Well-conserved EIF5A protein, with two copies in L. infantum only
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 1 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 4 |
| Forrest at al. (procyclic) | no | yes: 4 |
| Silverman et al. | no | yes: 2 |
| Pissara et al. | yes | yes: 10 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 10 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 7 |
| GO:0110165 | cellular anatomical entity | 1 | 7 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006417 | regulation of translation | 6 | 12 |
| GO:0006448 | regulation of translational elongation | 7 | 12 |
| GO:0006449 | regulation of translational termination | 6 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 2 |
| GO:0008152 | metabolic process | 1 | 2 |
| GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine | 3 | 2 |
| GO:0009058 | biosynthetic process | 2 | 2 |
| GO:0009889 | regulation of biosynthetic process | 4 | 12 |
| GO:0009891 | positive regulation of biosynthetic process | 5 | 12 |
| GO:0009893 | positive regulation of metabolic process | 4 | 12 |
| GO:0010468 | regulation of gene expression | 5 | 12 |
| GO:0010556 | regulation of macromolecule biosynthetic process | 5 | 12 |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 6 | 12 |
| GO:0010604 | positive regulation of macromolecule metabolic process | 5 | 12 |
| GO:0010608 | post-transcriptional regulation of gene expression | 6 | 12 |
| GO:0010628 | positive regulation of gene expression | 6 | 12 |
| GO:0018193 | peptidyl-amino acid modification | 5 | 2 |
| GO:0018205 | peptidyl-lysine modification | 6 | 2 |
| GO:0019222 | regulation of metabolic process | 3 | 12 |
| GO:0019538 | protein metabolic process | 3 | 2 |
| GO:0031323 | regulation of cellular metabolic process | 4 | 12 |
| GO:0031325 | positive regulation of cellular metabolic process | 5 | 12 |
| GO:0031326 | regulation of cellular biosynthetic process | 5 | 12 |
| GO:0031328 | positive regulation of cellular biosynthetic process | 6 | 12 |
| GO:0034248 | regulation of amide metabolic process | 5 | 12 |
| GO:0034250 | positive regulation of amide metabolic process | 6 | 12 |
| GO:0036211 | protein modification process | 4 | 2 |
| GO:0043170 | macromolecule metabolic process | 3 | 2 |
| GO:0043243 | positive regulation of protein-containing complex disassembly | 6 | 12 |
| GO:0043244 | regulation of protein-containing complex disassembly | 5 | 12 |
| GO:0043412 | macromolecule modification | 4 | 2 |
| GO:0044238 | primary metabolic process | 2 | 2 |
| GO:0045727 | positive regulation of translation | 7 | 12 |
| GO:0045901 | positive regulation of translational elongation | 8 | 12 |
| GO:0045905 | positive regulation of translational termination | 7 | 12 |
| GO:0048518 | positive regulation of biological process | 3 | 12 |
| GO:0048522 | positive regulation of cellular process | 4 | 12 |
| GO:0050789 | regulation of biological process | 2 | 12 |
| GO:0050794 | regulation of cellular process | 3 | 12 |
| GO:0051128 | regulation of cellular component organization | 4 | 12 |
| GO:0051130 | positive regulation of cellular component organization | 5 | 12 |
| GO:0051171 | regulation of nitrogen compound metabolic process | 4 | 12 |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 5 | 12 |
| GO:0051246 | regulation of protein metabolic process | 5 | 12 |
| GO:0051247 | positive regulation of protein metabolic process | 6 | 12 |
| GO:0051604 | protein maturation | 4 | 2 |
| GO:0060255 | regulation of macromolecule metabolic process | 4 | 12 |
| GO:0065007 | biological regulation | 1 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 2 |
| GO:0080090 | regulation of primary metabolic process | 4 | 12 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 2 |
| GO:2000112 | obsolete regulation of cellular macromolecule biosynthetic process | 6 | 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | 3 | 12 |
| GO:0003723 | RNA binding | 4 | 12 |
| GO:0003743 | translation initiation factor activity | 4 | 12 |
| GO:0003746 | translation elongation factor activity | 4 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0008135 | translation factor activity, RNA binding | 3 | 12 |
