Thymine dioxygenase JBP1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

J-binding protein

Species:

Leishmania braziliensis

UniProt:

JBP1_LEIBR

TriTrypDb:

LbrM.09.1540 , LBRM2903_090022000

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H5X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5X5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006304	DNA modification	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0070580	base J metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0006281	DNA repair	5	1
GO:0006283	transcription-coupled nucleotide-excision repair	7	1
GO:0006289	nucleotide-excision repair	6	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	7
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0050341	thymine dioxygenase activity	5	7
GO:0051213	dioxygenase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005506	iron ion binding	6	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0008198	ferrous iron binding	7	1
GO:0046914	transition metal ion binding	5	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.450
CLV_C14_Caspase3-7	55	59	PF00656	0.398
CLV_NRD_NRD_1	122	124	PF00675	0.282
CLV_NRD_NRD_1	277	279	PF00675	0.439
CLV_NRD_NRD_1	402	404	PF00675	0.226
CLV_NRD_NRD_1	447	449	PF00675	0.449
CLV_NRD_NRD_1	516	518	PF00675	0.338
CLV_NRD_NRD_1	544	546	PF00675	0.348
CLV_NRD_NRD_1	547	549	PF00675	0.348
CLV_NRD_NRD_1	556	558	PF00675	0.348
CLV_NRD_NRD_1	68	70	PF00675	0.286
CLV_NRD_NRD_1	749	751	PF00675	0.272
CLV_PCSK_KEX2_1	254	256	PF00082	0.390
CLV_PCSK_KEX2_1	276	278	PF00082	0.464
CLV_PCSK_KEX2_1	402	404	PF00082	0.226
CLV_PCSK_KEX2_1	544	546	PF00082	0.344
CLV_PCSK_KEX2_1	556	558	PF00082	0.340
CLV_PCSK_KEX2_1	566	568	PF00082	0.578
CLV_PCSK_KEX2_1	6	8	PF00082	0.387
CLV_PCSK_KEX2_1	749	751	PF00082	0.272
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.390
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.197
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.680
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.387
CLV_PCSK_SKI1_1	254	258	PF00082	0.379
CLV_PCSK_SKI1_1	263	267	PF00082	0.376
CLV_PCSK_SKI1_1	439	443	PF00082	0.310
CLV_PCSK_SKI1_1	449	453	PF00082	0.407
CLV_PCSK_SKI1_1	532	536	PF00082	0.348
CLV_PCSK_SKI1_1	591	595	PF00082	0.454
CLV_PCSK_SKI1_1	597	601	PF00082	0.441
CLV_PCSK_SKI1_1	6	10	PF00082	0.503
CLV_PCSK_SKI1_1	684	688	PF00082	0.452
CLV_PCSK_SKI1_1	69	73	PF00082	0.391
