Flap endonuclease 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Flap endonuclease 1

Gene product:

flap endonuclease-1 (FEN-1), putative

Species:

Leishmania major

UniProt:

FEN1_LEIMA

TriTrypDb:

LmjF.27.0250 , LMJLV39_270007600 , LMJSD75_270007500

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	12
GO:0005730	nucleolus	5	12
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4FYU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4FYU7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006284	base-excision repair	6	12
GO:0006401	RNA catabolic process	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0019439	aromatic compound catabolic process	4	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034655	nucleobase-containing compound catabolic process	4	12
GO:0043137	DNA replication, removal of RNA primer	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0044270	cellular nitrogen compound catabolic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046700	heterocycle catabolic process	4	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901361	organic cyclic compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0004520	DNA endonuclease activity	5	12
GO:0004527	exonuclease activity	5	12
GO:0004536	DNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008409	5'-3' exonuclease activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	12
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	12
GO:0017108	5'-flap endonuclease activity	7	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0048256	flap endonuclease activity	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.406
CLV_NRD_NRD_1	104	106	PF00675	0.207
CLV_NRD_NRD_1	29	31	PF00675	0.206
CLV_NRD_NRD_1	337	339	PF00675	0.469
CLV_NRD_NRD_1	382	384	PF00675	0.612
CLV_PCSK_KEX2_1	104	106	PF00082	0.221
CLV_PCSK_KEX2_1	132	134	PF00082	0.369
CLV_PCSK_KEX2_1	205	207	PF00082	0.206
CLV_PCSK_KEX2_1	29	31	PF00082	0.206
CLV_PCSK_KEX2_1	368	370	PF00082	0.584
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.369
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.206
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.584
CLV_PCSK_SKI1_1	146	150	PF00082	0.303
CLV_PCSK_SKI1_1	24	28	PF00082	0.276
CLV_PCSK_SKI1_1	284	288	PF00082	0.298
CLV_PCSK_SKI1_1	333	337	PF00082	0.411
CLV_PCSK_SKI1_1	383	387	PF00082	0.561
CLV_PCSK_SKI1_1	391	395	PF00082	0.491
DOC_MAPK_gen_1	129	137	PF00069	0.358
DOC_MAPK_gen_1	146	156	PF00069	0.313
DOC_MAPK_gen_1	204	213	PF00069	0.510
DOC_MAPK_gen_1	368	378	PF00069	0.543
DOC_MAPK_MEF2A_6	147	156	PF00069	0.332
DOC_MAPK_MEF2A_6	204	213	PF00069	0.440
DOC_MAPK_MEF2A_6	294	302	PF00069	0.342
DOC_PP4_FxxP_1	287	290	PF00568	0.311
DOC_PP4_FxxP_1	302	305	PF00568	0.322
DOC_USP7_MATH_1	35	39	PF00917	0.473
DOC_USP7_UBL2_3	390	394	PF12436	0.546
DOC_WW_Pin1_4	11	16	PF00397	0.430
LIG_14-3-3_CanoR_1	338	344	PF00244	0.479
LIG_Actin_WH2_2	61	79	PF00022	0.406
LIG_APCC_ABBA_1	209	214	PF00400	0.440
LIG_FHA_1	132	138	PF00498	0.401
LIG_FHA_1	190	196	PF00498	0.452
LIG_FHA_1	217	223	PF00498	0.428
LIG_FHA_1	63	69	PF00498	0.406
LIG_FHA_2	291	297	PF00498	0.384
LIG_IRF3_LxIS_1	195	201	PF10401	0.510
LIG_LIR_Apic_2	299	305	PF02991	0.304
LIG_LIR_Gen_1	225	234	PF02991	0.475
LIG_LIR_Gen_1	372	382	PF02991	0.528
LIG_LIR_Gen_1	38	46	PF02991	0.417
LIG_LIR_Nem_3	225	230	PF02991	0.476
LIG_LIR_Nem_3	345	350	PF02991	0.440
LIG_LIR_Nem_3	372	378	PF02991	0.528
LIG_LIR_Nem_3	38	43	PF02991	0.417
LIG_NRBOX	229	235	PF00104	0.406
LIG_NRBOX	5	11	PF00104	0.406
LIG_PCNA_PIPBox_1	341	350	PF02747	0.427
LIG_PCNA_yPIPBox_3	338	348	PF02747	0.414
LIG_REV1ctd_RIR_1	24	34	PF16727	0.510
LIG_SH2_CRK	40	44	PF00017	0.406
LIG_SH2_PTP2	375	378	PF00017	0.530
LIG_SH2_SRC	375	378	PF00017	0.530
LIG_SH2_STAT5	238	241	PF00017	0.300
LIG_SH2_STAT5	375	378	PF00017	0.673
LIG_SH2_STAT5	87	90	PF00017	0.406
LIG_SH3_3	237	243	PF00018	0.349
LIG_UBA3_1	126	132	PF00899	0.368
LIG_UBA3_1	3	8	PF00899	0.417
LIG_UBA3_1	310	318	PF00899	0.310
LIG_UBA3_1	43	47	PF00899	0.430
LIG_WRC_WIRS_1	260	265	PF05994	0.375
LIG_WRC_WIRS_1	344	349	PF05994	0.505
