Bifunctional NAD(P)H-hydrate repair enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bifunctional NAD(P)H-hydrate repair enzyme

Species:

Leishmania major

UniProt:

NNR_LEIMA

TriTrypDb:

LmjF.14.1190 , LMJLV39_140019700 , LMJSD75_140019200

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006753	nucleoside phosphate metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009117	nucleotide metabolic process	5	8
GO:0009987	cellular process	1	8
GO:0019362	pyridine nucleotide metabolic process	5	8
GO:0019637	organophosphate metabolic process	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044281	small molecule metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0046496	nicotinamide nucleotide metabolic process	6	8
GO:0055086	nucleobase-containing small molecule metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0072524	pyridine-containing compound metabolic process	4	8
GO:0110051	metabolite repair	3	2
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0016310	phosphorylation	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0016853	isomerase activity	2	8
GO:0016854	racemase and epimerase activity	3	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0047453	ATP-dependent NAD(P)H-hydrate dehydratase activity	5	8
GO:0052855	ADP-dependent NAD(P)H-hydrate dehydratase activity	5	8
GO:0052856	NADHX epimerase activity	4	8
GO:0052857	NADPHX epimerase activity	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	245	247	PF00675	0.355
CLV_NRD_NRD_1	259	261	PF00675	0.589
CLV_NRD_NRD_1	402	404	PF00675	0.274
CLV_NRD_NRD_1	441	443	PF00675	0.331
CLV_PCSK_KEX2_1	245	247	PF00082	0.366
CLV_PCSK_KEX2_1	259	261	PF00082	0.589
CLV_PCSK_KEX2_1	441	443	PF00082	0.331
CLV_PCSK_SKI1_1	240	244	PF00082	0.548
CLV_PCSK_SKI1_1	246	250	PF00082	0.460
CLV_PCSK_SKI1_1	260	264	PF00082	0.477
CLV_PCSK_SKI1_1	271	275	PF00082	0.355
CLV_PCSK_SKI1_1	301	305	PF00082	0.267
CLV_PCSK_SKI1_1	94	98	PF00082	0.405
DEG_APCC_DBOX_1	245	253	PF00400	0.511
DEG_APCC_DBOX_1	402	410	PF00400	0.415
DEG_Kelch_Keap1_1	184	189	PF01344	0.476
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_CKS1_1	413	418	PF01111	0.493
DOC_CYCLIN_RxL_1	222	231	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.399
DOC_PP2B_LxvP_1	134	137	PF13499	0.476
DOC_PP2B_LxvP_1	170	173	PF13499	0.316
DOC_PP2B_LxvP_1	99	102	PF13499	0.351
DOC_USP7_MATH_1	285	289	PF00917	0.415
DOC_USP7_MATH_1	36	40	PF00917	0.486
DOC_USP7_MATH_2	108	114	PF00917	0.360
DOC_WW_Pin1_4	126	131	PF00397	0.243
DOC_WW_Pin1_4	412	417	PF00397	0.493
DOC_WW_Pin1_4	547	552	PF00397	0.641
LIG_14-3-3_CanoR_1	4	11	PF00244	0.449
LIG_14-3-3_CanoR_1	532	540	PF00244	0.543
LIG_Actin_WH2_2	16	32	PF00022	0.399
LIG_BIR_III_2	31	35	PF00653	0.563
LIG_FHA_1	298	304	PF00498	0.508
LIG_FHA_1	343	349	PF00498	0.531
LIG_FHA_1	361	367	PF00498	0.572
LIG_FHA_1	374	380	PF00498	0.456
LIG_FHA_1	448	454	PF00498	0.493
LIG_FHA_1	466	472	PF00498	0.533
