Acireductone dioxygenase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

1 -2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase - putative

Species:

Leishmania infantum

UniProt:

MTND_LEIIN

TriTrypDb:

LINF_200014700

Length:

344

Annotations

Annotations by Jardim et al.

Amino acid metabolism, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0005737	cytoplasm	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HYT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYT9

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	13
GO:0000097	sulfur amino acid biosynthetic process	5	13
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006555	methionine metabolic process	5	13
GO:0006790	sulfur compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0008652	amino acid biosynthetic process	4	13
GO:0009058	biosynthetic process	2	13
GO:0009066	aspartate family amino acid metabolic process	5	13
GO:0009067	aspartate family amino acid biosynthetic process	6	13
GO:0009086	methionine biosynthetic process	6	13
GO:0009987	cellular process	1	13
GO:0016053	organic acid biosynthetic process	4	13
GO:0019509	L-methionine salvage from methylthioadenosine	6	8
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043094	cellular metabolic compound salvage	3	8
GO:0043102	amino acid salvage	4	8
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044272	sulfur compound biosynthetic process	4	13
GO:0044281	small molecule metabolic process	2	13
GO:0044283	small molecule biosynthetic process	3	13
GO:0046394	carboxylic acid biosynthetic process	5	13
GO:0071265	L-methionine biosynthetic process	7	8
GO:0071267	L-methionine salvage	5	8
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13
GO:1901605	alpha-amino acid metabolic process	4	13
GO:1901607	alpha-amino acid biosynthetic process	5	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	8
GO:0005506	iron ion binding	6	8
GO:0010308	acireductone dioxygenase (Ni2+-requiring) activity	5	4
GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	5	13
GO:0016491	oxidoreductase activity	2	13
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	13
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	13
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8
GO:0051213	dioxygenase activity	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.419
CLV_NRD_NRD_1	173	175	PF00675	0.623
CLV_PCSK_KEX2_1	14	16	PF00082	0.419
CLV_PCSK_KEX2_1	215	217	PF00082	0.520
CLV_PCSK_KEX2_1	223	225	PF00082	0.433
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.520
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.433
CLV_PCSK_SKI1_1	100	104	PF00082	0.432
CLV_PCSK_SKI1_1	145	149	PF00082	0.437
CLV_PCSK_SKI1_1	151	155	PF00082	0.437
CLV_PCSK_SKI1_1	195	199	PF00082	0.525
CLV_PCSK_SKI1_1	215	219	PF00082	0.473
CLV_PCSK_SKI1_1	270	274	PF00082	0.346
CLV_PCSK_SKI1_1	312	316	PF00082	0.648
DOC_CDC14_PxL_1	299	307	PF14671	0.579
DOC_CKS1_1	307	312	PF01111	0.627
DOC_CYCLIN_RxL_1	212	222	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.590
DOC_MAPK_gen_1	223	230	PF00069	0.661
DOC_MAPK_JIP1_4	224	230	PF00069	0.499
DOC_MAPK_MEF2A_6	201	210	PF00069	0.561
DOC_MAPK_MEF2A_6	223	232	PF00069	0.562
DOC_MAPK_MEF2A_6	270	278	PF00069	0.632
DOC_MAPK_MEF2A_6	292	299	PF00069	0.546
DOC_PP2B_LxvP_1	181	184	PF13499	0.667
DOC_PP2B_LxvP_1	274	277	PF13499	0.652
DOC_PP4_FxxP_1	53	56	PF00568	0.637
