Ecotin-like protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ecotin, putative

Species:

Leishmania major

UniProt:

ECOT3_LEIMA

TriTrypDb:

LmjF.15.0520 , LMJLV39_150011000 , LMJSD75_150011000

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFD3

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	2
GO:0009607	response to biotic stimulus	2	2
GO:0042783	evasion of host immune response	6	2
GO:0042784	evasion of host immune response via modulation of host complement system	7	2
GO:0043207	response to external biotic stimulus	3	2
GO:0044403	biological process involved in symbiotic interaction	2	2
GO:0044419	biological process involved in interspecies interaction between organisms	1	2
GO:0050896	response to stimulus	1	2
GO:0051701	biological process involved in interaction with host	3	2
GO:0051707	response to other organism	2	2
GO:0052173	response to defenses of other organism	3	2
GO:0052200	response to host defenses	4	2
GO:0052572	response to host immune response	5	2
GO:0075136	response to host	3	2

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	7
GO:0004866	endopeptidase inhibitor activity	5	7
GO:0004867	serine-type endopeptidase inhibitor activity	6	7
GO:0030234	enzyme regulator activity	2	7
GO:0030414	peptidase inhibitor activity	4	7
GO:0061134	peptidase regulator activity	3	7
GO:0061135	endopeptidase regulator activity	4	7
GO:0098772	molecular function regulator activity	1	7
GO:0140678	molecular function inhibitor activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.323
CLV_NRD_NRD_1	306	308	PF00675	0.773
CLV_NRD_NRD_1	335	337	PF00675	0.599
CLV_NRD_NRD_1	359	361	PF00675	0.709
CLV_PCSK_KEX2_1	296	298	PF00082	0.758
CLV_PCSK_KEX2_1	306	308	PF00082	0.678
CLV_PCSK_KEX2_1	335	337	PF00082	0.604
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.688
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.630
CLV_PCSK_SKI1_1	345	349	PF00082	0.515
CLV_Separin_Metazoa	165	169	PF03568	0.642
DOC_CKS1_1	319	324	PF01111	0.576
DOC_MAPK_MEF2A_6	111	118	PF00069	0.466
DOC_USP7_MATH_1	107	111	PF00917	0.466
DOC_USP7_MATH_1	217	221	PF00917	0.723
DOC_USP7_MATH_1	272	276	PF00917	0.718
DOC_USP7_MATH_1	305	309	PF00917	0.653
DOC_USP7_MATH_1	362	366	PF00917	0.684
DOC_USP7_MATH_1	84	88	PF00917	0.330
DOC_USP7_MATH_2	249	255	PF00917	0.717
DOC_WW_Pin1_4	100	105	PF00397	0.313
DOC_WW_Pin1_4	194	199	PF00397	0.645
DOC_WW_Pin1_4	273	278	PF00397	0.791
DOC_WW_Pin1_4	295	300	PF00397	0.742
DOC_WW_Pin1_4	318	323	PF00397	0.610
DOC_WW_Pin1_4	355	360	PF00397	0.733
LIG_14-3-3_CanoR_1	127	135	PF00244	0.621
LIG_14-3-3_CanoR_1	259	267	PF00244	0.753
LIG_14-3-3_CanoR_1	268	277	PF00244	0.510
LIG_14-3-3_CanoR_1	279	289	PF00244	0.692
LIG_14-3-3_CanoR_1	306	314	PF00244	0.711
LIG_14-3-3_CanoR_1	86	91	PF00244	0.376
LIG_14-3-3_CanoR_1	93	98	PF00244	0.295
LIG_FHA_1	195	201	PF00498	0.558
LIG_FHA_1	56	62	PF00498	0.511
LIG_FHA_1	93	99	PF00498	0.414
LIG_FHA_2	75	81	PF00498	0.430
LIG_LIR_Apic_2	6	10	PF02991	0.458
LIG_LIR_Gen_1	95	105	PF02991	0.353
LIG_LIR_Nem_3	72	76	PF02991	0.453
LIG_LIR_Nem_3	95	100	PF02991	0.376
LIG_MYND_1	151	155	PF01753	0.642
LIG_MYND_1	198	202	PF01753	0.652
LIG_Pex14_1	69	73	PF04695	0.339
LIG_SH2_CRK	7	11	PF00017	0.339
LIG_SH2_STAP1	343	347	PF00017	0.524
LIG_SH2_STAP1	71	75	PF00017	0.348
LIG_SH2_STAT3	175	178	PF00017	0.682
LIG_SH2_STAT3	287	290	PF00017	0.647
LIG_SH2_STAT5	117	120	PF00017	0.450
LIG_SH2_STAT5	175	178	PF00017	0.682
LIG_SH2_STAT5	24	27	PF00017	0.339