MOD_CK1_1	131	137	PF00069	0.417
MOD_CK1_1	259	265	PF00069	0.381
MOD_CK1_1	266	272	PF00069	0.339
MOD_CK1_1	346	352	PF00069	0.537
MOD_CK2_1	158	164	PF00069	0.417
MOD_CK2_1	259	265	PF00069	0.493
MOD_CK2_1	290	296	PF00069	0.386
MOD_Cter_Amidation	27	30	PF01082	0.206
MOD_GlcNHglycan	378	381	PF01048	0.562
MOD_GlcNHglycan	386	389	PF01048	0.543
MOD_GSK3_1	131	138	PF00069	0.377
MOD_GSK3_1	185	192	PF00069	0.510
MOD_GSK3_1	216	223	PF00069	0.461
MOD_GSK3_1	259	266	PF00069	0.355
MOD_N-GLC_1	198	203	PF02516	0.310
MOD_NEK2_1	189	194	PF00069	0.510
MOD_NEK2_1	217	222	PF00069	0.417
MOD_NEK2_1	267	272	PF00069	0.411
MOD_NEK2_1	348	353	PF00069	0.474
MOD_NEK2_1	364	369	PF00069	0.525
MOD_NEK2_1	4	9	PF00069	0.406
MOD_NEK2_1	72	77	PF00069	0.406
MOD_NEK2_2	35	40	PF00069	0.417
MOD_PIKK_1	337	343	PF00454	0.416
MOD_PK_1	256	262	PF00069	0.380
MOD_PKA_1	383	389	PF00069	0.656
MOD_PKA_2	135	141	PF00069	0.390
MOD_PKA_2	337	343	PF00069	0.495
MOD_Plk_1	33	39	PF00069	0.406
MOD_Plk_4	189	195	PF00069	0.510
MOD_Plk_4	259	265	PF00069	0.401
MOD_Plk_4	343	349	PF00069	0.552
MOD_Plk_4	35	41	PF00069	0.407
MOD_ProDKin_1	11	17	PF00069	0.430
MOD_SUMO_rev_2	138	148	PF00179	0.323
MOD_SUMO_rev_2	20	26	PF00179	0.473
TRG_DiLeu_BaEn_1	144	149	PF01217	0.290
TRG_ENDOCYTIC_2	257	260	PF00928	0.360
TRG_ENDOCYTIC_2	375	378	PF00928	0.563
TRG_ENDOCYTIC_2	40	43	PF00928	0.406
TRG_ER_diArg_1	103	105	PF00400	0.450
TRG_ER_diArg_1	29	31	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.199
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC1	Leptomonas seymouri	83%	100%
A0A0S4IVR8	Bodo saltans	67%	100%
A0A1X0NLQ8	Trypanosomatidae	74%	100%
A0A3Q8IDY8	Leishmania donovani	97%	100%
A0A3R7KUS1	Trypanosoma rangeli	72%	100%
A0B9M7	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	34%	100%
A0CXT3	Paramecium tetraurelia	44%	100%
A0CYG2	Paramecium tetraurelia	43%	100%
A0RU95	Cenarchaeum symbiosum (strain A)	35%	100%
A1CJ75	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	48%	100%
A1D8A4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	49%	100%
A1RSC7	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	43%	100%
A1RWY2	Thermofilum pendens (strain DSM 2475 / Hrk 5)	38%	100%
A2BMI0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	36%	100%
A2SQC6	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	35%	100%
A3CWV2	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	35%	100%
A3DMG2	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	35%	100%
A3FPN7	Cryptosporidium parvum (strain Iowa II)	40%	81%
A3M056	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	48%	100%
A3MY15	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	40%	100%
A4HFE4	Leishmania braziliensis	90%	100%
A4I2L4	Leishmania infantum	97%	100%
A4QS18	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	51%	100%
A4S1G4	Ostreococcus lucimarinus (strain CCE9901)	47%	100%
A4VDN2	Tetrahymena thermophila (strain SB210)	41%	100%
A4WNC4	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	40%	100%
A5ABU3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	50%	100%
A5DCF5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	47%	100%
A5E121	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	48%	100%
A5UL52	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	34%	100%
A6QV55	Ajellomyces capsulatus (strain NAm1 / WU24)	50%	100%
A6UX46	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	36%	100%
A6ZZK4	Saccharomyces cerevisiae (strain YJM789)	49%	100%
A7IA59	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	34%	100%
A7RRJ0	Nematostella vectensis	56%	100%
A7TJ59	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	48%	100%
A7UW97	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	49%	100%
A8AAC1	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	39%	100%
A8B672	Giardia intestinalis (strain ATCC 50803 / WB clone C6)	40%	100%
A8J2Z9	Chlamydomonas reinhardtii	52%	100%
A8M9L3	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	40%	100%
A8NQC2	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	52%	86%
A8QCH0	Brugia malayi	52%	100%
A8XL25	Caenorhabditis briggsae	53%	100%
