Major vault protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Major vault protein

Gene product:

major vault protein, putative

Species:

Leishmania braziliensis

UniProt:

MVP_LEIBR

TriTrypDb:

LbrM.05.0060 , LBRM2903_050005500

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

A4H452

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H452

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.507
CLV_C14_Caspase3-7	130	134	PF00656	0.454
CLV_C14_Caspase3-7	253	257	PF00656	0.483
CLV_MEL_PAP_1	510	516	PF00089	0.297
CLV_NRD_NRD_1	111	113	PF00675	0.306
CLV_NRD_NRD_1	186	188	PF00675	0.153
CLV_NRD_NRD_1	244	246	PF00675	0.243
CLV_NRD_NRD_1	303	305	PF00675	0.402
CLV_NRD_NRD_1	374	376	PF00675	0.433
CLV_NRD_NRD_1	443	445	PF00675	0.290
CLV_NRD_NRD_1	775	777	PF00675	0.438
CLV_PCSK_FUR_1	7	11	PF00082	0.392
CLV_PCSK_KEX2_1	186	188	PF00082	0.266
CLV_PCSK_KEX2_1	244	246	PF00082	0.258
CLV_PCSK_KEX2_1	303	305	PF00082	0.418
CLV_PCSK_KEX2_1	374	376	PF00082	0.434
CLV_PCSK_KEX2_1	443	445	PF00082	0.290
CLV_PCSK_KEX2_1	775	777	PF00082	0.526
CLV_PCSK_KEX2_1	9	11	PF00082	0.421
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.404
CLV_PCSK_SKI1_1	129	133	PF00082	0.315
CLV_PCSK_SKI1_1	187	191	PF00082	0.297
CLV_PCSK_SKI1_1	234	238	PF00082	0.265
CLV_PCSK_SKI1_1	471	475	PF00082	0.229
CLV_PCSK_SKI1_1	744	748	PF00082	0.542
DEG_APCC_DBOX_1	782	790	PF00400	0.594
DEG_COP1_1	547	556	PF00400	0.515
DEG_ODPH_VHL_1	481	492	PF01847	0.490
DOC_CYCLIN_RxL_1	600	611	PF00134	0.515
DOC_CYCLIN_RxL_1	681	692	PF00134	0.474
DOC_MAPK_gen_1	129	139	PF00069	0.353
DOC_MAPK_gen_1	186	192	PF00069	0.463
DOC_MAPK_gen_1	443	452	PF00069	0.369
DOC_MAPK_gen_1	466	474	PF00069	0.429
DOC_MAPK_gen_1	669	678	PF00069	0.426
DOC_MAPK_gen_1	7	16	PF00069	0.353
DOC_MAPK_gen_1	706	714	PF00069	0.430
DOC_MAPK_MEF2A_6	466	474	PF00069	0.429
DOC_MAPK_MEF2A_6	635	643	PF00069	0.423
DOC_MAPK_MEF2A_6	708	716	PF00069	0.451
DOC_PP1_RVXF_1	446	453	PF00149	0.316
DOC_PP1_RVXF_1	601	608	PF00149	0.515
DOC_PP4_FxxP_1	310	313	PF00568	0.366
DOC_PP4_FxxP_1	509	512	PF00568	0.454
DOC_PP4_FxxP_1	551	554	PF00568	0.429
DOC_SPAK_OSR1_1	451	455	PF12202	0.429
DOC_USP7_MATH_1	232	236	PF00917	0.515
DOC_USP7_MATH_1	273	277	PF00917	0.499
DOC_USP7_MATH_1	427	431	PF00917	0.547
DOC_USP7_MATH_1	47	51	PF00917	0.428
DOC_USP7_MATH_1	544	548	PF00917	0.437
DOC_USP7_UBL2_3	671	675	PF12436	0.416
DOC_WW_Pin1_4	423	428	PF00397	0.459
DOC_WW_Pin1_4	493	498	PF00397	0.479
DOC_WW_Pin1_4	813	818	PF00397	0.528
LIG_14-3-3_CanoR_1	229	236	PF00244	0.512
LIG_14-3-3_CanoR_1	46	52	PF00244	0.311
LIG_14-3-3_CanoR_1	513	521	PF00244	0.440
LIG_14-3-3_CanoR_1	530	536	PF00244	0.440
LIG_14-3-3_CanoR_1	549	554	PF00244	0.530
LIG_14-3-3_CanoR_1	582	590	PF00244	0.429
LIG_14-3-3_CanoR_1	731	738	PF00244	0.438
LIG_Actin_WH2_2	214	231	PF00022	0.421
LIG_APCC_ABBA_1	481	486	PF00400	0.515
LIG_BIR_III_4	290	294	PF00653	0.320
LIG_BIR_III_4	779	783	PF00653	0.493
LIG_eIF4E_1	170	176	PF01652	0.534
LIG_FHA_1	171	177	PF00498	0.473
LIG_FHA_1	22	28	PF00498	0.423
LIG_FHA_1	306	312	PF00498	0.492
LIG_FHA_1	390	396	PF00498	0.430
LIG_FHA_1	494	500	PF00498	0.506