LIG_SH2_STAT5	74	77	PF00017	0.508
LIG_SH3_3	113	119	PF00018	0.326
LIG_SH3_3	140	146	PF00018	0.640
LIG_SH3_3	196	202	PF00018	0.647
LIG_SH3_3	274	280	PF00018	0.717
LIG_SH3_3	316	322	PF00018	0.670
LIG_SH3_3	6	12	PF00018	0.484
LIG_SUMO_SIM_par_1	183	189	PF11976	0.640
LIG_SUMO_SIM_par_1	74	80	PF11976	0.366
LIG_TRAF2_1	186	189	PF00917	0.674
LIG_TRAF2_1	249	252	PF00917	0.687
LIG_TRAF2_1	313	316	PF00917	0.705
MOD_CDC14_SPxK_1	276	279	PF00782	0.672
MOD_CDC14_SPxK_1	358	361	PF00782	0.738
MOD_CDK_SPK_2	318	323	PF00069	0.572
MOD_CDK_SPK_2	355	360	PF00069	0.733
MOD_CDK_SPxK_1	273	279	PF00069	0.671
MOD_CDK_SPxK_1	318	324	PF00069	0.612
MOD_CDK_SPxK_1	355	361	PF00069	0.719
MOD_CK1_1	183	189	PF00069	0.644
MOD_CK1_1	194	200	PF00069	0.536
MOD_CK1_1	260	266	PF00069	0.799
MOD_CK1_1	275	281	PF00069	0.695
MOD_CK1_1	308	314	PF00069	0.622
MOD_CK1_1	328	334	PF00069	0.804
MOD_CK1_1	363	369	PF00069	0.656
MOD_CK2_1	183	189	PF00069	0.678
MOD_CK2_1	205	211	PF00069	0.662
MOD_CK2_1	268	274	PF00069	0.703
MOD_CK2_1	57	63	PF00069	0.339
MOD_DYRK1A_RPxSP_1	355	359	PF00069	0.682
MOD_GlcNHglycan	202	205	PF01048	0.668
MOD_GlcNHglycan	207	210	PF01048	0.598
MOD_GlcNHglycan	219	222	PF01048	0.540
MOD_GlcNHglycan	270	273	PF01048	0.747
MOD_GlcNHglycan	299	302	PF01048	0.649
MOD_GlcNHglycan	310	313	PF01048	0.650
MOD_GlcNHglycan	328	331	PF01048	0.515
MOD_GlcNHglycan	362	365	PF01048	0.817
MOD_GlcNHglycan	368	371	PF01048	0.725
MOD_GSK3_1	127	134	PF00069	0.586
MOD_GSK3_1	257	264	PF00069	0.647
MOD_GSK3_1	268	275	PF00069	0.568
MOD_GSK3_1	295	302	PF00069	0.687
MOD_GSK3_1	314	321	PF00069	0.554
MOD_GSK3_1	324	331	PF00069	0.634
MOD_GSK3_1	360	367	PF00069	0.658
MOD_GSK3_1	55	62	PF00069	0.433
MOD_N-GLC_1	194	199	PF02516	0.545
MOD_N-GLC_1	240	245	PF02516	0.613
MOD_N-GLC_1	272	277	PF02516	0.591
MOD_N-GLC_1	324	329	PF02516	0.739
MOD_N-GLC_1	370	375	PF02516	0.721
MOD_NEK2_1	135	140	PF00069	0.627
MOD_NEK2_1	282	287	PF00069	0.552
MOD_NEK2_1	57	62	PF00069	0.466
MOD_NEK2_2	343	348	PF00069	0.586
MOD_PKA_1	306	312	PF00069	0.777
MOD_PKA_1	360	366	PF00069	0.701
MOD_PKA_2	191	197	PF00069	0.673
MOD_PKA_2	258	264	PF00069	0.617
MOD_PKA_2	280	286	PF00069	0.760
MOD_PKA_2	305	311	PF00069	0.729
MOD_PKA_2	325	331	PF00069	0.639
MOD_PKA_2	85	91	PF00069	0.399
MOD_PKA_2	92	98	PF00069	0.324
MOD_PKB_1	125	133	PF00069	0.399
MOD_PKB_1	279	287	PF00069	0.678
MOD_Plk_1	131	137	PF00069	0.561
MOD_Plk_1	251	257	PF00069	0.682
MOD_Plk_1	343	349	PF00069	0.607
MOD_Plk_1	62	68	PF00069	0.339
MOD_Plk_4	180	186	PF00069	0.646
MOD_Plk_4	69	75	PF00069	0.379
MOD_Plk_4	93	99	PF00069	0.484
MOD_ProDKin_1	100	106	PF00069	0.313
MOD_ProDKin_1	194	200	PF00069	0.637
MOD_ProDKin_1	273	279	PF00069	0.793
MOD_ProDKin_1	295	301	PF00069	0.741
MOD_ProDKin_1	318	324	PF00069	0.612
MOD_ProDKin_1	355	361	PF00069	0.742
MOD_SUMO_rev_2	173	183	PF00179	0.641
TRG_DiLeu_BaEn_4	188	194	PF01217	0.652
TRG_DiLeu_BaEn_4	251	257	PF01217	0.682
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.664
TRG_ENDOCYTIC_2	73	76	PF00928	0.499
TRG_ER_diArg_1	279	282	PF00400	0.725
TRG_ER_diArg_1	305	307	PF00400	0.790
TRG_NLS_Bipartite_1	306	327	PF00514	0.773
TRG_NLS_MonoExtN_4	322	327	PF00514	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ51	Leptomonas seymouri	34%	100%
A0A3S7WTD9	Leishmania donovani	90%	100%
A4H824	Leishmania braziliensis	46%	100%
A4HWF0	Leishmania infantum	90%	100%
E9AQ49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QFD3	Leishmania major	100%	100%