LeishMANIAdb
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Major vault protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Major vault protein
Gene product:
major vault protein - putative
Species:
Leishmania infantum
UniProt:
MVP_LEIIN
TriTrypDb:
LINF_050005500
Length:
833

Annotations

Annotations by Jardim et al.

Nuclear proteins, Major vault PE=3 SV=1 - [MVP_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12

Expansion

Sequence features

A4HSC9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSC9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 104 108 PF00656 0.570
CLV_C14_Caspase3-7 130 134 PF00656 0.454
CLV_C14_Caspase3-7 253 257 PF00656 0.481
CLV_C14_Caspase3-7 340 344 PF00656 0.381
CLV_MEL_PAP_1 510 516 PF00089 0.297
CLV_NRD_NRD_1 136 138 PF00675 0.242
CLV_NRD_NRD_1 244 246 PF00675 0.243
CLV_NRD_NRD_1 303 305 PF00675 0.404
CLV_NRD_NRD_1 34 36 PF00675 0.412
CLV_NRD_NRD_1 374 376 PF00675 0.436
CLV_NRD_NRD_1 465 467 PF00675 0.306
CLV_NRD_NRD_1 548 550 PF00675 0.297
CLV_PCSK_FUR_1 7 11 PF00082 0.397
CLV_PCSK_KEX2_1 136 138 PF00082 0.242
CLV_PCSK_KEX2_1 244 246 PF00082 0.258
CLV_PCSK_KEX2_1 303 305 PF00082 0.420
CLV_PCSK_KEX2_1 347 349 PF00082 0.278
CLV_PCSK_KEX2_1 374 376 PF00082 0.437
CLV_PCSK_KEX2_1 548 550 PF00082 0.181
CLV_PCSK_KEX2_1 775 777 PF00082 0.495
CLV_PCSK_KEX2_1 9 11 PF00082 0.424
CLV_PCSK_PC1ET2_1 347 349 PF00082 0.278
CLV_PCSK_PC1ET2_1 775 777 PF00082 0.547
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.407
CLV_PCSK_SKI1_1 129 133 PF00082 0.315
CLV_PCSK_SKI1_1 234 238 PF00082 0.265
CLV_PCSK_SKI1_1 471 475 PF00082 0.229
CLV_PCSK_SKI1_1 744 748 PF00082 0.513
DEG_APCC_DBOX_1 782 790 PF00400 0.565
DEG_COP1_1 547 556 PF00400 0.515
DEG_ODPH_VHL_1 481 492 PF01847 0.490
DOC_CYCLIN_RxL_1 600 611 PF00134 0.515
DOC_CYCLIN_RxL_1 681 692 PF00134 0.485
DOC_CYCLIN_yCln2_LP_2 116 119 PF00134 0.478
DOC_MAPK_gen_1 106 116 PF00069 0.523
DOC_MAPK_gen_1 444 452 PF00069 0.356
DOC_MAPK_gen_1 466 474 PF00069 0.429
DOC_MAPK_gen_1 669 678 PF00069 0.454
DOC_MAPK_gen_1 7 16 PF00069 0.358
DOC_MAPK_gen_1 706 714 PF00069 0.429
DOC_MAPK_JIP1_4 401 407 PF00069 0.451
DOC_MAPK_MEF2A_6 466 474 PF00069 0.429
DOC_MAPK_MEF2A_6 635 643 PF00069 0.490
DOC_MAPK_MEF2A_6 708 716 PF00069 0.447
DOC_PP1_RVXF_1 446 453 PF00149 0.316
DOC_PP1_RVXF_1 601 608 PF00149 0.515
DOC_PP2B_LxvP_1 116 119 PF13499 0.478
DOC_PP4_FxxP_1 310 313 PF00568 0.372
DOC_PP4_FxxP_1 509 512 PF00568 0.454
DOC_PP4_FxxP_1 551 554 PF00568 0.429
DOC_SPAK_OSR1_1 451 455 PF12202 0.429
DOC_USP7_MATH_1 232 236 PF00917 0.515
DOC_USP7_MATH_1 273 277 PF00917 0.499
DOC_USP7_MATH_1 427 431 PF00917 0.549
DOC_USP7_MATH_1 47 51 PF00917 0.428
DOC_USP7_MATH_1 544 548 PF00917 0.437
DOC_USP7_UBL2_3 109 113 PF12436 0.509
DOC_USP7_UBL2_3 671 675 PF12436 0.446
DOC_WW_Pin1_4 423 428 PF00397 0.459
DOC_WW_Pin1_4 493 498 PF00397 0.479
DOC_WW_Pin1_4 813 818 PF00397 0.495
LIG_14-3-3_CanoR_1 229 236 PF00244 0.512
LIG_14-3-3_CanoR_1 513 521 PF00244 0.440
LIG_14-3-3_CanoR_1 530 536 PF00244 0.440
LIG_14-3-3_CanoR_1 548 554 PF00244 0.298
LIG_14-3-3_CanoR_1 582 588 PF00244 0.429
LIG_14-3-3_CanoR_1 606 614 PF00244 0.459
LIG_14-3-3_CanoR_1 731 738 PF00244 0.422
