Ecotin-like protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ecotin, putative

Species:

Leishmania braziliensis

UniProt:

ECOT3_LEIBR

TriTrypDb:

LbrM.15.0550 , LBRM2903_150011300

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H824

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H824

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0042783	evasion of host immune response	6	1
GO:0042784	evasion of host immune response via modulation of host complement system	7	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0050896	response to stimulus	1	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1
GO:0052173	response to defenses of other organism	3	1
GO:0052200	response to host defenses	4	1
GO:0052572	response to host immune response	5	1
GO:0075136	response to host	3	1

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	7
GO:0004866	endopeptidase inhibitor activity	5	7
GO:0004867	serine-type endopeptidase inhibitor activity	6	7
GO:0030234	enzyme regulator activity	2	7
GO:0030414	peptidase inhibitor activity	4	7
GO:0061134	peptidase regulator activity	3	7
GO:0061135	endopeptidase regulator activity	4	7
GO:0098772	molecular function regulator activity	1	7
GO:0140678	molecular function inhibitor activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.577
CLV_C14_Caspase3-7	301	305	PF00656	0.614
CLV_NRD_NRD_1	240	242	PF00675	0.863
CLV_NRD_NRD_1	256	258	PF00675	0.654
CLV_NRD_NRD_1	266	268	PF00675	0.750
CLV_NRD_NRD_1	306	308	PF00675	0.676
CLV_PCSK_FUR_1	257	261	PF00082	0.632
CLV_PCSK_KEX2_1	111	113	PF00082	0.311
CLV_PCSK_KEX2_1	19	21	PF00082	0.340
CLV_PCSK_KEX2_1	239	241	PF00082	0.778
CLV_PCSK_KEX2_1	259	261	PF00082	0.670
CLV_PCSK_KEX2_1	293	295	PF00082	0.700
CLV_PCSK_KEX2_1	306	308	PF00082	0.652
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.311
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.311
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.715
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.675
CLV_PCSK_SKI1_1	205	209	PF00082	0.608
CLV_PCSK_SKI1_1	277	281	PF00082	0.650
DEG_SCF_FBW7_1	216	223	PF00400	0.620
DOC_MAPK_gen_1	111	118	PF00069	0.311
DOC_MAPK_gen_1	19	25	PF00069	0.340
DOC_MAPK_MEF2A_6	111	118	PF00069	0.479
DOC_PP2B_LxvP_1	143	146	PF13499	0.549
DOC_USP7_MATH_1	107	111	PF00917	0.461
DOC_USP7_MATH_1	146	150	PF00917	0.626
DOC_USP7_MATH_1	178	182	PF00917	0.615
DOC_USP7_MATH_1	211	215	PF00917	0.817
DOC_USP7_MATH_1	229	233	PF00917	0.780
DOC_USP7_MATH_1	292	296	PF00917	0.790
DOC_USP7_MATH_1	298	302	PF00917	0.814
DOC_USP7_UBL2_3	191	195	PF12436	0.622
DOC_WW_Pin1_4	100	105	PF00397	0.470
DOC_WW_Pin1_4	174	179	PF00397	0.578
DOC_WW_Pin1_4	212	217	PF00397	0.865
DOC_WW_Pin1_4	288	293	PF00397	0.835
DOC_WW_Pin1_4	294	299	PF00397	0.757
DOC_WW_Pin1_4	84	89	PF00397	0.382
LIG_14-3-3_CanoR_1	127	136	PF00244	0.679
LIG_14-3-3_CanoR_1	287	292	PF00244	0.617
LIG_14-3-3_CterR_2	306	309	PF00244	0.617
LIG_FHA_1	56	62	PF00498	0.504
LIG_FHA_2	58	64	PF00498	0.358
LIG_FHA_2	75	81	PF00498	0.402
LIG_LIR_Apic_2	5	10	PF02991	0.532
LIG_LIR_Apic_2	68	72	PF02991	0.299
LIG_LIR_Nem_3	51	57	PF02991	0.311