LIG_FHA_1	486	492	PF00498	0.493
LIG_FHA_1	526	532	PF00498	0.531
LIG_FHA_2	11	17	PF00498	0.487
LIG_FHA_2	232	238	PF00498	0.425
LIG_FHA_2	302	308	PF00498	0.509
LIG_FHA_2	320	326	PF00498	0.346
LIG_GBD_Chelix_1	11	19	PF00786	0.461
LIG_LIR_Apic_2	307	311	PF02991	0.531
LIG_LIR_Gen_1	158	167	PF02991	0.353
LIG_LIR_Gen_1	200	211	PF02991	0.351
LIG_LIR_Gen_1	250	258	PF02991	0.460
LIG_LIR_Gen_1	57	63	PF02991	0.386
LIG_LIR_Nem_3	158	163	PF02991	0.353
LIG_LIR_Nem_3	200	206	PF02991	0.351
LIG_LIR_Nem_3	250	256	PF02991	0.475
LIG_LIR_Nem_3	57	62	PF02991	0.372
LIG_MAD2	94	102	PF02301	0.360
LIG_NRBOX	486	492	PF00104	0.531
LIG_PCNA_yPIPBox_3	41	53	PF02747	0.373
LIG_SH2_CRK	224	228	PF00017	0.399
LIG_SH2_CRK	308	312	PF00017	0.508
LIG_SH2_SRC	160	163	PF00017	0.405
LIG_SH2_SRC	83	86	PF00017	0.380
LIG_SH2_STAP1	160	164	PF00017	0.351
LIG_SH2_STAP1	56	60	PF00017	0.373
LIG_SH2_STAT3	218	221	PF00017	0.465
LIG_SH2_STAT3	63	66	PF00017	0.405
LIG_SH2_STAT5	218	221	PF00017	0.411
LIG_SH2_STAT5	22	25	PF00017	0.317
LIG_SH2_STAT5	255	258	PF00017	0.548
LIG_SH2_STAT5	63	66	PF00017	0.399
LIG_SH2_STAT5	83	86	PF00017	0.286
LIG_SH3_1	404	410	PF00018	0.582
LIG_SH3_3	127	133	PF00018	0.406
LIG_SH3_3	404	410	PF00018	0.546
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.352
LIG_SUMO_SIM_par_1	374	380	PF11976	0.522
LIG_SUMO_SIM_par_1	69	75	PF11976	0.438
LIG_TYR_ITIM	222	227	PF00017	0.385
LIG_WW_3	154	158	PF00397	0.476
MOD_CDK_SPxxK_3	547	554	PF00069	0.656
MOD_CK1_1	126	132	PF00069	0.443
MOD_CK1_1	3	9	PF00069	0.580
MOD_CK1_1	412	418	PF00069	0.405
MOD_CK1_1	465	471	PF00069	0.476
MOD_CK1_1	547	553	PF00069	0.649
MOD_CK2_1	10	16	PF00069	0.486
MOD_CK2_1	231	237	PF00069	0.433
MOD_CK2_1	301	307	PF00069	0.375
MOD_CK2_1	319	325	PF00069	0.146
MOD_GlcNHglycan	112	115	PF01048	0.381
MOD_GlcNHglycan	180	183	PF01048	0.351
MOD_GlcNHglycan	24	27	PF01048	0.422
MOD_GlcNHglycan	260	263	PF01048	0.527
MOD_GlcNHglycan	287	290	PF01048	0.482
MOD_GlcNHglycan	43	47	PF01048	0.433
MOD_GlcNHglycan	464	467	PF01048	0.411
MOD_GlcNHglycan	479	482	PF01048	0.360
MOD_GlcNHglycan	546	549	PF01048	0.629
MOD_GlcNHglycan	557	560	PF01048	0.650
MOD_GlcNHglycan	74	77	PF01048	0.396
MOD_GSK3_1	106	113	PF00069	0.356
MOD_GSK3_1	297	304	PF00069	0.398
MOD_GSK3_1	3	10	PF00069	0.565
MOD_GSK3_1	319	326	PF00069	0.476
MOD_GSK3_1	461	468	PF00069	0.438
MOD_GSK3_1	499	506	PF00069	0.444
MOD_N-GLC_1	544	549	PF02516	0.562
MOD_NEK2_1	147	152	PF00069	0.351
MOD_NEK2_1	447	452	PF00069	0.405
MOD_NEK2_1	503	508	PF00069	0.483
MOD_NEK2_1	62	67	PF00069	0.444
MOD_NEK2_1	72	77	PF00069	0.351
MOD_PIKK_1	62	68	PF00454	0.476
MOD_PKA_2	258	264	PF00069	0.592
MOD_PKA_2	3	9	PF00069	0.519
MOD_PKA_2	525	531	PF00069	0.365
MOD_Plk_1	124	130	PF00069	0.385
MOD_Plk_1	373	379	PF00069	0.334
MOD_Plk_4	199	205	PF00069	0.316
MOD_Plk_4	373	379	PF00069	0.334
MOD_Plk_4	409	415	PF00069	0.351
MOD_Plk_4	455	461	PF00069	0.341
MOD_Plk_4	94	100	PF00069	0.351
MOD_ProDKin_1	126	132	PF00069	0.243
