LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Probable flavin mononucleotide-dependent alkene reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable flavin mononucleotide-dependent alkene reductase
Gene product:
NADH:flavin oxidoreductase/NADH oxidase - putative
Species:
Leishmania infantum
UniProt:
NTR2_LEIIN
TriTrypDb:
LINF_120015500
Length:
365

Annotations

Annotations by Jardim et al.

Oxidoreductase, NADH:flavin oxidoreductase/NADH oxidase LINJ.12.0730

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 2
GO:0110165 cellular anatomical entity 1 11
GO:0005737 cytoplasm 2 9

Expansion

Sequence features

E9AGH7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGH7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0010181 FMN binding 4 11
GO:0016491 oxidoreductase activity 2 11
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 2
GO:0016657 oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor 4 2
GO:0032553 ribonucleotide binding 3 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.562
CLV_C14_Caspase3-7 83 87 PF00656 0.558
CLV_NRD_NRD_1 88 90 PF00675 0.306
CLV_PCSK_SKI1_1 13 17 PF00082 0.297
CLV_PCSK_SKI1_1 217 221 PF00082 0.335
CLV_PCSK_SKI1_1 89 93 PF00082 0.335
DEG_COP1_1 37 44 PF00400 0.586
DOC_CYCLIN_RxL_1 214 224 PF00134 0.562
DOC_MAPK_gen_1 232 239 PF00069 0.562
DOC_MAPK_MEF2A_6 232 239 PF00069 0.562
DOC_MAPK_MEF2A_6 53 60 PF00069 0.562
DOC_MAPK_NFAT4_5 53 61 PF00069 0.562
DOC_PP1_RVXF_1 265 272 PF00149 0.562
DOC_PP4_FxxP_1 279 282 PF00568 0.546
DOC_USP7_MATH_1 241 245 PF00917 0.539
DOC_USP7_MATH_1 312 316 PF00917 0.550
DOC_USP7_MATH_1 4 8 PF00917 0.540
DOC_WW_Pin1_4 237 242 PF00397 0.483
DOC_WW_Pin1_4 278 283 PF00397 0.503
LIG_14-3-3_CanoR_1 111 115 PF00244 0.522
LIG_14-3-3_CanoR_1 143 149 PF00244 0.503
LIG_14-3-3_CanoR_1 258 266 PF00244 0.491
LIG_14-3-3_CanoR_1 53 57 PF00244 0.483
LIG_Actin_WH2_2 223 240 PF00022 0.496
LIG_Actin_WH2_2 253 269 PF00022 0.461
LIG_BIR_II_1 1 5 PF00653 0.525
LIG_BRCT_BRCA1_1 22 26 PF00533 0.544
LIG_FHA_1 255 261 PF00498 0.496
LIG_FHA_1 323 329 PF00498 0.562
LIG_FHA_1 90 96 PF00498 0.535
LIG_FHA_2 351 357 PF00498 0.559
LIG_Integrin_RGD_1 276 278 PF01839 0.289
LIG_IRF3_LxIS_1 235 240 PF10401 0.513
LIG_LIR_Apic_2 147 153 PF02991 0.490
LIG_LIR_Apic_2 278 282 PF02991 0.546
LIG_LIR_Gen_1 163 172 PF02991 0.503
LIG_LIR_Gen_1 268 279 PF02991 0.511
LIG_LIR_Nem_3 163 167 PF02991 0.587
LIG_LIR_Nem_3 268 274 PF02991 0.471
LIG_LIR_Nem_3 292 297 PF02991 0.507
LIG_LIR_Nem_3 356 362 PF02991 0.441
LIG_LIR_Nem_3 86 91 PF02991 0.488
LIG_LYPXL_yS_3 362 365 PF13949 0.532
LIG_SH2_GRB2like 164 167 PF00017 0.391
LIG_SH2_NCK_1 168 172 PF00017 0.535
LIG_SH2_PTP2 164 167 PF00017 0.558
LIG_SH2_STAP1 168 172 PF00017 0.535
LIG_SH2_STAP1 50 54 PF00017 0.496
LIG_SH2_STAP1 70 74 PF00017 0.350
LIG_SH2_STAT5 164 167 PF00017 0.565
LIG_SH2_STAT5 191 194 PF00017 0.480
LIG_SH2_STAT5 259 262 PF00017 0.506
LIG_SH2_STAT5 352 355 PF00017 0.455
LIG_SH3_3 24 30 PF00018 0.528
LIG_SUMO_SIM_anti_2 7 12 PF11976 0.328
LIG_TRAF2_1 157 160 PF00917 0.528
LIG_TRAF2_1 290 293 PF00917 0.530
LIG_WRC_WIRS_1 242 247 PF05994 0.583
LIG_WRC_WIRS_1 70 75 PF05994 0.558
MOD_CDC14_SPxK_1 281 284 PF00782 0.503
MOD_CDK_SPxK_1 278 284 PF00069 0.503
MOD_CK1_1 2 8 PF00069 0.522
MOD_CK2_1 350 356 PF00069 0.544
MOD_GlcNHglycan 1 4 PF01048 0.583
MOD_GlcNHglycan 127 130 PF01048 0.293
MOD_GlcNHglycan 314 317 PF01048 0.386
MOD_GSK3_1 109 116 PF00069 0.563
MOD_GSK3_1 198 205 PF00069 0.504
MOD_GSK3_1 237 244 PF00069 0.513
MOD_GSK3_1 347 354 PF00069 0.552
MOD_GSK3_1 48 55 PF00069 0.521
MOD_N-GLC_2 214 216 PF02516 0.358
MOD_NEK2_1 196 201 PF00069 0.475
MOD_PIKK_1 144 150 PF00454 0.503
MOD_PIKK_1 259 265 PF00454 0.587
MOD_PIKK_1 61 67 PF00454 0.586
MOD_PKA_1 89 95 PF00069 0.535
MOD_PKA_2 110 116 PF00069 0.562
MOD_PKA_2 52 58 PF00069 0.513
MOD_Plk_1 61 67 PF00069 0.496
MOD_Plk_4 160 166 PF00069 0.503
MOD_Plk_4 347 353 PF00069 0.555
MOD_ProDKin_1 237 243 PF00069 0.483
MOD_ProDKin_1 278 284 PF00069 0.503
TRG_DiLeu_BaLyEn_6 11 16 PF01217 0.403
TRG_ENDOCYTIC_2 164 167 PF00928 0.558
TRG_ENDOCYTIC_2 294 297 PF00928 0.513
TRG_ENDOCYTIC_2 362 365 PF00928 0.544
TRG_ENDOCYTIC_2 70 73 PF00928 0.496
TRG_ER_diArg_1 215 218 PF00400 0.535
TRG_Pf-PMV_PEXEL_1 217 221 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2A2 Leptomonas seymouri 68% 100%
A0A0N0P2S0 Leptomonas seymouri 31% 97%
A0A0S4IVY9 Bodo saltans 33% 100%
A0A0S4IYW9 Bodo saltans 42% 100%
A0A1D8PPK1 Candida albicans (strain SC5314 / ATCC MYA-2876) 33% 90%
A0A1U8QTA2 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 38% 94%
A0A1X0P653 Trypanosomatidae 47% 97%
A0A3Q8ICQ9 Leishmania donovani 99% 95%
A0A422NKC3 Trypanosoma rangeli 46% 96%
A0A482N8M8 Talaromyces variabilis 25% 88%
A0A482NAR8 Talaromyces variabilis 29% 90%
A2TBU0 Epichloe festucae var. lolii 35% 96%
A4H6Z3 Leishmania braziliensis 84% 100%
A4IQK7 Geobacillus thermodenitrificans (strain NG80-2) 33% 100%
A8C7R3 Claviceps fusiformis 33% 96%
B8N8Q9 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 31% 88%
B8NWW6 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 37% 97%
B9FFD2 Oryza sativa subsp. japonica 41% 90%
B9FFD3 Oryza sativa subsp. japonica 40% 97%
B9FSC8 Oryza sativa subsp. japonica 39% 99%
C5D427 Geobacillus sp. (strain WCH70) 32% 100%
C5H429 Artemisia annua 40% 94%
E9AGH7 Leishmania infantum 100% 100%
E9AP13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
G0REX8 Hypocrea jecorina (strain QM6a) 26% 91%
I1RV17 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 32% 88%
M1W0Y0 Claviceps purpurea (strain 20.1) 34% 96%
O94467 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 92%
P0DI08 Arabidopsis thaliana 41% 100%
P0DI09 Arabidopsis thaliana 41% 100%
P40952 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 33% 92%
P41816 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 91%
P43084 Candida albicans 33% 90%
P54524 Bacillus subtilis (strain 168) 32% 98%
P77258 Escherichia coli (strain K12) 38% 100%
Q02899 Saccharomyces pastorianus 34% 91%
Q03558 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 91%
Q09670 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 96%
Q09671 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 93%
Q0E0C6 Oryza sativa subsp. japonica 39% 90%
Q0JMR0 Oryza sativa subsp. japonica 41% 100%
Q4QGH6 Leishmania major 93% 100%
Q4WZ70 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 37% 97%
Q5KXG9 Geobacillus kaustophilus (strain HTA426) 32% 100%
Q69TH4 Oryza sativa subsp. japonica 39% 97%
Q69TH6 Oryza sativa subsp. japonica 40% 96%
Q69TH8 Oryza sativa subsp. japonica 38% 96%
Q69TI0 Oryza sativa subsp. japonica 41% 98%
Q69TI2 Oryza sativa subsp. japonica 40% 93%
Q6Z965 Oryza sativa subsp. japonica 41% 93%
Q6ZXC1 Claviceps purpurea 35% 96%
Q84QK0 Oryza sativa subsp. japonica 40% 96%
Q8GYA3 Arabidopsis thaliana 37% 100%
Q8GYB8 Arabidopsis thaliana 39% 98%
Q8LAH7 Arabidopsis thaliana 40% 98%
Q97E86 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) 31% 100%
Q9FEW9 Solanum lycopersicum 38% 92%
Q9FEX0 Solanum lycopersicum 34% 100%
Q9FUP0 Arabidopsis thaliana 39% 93%
Q9XG54 Solanum lycopersicum 39% 97%
V5BT91 Trypanosoma cruzi 44% 96%
W6Q2D7 Penicillium roqueforti (strain FM164) 40% 97%
W6Q9S9 Penicillium roqueforti (strain FM164) 39% 99%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS