PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

O97009_LEIMA

TriTrypDb:

LmjF.04.0920 , LMJLV39_040014700 , LMJSD75_040015100

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97009

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97009

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.666
CLV_C14_Caspase3-7	251	255	PF00656	0.677
CLV_C14_Caspase3-7	335	339	PF00656	0.563
CLV_C14_Caspase3-7	53	57	PF00656	0.710
CLV_NRD_NRD_1	108	110	PF00675	0.643
CLV_NRD_NRD_1	170	172	PF00675	0.667
CLV_NRD_NRD_1	265	267	PF00675	0.707
CLV_NRD_NRD_1	35	37	PF00675	0.674
CLV_NRD_NRD_1	66	68	PF00675	0.711
CLV_PCSK_KEX2_1	170	172	PF00082	0.667
CLV_PCSK_KEX2_1	265	267	PF00082	0.679
CLV_PCSK_KEX2_1	35	37	PF00082	0.674
CLV_PCSK_KEX2_1	66	68	PF00082	0.711
CLV_PCSK_SKI1_1	580	584	PF00082	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.694
DEG_SCF_FBW7_1	45	51	PF00400	0.632
DEG_SPOP_SBC_1	147	151	PF00917	0.662
DEG_SPOP_SBC_1	248	252	PF00917	0.592
DEG_SPOP_SBC_1	398	402	PF00917	0.677
DEG_SPOP_SBC_1	418	422	PF00917	0.546
DEG_SPOP_SBC_1	80	84	PF00917	0.686
DOC_CKS1_1	317	322	PF01111	0.629
DOC_CKS1_1	45	50	PF01111	0.543
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	574	577	PF00134	0.513
DOC_MAPK_gen_1	380	389	PF00069	0.694
DOC_MAPK_MEF2A_6	35	42	PF00069	0.670
DOC_MAPK_MEF2A_6	380	389	PF00069	0.694
DOC_PP2B_LxvP_1	133	136	PF13499	0.563
DOC_PP2B_LxvP_1	574	577	PF13499	0.534
DOC_USP7_MATH_1	147	151	PF00917	0.662
DOC_USP7_MATH_1	247	251	PF00917	0.591
DOC_USP7_MATH_1	370	374	PF00917	0.699
DOC_USP7_MATH_1	383	387	PF00917	0.539
DOC_USP7_MATH_1	411	415	PF00917	0.670
DOC_USP7_MATH_1	465	469	PF00917	0.648
DOC_USP7_MATH_1	582	586	PF00917	0.550
DOC_USP7_MATH_1	80	84	PF00917	0.809
DOC_USP7_MATH_2	5	11	PF00917	0.626
DOC_WW_Pin1_4	218	223	PF00397	0.667
DOC_WW_Pin1_4	275	280	PF00397	0.651
DOC_WW_Pin1_4	316	321	PF00397	0.626
DOC_WW_Pin1_4	439	444	PF00397	0.691
DOC_WW_Pin1_4	44	49	PF00397	0.635
DOC_WW_Pin1_4	461	466	PF00397	0.682
DOC_WW_Pin1_4	8	13	PF00397	0.658
DOC_WW_Pin1_4	81	86	PF00397	0.613
LIG_14-3-3_CanoR_1	183	188	PF00244	0.676
LIG_14-3-3_CanoR_1	293	302	PF00244	0.586
LIG_14-3-3_CanoR_1	347	354	PF00244	0.679
LIG_14-3-3_CanoR_1	548	552	PF00244	0.556
LIG_Clathr_ClatBox_1	450	454	PF01394	0.713
LIG_EVH1_1	24	28	PF00568	0.660
LIG_FHA_1	418	424	PF00498	0.729
LIG_FHA_1	49	55	PF00498	0.703
LIG_FHA_1	561	567	PF00498	0.515
LIG_FHA_1	60	66	PF00498	0.596
LIG_FHA_2	333	339	PF00498	0.708
LIG_FHA_2	51	57	PF00498	0.709
LIG_GBD_Chelix_1	125	133	PF00786	0.530
LIG_LIR_Apic_2	7	12	PF02991	0.600
LIG_LIR_Gen_1	512	522	PF02991	0.766
LIG_LIR_Nem_3	299	305	PF02991	0.567
LIG_LIR_Nem_3	512	517	PF02991	0.772
LIG_NRBOX	128	134	PF00104	0.535
LIG_PDZ_Class_2	594	599	PF00595	0.533
LIG_Pex14_2	120	124	PF04695	0.545
LIG_SH2_PTP2	93	96	PF00017	0.743
LIG_SH2_STAP1	302	306	PF00017	0.555
LIG_SH2_STAP1	514	518	PF00017	0.776
LIG_SH2_STAT3	305	308	PF00017	0.637
LIG_SH2_STAT5	305	308	PF00017	0.630
LIG_SH2_STAT5	514	517	PF00017	0.678
LIG_SH2_STAT5	93	96	PF00017	0.743
LIG_SH3_3	109	115	PF00018	0.685
LIG_SH3_3	187	193	PF00018	0.605
LIG_SH3_3	22	28	PF00018	0.660
LIG_SH3_3	357	363	PF00018	0.665
LIG_SH3_3	410	416	PF00018	0.578
LIG_SH3_3	42	48	PF00018	0.505
