Putative tRNA nucleotidyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA nucleotidyltransferase, putative

Species:

Leishmania major

UniProt:

O97001_LEIMA

TriTrypDb:

LmjF.04.1190 , LMJLV39_040017600 , LMJSD75_040017900

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

O97001

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97001

Function

Biological processes
Term	Name	Level	Count
GO:0001680	tRNA 3'-terminal CCA addition	9	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0031123	RNA 3'-end processing	7	12
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	11
GO:0042780	tRNA 3'-end processing	8	11
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071076	RNA 3' uridylation	8	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	13
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	4
GO:0004810	CCA tRNA nucleotidyltransferase activity	8	4
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0050265	RNA uridylyltransferase activity	4	12
GO:0052929	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity	9	4
GO:0070566	adenylyltransferase activity	5	4
GO:0070569	uridylyltransferase activity	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:1990817	poly(A) RNA polymerase activity	7	4
GO:0052927	CTP:tRNA cytidylyltransferase activity	5	2
GO:0070567	cytidylyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.256
CLV_NRD_NRD_1	374	376	PF00675	0.350
CLV_NRD_NRD_1	403	405	PF00675	0.479
CLV_PCSK_KEX2_1	146	148	PF00082	0.256
CLV_PCSK_KEX2_1	301	303	PF00082	0.514
CLV_PCSK_KEX2_1	374	376	PF00082	0.358
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.514
CLV_PCSK_SKI1_1	147	151	PF00082	0.289
CLV_PCSK_SKI1_1	345	349	PF00082	0.543
CLV_PCSK_SKI1_1	404	408	PF00082	0.425
CLV_PCSK_SKI1_1	416	420	PF00082	0.375
CLV_PCSK_SKI1_1	44	48	PF00082	0.276
CLV_PCSK_SKI1_1	501	505	PF00082	0.459
CLV_PCSK_SKI1_1	66	70	PF00082	0.330
DEG_APCC_DBOX_1	419	427	PF00400	0.440
DEG_APCC_DBOX_1	43	51	PF00400	0.480
DEG_MDM2_SWIB_1	452	459	PF02201	0.491
DOC_MAPK_gen_1	301	309	PF00069	0.490
DOC_MAPK_gen_1	31	38	PF00069	0.396
DOC_MAPK_gen_1	404	412	PF00069	0.485
DOC_MAPK_gen_1	497	504	PF00069	0.477
DOC_MAPK_MEF2A_6	110	118	PF00069	0.538
DOC_MAPK_MEF2A_6	331	338	PF00069	0.469
DOC_MAPK_MEF2A_6	420	429	PF00069	0.406
DOC_MAPK_MEF2A_6	497	504	PF00069	0.479
DOC_MAPK_NFAT4_5	497	505	PF00069	0.467
DOC_MAPK_RevD_3	266	280	PF00069	0.554
DOC_PP1_RVXF_1	195	202	PF00149	0.311
DOC_PP2B_LxvP_1	339	342	PF13499	0.320
DOC_PP2B_LxvP_1	363	366	PF13499	0.380
DOC_PP2B_LxvP_1	471	474	PF13499	0.502
DOC_USP7_MATH_1	15	19	PF00917	0.478
DOC_USP7_MATH_1	297	301	PF00917	0.544
DOC_USP7_MATH_1	366	370	PF00917	0.383
DOC_USP7_UBL2_3	239	243	PF12436	0.507
DOC_USP7_UBL2_3	478	482	PF12436	0.494
DOC_USP7_UBL2_3	497	501	PF12436	0.439
DOC_WW_Pin1_4	506	511	PF00397	0.526
LIG_14-3-3_CanoR_1	185	189	PF00244	0.475
LIG_14-3-3_CanoR_1	308	315	PF00244	0.436
LIG_14-3-3_CanoR_1	76	82	PF00244	0.497
LIG_14-3-3_CanoR_1	87	92	PF00244	0.456
LIG_Actin_WH2_2	17	35	PF00022	0.473
LIG_Actin_WH2_2	488	503	PF00022	0.515
LIG_APCC_ABBA_1	293	298	PF00400	0.519
LIG_FHA_1	104	110	PF00498	0.494
LIG_FHA_1	158	164	PF00498	0.456
LIG_FHA_1	165	171	PF00498	0.455
LIG_FHA_1	215	221	PF00498	0.402
LIG_FHA_1	33	39	PF00498	0.327
LIG_FHA_1	346	352	PF00498	0.495
LIG_FHA_1	491	497	PF00498	0.452
LIG_FHA_1	88	94	PF00498	0.443
