LeishMANIAdb
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Ecotin-like protein 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ecotin-like protein 3
Gene product:
ecotin - putative
Species:
Leishmania infantum
UniProt:
ECOT3_LEIIN
TriTrypDb:
LINF_150012500
Length:
378

Annotations

Annotations by Jardim et al.

Protease inhibitors, Ecotin-like 3 LinJ15.0540 PE=3 SV=1 - [ECOT3_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWF0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWF0

Function

Biological processes
Term Name Level Count
GO:0009605 response to external stimulus 2 1
GO:0009607 response to biotic stimulus 2 1
GO:0042783 evasion of host immune response 6 1
GO:0042784 evasion of host immune response via modulation of host complement system 7 1
GO:0043207 response to external biotic stimulus 3 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0050896 response to stimulus 1 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0051707 response to other organism 2 1
GO:0052173 response to defenses of other organism 3 1
GO:0052200 response to host defenses 4 1
GO:0052572 response to host immune response 5 1
GO:0075136 response to host 3 1
Molecular functions
Term Name Level Count
GO:0004857 enzyme inhibitor activity 3 6
GO:0004866 endopeptidase inhibitor activity 5 6
GO:0004867 serine-type endopeptidase inhibitor activity 6 6
GO:0030234 enzyme regulator activity 2 6
GO:0030414 peptidase inhibitor activity 4 6
GO:0061134 peptidase regulator activity 3 6
GO:0061135 endopeptidase regulator activity 4 6
GO:0098772 molecular function regulator activity 1 6
GO:0140678 molecular function inhibitor activity 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.495
CLV_NRD_NRD_1 258 260 PF00675 0.665
CLV_NRD_NRD_1 307 309 PF00675 0.796
CLV_NRD_NRD_1 336 338 PF00675 0.662
CLV_NRD_NRD_1 360 362 PF00675 0.739
CLV_PCSK_KEX2_1 257 259 PF00082 0.666
CLV_PCSK_KEX2_1 297 299 PF00082 0.782
CLV_PCSK_KEX2_1 307 309 PF00082 0.706
CLV_PCSK_KEX2_1 336 338 PF00082 0.672
CLV_PCSK_PC1ET2_1 257 259 PF00082 0.666
CLV_PCSK_PC1ET2_1 297 299 PF00082 0.716
CLV_PCSK_PC1ET2_1 336 338 PF00082 0.672
CLV_PCSK_SKI1_1 346 350 PF00082 0.647
CLV_Separin_Metazoa 165 169 PF03568 0.670
DOC_ANK_TNKS_1 167 174 PF00023 0.587
DOC_MAPK_MEF2A_6 111 118 PF00069 0.546
DOC_USP7_MATH_1 107 111 PF00917 0.495
DOC_USP7_MATH_1 217 221 PF00917 0.739
DOC_USP7_MATH_1 276 280 PF00917 0.748
DOC_USP7_MATH_1 306 310 PF00917 0.773
DOC_USP7_MATH_1 363 367 PF00917 0.793
DOC_USP7_MATH_1 84 88 PF00917 0.431
DOC_USP7_MATH_2 249 255 PF00917 0.748
DOC_WW_Pin1_4 194 199 PF00397 0.670
DOC_WW_Pin1_4 274 279 PF00397 0.803
DOC_WW_Pin1_4 296 301 PF00397 0.734
DOC_WW_Pin1_4 356 361 PF00397 0.737
LIG_14-3-3_CanoR_1 127 136 PF00244 0.634
LIG_14-3-3_CanoR_1 192 198 PF00244 0.616
LIG_14-3-3_CanoR_1 258 268 PF00244 0.702
LIG_14-3-3_CanoR_1 269 278 PF00244 0.629
LIG_14-3-3_CanoR_1 280 290 PF00244 0.646
LIG_14-3-3_CanoR_1 307 315 PF00244 0.738
LIG_14-3-3_CanoR_1 86 91 PF00244 0.431
LIG_14-3-3_CanoR_1 93 98 PF00244 0.338
LIG_FHA_1 131 137 PF00498 0.545
LIG_FHA_1 180 186 PF00498 0.620
LIG_FHA_1 195 201 PF00498 0.603
LIG_FHA_1 56 62 PF00498 0.495
LIG_FHA_1 93 99 PF00498 0.453
LIG_LIR_Apic_2 6 10 PF02991 0.682
LIG_LIR_Gen_1 95 105 PF02991 0.431
LIG_LIR_Nem_3 72 76 PF02991 0.482
LIG_LIR_Nem_3 95 100 PF02991 0.492
LIG_MYND_1 151 155 PF01753 0.663
LIG_MYND_1 198 202 PF01753 0.703
LIG_Pex14_1 69 73 PF04695 0.558
LIG_SH2_CRK 7 11 PF00017 0.558
LIG_SH2_STAP1 344 348 PF00017 0.684
LIG_SH2_STAP1 71 75 PF00017 0.431
LIG_SH2_STAT3 175 178 PF00017 0.699
LIG_SH2_STAT3 24 27 PF00017 0.415
LIG_SH2_STAT5 117 120 PF00017 0.558
LIG_SH2_STAT5 175 178 PF00017 0.699
LIG_SH2_STAT5 24 27 PF00017 0.549
LIG_SH2_STAT5 74 77 PF00017 0.498
LIG_SH3_3 113 119 PF00018 0.520
LIG_SH3_3 140 146 PF00018 0.664
LIG_SH3_3 196 202 PF00018 0.690
LIG_SH3_3 275 281 PF00018 0.739
LIG_SH3_3 317 323 PF00018 0.707
LIG_SH3_3 6 12 PF00018 0.431
LIG_SUMO_SIM_par_1 182 189 PF11976 0.678
LIG_TRAF2_1 186 189 PF00917 0.715
LIG_TRAF2_1 249 252 PF00917 0.722
LIG_TRAF2_1 314 317 PF00917 0.734
LIG_WRC_WIRS_1 94 99 PF05994 0.320
MOD_CDC14_SPxK_1 277 280 PF00782 0.709
MOD_CDC14_SPxK_1 359 362 PF00782 0.764
MOD_CDK_SPK_2 356 361 PF00069 0.737
MOD_CDK_SPxK_1 274 280 PF00069 0.709
MOD_CDK_SPxK_1 356 362 PF00069 0.745
MOD_CK1_1 183 189 PF00069 0.682
MOD_CK1_1 194 200 PF00069 0.577
MOD_CK1_1 260 266 PF00069 0.793
MOD_CK1_1 309 315 PF00069 0.712
MOD_CK1_1 328 334 PF00069 0.592
MOD_CK1_1 364 370 PF00069 0.737
MOD_CK2_1 183 189 PF00069 0.714
MOD_CK2_1 205 211 PF00069 0.729
MOD_CK2_1 269 275 PF00069 0.747
MOD_CK2_1 281 287 PF00069 0.621
MOD_CK2_1 57 63 PF00069 0.504
MOD_DYRK1A_RPxSP_1 356 360 PF00069 0.708
MOD_GlcNHglycan 202 205 PF01048 0.721
MOD_GlcNHglycan 207 210 PF01048 0.669
MOD_GlcNHglycan 219 222 PF01048 0.568
MOD_GlcNHglycan 271 274 PF01048 0.777
MOD_GlcNHglycan 300 303 PF01048 0.802
MOD_GlcNHglycan 311 314 PF01048 0.654
MOD_GlcNHglycan 331 334 PF01048 0.504
MOD_GlcNHglycan 363 366 PF01048 0.800
MOD_GlcNHglycan 369 372 PF01048 0.725
MOD_GSK3_1 127 134 PF00069 0.617
MOD_GSK3_1 179 186 PF00069 0.617
MOD_GSK3_1 257 264 PF00069 0.797
MOD_GSK3_1 296 303 PF00069 0.748
MOD_GSK3_1 325 332 PF00069 0.675
MOD_GSK3_1 363 370 PF00069 0.775
MOD_GSK3_1 55 62 PF00069 0.463
MOD_N-GLC_1 325 330 PF02516 0.747
MOD_N-GLC_1 371 376 PF02516 0.750
MOD_NEK2_1 135 140 PF00069 0.658
MOD_NEK2_1 193 198 PF00069 0.597
MOD_NEK2_1 57 62 PF00069 0.495
MOD_NEK2_2 344 349 PF00069 0.621
MOD_PIKK_1 174 180 PF00454 0.623
MOD_PKA_1 257 263 PF00069 0.702
MOD_PKA_1 307 313 PF00069 0.801
MOD_PKA_1 361 367 PF00069 0.735
MOD_PKA_2 191 197 PF00069 0.700
MOD_PKA_2 205 211 PF00069 0.584
MOD_PKA_2 257 263 PF00069 0.733
MOD_PKA_2 281 287 PF00069 0.780
MOD_PKA_2 306 312 PF00069 0.754
MOD_PKA_2 326 332 PF00069 0.532
MOD_PKA_2 85 91 PF00069 0.431
MOD_PKA_2 92 98 PF00069 0.338
MOD_PKB_1 125 133 PF00069 0.495
MOD_PKB_1 280 288 PF00069 0.716
MOD_Plk_1 130 136 PF00069 0.583
MOD_Plk_1 251 257 PF00069 0.712
MOD_Plk_1 344 350 PF00069 0.621
MOD_Plk_1 62 68 PF00069 0.558
MOD_Plk_4 131 137 PF00069 0.491
MOD_Plk_4 180 186 PF00069 0.680
MOD_Plk_4 69 75 PF00069 0.412
MOD_Plk_4 93 99 PF00069 0.470
MOD_ProDKin_1 194 200 PF00069 0.673
MOD_ProDKin_1 274 280 PF00069 0.804
MOD_ProDKin_1 296 302 PF00069 0.733
MOD_ProDKin_1 356 362 PF00069 0.745
MOD_SUMO_rev_2 174 183 PF00179 0.668
TRG_DiLeu_BaEn_4 188 194 PF01217 0.686
TRG_DiLeu_BaEn_4 251 257 PF01217 0.712
TRG_DiLeu_BaLyEn_6 196 201 PF01217 0.704
TRG_ENDOCYTIC_2 73 76 PF00928 0.558
TRG_ER_diArg_1 280 283 PF00400 0.711
TRG_ER_diArg_1 306 308 PF00400 0.811
TRG_NLS_Bipartite_1 307 328 PF00514 0.801
TRG_NLS_MonoExtN_4 323 328 PF00514 0.712

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WTD9 Leishmania donovani 99% 100%
A4H824 Leishmania braziliensis 46% 82%
A4HWF0 Leishmania infantum 100% 100%
E9AQ49 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
Q4QFD3 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS