Glycosyl hydrolases 18 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chitinase

Species:

Leishmania donovani

UniProt:

O60994_LEIDO

TriTrypDb:

LdBPK_160790.1 , LdCL_160013200 , LDHU3_16.0950

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 4
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O60994

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	7
GO:0004568	chitinase activity	5	5
GO:0005488	binding	1	8
GO:0008061	chitin binding	3	8
GO:0016787	hydrolase activity	2	8
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0097367	carbohydrate derivative binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.354
CLV_NRD_NRD_1	164	166	PF00675	0.306
CLV_NRD_NRD_1	215	217	PF00675	0.306
CLV_NRD_NRD_1	291	293	PF00675	0.318
CLV_NRD_NRD_1	298	300	PF00675	0.308
CLV_NRD_NRD_1	307	309	PF00675	0.337
CLV_NRD_NRD_1	324	326	PF00675	0.337
CLV_NRD_NRD_1	374	376	PF00675	0.337
CLV_NRD_NRD_1	70	72	PF00675	0.197
CLV_PCSK_FUR_1	116	120	PF00082	0.354
CLV_PCSK_KEX2_1	118	120	PF00082	0.354
CLV_PCSK_KEX2_1	215	217	PF00082	0.306
CLV_PCSK_KEX2_1	291	293	PF00082	0.342
CLV_PCSK_KEX2_1	298	300	PF00082	0.331
CLV_PCSK_KEX2_1	307	309	PF00082	0.337
CLV_PCSK_KEX2_1	324	326	PF00082	0.337
CLV_PCSK_KEX2_1	374	376	PF00082	0.337
CLV_PCSK_KEX2_1	70	72	PF00082	0.197
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.337
CLV_PCSK_SKI1_1	127	131	PF00082	0.327
CLV_PCSK_SKI1_1	151	155	PF00082	0.314
CLV_PCSK_SKI1_1	308	312	PF00082	0.362
CLV_PCSK_SKI1_1	4	8	PF00082	0.285
DEG_APCC_DBOX_1	3	11	PF00400	0.394
DOC_MAPK_gen_1	165	172	PF00069	0.480
DOC_MAPK_gen_1	307	316	PF00069	0.337
DOC_MAPK_MEF2A_6	307	316	PF00069	0.282
DOC_MAPK_NFAT4_5	307	315	PF00069	0.337
DOC_PP2B_LxvP_1	312	315	PF13499	0.278
DOC_USP7_MATH_1	232	236	PF00917	0.337
DOC_USP7_MATH_1	265	269	PF00917	0.351
DOC_USP7_MATH_1	42	46	PF00917	0.524
DOC_USP7_MATH_1	444	448	PF00917	0.810
DOC_WW_Pin1_4	399	404	PF00397	0.538
DOC_WW_Pin1_4	445	450	PF00397	0.582
DOC_WW_Pin1_4	46	51	PF00397	0.446
DOC_WW_Pin1_4	52	57	PF00397	0.387
LIG_14-3-3_CanoR_1	194	198	PF00244	0.306
LIG_14-3-3_CanoR_1	244	250	PF00244	0.354
LIG_14-3-3_CanoR_1	307	313	PF00244	0.354
LIG_14-3-3_CanoR_1	357	365	PF00244	0.277
LIG_Actin_WH2_2	87	102	PF00022	0.354
LIG_APCC_ABBA_1	281	286	PF00400	0.330
LIG_BRCT_BRCA1_1	137	141	PF00533	0.278
LIG_BRCT_BRCA1_1	56	60	PF00533	0.320
LIG_Clathr_ClatBox_1	101	105	PF01394	0.306
LIG_deltaCOP1_diTrp_1	182	189	PF00928	0.280
LIG_deltaCOP1_diTrp_1	332	341	PF00928	0.337
LIG_EH1_1	123	131	PF00400	0.251
LIG_eIF4E_1	331	337	PF01652	0.245
LIG_FHA_1	179	185	PF00498	0.365
LIG_FHA_1	278	284	PF00498	0.281
LIG_FHA_1	309	315	PF00498	0.337
LIG_FHA_1	83	89	PF00498	0.278
LIG_FHA_1	96	102	PF00498	0.278
LIG_FHA_2	177	183	PF00498	0.448
LIG_FHA_2	300	306	PF00498	0.281
LIG_FHA_2	346	352	PF00498	0.463
LIG_FHA_2	366	372	PF00498	0.149
LIG_LIR_Apic_2	171	177	PF02991	0.278
LIG_LIR_Apic_2	434	440	PF02991	0.544
LIG_LIR_Gen_1	112	121	PF02991	0.351
LIG_LIR_Gen_1	138	149	PF02991	0.337
LIG_LIR_Gen_1	181	191	PF02991	0.337
LIG_LIR_Gen_1	248	257	PF02991	0.306
LIG_LIR_Gen_1	329	338	PF02991	0.337
LIG_LIR_Gen_1	368	377	PF02991	0.354
LIG_LIR_Gen_1	57	67	PF02991	0.303
LIG_LIR_Gen_1	73	84	PF02991	0.418
LIG_LIR_Nem_3	112	117	PF02991	0.336
