu_D

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005984	disaccharide metabolic process	4	2
GO:0005985	sucrose metabolic process	5	2
GO:0005986	sucrose biosynthetic process	6	2
GO:0005996	monosaccharide metabolic process	3	2
GO:0006000	fructose metabolic process	5	2
GO:0006002	fructose 6-phosphate metabolic process	4	2
GO:0006006	glucose metabolic process	5	2
GO:0006094	gluconeogenesis	6	2
GO:0006793	phosphorus metabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0019203	carbohydrate phosphatase activity	6	12
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	8	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.426
CLV_NRD_NRD_1	109	111	PF00675	0.232
CLV_NRD_NRD_1	4	6	PF00675	0.619
CLV_NRD_NRD_1	47	49	PF00675	0.291
CLV_PCSK_KEX2_1	109	111	PF00082	0.232
CLV_PCSK_KEX2_1	211	213	PF00082	0.333
CLV_PCSK_KEX2_1	4	6	PF00082	0.619
CLV_PCSK_KEX2_1	47	49	PF00082	0.291
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.331
CLV_PCSK_SKI1_1	158	162	PF00082	0.299

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R2	Leptomonas seymouri	81%	100%
A0A0S4JL09	Bodo saltans	31%	100%
A0A0S4JUU8	Bodo saltans	57%	100%
A0A1X0NML3	Trypanosomatidae	65%	100%
A0A1X0NRD7	Trypanosomatidae	30%	100%
A0A3R7N9Y6	Trypanosoma rangeli	30%	100%
A0A3S5H5F1	Leishmania donovani	97%	100%
A0A422NP15	Trypanosoma rangeli	65%	100%
A0K5J0	Burkholderia cenocepacia (strain HI2424)	41%	100%
A0KJT2	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	46%	100%

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