LIG_FHA_1	516	522	PF00498	0.454
LIG_FHA_1	548	554	PF00498	0.515
LIG_FHA_1	681	687	PF00498	0.411
LIG_FHA_2	251	257	PF00498	0.557
LIG_FHA_2	32	38	PF00498	0.404
LIG_FHA_2	389	395	PF00498	0.470
LIG_FHA_2	613	619	PF00498	0.409
LIG_GBD_Chelix_1	198	206	PF00786	0.334
LIG_GBD_Chelix_1	213	221	PF00786	0.262
LIG_LIR_Apic_2	308	313	PF02991	0.387
LIG_LIR_Apic_2	550	554	PF02991	0.515
LIG_LIR_Gen_1	235	243	PF02991	0.432
LIG_LIR_Gen_1	281	289	PF02991	0.367
LIG_LIR_Gen_1	485	492	PF02991	0.431
LIG_LIR_Gen_1	575	585	PF02991	0.439
LIG_LIR_Gen_1	683	690	PF02991	0.413
LIG_LIR_LC3C_4	135	139	PF02991	0.353
LIG_LIR_LC3C_4	322	327	PF02991	0.508
LIG_LIR_Nem_3	235	239	PF02991	0.443
LIG_LIR_Nem_3	281	285	PF02991	0.353
LIG_LIR_Nem_3	445	450	PF02991	0.505
LIG_LIR_Nem_3	485	490	PF02991	0.431
LIG_LIR_Nem_3	534	538	PF02991	0.456
LIG_LIR_Nem_3	575	580	PF02991	0.428
LIG_LIR_Nem_3	683	688	PF02991	0.416
LIG_LIR_Nem_3	93	98	PF02991	0.510
LIG_SH2_CRK	447	451	PF00017	0.428
LIG_SH2_CRK	56	60	PF00017	0.429
LIG_SH2_PTP2	13	16	PF00017	0.322
LIG_SH2_PTP2	282	285	PF00017	0.478
LIG_SH2_SRC	13	16	PF00017	0.379
LIG_SH2_SRC	205	208	PF00017	0.357
LIG_SH2_SRC	282	285	PF00017	0.452
LIG_SH2_SRC	362	365	PF00017	0.515
LIG_SH2_STAP1	265	269	PF00017	0.446
LIG_SH2_STAT3	33	36	PF00017	0.424
LIG_SH2_STAT5	13	16	PF00017	0.322
LIG_SH2_STAT5	152	155	PF00017	0.454
LIG_SH2_STAT5	205	208	PF00017	0.429
LIG_SH2_STAT5	282	285	PF00017	0.347
LIG_SH2_STAT5	33	36	PF00017	0.212
LIG_SH2_STAT5	362	365	PF00017	0.440
LIG_SH2_STAT5	386	389	PF00017	0.429
LIG_SH2_STAT5	538	541	PF00017	0.456
LIG_SH2_STAT5	56	59	PF00017	0.429
LIG_SH2_STAT5	751	754	PF00017	0.534
LIG_SH2_STAT5	809	812	PF00017	0.527
LIG_SH3_3	113	119	PF00018	0.175
LIG_SH3_3	143	149	PF00018	0.454
LIG_SH3_3	165	171	PF00018	0.366
LIG_SH3_3	353	359	PF00018	0.516
LIG_SH3_3	46	52	PF00018	0.299
LIG_SH3_3	470	476	PF00018	0.429
LIG_SH3_3	494	500	PF00018	0.451
LIG_SH3_3	56	62	PF00018	0.438
LIG_SH3_3	93	99	PF00018	0.430
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.400
LIG_SUMO_SIM_anti_2	210	218	PF11976	0.424
LIG_SUMO_SIM_anti_2	322	328	PF11976	0.468
LIG_SUMO_SIM_par_1	416	422	PF11976	0.490
LIG_SUMO_SIM_par_1	488	493	PF11976	0.457
LIG_SUMO_SIM_par_1	515	525	PF11976	0.454
LIG_SUMO_SIM_par_1	712	719	PF11976	0.446
LIG_SxIP_EBH_1	146	155	PF03271	0.534
LIG_TRAF2_1	105	108	PF00917	0.568
LIG_TRAF2_1	208	211	PF00917	0.358
LIG_TRAF2_1	34	37	PF00917	0.444
LIG_TRAF2_1	419	422	PF00917	0.515
LIG_TRAF2_1	483	486	PF00917	0.441
LIG_TRAF2_1	99	102	PF00917	0.494
LIG_TRFH_1	309	313	PF08558	0.363
LIG_TRFH_1	95	99	PF08558	0.281
LIG_UBA3_1	221	226	PF00899	0.428
LIG_UBA3_1	800	807	PF00899	0.531
LIG_WRC_WIRS_1	233	238	PF05994	0.365
LIG_WRC_WIRS_1	577	582	PF05994	0.281
LIG_WW_3	51	55	PF00397	0.316
MOD_CDK_SPK_2	493	498	PF00069	0.396
MOD_CK1_1	430	436	PF00069	0.565
MOD_CK1_1	493	499	PF00069	0.399
MOD_CK1_1	502	508	PF00069	0.347
MOD_CK1_1	515	521	PF00069	0.241
MOD_CK1_1	547	553	PF00069	0.428
MOD_CK1_1	698	704	PF00069	0.457
MOD_CK2_1	102	108	PF00069	0.175
MOD_CK2_1	205	211	PF00069	0.383
MOD_CK2_1	31	37	PF00069	0.425
MOD_CK2_1	388	394	PF00069	0.338