DOC_USP7_MATH_2	277	283	PF00917	0.597
DOC_USP7_UBL2_3	171	175	PF12436	0.662
DOC_WW_Pin1_4	18	23	PF00397	0.550
DOC_WW_Pin1_4	306	311	PF00397	0.631
DOC_WW_Pin1_4	69	74	PF00397	0.637
LIG_14-3-3_CanoR_1	138	147	PF00244	0.590
LIG_14-3-3_CanoR_1	195	201	PF00244	0.581
LIG_14-3-3_CanoR_1	280	284	PF00244	0.648
LIG_APCC_ABBA_1	150	155	PF00400	0.614
LIG_FHA_1	147	153	PF00498	0.591
LIG_FHA_1	212	218	PF00498	0.603
LIG_FHA_1	294	300	PF00498	0.602
LIG_FHA_1	302	308	PF00498	0.546
LIG_FHA_2	237	243	PF00498	0.597
LIG_FHA_2	81	87	PF00498	0.634
LIG_Integrin_isoDGR_2	193	195	PF01839	0.536
LIG_LIR_Apic_2	2	8	PF02991	0.606
LIG_LIR_Apic_2	51	56	PF02991	0.637
LIG_LIR_Gen_1	116	125	PF02991	0.548
LIG_LIR_Gen_1	257	266	PF02991	0.499
LIG_LIR_Gen_1	27	36	PF02991	0.636
LIG_LIR_Gen_1	319	330	PF02991	0.419
LIG_LIR_Gen_1	65	74	PF02991	0.637
LIG_LIR_Gen_1	79	89	PF02991	0.637
LIG_LIR_Nem_3	116	121	PF02991	0.558
LIG_LIR_Nem_3	257	262	PF02991	0.499
LIG_LIR_Nem_3	27	31	PF02991	0.607
LIG_LIR_Nem_3	319	325	PF02991	0.606
LIG_LIR_Nem_3	65	69	PF02991	0.637
LIG_LIR_Nem_3	79	84	PF02991	0.637
LIG_Pex14_2	37	41	PF04695	0.652
LIG_PTB_Apo_2	283	290	PF02174	0.546
LIG_SH2_CRK	66	70	PF00017	0.637
LIG_SH2_NCK_1	66	70	PF00017	0.595
LIG_SH2_STAT5	108	111	PF00017	0.537
LIG_SH2_STAT5	177	180	PF00017	0.546
LIG_SH2_STAT5	231	234	PF00017	0.629
LIG_SH2_STAT5	283	286	PF00017	0.550
LIG_SH2_STAT5	6	9	PF00017	0.652
LIG_SH3_1	19	25	PF00018	0.608
LIG_SH3_2	287	292	PF14604	0.548
LIG_SH3_3	19	25	PF00018	0.534
LIG_SH3_3	284	290	PF00018	0.548
LIG_SH3_3	304	310	PF00018	0.621
LIG_SH3_4	171	178	PF00018	0.651
LIG_SUMO_SIM_anti_2	304	309	PF11976	0.614
LIG_SUMO_SIM_par_1	303	309	PF11976	0.614
LIG_SUMO_SIM_par_1	339	344	PF11976	0.531
LIG_UBA3_1	197	205	PF00899	0.608
LIG_UBA3_1	305	312	PF00899	0.637
MOD_CDK_SPxK_1	306	312	PF00069	0.637
MOD_CK1_1	301	307	PF00069	0.637
MOD_CK2_1	236	242	PF00069	0.597
MOD_CK2_1	80	86	PF00069	0.573
MOD_GSK3_1	137	144	PF00069	0.642
MOD_GSK3_1	232	239	PF00069	0.553
MOD_N-GLC_1	69	74	PF02516	0.433
MOD_PKA_2	137	143	PF00069	0.602
MOD_PKA_2	279	285	PF00069	0.629
MOD_Plk_1	208	214	PF00069	0.498
MOD_Plk_4	279	285	PF00069	0.646
MOD_Plk_4	301	307	PF00069	0.614
MOD_ProDKin_1	18	24	PF00069	0.550
MOD_ProDKin_1	306	312	PF00069	0.631
MOD_ProDKin_1	69	75	PF00069	0.637
MOD_SUMO_rev_2	142	150	PF00179	0.598
MOD_SUMO_rev_2	167	173	PF00179	0.660
MOD_SUMO_rev_2	324	330	PF00179	0.605
TRG_DiLeu_BaEn_3	268	274	PF01217	0.627
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.652
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.598
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.617
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.637
TRG_ENDOCYTIC_2	108	111	PF00928	0.537
TRG_ENDOCYTIC_2	136	139	PF00928	0.549
TRG_ENDOCYTIC_2	28	31	PF00928	0.626
TRG_ENDOCYTIC_2	38	41	PF00928	0.589
TRG_ENDOCYTIC_2	66	69	PF00928	0.582
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW0	Leptomonas seymouri	72%	100%
A0A0S4JKP7	Bodo saltans	38%	100%
A0A1X0P434	Trypanosomatidae	31%	100%
A0A1X0P4C0	Trypanosomatidae	32%	100%
A0A3Q8IDM9	Leishmania donovani	99%	100%
A0A422N1T2	Trypanosoma rangeli	31%	100%
A4HYT9	Leishmania infantum	100%	100%
D0A5U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AIE8	Leishmania braziliensis	87%	100%
E9AUN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCU9	Leishmania major	92%	100%
V5D947	Trypanosoma cruzi	30%	100%