Probable eukaryotic initiation factor 4A

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic initiation factor 4A-1

Species:

Leishmania major

UniProt:

IF4A_LEIMA

TriTrypDb:

LmjF.01.0770 , LMJLV39_010013100 , LMJSD75_010013100

Length:

403

Annotations

Annotations by Jardim et al.

Transcription, Probable eukaryotic initiation factor 4A LinJ01.0780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 3
Forrest at al. (metacyclic)	yes	yes: 3
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

O62591

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O62591

Function

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Biological processes
Term	Name	Level	Count
GO:0002183	cytoplasmic translational initiation	4	2
GO:0006412	translation	4	2
GO:0006413	translational initiation	3	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	4
GO:0003724	RNA helicase activity	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.353
CLV_NRD_NRD_1	277	279	PF00675	0.342
CLV_NRD_NRD_1	362	364	PF00675	0.552
CLV_PCSK_KEX2_1	163	165	PF00082	0.342
CLV_PCSK_KEX2_1	233	235	PF00082	0.549
CLV_PCSK_KEX2_1	277	279	PF00082	0.342
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.342
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.549
CLV_PCSK_PC7_1	229	235	PF00082	0.497
CLV_PCSK_SKI1_1	164	168	PF00082	0.402

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P395	Leptomonas seymouri	50%	100%
A0A0N0P3J5	Leptomonas seymouri	33%	93%
A0A0N0P6L6	Leptomonas seymouri	34%	77%
A0A0N0P7D9	Leptomonas seymouri	35%	81%
A0A0N0P7N8	Leptomonas seymouri	34%	71%
A0A0N1I0I8	Leptomonas seymouri	41%	100%
A0A0N1I458	Leptomonas seymouri	26%	69%
A0A0N1IH51	Leptomonas seymouri	97%	100%
A0A0N1PCZ7	Leptomonas seymouri	26%	67%
A0A0N1PDE7	Leptomonas seymouri	32%	70%

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