Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

O97008_LEIMA

TriTrypDb:

LmjF.04.0910 , LMJLV39_040014600 , LMJSD75_040015000

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97008

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97008

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	230	238	PF00400	0.391
DOC_MAPK_MEF2A_6	198	207	PF00069	0.333
DOC_PP2B_LxvP_1	184	187	PF13499	0.405
DOC_PP2B_LxvP_1	92	95	PF13499	0.636
DOC_USP7_MATH_1	111	115	PF00917	0.561
DOC_USP7_MATH_1	14	18	PF00917	0.559
DOC_USP7_MATH_1	145	149	PF00917	0.534
DOC_USP7_MATH_1	187	191	PF00917	0.441
DOC_USP7_MATH_1	44	48	PF00917	0.400
DOC_WW_Pin1_4	162	167	PF00397	0.517
DOC_WW_Pin1_4	168	173	PF00397	0.703
DOC_WW_Pin1_4	174	179	PF00397	0.501
DOC_WW_Pin1_4	64	69	PF00397	0.644
LIG_14-3-3_CanoR_1	227	235	PF00244	0.426
LIG_14-3-3_CanoR_1	5	10	PF00244	0.560
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BRCT_BRCA1_1	189	193	PF00533	0.330
LIG_FHA_1	16	22	PF00498	0.586
LIG_GSK3_LRP6_1	162	167	PF00069	0.503
LIG_LIR_Gen_1	148	157	PF02991	0.724
LIG_LIR_Gen_1	190	200	PF02991	0.394
LIG_LIR_Gen_1	201	210	PF02991	0.382
LIG_LIR_Gen_1	25	33	PF02991	0.400
LIG_LIR_LC3C_4	201	205	PF02991	0.382
LIG_LIR_Nem_3	148	152	PF02991	0.699
LIG_LIR_Nem_3	190	196	PF02991	0.422
LIG_LIR_Nem_3	201	205	PF02991	0.368
LIG_LIR_Nem_3	25	29	PF02991	0.396
LIG_LIR_Nem_3	78	83	PF02991	0.594
LIG_LYPXL_yS_3	80	83	PF13949	0.593
LIG_PDZ_Class_2	243	248	PF00595	0.381
LIG_SH2_CRK	149	153	PF00017	0.722
LIG_SH2_NCK_1	149	153	PF00017	0.610
LIG_SH2_PTP2	26	29	PF00017	0.384
LIG_SH2_STAP1	149	153	PF00017	0.566
LIG_SH2_STAT5	215	218	PF00017	0.573
LIG_SH2_STAT5	26	29	PF00017	0.384
LIG_SH2_STAT5	58	61	PF00017	0.500
LIG_SH3_3	116	122	PF00018	0.616
LIG_SH3_3	157	163	PF00018	0.584
LIG_SH3_3	170	176	PF00018	0.708
LIG_SH3_3	34	40	PF00018	0.371
LIG_TYR_ITIM	24	29	PF00017	0.439
MOD_CK1_1	25	31	PF00069	0.458
MOD_CK1_1	4	10	PF00069	0.555
MOD_CK1_1	97	103	PF00069	0.656
MOD_GlcNHglycan	102	105	PF01048	0.636
MOD_GlcNHglycan	113	116	PF01048	0.537
MOD_GlcNHglycan	96	99	PF01048	0.654
MOD_GSK3_1	1	8	PF00069	0.663
MOD_GSK3_1	162	169	PF00069	0.663
MOD_GSK3_1	187	194	PF00069	0.398
MOD_GSK3_1	94	101	PF00069	0.673
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	167	172	PF00069	0.626
MOD_NEK2_1	191	196	PF00069	0.368
MOD_PKA_2	226	232	PF00069	0.433
MOD_PKA_2	4	10	PF00069	0.593
MOD_Plk_1	191	197	PF00069	0.369
MOD_Plk_2-3	226	232	PF00069	0.514
MOD_Plk_4	192	198	PF00069	0.449
MOD_Plk_4	22	28	PF00069	0.433
MOD_ProDKin_1	162	168	PF00069	0.524
MOD_ProDKin_1	174	180	PF00069	0.538
MOD_ProDKin_1	64	70	PF00069	0.651
MOD_SUMO_rev_2	114	119	PF00179	0.659
MOD_SUMO_rev_2	28	37	PF00179	0.410
TRG_DiLeu_BaEn_1	192	197	PF01217	0.451
TRG_DiLeu_BaEn_1	230	235	PF01217	0.500
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.587
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.572
TRG_ENDOCYTIC_2	149	152	PF00928	0.687
TRG_ENDOCYTIC_2	26	29	PF00928	0.423
TRG_ENDOCYTIC_2	80	83	PF00928	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P497	Leptomonas seymouri	50%	100%
A0A3S7WNU9	Leishmania donovani	92%	100%
A4H3Y4	Leishmania braziliensis	74%	100%
A4HS84	Leishmania infantum	91%	100%
E9AK72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%