| GO:0043021 | ribonucleoprotein complex binding | 3 | 12 |
| GO:0043022 | ribosome binding | 4 | 12 |
| GO:0044877 | protein-containing complex binding | 2 | 12 |
| GO:0045182 | translation regulator activity | 1 | 12 |
| GO:0090079 | translation regulator activity, nucleic acid binding | 2 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_SKI1_1 | 142 | 146 | PF00082 | 0.298 |
| CLV_PCSK_SKI1_1 | 88 | 92 | PF00082 | 0.291 |
| DOC_MAPK_gen_1 | 29 | 36 | PF00069 | 0.395 |
| DOC_MAPK_gen_1 | 39 | 48 | PF00069 | 0.435 |
| DOC_MAPK_HePTP_8 | 36 | 48 | PF00069 | 0.407 |
| DOC_MAPK_MEF2A_6 | 142 | 149 | PF00069 | 0.490 |
| DOC_MAPK_MEF2A_6 | 39 | 48 | PF00069 | 0.406 |
| DOC_PP2B_LxvP_1 | 122 | 125 | PF13499 | 0.478 |
| DOC_USP7_MATH_1 | 57 | 61 | PF00917 | 0.383 |
| DOC_USP7_MATH_2 | 99 | 105 | PF00917 | 0.491 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.586 |
| LIG_FHA_1 | 152 | 158 | PF00498 | 0.565 |
| LIG_FHA_1 | 77 | 83 | PF00498 | 0.434 |
| LIG_FHA_1 | 89 | 95 | PF00498 | 0.467 |
| LIG_Integrin_isoDGR_2 | 37 | 39 | PF01839 | 0.428 |
| LIG_LIR_Gen_1 | 89 | 99 | PF02991 | 0.484 |
| LIG_LIR_LC3C_4 | 143 | 147 | PF02991 | 0.532 |
| LIG_LIR_Nem_3 | 89 | 95 | PF02991 | 0.484 |
| LIG_Pex14_2 | 86 | 90 | PF04695 | 0.541 |
| LIG_SH2_PTP2 | 33 | 36 | PF00017 | 0.388 |
| LIG_SH2_STAT5 | 33 | 36 | PF00017 | 0.368 |
| LIG_SH3_3 | 100 | 106 | PF00018 | 0.471 |
| LIG_SH3_3 | 79 | 85 | PF00018 | 0.412 |
| LIG_SUMO_SIM_anti_2 | 107 | 115 | PF11976 | 0.491 |
| LIG_SUMO_SIM_anti_2 | 143 | 150 | PF11976 | 0.490 |
| LIG_SUMO_SIM_par_1 | 143 | 150 | PF11976 | 0.490 |
| LIG_SUMO_SIM_par_1 | 42 | 47 | PF11976 | 0.398 |
| LIG_WRC_WIRS_1 | 87 | 92 | PF05994 | 0.491 |
| MOD_CK1_1 | 104 | 110 | PF00069 | 0.491 |
| MOD_CK2_1 | 137 | 143 | PF00069 | 0.566 |
| MOD_GlcNHglycan | 139 | 142 | PF01048 | 0.350 |
| MOD_GlcNHglycan | 149 | 152 | PF01048 | 0.188 |
| MOD_GSK3_1 | 147 | 154 | PF00069 | 0.545 |
| MOD_GSK3_1 | 44 | 51 | PF00069 | 0.432 |
| MOD_GSK3_1 | 57 | 64 | PF00069 | 0.421 |
| MOD_GSK3_1 | 86 | 93 | PF00069 | 0.490 |
| MOD_N-GLC_1 | 15 | 20 | PF02516 | 0.625 |
| MOD_NEK2_1 | 46 | 51 | PF00069 | 0.439 |
| MOD_NEK2_1 | 86 | 91 | PF00069 | 0.494 |
| MOD_PIKK_1 | 129 | 135 | PF00454 | 0.486 |
| MOD_Plk_1 | 44 | 50 | PF00069 | 0.427 |
| MOD_Plk_4 | 107 | 113 | PF00069 | 0.467 |
| MOD_Plk_4 | 57 | 63 | PF00069 | 0.410 |
| MOD_Plk_4 | 90 | 96 | PF00069 | 0.477 |
| TRG_ENDOCYTIC_2 | 33 | 36 | PF00928 | 0.368 |
| TRG_ENDOCYTIC_2 | 92 | 95 | PF00928 | 0.467 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0S4IWX1 | Bodo saltans | 59% | 100% |
| A0A1X0P4D2 | Trypanosomatidae | 77% | 99% |
| A0A1X0P4J3 | Trypanosomatidae | 77% | 99% |
| A0A3R7M6M8 | Trypanosoma rangeli | 77% | 100% |
| A0A3R7NI17 | Trypanosoma rangeli | 79% | 99% |
| A0A3S7WYW3 | Leishmania donovani | 98% | 100% |
| A0B9S8 | Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) | 33% | 100% |
| A1RX88 | Thermofilum pendens (strain DSM 2475 / Hrk 5) | 35% | 100% |
| A2BNB6 | Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) | 33% | 100% |
| A3DNK3 | Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) | 34% | 100% |
| A4FXY5 | Methanococcus maripaludis (strain C5 / ATCC BAA-1333) | 36% | 100% |
| A4GVE9 | Leishmania donovani | 98% | 100% |
| A4HE05 | Leishmania braziliensis | 96% | 100% |
| A4YHK9 | Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) | 32% | 100% |
| A5ULK4 | Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) | 32% | 100% |
| A6UNS4 | Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) | 33% | 100% |
| A6UVH4 | Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) | 32% | 100% |
| A6VFP3 | Methanococcus maripaludis (strain C7 / ATCC BAA-1331) | 34% | 100% |
| A7I807 | Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) | 31% | 100% |
| A8MD73 | Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) | 30% | 100% |
| A9AAZ2 | Methanococcus maripaludis (strain C6 / ATCC BAA-1332) | 34% | 100% |
| B1L7A5 | Korarchaeum cryptofilum (strain OPF8) | 35% | 100% |
| B6YTM4 | Thermococcus onnurineus (strain NA1) | 33% | 100% |
| B8D4W8 | Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) | 29% | 100% |
| C3MPN5 | Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) | 33% | 100% |