LIG_SH3_3	438	444	PF00018	0.626
LIG_SH3_3	523	529	PF00018	0.633
LIG_SH3_3	82	88	PF00018	0.618
LIG_SUMO_SIM_par_1	50	56	PF11976	0.706
LIG_TRAF2_1	469	472	PF00917	0.757
LIG_TYR_ITIM	91	96	PF00017	0.588
MOD_CDK_SPxxK_3	439	446	PF00069	0.665
MOD_CDK_SPxxK_3	463	470	PF00069	0.727
MOD_CK1_1	10	16	PF00069	0.622
MOD_CK1_1	146	152	PF00069	0.804
MOD_CK1_1	181	187	PF00069	0.654
MOD_CK1_1	231	237	PF00069	0.799
MOD_CK1_1	373	379	PF00069	0.699
MOD_CK1_1	414	420	PF00069	0.792
MOD_CK1_1	512	518	PF00069	0.678
MOD_CK2_1	183	189	PF00069	0.852
MOD_CK2_1	439	445	PF00069	0.663
MOD_CK2_1	465	471	PF00069	0.776
MOD_Cter_Amidation	107	110	PF01082	0.602
MOD_DYRK1A_RPxSP_1	220	224	PF00069	0.678
MOD_GlcNHglycan	139	142	PF01048	0.651
MOD_GlcNHglycan	145	148	PF01048	0.661
MOD_GlcNHglycan	161	164	PF01048	0.513
MOD_GlcNHglycan	17	20	PF01048	0.689
MOD_GlcNHglycan	174	177	PF01048	0.614
MOD_GlcNHglycan	251	254	PF01048	0.791
MOD_GlcNHglycan	261	264	PF01048	0.649
MOD_GlcNHglycan	29	32	PF01048	0.574
MOD_GlcNHglycan	349	352	PF01048	0.679
MOD_GlcNHglycan	372	375	PF01048	0.640
MOD_GlcNHglycan	406	409	PF01048	0.668
MOD_GlcNHglycan	433	436	PF01048	0.695
MOD_GlcNHglycan	483	488	PF01048	0.800
MOD_GSK3_1	143	150	PF00069	0.690
MOD_GSK3_1	178	185	PF00069	0.636
MOD_GSK3_1	214	221	PF00069	0.727
MOD_GSK3_1	228	235	PF00069	0.634
MOD_GSK3_1	285	292	PF00069	0.677
MOD_GSK3_1	398	405	PF00069	0.666
MOD_GSK3_1	414	421	PF00069	0.560
MOD_GSK3_1	429	436	PF00069	0.714
MOD_GSK3_1	44	51	PF00069	0.716
MOD_GSK3_1	461	468	PF00069	0.720
MOD_GSK3_1	478	485	PF00069	0.815
MOD_GSK3_1	496	503	PF00069	0.715
MOD_GSK3_1	512	519	PF00069	0.579
MOD_GSK3_1	74	81	PF00069	0.625
MOD_LATS_1	323	329	PF00433	0.582
MOD_N-GLC_1	159	164	PF02516	0.714
MOD_N-GLC_1	461	466	PF02516	0.731
MOD_N-GLC_1	78	83	PF02516	0.616
MOD_NEK2_1	120	125	PF00069	0.544
MOD_NEK2_1	143	148	PF00069	0.701
MOD_NEK2_1	232	237	PF00069	0.729
MOD_NEK2_2	383	388	PF00069	0.641
MOD_PIKK_1	285	291	PF00454	0.681
MOD_PIKK_1	332	338	PF00454	0.708
MOD_PKA_2	182	188	PF00069	0.672
MOD_PKA_2	248	254	PF00069	0.695
MOD_PKA_2	500	506	PF00069	0.718
MOD_PKA_2	512	518	PF00069	0.548
MOD_PKA_2	547	553	PF00069	0.549
MOD_Plk_1	120	126	PF00069	0.539
MOD_Plk_1	159	165	PF00069	0.712
MOD_Plk_1	228	234	PF00069	0.701
MOD_Plk_1	497	503	PF00069	0.692
MOD_Plk_4	120	126	PF00069	0.539
MOD_Plk_4	383	389	PF00069	0.694
MOD_ProDKin_1	218	224	PF00069	0.662
MOD_ProDKin_1	275	281	PF00069	0.650
MOD_ProDKin_1	316	322	PF00069	0.627
MOD_ProDKin_1	439	445	PF00069	0.689
MOD_ProDKin_1	44	50	PF00069	0.635
MOD_ProDKin_1	461	467	PF00069	0.678
MOD_ProDKin_1	8	14	PF00069	0.654
MOD_ProDKin_1	81	87	PF00069	0.610
TRG_DiLeu_BaEn_2	591	597	PF01217	0.474
TRG_DiLeu_BaEn_4	341	347	PF01217	0.689
TRG_DiLeu_BaEn_4	473	479	PF01217	0.682
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.536
TRG_ENDOCYTIC_2	514	517	PF00928	0.777
TRG_ENDOCYTIC_2	93	96	PF00928	0.588
TRG_ER_diArg_1	34	36	PF00400	0.682
TRG_ER_diArg_1	65	67	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	573	578	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V5	Leptomonas seymouri	39%	100%
A0A3S7WNU3	Leishmania donovani	91%	100%
A4H3Y5	Leishmania braziliensis	75%	100%
E9AK73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%