LIG_FHA_2	166	172	PF00498	0.466
LIG_FHA_2	185	191	PF00498	0.243
LIG_FHA_2	507	513	PF00498	0.510
LIG_LIR_Gen_1	18	28	PF02991	0.428
LIG_LIR_Gen_1	240	248	PF02991	0.496
LIG_LIR_Gen_1	378	388	PF02991	0.403
LIG_LIR_Gen_1	453	464	PF02991	0.417
LIG_LIR_Nem_3	18	23	PF02991	0.425
LIG_LIR_Nem_3	378	383	PF02991	0.380
LIG_LIR_Nem_3	453	459	PF02991	0.416
LIG_OCRL_FandH_1	154	166	PF00620	0.514
LIG_Pex14_2	452	456	PF04695	0.493
LIG_REV1ctd_RIR_1	341	349	PF16727	0.503
LIG_SH2_CRK	484	488	PF00017	0.568
LIG_SH2_GRB2like	126	129	PF00017	0.470
LIG_SH2_STAT5	126	129	PF00017	0.456
LIG_SH2_STAT5	166	169	PF00017	0.491
LIG_SH3_3	134	140	PF00018	0.449
LIG_SH3_3	178	184	PF00018	0.489
LIG_SH3_3	309	315	PF00018	0.467
LIG_SH3_3	500	506	PF00018	0.471
LIG_SUMO_SIM_anti_2	90	95	PF11976	0.439
LIG_SUMO_SIM_par_1	265	270	PF11976	0.495
LIG_SUMO_SIM_par_1	461	467	PF11976	0.470
LIG_TYR_ITIM	428	433	PF00017	0.441
LIG_UBA3_1	224	231	PF00899	0.398
LIG_UBA3_1	495	501	PF00899	0.479
MOD_CK1_1	215	221	PF00069	0.427
MOD_CK1_1	450	456	PF00069	0.463
MOD_CK2_1	165	171	PF00069	0.480
MOD_CK2_1	208	214	PF00069	0.456
MOD_Cter_Amidation	277	280	PF01082	0.601
MOD_GlcNHglycan	309	312	PF01048	0.436
MOD_GlcNHglycan	434	438	PF01048	0.467
MOD_GlcNHglycan	440	443	PF01048	0.471
MOD_GlcNHglycan	451	455	PF01048	0.468
MOD_GSK3_1	120	127	PF00069	0.475
MOD_GSK3_1	208	215	PF00069	0.404
MOD_GSK3_1	446	453	PF00069	0.466
MOD_N-GLC_1	127	132	PF02516	0.270
MOD_N-GLC_1	208	213	PF02516	0.421
MOD_N-GLC_2	357	359	PF02516	0.462
MOD_NEK2_1	212	217	PF00069	0.337
MOD_NEK2_1	22	27	PF00069	0.479
MOD_NEK2_1	267	272	PF00069	0.403
MOD_NEK2_1	307	312	PF00069	0.402
MOD_NEK2_1	32	37	PF00069	0.457
MOD_NEK2_2	15	20	PF00069	0.420
MOD_NEK2_2	394	399	PF00069	0.522
MOD_PKA_2	184	190	PF00069	0.404
MOD_PKA_2	307	313	PF00069	0.498
MOD_PKA_2	75	81	PF00069	0.497
MOD_Plk_1	127	133	PF00069	0.534
MOD_Plk_1	147	153	PF00069	0.456
MOD_Plk_1	208	214	PF00069	0.371
MOD_Plk_1	220	226	PF00069	0.344
MOD_Plk_1	351	357	PF00069	0.516
MOD_Plk_4	15	21	PF00069	0.479
MOD_Plk_4	184	190	PF00069	0.421
MOD_Plk_4	220	226	PF00069	0.385
MOD_Plk_4	267	273	PF00069	0.428
MOD_Plk_4	302	308	PF00069	0.463
MOD_Plk_4	491	497	PF00069	0.499
MOD_Plk_4	89	95	PF00069	0.466
MOD_ProDKin_1	506	512	PF00069	0.525
MOD_SUMO_rev_2	25	32	PF00179	0.491
TRG_DiLeu_BaEn_1	435	440	PF01217	0.372
TRG_DiLeu_BaEn_1	461	466	PF01217	0.499
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.368
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.467
TRG_ENDOCYTIC_2	380	383	PF00928	0.387
TRG_ENDOCYTIC_2	430	433	PF00928	0.364
TRG_ER_diArg_1	173	176	PF00400	0.519
TRG_ER_diArg_1	373	375	PF00400	0.376
TRG_NES_CRM1_1	285	298	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUG7	Leptomonas seymouri	68%	99%
A0A0S4JS32	Bodo saltans	33%	100%
A0A0S4JSB5	Bodo saltans	46%	100%
A0A1X0NL45	Trypanosomatidae	47%	99%
A0A3S7WNX9	Leishmania donovani	96%	100%
A0A422NNU3	Trypanosoma rangeli	47%	100%
A4H434	Leishmania braziliensis	82%	100%
A4HSB8	Leishmania infantum	97%	100%
A5UCK0	Haemophilus influenzae (strain PittEE)	24%	100%
A5UJ23	Haemophilus influenzae (strain PittGG)	24%	100%
C1DAG2	Laribacter hongkongensis (strain HLHK9)	27%	100%
C9ZYB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9AKA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P45269	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
V5BI79	Trypanosoma cruzi	46%	99%