LIG_LIR_Nem_3	138	144	PF02991	0.337
LIG_LIR_Nem_3	181	186	PF02991	0.318
LIG_LIR_Nem_3	248	254	PF02991	0.306
LIG_LIR_Nem_3	329	334	PF02991	0.280
LIG_LIR_Nem_3	360	365	PF02991	0.331
LIG_LIR_Nem_3	366	370	PF02991	0.346
LIG_LIR_Nem_3	416	420	PF02991	0.513
LIG_LIR_Nem_3	57	63	PF02991	0.302
LIG_LIR_Nem_3	73	79	PF02991	0.353
LIG_NRBOX	21	27	PF00104	0.230
LIG_Pex14_2	337	341	PF04695	0.314
LIG_REV1ctd_RIR_1	77	85	PF16727	0.330
LIG_SH2_CRK	437	441	PF00017	0.568
LIG_SH2_NCK_1	199	203	PF00017	0.306
LIG_SH2_NCK_1	437	441	PF00017	0.568
LIG_SH2_PTP2	251	254	PF00017	0.306
LIG_SH2_SRC	257	260	PF00017	0.337
LIG_SH2_SRC	370	373	PF00017	0.265
LIG_SH2_STAP1	199	203	PF00017	0.306
LIG_SH2_STAP1	257	261	PF00017	0.308
LIG_SH2_STAP1	271	275	PF00017	0.228
LIG_SH2_STAP1	331	335	PF00017	0.315
LIG_SH2_STAP1	76	80	PF00017	0.278
LIG_SH2_STAT5	251	254	PF00017	0.337
LIG_SH2_STAT5	65	68	PF00017	0.278
LIG_SH3_1	437	443	PF00018	0.545
LIG_SH3_3	437	443	PF00018	0.545
LIG_TYR_ITIM	249	254	PF00017	0.306
LIG_TYR_ITSM	366	373	PF00017	0.354
MOD_CK1_1	20	26	PF00069	0.342
MOD_CK1_1	274	280	PF00069	0.387
MOD_CK1_1	402	408	PF00069	0.551
MOD_CK2_1	107	113	PF00069	0.337
MOD_CK2_1	176	182	PF00069	0.337
MOD_CK2_1	264	270	PF00069	0.337
MOD_CK2_1	345	351	PF00069	0.463
MOD_GlcNHglycan	109	112	PF01048	0.201
MOD_GlcNHglycan	137	140	PF01048	0.349
MOD_GlcNHglycan	22	25	PF01048	0.202
MOD_GlcNHglycan	241	244	PF01048	0.354
MOD_GlcNHglycan	385	388	PF01048	0.351
MOD_GlcNHglycan	4	7	PF01048	0.312
MOD_GlcNHglycan	426	429	PF01048	0.547
MOD_GlcNHglycan	90	93	PF01048	0.332
MOD_GSK3_1	16	23	PF00069	0.331
MOD_GSK3_1	260	267	PF00069	0.354
MOD_GSK3_1	38	45	PF00069	0.524
MOD_GSK3_1	398	405	PF00069	0.476
MOD_GSK3_1	54	61	PF00069	0.388
MOD_LATS_1	297	303	PF00433	0.281
MOD_LATS_1	306	312	PF00433	0.354
MOD_N-GLC_1	383	388	PF02516	0.354
MOD_NEK2_1	17	22	PF00069	0.328
MOD_NEK2_1	193	198	PF00069	0.306
MOD_NEK2_1	25	30	PF00069	0.352
MOD_NEK2_1	377	382	PF00069	0.259
MOD_NEK2_2	58	63	PF00069	0.337
MOD_PKA_1	308	314	PF00069	0.362
MOD_PKA_1	70	76	PF00069	0.197
MOD_PKA_2	193	199	PF00069	0.306
MOD_PKA_2	38	44	PF00069	0.449
MOD_PKA_2	424	430	PF00069	0.434
MOD_PKA_2	70	76	PF00069	0.243
MOD_Plk_1	277	283	PF00069	0.402
MOD_Plk_4	271	277	PF00069	0.337
MOD_Plk_4	345	351	PF00069	0.306
MOD_Plk_4	402	408	PF00069	0.491
MOD_ProDKin_1	399	405	PF00069	0.542
MOD_ProDKin_1	445	451	PF00069	0.582
MOD_ProDKin_1	46	52	PF00069	0.440
MOD_ProDKin_1	54	60	PF00069	0.361
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.306
TRG_ENDOCYTIC_2	251	254	PF00928	0.362
TRG_ENDOCYTIC_2	257	260	PF00928	0.315
TRG_ENDOCYTIC_2	331	334	PF00928	0.278
TRG_ENDOCYTIC_2	370	373	PF00928	0.337
TRG_ENDOCYTIC_2	76	79	PF00928	0.376
TRG_ER_diArg_1	116	119	PF00400	0.354
TRG_ER_diArg_1	215	218	PF00400	0.348
TRG_ER_diArg_1	291	293	PF00400	0.323
TRG_ER_diArg_1	298	301	PF00400	0.329
TRG_ER_diArg_1	324	326	PF00400	0.354
TRG_ER_diArg_1	69	71	PF00400	0.224
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072VEP0	Medicago truncatula	22%	100%
A0A0N0P753	Leptomonas seymouri	56%	93%
A0A0S4J833	Bodo saltans	32%	100%
A4H8K3	Leishmania braziliensis	78%	100%
A4HWX6	Leishmania infantum	99%	100%
E9AQN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QEU0	Leishmania major	94%	100%