A9A4B0	Nitrosopumilus maritimus (strain SCM1)	35%	100%
A9S0B8	Physcomitrium patens	50%	100%
A9U328	Physcomitrium patens	49%	100%
A9VB27	Monosiga brevicollis	51%	100%
B0DSN9	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	48%	100%
B0E412	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	50%	84%
B0EN90	Entamoeba dispar (strain ATCC PRA-260 / SAW760)	49%	100%
B0R5F5	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	29%	100%
B0UXL7	Danio rerio	36%	100%
B0XZ33	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	49%	100%
B1H158	Xenopus tropicalis	53%	100%
B1L6R9	Korarchaeum cryptofilum (strain OPF8)	34%	100%
B1YC46	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	40%	100%
B2VTT3	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	49%	100%
B3L014	Plasmodium knowlesi (strain H)	47%	66%
B3LQY3	Saccharomyces cerevisiae (strain RM11-1a)	49%	100%
B3MDA3	Drosophila ananassae	52%	100%
B3NP61	Drosophila erecta	52%	100%
B3RVF0	Trichoplax adhaerens	54%	100%
B4FHY0	Zea mays	50%	100%
B4GIM3	Drosophila persimilis	52%	100%
B4HTA1	Drosophila sechellia	52%	100%
B4J6M4	Drosophila grimshawi	51%	100%
B4KNM1	Drosophila mojavensis	53%	100%
B4LM90	Drosophila virilis	51%	100%
B4MR84	Drosophila willistoni	53%	100%
B4P5U9	Drosophila yakuba	52%	100%
B4QIG6	Drosophila simulans	52%	100%
B5DUR8	Drosophila pseudoobscura pseudoobscura	52%	100%
B6AFP1	Cryptosporidium muris (strain RN66)	43%	84%
B6HEM2	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	51%	100%
B6JYI7	Schizosaccharomyces japonicus (strain yFS275 / FY16936)	50%	100%
B6QT52	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	49%	100%
B6YWX4	Thermococcus onnurineus (strain NA1)	40%	100%
B7G7Y7	Phaeodactylum tricornutum (strain CCAP 1055/1)	41%	94%
B7XHS8	Enterocytozoon bieneusi (strain H348)	39%	100%
B8AMS4	Oryza sativa subsp. indica	44%	96%
B8AW67	Oryza sativa subsp. indica	51%	100%
B8C6S5	Thalassiosira pseudonana	47%	100%
B8GIA0	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	35%	100%
B8MNF2	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	49%	100%
B8NV37	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	50%	100%
B9EMY6	Salmo salar	54%	100%
B9WLQ5	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	48%	100%
C1BM18	Osmerus mordax	56%	100%
C1E3X9	Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709)	48%	100%
C3KJE6	Anoplopoma fimbria	55%	100%
C3ZBT0	Branchiostoma floridae	54%	100%
C4JDR3	Uncinocarpus reesii (strain UAMH 1704)	49%	100%
C4M6G8	Entamoeba histolytica	48%	100%
C4QZ20	Komagataella phaffii (strain GS115 / ATCC 20864)	47%	100%
C4YBJ8	Clavispora lusitaniae (strain ATCC 42720)	48%	100%
C4YLS2	Candida albicans (strain WO-1)	48%	100%
C5A639	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	38%	100%
C5DGG4	Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)	48%	100%
C5DZA9	Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)	49%	100%
C5FZT5	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	48%	100%
C5GPA7	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	49%	100%
C5JVG7	Blastomyces gilchristii (strain SLH14081)	49%	100%
C5M2X8	Candida tropicalis (strain ATCC MYA-3404 / T1)	49%	100%
C5WU23	Sorghum bicolor	44%	92%
C5YUK3	Sorghum bicolor	50%	100%
C6A1U9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	38%	100%
C6HQJ2	Ajellomyces capsulatus (strain H143)	50%	100%
C6TEX6	Glycine max	50%	100%
C7GVJ8	Saccharomyces cerevisiae (strain JAY291)	49%	100%
C7Z125	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	50%	100%
C8BKD0	Ovis aries	53%	100%
C8ZC62	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	49%	100%
C9ZKW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
D0MY34	Phytophthora infestans (strain T30-4)	48%	100%
D1ZT73	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	48%	100%
D2V434	Naegleria gruberi	50%	100%
D3BN56	Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500)	48%	100%
D3TQJ5	Glossina morsitans morsitans	49%	100%
E9AYS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O27670	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	100%