LIG_LIR_Nem_3	68	74	PF02991	0.447
LIG_LIR_Nem_3	96	100	PF02991	0.485
LIG_MYND_3	1	5	PF01753	0.444
LIG_Pex14_1	69	73	PF04695	0.403
LIG_SH2_CRK	7	11	PF00017	0.512
LIG_SH2_STAP1	275	279	PF00017	0.656
LIG_SH2_STAT3	24	27	PF00017	0.510
LIG_SH2_STAT3	82	85	PF00017	0.311
LIG_SH2_STAT5	117	120	PF00017	0.440
LIG_SH2_STAT5	24	27	PF00017	0.410
LIG_SH2_STAT5	74	77	PF00017	0.461
LIG_SH3_1	101	107	PF00018	0.311
LIG_SH3_3	101	107	PF00018	0.407
LIG_SH3_3	113	119	PF00018	0.389
LIG_SH3_3	172	178	PF00018	0.570
LIG_SH3_3	85	91	PF00018	0.348
LIG_SUMO_SIM_par_1	168	174	PF11976	0.570
LIG_SUMO_SIM_par_1	74	80	PF11976	0.447
LIG_TRAF2_1	139	142	PF00917	0.526
MOD_CDC14_SPxK_1	291	294	PF00782	0.860
MOD_CDC14_SPxK_1	297	300	PF00782	0.757
MOD_CDK_SPK_2	212	217	PF00069	0.620
MOD_CDK_SPK_2	288	293	PF00069	0.835
MOD_CDK_SPK_2	294	299	PF00069	0.757
MOD_CDK_SPxK_1	288	294	PF00069	0.841
MOD_CK1_1	174	180	PF00069	0.583
MOD_CK1_1	201	207	PF00069	0.833
MOD_CK1_1	212	218	PF00069	0.637
MOD_CK1_1	223	229	PF00069	0.606
MOD_CK1_1	261	267	PF00069	0.836
MOD_CK1_1	62	68	PF00069	0.518
MOD_CK2_1	136	142	PF00069	0.514
MOD_CK2_1	27	33	PF00069	0.311
MOD_CK2_1	270	276	PF00069	0.544
MOD_CK2_1	57	63	PF00069	0.461
MOD_DYRK1A_RPxSP_1	294	298	PF00069	0.779
MOD_GlcNHglycan	179	183	PF01048	0.621
MOD_GlcNHglycan	209	212	PF01048	0.834
MOD_GlcNHglycan	233	236	PF01048	0.782
MOD_GlcNHglycan	244	248	PF01048	0.763
MOD_GlcNHglycan	272	275	PF01048	0.638
MOD_GlcNHglycan	29	32	PF01048	0.311
MOD_GlcNHglycan	294	297	PF01048	0.869
MOD_GlcNHglycan	300	303	PF01048	0.774
MOD_GSK3_1	174	181	PF00069	0.588
MOD_GSK3_1	196	203	PF00069	0.748
MOD_GSK3_1	207	214	PF00069	0.755
MOD_GSK3_1	216	223	PF00069	0.672
MOD_GSK3_1	239	246	PF00069	0.743
MOD_GSK3_1	258	265	PF00069	0.769
MOD_GSK3_1	288	295	PF00069	0.739
MOD_GSK3_1	298	305	PF00069	0.785
MOD_GSK3_1	55	62	PF00069	0.524
MOD_N-GLC_1	201	206	PF02516	0.655
MOD_N-GLC_1	288	293	PF02516	0.670
MOD_NEK2_1	190	195	PF00069	0.623
MOD_NEK2_1	196	201	PF00069	0.564
MOD_NEK2_1	207	212	PF00069	0.581
MOD_NEK2_1	57	62	PF00069	0.493
MOD_PIKK_1	136	142	PF00454	0.514
MOD_PIKK_1	146	152	PF00454	0.531
MOD_PKA_1	191	197	PF00069	0.713
MOD_PKA_1	239	245	PF00069	0.866
MOD_PKA_1	258	264	PF00069	0.585
MOD_PKA_2	223	229	PF00069	0.761
MOD_PKA_2	239	245	PF00069	0.816
MOD_PKA_2	302	308	PF00069	0.803
MOD_PKB_1	285	293	PF00069	0.607
MOD_Plk_1	229	235	PF00069	0.623
MOD_Plk_1	243	249	PF00069	0.553
MOD_Plk_1	62	68	PF00069	0.461
MOD_ProDKin_1	100	106	PF00069	0.470
MOD_ProDKin_1	174	180	PF00069	0.583
MOD_ProDKin_1	212	218	PF00069	0.865
MOD_ProDKin_1	288	294	PF00069	0.841
MOD_ProDKin_1	84	90	PF00069	0.382
MOD_SUMO_rev_2	270	279	PF00179	0.563
TRG_ENDOCYTIC_2	73	76	PF00928	0.461
TRG_ER_diArg_1	239	241	PF00400	0.892
TRG_NLS_Bipartite_1	239	261	PF00514	0.864
TRG_NLS_MonoCore_2	256	261	PF00514	0.629
TRG_NLS_MonoExtC_3	256	262	PF00514	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ51	Leptomonas seymouri	34%	91%
A0A3S7WTD9	Leishmania donovani	46%	82%
A4H824	Leishmania braziliensis	100%	100%
A4HWF0	Leishmania infantum	46%	82%
E9AQ49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	83%
Q4QFD3	Leishmania major	46%	100%