| C3MYM9 | Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) | 33% | 100% |
| C3N5B1 | Sulfolobus islandicus (strain M.16.27) | 33% | 100% |
| C3NDW5 | Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) | 33% | 100% |
| C3NHT8 | Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) | 33% | 100% |
| C4KGX7 | Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) | 33% | 100% |
| C5A5M5 | Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) | 32% | 100% |
| C6A117 | Thermococcus sibiricus (strain DSM 12597 / MM 739) | 32% | 100% |
| D0A5K8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 78% | 100% |
| E9AXF0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 100% | 100% |
| O26955 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 31% | 100% |
| O29612 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 32% | 100% |
| O50089 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 30% | 100% |
| O94083 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 46% | 100% |
| P10160 | Oryctolagus cuniculus | 46% | 100% |
| P13651 | Dictyostelium discoideum | 47% | 100% |
| P19211 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 50% | 100% |
| P23301 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 48% | 100% |
| P24922 | Nicotiana plumbaginifolia | 49% | 100% |
| P26564 | Medicago sativa | 47% | 100% |
| P28461 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 33% | 100% |
| P34563 | Caenorhabditis elegans | 44% | 100% |
| P38672 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 50% | 100% |
| P56289 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 47% | 100% |
| P56333 | Solanum tuberosum | 46% | 100% |
| P56335 | Solanum tuberosum | 48% | 100% |
| P56336 | Solanum tuberosum | 49% | 100% |
| P56337 | Solanum tuberosum | 46% | 100% |
| P62924 | Spodoptera exigua | 48% | 100% |
| P62925 | Spodoptera frugiperda | 48% | 100% |
| P63241 | Homo sapiens | 45% | 100% |
| P63242 | Mus musculus | 45% | 100% |
| P69039 | Nicotiana plumbaginifolia | 45% | 100% |
| P69040 | Nicotiana tabacum | 45% | 100% |
| P80639 | Zea mays | 47% | 100% |
| P87252 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 29% | 94% |
| Q07460 | Gallus gallus | 45% | 100% |
| Q09121 | Gallus gallus | 45% | 100% |
| Q0W941 | Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) | 30% | 100% |
| Q12UU7 | Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) | 31% | 100% |
| Q20751 | Caenorhabditis elegans | 46% | 100% |
| Q2FQ93 | Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) | 30% | 100% |
| Q2NEM4 | Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) | 32% | 100% |
| Q387H6 | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | 78% | 100% |
| Q3T1J1 | Rattus norvegicus | 45% | 100% |
| Q4QA21 | Leishmania major | 97% | 100% |
| Q5JI42 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 32% | 100% |
| Q5R898 | Pongo abelii | 45% | 100% |
| Q6EWQ7 | Bos taurus | 45% | 100% |
| Q6IS14 | Homo sapiens | 44% | 100% |
| Q6LYN8 | Methanococcus maripaludis (strain S2 / LL) | 37% | 100% |
| Q8BGY2 | Mus musculus | 45% | 100% |
| Q8U1E4 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 29% | 100% |
| Q93VP3 | Arabidopsis thaliana | 47% | 100% |
| Q945F4 | Medicago sativa | 49% | 100% |
| Q971T0 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 37% | 100% |
| Q97BB9 | Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) | 31% | 100% |
| Q97ZE8 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 34% | 100% |
| Q9AXJ4 | Manihot esculenta | 46% | 100% |
| Q9AXQ3 | Solanum lycopersicum | 45% | 100% |
| Q9AXQ4 | Solanum lycopersicum | 49% | 100% |
| Q9AXQ5 | Solanum lycopersicum | 46% | 100% |
| Q9AXQ6 | Solanum lycopersicum | 47% | 100% |
| Q9AXQ7 | Dianthus caryophyllus | 46% | 100% |
| Q9C505 | Arabidopsis thaliana | 49% | 100% |
| Q9GU68 | Drosophila melanogaster | 44% | 100% |
| Q9GZV4 | Homo sapiens | 45% | 100% |
| Q9N9V6 | Leishmania infantum | 98% | 100% |
| Q9SC12 | Senecio vernalis | 47% | 100% |
| Q9UST4 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 47% | 98% |
| Q9V0M2 | Pyrococcus abyssi (strain GE5 / Orsay) | 30% | 100% |
| Q9XI91 | Arabidopsis thaliana | 49% | 100% |