MOD_ProDKin_1	412	418	PF00069	0.351
MOD_ProDKin_1	547	553	PF00069	0.647
TRG_DiLeu_BaEn_1	420	425	PF01217	0.351
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.351
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.446
TRG_DiLeu_LyEn_5	420	425	PF01217	0.351
TRG_ENDOCYTIC_2	160	163	PF00928	0.351
TRG_ENDOCYTIC_2	224	227	PF00928	0.389
TRG_ENDOCYTIC_2	253	256	PF00928	0.530
TRG_ENDOCYTIC_2	56	59	PF00928	0.377
TRG_ER_diArg_1	238	241	PF00400	0.434
TRG_ER_diArg_1	245	247	PF00400	0.342
TRG_ER_diArg_1	258	260	PF00400	0.585
TRG_ER_diArg_1	441	443	PF00400	0.405
TRG_ER_diArg_1	554	557	PF00400	0.577
TRG_NES_CRM1_1	237	251	PF08389	0.529
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B5	Leptomonas seymouri	69%	97%
A0A1X0NNH9	Trypanosomatidae	45%	91%
A0A3R7M9Q9	Trypanosoma rangeli	45%	96%
A0A3S7WT52	Leishmania donovani	95%	100%
A1S0R2	Thermofilum pendens (strain DSM 2475 / Hrk 5)	30%	100%
A2BLC0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	32%	100%
A4H7T9	Leishmania braziliensis	85%	100%
A4HW65	Leishmania infantum	95%	100%
B1L3W1	Korarchaeum cryptofilum (strain OPF8)	29%	100%
B5YIM0	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	30%	100%
B8E2P6	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	26%	100%
C9ZSV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
D1BAA5	Thermanaerovibrio acidaminovorans (strain ATCC 49978 / DSM 6589 / Su883)	32%	100%
E9APW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O27324	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
O29407	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	30%	100%
O67377	Aquifex aeolicus (strain VF5)	28%	100%
P31806	Escherichia coli (strain K12)	47%	100%
P37391	Mycobacterium leprae (strain TN)	30%	100%
P56176	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
P74217	Synechocystis sp. (strain PCC 6803 / Kazusa)	30%	100%
P9WF10	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WF11	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q2FT57	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	28%	100%
Q2RGI2	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	32%	100%
Q2S580	Salinibacter ruber (strain DSM 13855 / M31)	32%	100%
Q4QFL5	Leishmania major	100%	100%
Q58981	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q7NIE6	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	33%	100%
Q83CM5	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	37%	100%
Q8DGC3	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	33%	100%
Q8NSS3	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	25%	98%
Q8TX67	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	29%	100%
Q8ZV04	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	100%
Q9KMX5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	39%	100%
Q9X024	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	30%	100%
Q9ZJM4	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
V5BG46	Trypanosoma cruzi	47%	95%