LIG_Actin_WH2_2 214 231 PF00022 0.421
LIG_APCC_ABBA_1 481 486 PF00400 0.515
LIG_eIF4E_1 170 176 PF01652 0.534
LIG_FHA_1 171 177 PF00498 0.473
LIG_FHA_1 22 28 PF00498 0.424
LIG_FHA_1 306 312 PF00498 0.493
LIG_FHA_1 390 396 PF00498 0.430
LIG_FHA_1 494 500 PF00498 0.506
LIG_FHA_1 516 522 PF00498 0.454
LIG_FHA_1 548 554 PF00498 0.515
LIG_FHA_1 681 687 PF00498 0.423
LIG_FHA_2 251 257 PF00498 0.557
LIG_FHA_2 32 38 PF00498 0.400
LIG_FHA_2 389 395 PF00498 0.470
LIG_FHA_2 606 612 PF00498 0.450
LIG_FHA_2 613 619 PF00498 0.409
LIG_GBD_Chelix_1 198 206 PF00786 0.334
LIG_LIR_Apic_2 308 313 PF02991 0.390
LIG_LIR_Apic_2 550 554 PF02991 0.515
LIG_LIR_Gen_1 235 243 PF02991 0.432
LIG_LIR_Gen_1 281 289 PF02991 0.372
LIG_LIR_Gen_1 485 492 PF02991 0.431
LIG_LIR_Gen_1 575 585 PF02991 0.439
LIG_LIR_Gen_1 683 690 PF02991 0.423
LIG_LIR_Gen_1 710 720 PF02991 0.268
LIG_LIR_LC3C_4 322 327 PF02991 0.507
LIG_LIR_Nem_3 235 239 PF02991 0.443
LIG_LIR_Nem_3 281 285 PF02991 0.359
LIG_LIR_Nem_3 445 450 PF02991 0.505
LIG_LIR_Nem_3 485 490 PF02991 0.431
LIG_LIR_Nem_3 534 538 PF02991 0.456
LIG_LIR_Nem_3 575 580 PF02991 0.428
LIG_LIR_Nem_3 683 688 PF02991 0.427
LIG_LIR_Nem_3 710 716 PF02991 0.270
LIG_LIR_Nem_3 93 98 PF02991 0.510
LIG_PTB_Apo_2 434 441 PF02174 0.488
LIG_SH2_CRK 11 15 PF00017 0.452
LIG_SH2_CRK 447 451 PF00017 0.428
LIG_SH2_CRK 56 60 PF00017 0.429
LIG_SH2_PTP2 13 16 PF00017 0.329
LIG_SH2_PTP2 282 285 PF00017 0.484
LIG_SH2_SRC 13 16 PF00017 0.386
LIG_SH2_SRC 282 285 PF00017 0.457
LIG_SH2_SRC 362 365 PF00017 0.515
LIG_SH2_STAP1 265 269 PF00017 0.448
LIG_SH2_STAT5 13 16 PF00017 0.329
LIG_SH2_STAT5 152 155 PF00017 0.454
LIG_SH2_STAT5 205 208 PF00017 0.465
LIG_SH2_STAT5 282 285 PF00017 0.352
LIG_SH2_STAT5 33 36 PF00017 0.209
LIG_SH2_STAT5 362 365 PF00017 0.440
LIG_SH2_STAT5 386 389 PF00017 0.429
LIG_SH2_STAT5 538 541 PF00017 0.456
LIG_SH2_STAT5 56 59 PF00017 0.429
LIG_SH2_STAT5 751 754 PF00017 0.503
LIG_SH2_STAT5 809 812 PF00017 0.487
LIG_SH3_3 143 149 PF00018 0.454
LIG_SH3_3 165 171 PF00018 0.366
LIG_SH3_3 353 359 PF00018 0.516
LIG_SH3_3 46 52 PF00018 0.299
LIG_SH3_3 470 476 PF00018 0.429
LIG_SH3_3 494 500 PF00018 0.451
LIG_SH3_3 56 62 PF00018 0.438
LIG_SH3_3 93 99 PF00018 0.430
LIG_SUMO_SIM_anti_2 157 163 PF11976 0.399
LIG_SUMO_SIM_anti_2 322 328 PF11976 0.467
LIG_SUMO_SIM_par_1 157 163 PF11976 0.434
LIG_SUMO_SIM_par_1 403 409 PF11976 0.533
LIG_SUMO_SIM_par_1 416 422 PF11976 0.490
LIG_SUMO_SIM_par_1 488 493 PF11976 0.457
LIG_SUMO_SIM_par_1 515 525 PF11976 0.454
LIG_SxIP_EBH_1 146 155 PF03271 0.534
LIG_TRAF2_1 208 211 PF00917 0.349
LIG_TRAF2_1 419 422 PF00917 0.515
LIG_TRAF2_1 483 486 PF00917 0.441
LIG_TRAF2_1 99 102 PF00917 0.494
LIG_TRFH_1 309 313 PF08558 0.368
LIG_TRFH_1 95 99 PF08558 0.281
LIG_UBA3_1 221 226 PF00899 0.428
LIG_UBA3_1 376 381 PF00899 0.390
LIG_UBA3_1 800 807 PF00899 0.483
LIG_WRC_WIRS_1 233 238 PF05994 0.365
LIG_WRC_WIRS_1 577 582 PF05994 0.281
LIG_WW_3 51 55 PF00397 0.316
MOD_CDK_SPK_2 493 498 PF00069 0.396
MOD_CK1_1 430 436 PF00069 0.564
MOD_CK1_1 493 499 PF00069 0.400
MOD_CK1_1 502 508 PF00069 0.347
MOD_CK1_1 515 521 PF00069 0.241
MOD_CK1_1 547 553 PF00069 0.428
MOD_CK1_1 622 628 PF00069 0.390
MOD_CK1_1 698 704 PF00069 0.465