MOD_CK2_1	439	445	PF00069	0.508
MOD_CK2_1	698	704	PF00069	0.457
MOD_GlcNHglycan	230	233	PF01048	0.432
MOD_GlcNHglycan	27	30	PF01048	0.517
MOD_GlcNHglycan	492	495	PF01048	0.281
MOD_GlcNHglycan	583	586	PF01048	0.297
MOD_GlcNHglycan	620	623	PF01048	0.339
MOD_GlcNHglycan	697	700	PF01048	0.424
MOD_GlcNHglycan	732	735	PF01048	0.502
MOD_GlcNHglycan	74	78	PF01048	0.326
MOD_GSK3_1	205	212	PF00069	0.434
MOD_GSK3_1	21	28	PF00069	0.512
MOD_GSK3_1	228	235	PF00069	0.369
MOD_GSK3_1	423	430	PF00069	0.537
MOD_GSK3_1	618	625	PF00069	0.332
MOD_GSK3_1	629	636	PF00069	0.426
MOD_GSK3_1	809	816	PF00069	0.522
MOD_N-GLC_1	18	23	PF02516	0.390
MOD_N-GLC_1	181	186	PF02516	0.356
MOD_N-GLC_1	388	393	PF02516	0.337
MOD_N-GLC_1	427	432	PF02516	0.548
MOD_NEK2_1	1	6	PF00069	0.535
MOD_NEK2_1	198	203	PF00069	0.196
MOD_NEK2_1	228	233	PF00069	0.387
MOD_NEK2_1	297	302	PF00069	0.531
MOD_NEK2_1	388	393	PF00069	0.316
MOD_NEK2_1	490	495	PF00069	0.316
MOD_NEK2_1	531	536	PF00069	0.283
MOD_NEK2_1	612	617	PF00069	0.271
MOD_NEK2_1	633	638	PF00069	0.431
MOD_NEK2_1	73	78	PF00069	0.428
MOD_NEK2_1	749	754	PF00069	0.516
MOD_NEK2_1	800	805	PF00069	0.633
MOD_NEK2_2	250	255	PF00069	0.428
MOD_NEK2_2	305	310	PF00069	0.402
MOD_NEK2_2	427	432	PF00069	0.298
MOD_PIKK_1	544	550	PF00454	0.404
MOD_PIKK_1	644	650	PF00454	0.418
MOD_PIKK_1	749	755	PF00454	0.574
MOD_PK_1	549	555	PF00069	0.297
MOD_PKA_2	228	234	PF00069	0.398
MOD_PKA_2	512	518	PF00069	0.297
MOD_PKA_2	531	537	PF00069	0.210
MOD_PKA_2	581	587	PF00069	0.281
MOD_PKA_2	629	635	PF00069	0.433
MOD_PKA_2	730	736	PF00069	0.439
MOD_PKA_2	782	788	PF00069	0.506
MOD_Plk_1	107	113	PF00069	0.348
MOD_Plk_1	209	215	PF00069	0.463
MOD_Plk_1	305	311	PF00069	0.398
MOD_Plk_1	313	319	PF00069	0.408
MOD_Plk_1	485	491	PF00069	0.297
MOD_Plk_4	1	7	PF00069	0.534
MOD_Plk_4	148	154	PF00069	0.280
MOD_Plk_4	164	170	PF00069	0.262
MOD_Plk_4	209	215	PF00069	0.423
MOD_Plk_4	217	223	PF00069	0.399
MOD_Plk_4	297	303	PF00069	0.453
MOD_Plk_4	305	311	PF00069	0.361
MOD_Plk_4	474	480	PF00069	0.175
MOD_Plk_4	515	521	PF00069	0.318
MOD_Plk_4	782	788	PF00069	0.487
MOD_ProDKin_1	423	429	PF00069	0.323
MOD_ProDKin_1	493	499	PF00069	0.352
MOD_ProDKin_1	813	819	PF00069	0.527
MOD_SUMO_for_1	690	693	PF00179	0.503
MOD_SUMO_rev_2	157	167	PF00179	0.446
MOD_SUMO_rev_2	223	228	PF00179	0.412
MOD_SUMO_rev_2	263	270	PF00179	0.451
MOD_SUMO_rev_2	361	371	PF00179	0.498
MOD_SUMO_rev_2	621	629	PF00179	0.283
MOD_SUMO_rev_2	698	707	PF00179	0.418
TRG_DiLeu_BaEn_1	330	335	PF01217	0.368
TRG_DiLeu_BaEn_1	668	673	PF01217	0.424
TRG_DiLeu_BaEn_2	305	311	PF01217	0.383
TRG_DiLeu_BaEn_4	330	336	PF01217	0.428
TRG_DiLeu_BaEn_4	485	491	PF01217	0.316
TRG_ENDOCYTIC_2	11	14	PF00928	0.351
TRG_ENDOCYTIC_2	282	285	PF00928	0.345
TRG_ENDOCYTIC_2	447	450	PF00928	0.495
TRG_ENDOCYTIC_2	538	541	PF00928	0.338
TRG_ENDOCYTIC_2	56	59	PF00928	0.281
TRG_ER_diArg_1	302	304	PF00400	0.426
TRG_ER_diArg_1	374	376	PF00400	0.496
TRG_ER_diArg_1	528	531	PF00400	0.402
TRG_ER_diArg_1	774	776	PF00400	0.443
TRG_NES_CRM1_1	315	331	PF08389	0.444
TRG_NLS_MonoCore_2	467	472	PF00514	0.251
TRG_NLS_MonoExtN_4	466	472	PF00514	0.196