O29975	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	38%	100%
O50123	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	41%	100%
O65251	Arabidopsis thaliana	51%	100%
O93634	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	40%	100%
P0CS60	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	54%	87%
P0CS61	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	54%	87%
P26793	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P39748	Homo sapiens	53%	100%
P39749	Mus musculus	52%	100%
P39750	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
P61942	Nanoarchaeum equitans (strain Kin4-M)	39%	100%
P70040	Xenopus laevis	52%	100%
P70054	Xenopus laevis	52%	100%
Q013G9	Ostreococcus tauri	49%	100%
Q0CBS0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	49%	100%
Q0UZR3	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	49%	100%
Q0W6I0	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	35%	100%
Q12UT1	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	35%	100%
Q178M1	Aedes aegypti	51%	100%
Q18HK0	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	28%	100%
Q196Y4	Invertebrate iridescent virus 3	25%	100%
Q2FNC9	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	34%	100%
Q2NFD4	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	38%	100%
Q46D63	Methanosarcina barkeri (strain Fusaro / DSM 804)	34%	100%
Q4DKQ5	Trypanosoma cruzi (strain CL Brener)	73%	100%
Q4FYU7	Leishmania major	100%	100%
Q4JAN1	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	40%	100%
Q4N3S6	Theileria parva	41%	80%
Q4P1V1	Ustilago maydis (strain 521 / FGSC 9021)	47%	100%
Q4R5U5	Macaca fascicularis	53%	100%
Q4UFP0	Theileria annulata	41%	78%
Q4WWJ1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	100%
Q4XXP8	Plasmodium chabaudi	48%	82%
Q4Z015	Plasmodium berghei (strain Anka)	47%	83%
Q54NU0	Dictyostelium discoideum	49%	100%
Q57WW6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	72%	100%
Q58839	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	38%	100%
Q58DH8	Bos taurus	53%	100%
Q5A6K8	Candida albicans (strain SC5314 / ATCC MYA-2876)	48%	100%
Q5B9L6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	48%	100%
Q5I4H3	Xiphophorus maculatus	55%	100%
Q5JGN0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	39%	100%
Q5V5T7	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	29%	100%
Q5XIP6	Rattus norvegicus	53%	100%
Q5ZLN4	Gallus gallus	53%	100%
Q6BLF4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	47%	100%
Q6C116	Yarrowia lipolytica (strain CLIB 122 / E 150)	49%	100%
Q6CLH4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	46%	100%
Q6FM28	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	49%	100%
Q6GZN0	Frog virus 3 (isolate Goorha)	26%	100%
Q6L2I9	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	35%	100%
Q6TNU4	Danio rerio	55%	100%
Q75DS8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	100%
Q75LI2	Oryza sativa subsp. japonica	44%	96%
Q76F73	Coprinopsis cinerea	51%	86%
Q7K7A9	Drosophila melanogaster	52%	100%
Q7Q323	Anopheles gambiae	49%	100%
Q7RME3	Plasmodium yoelii yoelii	48%	82%
Q8PYF6	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	35%	100%
Q8SS91	Encephalitozoon cuniculi (strain GB-M1)	46%	100%
Q8TIY5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	35%	100%
Q8TXU4	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	41%	100%
Q8ZYN2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	41%	100%
Q91FF5	Invertebrate iridescent virus 6	25%	95%
Q976H6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	39%	100%
Q97B98	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	32%	100%
Q980U8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	39%	100%
Q9HJD4	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	33%	100%
Q9HQ27	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	29%	100%
Q9N3T2	Caenorhabditis elegans	52%	100%
Q9SXQ6	Oryza sativa subsp. japonica	51%	100%
Q9V0P9	Pyrococcus abyssi (strain GE5 / Orsay)	40%	100%
Q9YFY5	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	39%	100%
V5AWB7	Trypanosoma cruzi	77%	100%