CLV_PCSK_SKI1_1	74	78	PF00082	0.395
CLV_Separin_Metazoa	616	620	PF03568	0.259
DEG_APCC_DBOX_1	89	97	PF00400	0.567
DEG_APCC_KENBOX_2	297	301	PF00400	0.579
DEG_Nend_UBRbox_2	1	3	PF02207	0.586
DEG_SCF_FBW7_1	170	177	PF00400	0.482
DEG_SCF_FBW7_1	286	293	PF00400	0.343
DEG_SPOP_SBC_1	356	360	PF00917	0.436
DOC_CDC14_PxL_1	621	629	PF14671	0.265
DOC_CYCLIN_RxL_1	207	218	PF00134	0.555
DOC_CYCLIN_RxL_1	424	437	PF00134	0.323
DOC_CYCLIN_RxL_1	665	675	PF00134	0.557
DOC_MAPK_DCC_7	619	629	PF00069	0.261
DOC_MAPK_FxFP_2	13	16	PF00069	0.571
DOC_MAPK_gen_1	208	216	PF00069	0.375
DOC_MAPK_gen_1	424	433	PF00069	0.449
DOC_MAPK_gen_1	436	444	PF00069	0.226
DOC_MAPK_gen_1	517	523	PF00069	0.282
DOC_MAPK_gen_1	57	66	PF00069	0.411
DOC_MAPK_gen_1	6	12	PF00069	0.487
DOC_MAPK_MEF2A_6	208	216	PF00069	0.375
DOC_MAPK_MEF2A_6	60	68	PF00069	0.402
DOC_MAPK_MEF2A_6	614	622	PF00069	0.516
DOC_PP2B_LxvP_1	507	510	PF13499	0.348
DOC_PP2B_LxvP_1	670	673	PF13499	0.560
DOC_PP4_FxxP_1	13	16	PF00568	0.469
DOC_PP4_FxxP_1	318	321	PF00568	0.464
DOC_PP4_FxxP_1	353	356	PF00568	0.518
DOC_USP7_MATH_1	290	294	PF00917	0.582
DOC_USP7_MATH_1	333	337	PF00917	0.383
DOC_USP7_MATH_1	343	347	PF00917	0.536
DOC_USP7_MATH_1	723	727	PF00917	0.323
DOC_USP7_MATH_2	117	123	PF00917	0.482
DOC_USP7_UBL2_3	518	522	PF12436	0.348
DOC_USP7_UBL2_3	600	604	PF12436	0.557
DOC_USP7_UBL2_3	70	74	PF12436	0.249
DOC_WW_Pin1_4	113	118	PF00397	0.409
DOC_WW_Pin1_4	170	175	PF00397	0.482
DOC_WW_Pin1_4	20	25	PF00397	0.540
DOC_WW_Pin1_4	286	291	PF00397	0.611
DOC_WW_Pin1_4	305	310	PF00397	0.309
DOC_WW_Pin1_4	313	318	PF00397	0.424
DOC_WW_Pin1_4	653	658	PF00397	0.385
DOC_WW_Pin1_4	795	800	PF00397	0.389
DOC_WW_Pin1_4	805	810	PF00397	0.436
DOC_WW_Pin1_4	99	104	PF00397	0.462
LIG_14-3-3_CanoR_1	123	128	PF00244	0.482
LIG_14-3-3_CanoR_1	183	192	PF00244	0.555
LIG_14-3-3_CanoR_1	255	262	PF00244	0.365
LIG_14-3-3_CanoR_1	652	657	PF00244	0.386
LIG_14-3-3_CanoR_1	739	745	PF00244	0.396
LIG_14-3-3_CanoR_1	90	94	PF00244	0.472
LIG_APCC_ABBA_1	37	42	PF00400	0.266
LIG_BRCT_BRCA1_1	135	139	PF00533	0.375
LIG_BRCT_BRCA1_1	234	238	PF00533	0.506
LIG_BRCT_BRCA1_1	460	464	PF00533	0.348
LIG_BRCT_BRCA1_1	94	98	PF00533	0.446
LIG_CSL_BTD_1	318	321	PF09270	0.488
LIG_CSL_BTD_1	609	612	PF09270	0.336
LIG_deltaCOP1_diTrp_1	132	139	PF00928	0.482
LIG_deltaCOP1_diTrp_1	250	260	PF00928	0.408
LIG_deltaCOP1_diTrp_1	421	430	PF00928	0.338
LIG_EH1_1	218	226	PF00400	0.388
LIG_EVH1_2	314	318	PF00568	0.268
LIG_FHA_1	175	181	PF00498	0.482
LIG_FHA_1	287	293	PF00498	0.591
LIG_FHA_1	3	9	PF00498	0.355
LIG_FHA_1	601	607	PF00498	0.398
LIG_FHA_1	801	807	PF00498	0.498
LIG_FHA_2	15	21	PF00498	0.560
LIG_FHA_2	213	219	PF00498	0.396
LIG_FHA_2	240	246	PF00498	0.408
LIG_FHA_2	396	402	PF00498	0.348
LIG_FHA_2	53	59	PF00498	0.394
LIG_FHA_2	611	617	PF00498	0.315
LIG_FHA_2	641	647	PF00498	0.389
LIG_FHA_2	775	781	PF00498	0.409
LIG_Integrin_RGD_1	366	368	PF01839	0.341
LIG_LIR_Apic_2	11	16	PF02991	0.461
LIG_LIR_Apic_2	316	321	PF02991	0.490
LIG_LIR_Apic_2	350	356	PF02991	0.525
LIG_LIR_Gen_1	132	142	PF02991	0.375
LIG_LIR_Gen_1	173	180	PF02991	0.482
LIG_LIR_Gen_1	196	205	PF02991	0.482
LIG_LIR_Gen_1	215	224	PF02991	0.505
LIG_LIR_Gen_1	647	658	PF02991	0.421
LIG_LIR_Gen_1	693	704	PF02991	0.482
LIG_LIR_Nem_3	132	138	PF02991	0.482
LIG_LIR_Nem_3	146	152	PF02991	0.482
LIG_LIR_Nem_3	173	178	PF02991	0.482
LIG_LIR_Nem_3	196	202	PF02991	0.482
LIG_LIR_Nem_3	206	212	PF02991	0.482
LIG_LIR_Nem_3	215	219	PF02991	0.482
LIG_LIR_Nem_3	250	256	PF02991	0.428
LIG_LIR_Nem_3	270	275	PF02991	0.212
LIG_LIR_Nem_3	285	291	PF02991	0.493
LIG_LIR_Nem_3	461	466	PF02991	0.449
LIG_LIR_Nem_3	647	653	PF02991	0.430
LIG_LIR_Nem_3	693	699	PF02991	0.495
LIG_MLH1_MIPbox_1	460	464	PF16413	0.449
LIG_Pex14_1	135	139	PF04695	0.482
LIG_PTAP_UEV_1	808	813	PF05743	0.379
LIG_PTB_Apo_2	570	577	PF02174	0.448
LIG_SH2_CRK	199	203	PF00017	0.482
LIG_SH2_CRK	696	700	PF00017	0.251
LIG_SH2_CRK	752	756	PF00017	0.394
LIG_SH2_GRB2like	41	44	PF00017	0.388
LIG_SH2_NCK_1	199	203	PF00017	0.482
LIG_SH2_NCK_1	752	756	PF00017	0.394
LIG_SH2_SRC	31	34	PF00017	0.459
LIG_SH2_SRC	405	408	PF00017	0.449
LIG_SH2_SRC	41	44	PF00017	0.388
LIG_SH2_STAP1	199	203	PF00017	0.482
LIG_SH2_STAP1	31	35	PF00017	0.455
LIG_SH2_STAP1	495	499	PF00017	0.289
LIG_SH2_STAP1	696	700	PF00017	0.299
LIG_SH2_STAP1	742	746	PF00017	0.431
LIG_SH2_STAP1	75	79	PF00017	0.490
LIG_SH2_STAP1	752	756	PF00017	0.384
LIG_SH2_STAT3	793	796	PF00017	0.443
LIG_SH2_STAT5	110	113	PF00017	0.482
LIG_SH2_STAT5	144	147	PF00017	0.482
LIG_SH2_STAT5	405	408	PF00017	0.289
LIG_SH2_STAT5	533	536	PF00017	0.348
LIG_SH2_STAT5	717	720	PF00017	0.398
LIG_SH2_STAT5	742	745	PF00017	0.387
LIG_SH3_1	306	312	PF00018	0.498
LIG_SH3_3	306	312	PF00018	0.498
LIG_SH3_3	619	625	PF00018	0.377
LIG_SH3_3	651	657	PF00018	0.433
LIG_SH3_3	803	809	PF00018	0.514
LIG_SH3_5	140	144	PF00018	0.482