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z8	Leptomonas seymouri	35%	92%
A0A0N1I3S9	Leptomonas seymouri	82%	100%
A0A0S4ISQ0	Bodo saltans	40%	97%
A0A0S4JL46	Bodo saltans	59%	99%
A0A1X0NXD4	Trypanosomatidae	41%	100%
A0A1X0P2V2	Trypanosomatidae	66%	100%
A0A1X0P8P2	Trypanosomatidae	36%	97%
A0A3S7WNY9	Leishmania donovani	92%	100%
A0A3S7XAQ4	Leishmania donovani	36%	95%
A0A422NIL8	Trypanosoma rangeli	40%	99%
A0A422NLE5	Trypanosoma rangeli	35%	97%
A0A422NYK3	Trypanosoma rangeli	65%	98%
A4H452	Leishmania braziliensis	100%	100%
A4HP51	Leishmania braziliensis	35%	95%
A4HSC9	Leishmania infantum	92%	100%
A4IDF8	Leishmania infantum	36%	95%
C9ZPY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D0A1L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	97%
D0A336	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9AKB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9ASV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
P34118	Dictyostelium discoideum	51%	99%
P54659	Dictyostelium discoideum	49%	98%
Q14764	Homo sapiens	50%	93%
Q3SYU9	Bos taurus	49%	94%
Q4CUM2	Trypanosoma cruzi (strain CL Brener)	65%	99%
Q4Q1N7	Leishmania major	36%	99%
Q4QJJ7	Leishmania major	91%	100%
Q57Z03	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	64%	99%
Q5EAJ7	Strongylocentrotus purpuratus	50%	97%
Q5R9N2	Pongo abelii	50%	93%
Q5ZMI4	Gallus gallus	49%	98%
Q62667	Rattus norvegicus	48%	97%
Q6P3L0	Danio rerio	48%	97%
Q6PF69	Xenopus laevis	49%	98%
Q90405	Diplobatis ommata	49%	98%
Q9DGM7	Ictalurus punctatus	47%	96%
Q9EQK5	Mus musculus	49%	97%
V5AUX6	Trypanosoma cruzi	65%	99%
V5B0K2	Trypanosoma cruzi	39%	97%
V5BPE1	Trypanosoma cruzi	33%	100%