Protoporphyrinogen IX dehydrogenase [quinone]

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protoporphyrinogen oxidase-like protein

Species:

Leishmania major

UniProt:

HEMG_LEIMA

TriTrypDb:

LmjF.06.1280 , LMJLV39_060019700 , LMJSD75_060019800

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QIU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIU7

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006778	porphyrin-containing compound metabolic process	5	7
GO:0006779	porphyrin-containing compound biosynthetic process	6	7
GO:0006782	protoporphyrinogen IX biosynthetic process	7	7
GO:0006783	heme biosynthetic process	4	2
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0033013	tetrapyrrole metabolic process	4	7
GO:0033014	tetrapyrrole biosynthetic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0042168	heme metabolic process	3	2
GO:0042440	pigment metabolic process	2	2
GO:0044237	cellular metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0046148	pigment biosynthetic process	3	2
GO:0046483	heterocycle metabolic process	3	7
GO:0046501	protoporphyrinogen IX metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	5	7
GO:0005488	binding	1	7
GO:0010181	FMN binding	4	7
GO:0016491	oxidoreductase activity	2	7
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	7
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	7
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	4	7
GO:0032553	ribonucleotide binding	3	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0070818	protoporphyrinogen oxidase activity	4	7
GO:0070819	menaquinone-dependent protoporphyrinogen oxidase activity	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.497
CLV_C14_Caspase3-7	194	198	PF00656	0.486
CLV_C14_Caspase3-7	42	46	PF00656	0.569
CLV_NRD_NRD_1	111	113	PF00675	0.297
CLV_NRD_NRD_1	171	173	PF00675	0.486
CLV_NRD_NRD_1	97	99	PF00675	0.286
CLV_PCSK_KEX2_1	171	173	PF00082	0.470
CLV_PCSK_KEX2_1	229	231	PF00082	0.409
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.382
CLV_PCSK_SKI1_1	112	116	PF00082	0.297
CLV_PCSK_SKI1_1	56	60	PF00082	0.263
DOC_CYCLIN_RxL_1	53	62	PF00134	0.569
DOC_MAPK_gen_1	35	43	PF00069	0.514
DOC_MAPK_RevD_3	217	230	PF00069	0.393
DOC_PP1_SILK_1	197	202	PF00149	0.476
DOC_PP2B_LxvP_1	182	185	PF13499	0.405
DOC_USP7_MATH_1	85	89	PF00917	0.493
DOC_WW_Pin1_4	118	123	PF00397	0.427
DOC_WW_Pin1_4	2	7	PF00397	0.595
LIG_14-3-3_CanoR_1	171	181	PF00244	0.331
LIG_APCC_ABBAyCdc20_2	160	166	PF00400	0.350
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BRCT_BRCA1_1	68	72	PF00533	0.577
LIG_BRCT_BRCA1_1	87	91	PF00533	0.355
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.336
LIG_FHA_1	104	110	PF00498	0.522
LIG_FHA_1	157	163	PF00498	0.358
LIG_FHA_1	17	23	PF00498	0.497
LIG_FHA_2	150	156	PF00498	0.297
LIG_FHA_2	19	25	PF00498	0.491
LIG_LIR_Gen_1	165	174	PF02991	0.319
LIG_LIR_Gen_1	175	185	PF02991	0.375
LIG_LIR_Gen_1	53	61	PF02991	0.492
LIG_LIR_Nem_3	165	170	PF02991	0.333
LIG_LIR_Nem_3	175	180	PF02991	0.337
LIG_LIR_Nem_3	53	57	PF02991	0.468
LIG_LIR_Nem_3	62	68	PF02991	0.440
LIG_LIR_Nem_3	69	75	PF02991	0.424
LIG_LIR_Nem_3	88	93	PF02991	0.353
LIG_MLH1_MIPbox_1	87	91	PF16413	0.471
LIG_Pex14_1	133	137	PF04695	0.326
LIG_Pex14_2	173	177	PF04695	0.319
LIG_Pex14_2	68	72	PF04695	0.514
LIG_REV1ctd_RIR_1	137	146	PF16727	0.297
LIG_RPA_C_Fungi	167	179	PF08784	0.280
LIG_SH2_STAP1	110	114	PF00017	0.362
LIG_SH2_STAP1	164	168	PF00017	0.411
LIG_SH2_STAP1	54	58	PF00017	0.362
LIG_SH2_STAT3	75	78	PF00017	0.464
LIG_SH2_STAT5	110	113	PF00017	0.362
LIG_SH2_STAT5	164	167	PF00017	0.423
LIG_SH2_STAT5	49	52	PF00017	0.364
LIG_SH2_STAT5	75	78	PF00017	0.303
LIG_SH3_3	182	188	PF00018	0.531
LIG_SH3_3	190	196	PF00018	0.672
LIG_SUMO_SIM_par_1	39	45	PF11976	0.450
LIG_UBA3_1	144	150	PF00899	0.286
LIG_WW_3	184	188	PF00397	0.510
MOD_CDK_SPK_2	2	7	PF00069	0.499
MOD_CK1_1	118	124	PF00069	0.444
MOD_CK1_1	81	87	PF00069	0.269
MOD_CK2_1	149	155	PF00069	0.362
MOD_GlcNHglycan	201	204	PF01048	0.692
MOD_GlcNHglycan	215	218	PF01048	0.232
MOD_GlcNHglycan	68	71	PF01048	0.474
MOD_GlcNHglycan	82	86	PF01048	0.284
MOD_GlcNHglycan	87	90	PF01048	0.164
MOD_GSK3_1	104	111	PF00069	0.217
MOD_GSK3_1	12	19	PF00069	0.362
MOD_GSK3_1	149	156	PF00069	0.310
MOD_GSK3_1	81	88	PF00069	0.425
MOD_GSK3_1	89	96	PF00069	0.317
MOD_N-GLC_1	115	120	PF02516	0.386
MOD_N-GLC_1	93	98	PF02516	0.362
MOD_NEK2_1	10	15	PF00069	0.362
MOD_NEK2_1	115	120	PF00069	0.326
MOD_NEK2_1	149	154	PF00069	0.362
MOD_NEK2_1	59	64	PF00069	0.362
MOD_Plk_1	115	121	PF00069	0.347
MOD_Plk_1	81	87	PF00069	0.414
MOD_Plk_4	18	24	PF00069	0.354
MOD_Plk_4	45	51	PF00069	0.338
MOD_ProDKin_1	118	124	PF00069	0.427
MOD_ProDKin_1	2	8	PF00069	0.483
MOD_SUMO_rev_2	32	36	PF00179	0.393
TRG_ENDOCYTIC_2	137	140	PF00928	0.362
TRG_ENDOCYTIC_2	54	57	PF00928	0.362
TRG_ENDOCYTIC_2	65	68	PF00928	0.362
TRG_ER_diArg_1	170	172	PF00400	0.323
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.230

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q7	Leptomonas seymouri	65%	100%
A0A3S5H5V3	Leishmania donovani	91%	100%
A4H4U0	Leishmania braziliensis	78%	100%
A4HT19	Leishmania infantum	91%	100%
E9AL08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P0ACB4	Escherichia coli (strain K12)	49%	100%
P0ACB5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	49%	100%
P0ACB6	Escherichia coli O157:H7	49%	100%
Q4QIU7	Leishmania major	100%	100%
Q9L6L1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	49%	100%