MOD_CK2_1 205 211 PF00069 0.380
MOD_CK2_1 275 281 PF00069 0.386
MOD_CK2_1 31 37 PF00069 0.422
MOD_CK2_1 388 394 PF00069 0.338
MOD_CK2_1 439 445 PF00069 0.501
MOD_CK2_1 698 704 PF00069 0.465
MOD_GlcNHglycan 230 233 PF01048 0.432
MOD_GlcNHglycan 27 30 PF01048 0.513
MOD_GlcNHglycan 277 280 PF01048 0.445
MOD_GlcNHglycan 492 495 PF01048 0.281
MOD_GlcNHglycan 583 586 PF01048 0.297
MOD_GlcNHglycan 697 700 PF01048 0.436
MOD_GlcNHglycan 732 735 PF01048 0.488
MOD_GlcNHglycan 74 78 PF01048 0.326
MOD_GSK3_1 205 212 PF00069 0.431
MOD_GSK3_1 21 28 PF00069 0.514
MOD_GSK3_1 228 235 PF00069 0.369
MOD_GSK3_1 423 430 PF00069 0.538
MOD_GSK3_1 618 625 PF00069 0.332
MOD_GSK3_1 629 636 PF00069 0.479
MOD_GSK3_1 809 816 PF00069 0.490
MOD_N-GLC_1 18 23 PF02516 0.399
MOD_N-GLC_1 181 186 PF02516 0.356
MOD_N-GLC_1 388 393 PF02516 0.337
MOD_N-GLC_1 427 432 PF02516 0.550
MOD_NEK2_1 1 6 PF00069 0.561
MOD_NEK2_1 228 233 PF00069 0.387
MOD_NEK2_1 297 302 PF00069 0.545
MOD_NEK2_1 388 393 PF00069 0.316
MOD_NEK2_1 490 495 PF00069 0.316
MOD_NEK2_1 531 536 PF00069 0.283
MOD_NEK2_1 605 610 PF00069 0.290
MOD_NEK2_1 612 617 PF00069 0.271
MOD_NEK2_1 633 638 PF00069 0.483
MOD_NEK2_1 73 78 PF00069 0.428
MOD_NEK2_1 749 754 PF00069 0.485
MOD_NEK2_1 800 805 PF00069 0.585
MOD_NEK2_1 820 825 PF00069 0.322
MOD_NEK2_2 250 255 PF00069 0.428
MOD_NEK2_2 305 310 PF00069 0.401
MOD_PIKK_1 644 650 PF00454 0.484
MOD_PIKK_1 749 755 PF00454 0.541
MOD_PIKK_1 793 799 PF00454 0.565
MOD_PK_1 549 555 PF00069 0.297
MOD_PKA_2 228 234 PF00069 0.398
MOD_PKA_2 512 518 PF00069 0.297
MOD_PKA_2 531 537 PF00069 0.210
MOD_PKA_2 547 553 PF00069 0.262
MOD_PKA_2 581 587 PF00069 0.281
MOD_PKA_2 605 611 PF00069 0.323
MOD_PKA_2 629 635 PF00069 0.485
MOD_PKA_2 730 736 PF00069 0.424
MOD_PKA_2 782 788 PF00069 0.474
MOD_Plk_1 209 215 PF00069 0.454
MOD_Plk_1 305 311 PF00069 0.398
MOD_Plk_1 485 491 PF00069 0.297
MOD_Plk_4 1 7 PF00069 0.556
MOD_Plk_4 148 154 PF00069 0.280
MOD_Plk_4 164 170 PF00069 0.262
MOD_Plk_4 209 215 PF00069 0.414
MOD_Plk_4 217 223 PF00069 0.400
MOD_Plk_4 297 303 PF00069 0.466
MOD_Plk_4 305 311 PF00069 0.361
MOD_Plk_4 515 521 PF00069 0.318
MOD_Plk_4 782 788 PF00069 0.456
MOD_ProDKin_1 423 429 PF00069 0.323
MOD_ProDKin_1 493 499 PF00069 0.352
MOD_ProDKin_1 813 819 PF00069 0.496
MOD_SUMO_for_1 690 693 PF00179 0.511
MOD_SUMO_rev_2 101 111 PF00179 0.480
MOD_SUMO_rev_2 157 167 PF00179 0.444
MOD_SUMO_rev_2 223 228 PF00179 0.412
MOD_SUMO_rev_2 263 270 PF00179 0.453
MOD_SUMO_rev_2 361 371 PF00179 0.507
MOD_SUMO_rev_2 621 629 PF00179 0.283
MOD_SUMO_rev_2 698 707 PF00179 0.424
TRG_DiLeu_BaEn_1 330 335 PF01217 0.368
TRG_DiLeu_BaEn_1 668 673 PF01217 0.456
TRG_DiLeu_BaEn_2 305 311 PF01217 0.382
TRG_DiLeu_BaEn_4 330 336 PF01217 0.428
TRG_DiLeu_BaEn_4 485 491 PF01217 0.316
TRG_ENDOCYTIC_2 11 14 PF00928 0.353
TRG_ENDOCYTIC_2 282 285 PF00928 0.350
TRG_ENDOCYTIC_2 447 450 PF00928 0.493
TRG_ENDOCYTIC_2 538 541 PF00928 0.338
TRG_ENDOCYTIC_2 56 59 PF00928 0.281
TRG_ER_diArg_1 136 138 PF00400 0.350
TRG_ER_diArg_1 302 304 PF00400 0.439
TRG_ER_diArg_1 374 376 PF00400 0.498
TRG_ER_diArg_1 528 531 PF00400 0.402
TRG_NES_CRM1_1 315 331 PF08389 0.443
TRG_NLS_MonoExtC_3 465 470 PF00514 0.348