LIG_Sin3_3	80	87	PF02671	0.287
LIG_SUMO_SIM_par_1	116	122	PF11976	0.482
LIG_SUMO_SIM_par_1	176	182	PF11976	0.482
LIG_SUMO_SIM_par_1	620	626	PF11976	0.477
LIG_TRAF2_1	23	26	PF00917	0.530
LIG_TRAF2_1	485	488	PF00917	0.348
LIG_TRAF2_1	538	541	PF00917	0.449
LIG_TRAF2_1	613	616	PF00917	0.325
LIG_UBA3_1	419	424	PF00899	0.348
LIG_UBA3_1	441	449	PF00899	0.449
LIG_UBA3_1	474	480	PF00899	0.352
MOD_CK1_1	102	108	PF00069	0.311
MOD_CK1_1	122	128	PF00069	0.319
MOD_CK1_1	176	182	PF00069	0.482
MOD_CK1_1	716	722	PF00069	0.242
MOD_CK1_1	767	773	PF00069	0.440
MOD_CK1_1	78	84	PF00069	0.471
MOD_CK1_1	92	98	PF00069	0.324
MOD_CK2_1	113	119	PF00069	0.482
MOD_CK2_1	14	20	PF00069	0.550
MOD_CK2_1	237	243	PF00069	0.399
MOD_CK2_1	244	250	PF00069	0.471
MOD_CK2_1	268	274	PF00069	0.434
MOD_CK2_1	27	33	PF00069	0.436
MOD_CK2_1	333	339	PF00069	0.268
MOD_CK2_1	395	401	PF00069	0.348
MOD_CK2_1	610	616	PF00069	0.346
MOD_CK2_1	774	780	PF00069	0.419
MOD_GlcNHglycan	104	107	PF01048	0.209
MOD_GlcNHglycan	135	138	PF01048	0.237
MOD_GlcNHglycan	331	334	PF01048	0.286
MOD_GlcNHglycan	415	418	PF01048	0.449
MOD_GlcNHglycan	460	463	PF01048	0.449
MOD_GlcNHglycan	499	502	PF01048	0.197
MOD_GlcNHglycan	52	55	PF01048	0.379
MOD_GlcNHglycan	725	728	PF01048	0.343
MOD_GlcNHglycan	80	83	PF01048	0.393
MOD_GlcNHglycan	85	88	PF01048	0.447
MOD_GSK3_1	119	126	PF00069	0.482
MOD_GSK3_1	14	21	PF00069	0.631
MOD_GSK3_1	170	177	PF00069	0.482
MOD_GSK3_1	179	186	PF00069	0.482
MOD_GSK3_1	286	293	PF00069	0.541
MOD_GSK3_1	329	336	PF00069	0.460
MOD_GSK3_1	339	346	PF00069	0.453
MOD_GSK3_1	405	412	PF00069	0.374
MOD_GSK3_1	454	461	PF00069	0.414
MOD_GSK3_1	640	647	PF00069	0.515
MOD_GSK3_1	686	693	PF00069	0.510
MOD_GSK3_1	712	719	PF00069	0.317
MOD_GSK3_1	74	81	PF00069	0.434
MOD_GSK3_1	740	747	PF00069	0.376
MOD_GSK3_1	795	802	PF00069	0.316
MOD_GSK3_1	88	95	PF00069	0.400
MOD_LATS_1	598	604	PF00433	0.542
MOD_N-GLC_1	299	304	PF02516	0.601
MOD_N-GLC_1	454	459	PF02516	0.348
MOD_N-GLC_1	572	577	PF02516	0.440
MOD_N-GLC_1	800	805	PF02516	0.492
MOD_NEK2_1	1	6	PF00069	0.398
MOD_NEK2_1	279	284	PF00069	0.565
MOD_NEK2_1	394	399	PF00069	0.438
MOD_NEK2_1	50	55	PF00069	0.390
MOD_NEK2_1	528	533	PF00069	0.348
MOD_NEK2_1	687	692	PF00069	0.293
MOD_NEK2_1	713	718	PF00069	0.242
MOD_NEK2_1	744	749	PF00069	0.524
MOD_NEK2_1	800	805	PF00069	0.492
MOD_NEK2_1	83	88	PF00069	0.442
MOD_NEK2_2	333	338	PF00069	0.258
MOD_NEK2_2	490	495	PF00069	0.449
MOD_PIKK_1	343	349	PF00454	0.304
MOD_PKA_1	123	129	PF00069	0.482
MOD_PKA_1	254	260	PF00069	0.375
MOD_PKA_2	122	128	PF00069	0.482
MOD_PKA_2	254	260	PF00069	0.375
MOD_PKA_2	89	95	PF00069	0.467
MOD_PKB_1	183	191	PF00069	0.482
MOD_Plk_1	572	578	PF00069	0.432
MOD_Plk_1	800	806	PF00069	0.494
MOD_Plk_2-3	268	274	PF00069	0.434
MOD_Plk_2-3	52	58	PF00069	0.388
MOD_Plk_2-3	577	583	PF00069	0.516
MOD_Plk_4	713	719	PF00069	0.365
MOD_ProDKin_1	113	119	PF00069	0.409
MOD_ProDKin_1	170	176	PF00069	0.482
MOD_ProDKin_1	20	26	PF00069	0.538
MOD_ProDKin_1	286	292	PF00069	0.605
MOD_ProDKin_1	305	311	PF00069	0.301
MOD_ProDKin_1	313	319	PF00069	0.419
MOD_ProDKin_1	653	659	PF00069	0.380
MOD_ProDKin_1	795	801	PF00069	0.389
MOD_ProDKin_1	805	811	PF00069	0.455
MOD_ProDKin_1	99	105	PF00069	0.455
MOD_SUMO_for_1	485	488	PF00179	0.449
MOD_SUMO_rev_2	116	122	PF00179	0.482
MOD_SUMO_rev_2	200	209	PF00179	0.375
MOD_SUMO_rev_2	247	256	PF00179	0.452
MOD_SUMO_rev_2	368	372	PF00179	0.604
MOD_SUMO_rev_2	432	441	PF00179	0.226
MOD_SUMO_rev_2	632	638	PF00179	0.608
TRG_DiLeu_BaEn_1	649	654	PF01217	0.419
TRG_DiLeu_BaEn_1	780	785	PF01217	0.507
TRG_DiLeu_BaEn_2	446	452	PF01217	0.449
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.257
TRG_ENDOCYTIC_2	149	152	PF00928	0.482
TRG_ENDOCYTIC_2	199	202	PF00928	0.482
TRG_ENDOCYTIC_2	696	699	PF00928	0.251
TRG_ENDOCYTIC_2	741	744	PF00928	0.390
TRG_ENDOCYTIC_2	752	755	PF00928	0.400
TRG_ER_diArg_1	275	278	PF00400	0.456
TRG_ER_diArg_1	427	430	PF00400	0.197
TRG_ER_diArg_1	544	546	PF00400	0.348
TRG_ER_diArg_1	748	750	PF00400	0.261
TRG_NES_CRM1_1	465	479	PF08389	0.260
TRG_NLS_MonoExtC_3	5	11	PF00514	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A0	Leptomonas seymouri	65%	99%
A0A0S4JFS0	Bodo saltans	42%	95%
A0A1X0NHV5	Trypanosomatidae	46%	99%
A0A3Q8IAX2	Leishmania donovani	84%	100%
A0A422NZF9	Trypanosoma rangeli	47%	99%
A4H5X5	Leishmania braziliensis	100%	100%
A4HU70	Leishmania infantum	84%	100%
D0A9Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
E9AN00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P86937	Trypanosoma brucei brucei	44%	97%
P86938	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	44%	97%
Q4DBW3	Trypanosoma cruzi (strain CL Brener)	47%	98%
Q4DLX9	Trypanosoma cruzi (strain CL Brener)	48%	98%
Q4QHM7	Leishmania major	85%	100%
Q9U6M1	Leishmania tarentolae	85%	98%
Q9U6M2	Crithidia fasciculata	64%	100%
V5DE87	Trypanosoma cruzi	47%	98%