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Z8 Leptomonas seymouri 36% 92%
A0A0N1I3S9 Leptomonas seymouri 83% 100%
A0A0S4ISQ0 Bodo saltans 40% 97%
A0A0S4JL46 Bodo saltans 60% 99%
A0A1X0NXD4 Trypanosomatidae 41% 100%
A0A1X0P2V2 Trypanosomatidae 66% 100%
A0A1X0P8P2 Trypanosomatidae 36% 97%
A0A3S7WNY9 Leishmania donovani 100% 100%
A0A3S7XAQ4 Leishmania donovani 36% 95%
A0A422NIL8 Trypanosoma rangeli 40% 99%
A0A422NLE5 Trypanosoma rangeli 35% 97%
A0A422NYK3 Trypanosoma rangeli 65% 98%
A4H452 Leishmania braziliensis 92% 100%
A4HP51 Leishmania braziliensis 35% 100%
A4HSC9 Leishmania infantum 100% 100%
A4IDF8 Leishmania infantum 36% 95%
C9ZPY2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
D0A1L3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 97%
D0A336 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 97%
E9AIP9 Leishmania braziliensis 42% 100%
E9AKB0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9ASV9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 99%
P34118 Dictyostelium discoideum 50% 99%
P54659 Dictyostelium discoideum 49% 98%
Q14764 Homo sapiens 49% 93%
Q3SYU9 Bos taurus 50% 94%
Q4CUM2 Trypanosoma cruzi (strain CL Brener) 66% 99%
Q4Q1N7 Leishmania major 36% 99%
Q4QJJ7 Leishmania major 98% 100%
Q57Z03 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 64% 99%
Q5EAJ7 Strongylocentrotus purpuratus 50% 97%
Q5R9N2 Pongo abelii 49% 93%
Q5ZMI4 Gallus gallus 49% 98%
Q62667 Rattus norvegicus 49% 97%
Q6P3L0 Danio rerio 48% 97%
Q6PF69 Xenopus laevis 48% 98%
Q90405 Diplobatis ommata 48% 98%
Q9DGM7 Ictalurus punctatus 47% 96%
Q9EQK5 Mus musculus 49% 97%
V5AUX6 Trypanosoma cruzi 66% 99%
V5B0K2 Trypanosoma cruzi 38% 97%
V5BPE1 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS