LeishMANIAdb
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Ecotin-like protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ecotin-like protein 2
Gene product:
ecotin - putative
Species:
Leishmania infantum
UniProt:
ECOT2_LEIIN
TriTrypDb:
LINF_150012400
Length:
158

Annotations

Annotations by Jardim et al.

Protease inhibitors, Ecotin-like 2 LinJ15.0530 PE=3 SV=1 - [ECOT2_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWE9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWE9

Function

Biological processes
Term Name Level Count
GO:0009605 response to external stimulus 2 1
GO:0009607 response to biotic stimulus 2 1
GO:0042783 evasion of host immune response 6 1
GO:0042784 evasion of host immune response via modulation of host complement system 7 1
GO:0043207 response to external biotic stimulus 3 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0050896 response to stimulus 1 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0051707 response to other organism 2 1
GO:0052173 response to defenses of other organism 3 1
GO:0052200 response to host defenses 4 1
GO:0052572 response to host immune response 5 1
GO:0075136 response to host 3 1
Molecular functions
Term Name Level Count
GO:0004857 enzyme inhibitor activity 3 8
GO:0004866 endopeptidase inhibitor activity 5 8
GO:0004867 serine-type endopeptidase inhibitor activity 6 8
GO:0030234 enzyme regulator activity 2 8
GO:0030414 peptidase inhibitor activity 4 8
GO:0061134 peptidase regulator activity 3 8
GO:0061135 endopeptidase regulator activity 4 8
GO:0098772 molecular function regulator activity 1 8
GO:0140678 molecular function inhibitor activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 56 60 PF00656 0.251
CLV_NRD_NRD_1 28 30 PF00675 0.300
CLV_NRD_NRD_1 39 41 PF00675 0.198
CLV_PCSK_KEX2_1 104 106 PF00082 0.445
CLV_PCSK_KEX2_1 28 30 PF00082 0.282
CLV_PCSK_PC1ET2_1 104 106 PF00082 0.229
DOC_CKS1_1 127 132 PF01111 0.227
DOC_MAPK_gen_1 28 34 PF00069 0.248
DOC_MAPK_MEF2A_6 118 127 PF00069 0.227
DOC_PP1_RVXF_1 27 34 PF00149 0.218
DOC_PP2B_LxvP_1 94 97 PF13499 0.311
DOC_PP4_FxxP_1 16 19 PF00568 0.372
DOC_PP4_FxxP_1 33 36 PF00568 0.311
DOC_USP7_MATH_1 3 7 PF00917 0.616
DOC_USP7_UBL2_3 37 41 PF12436 0.311
DOC_WW_Pin1_4 126 131 PF00397 0.227
LIG_14-3-3_CanoR_1 118 127 PF00244 0.227
LIG_14-3-3_CanoR_1 138 143 PF00244 0.229
LIG_APCC_ABBAyCdc20_2 29 35 PF00400 0.218
LIG_FHA_1 111 117 PF00498 0.374
LIG_FHA_1 79 85 PF00498 0.153
LIG_FHA_2 127 133 PF00498 0.241
LIG_LIR_Nem_3 81 85 PF02991 0.347
LIG_Pex14_1 78 82 PF04695 0.227
LIG_SH2_STAP1 80 84 PF00017 0.227
LIG_SH2_STAT3 119 122 PF00017 0.227
LIG_SH2_STAT5 128 131 PF00017 0.208
LIG_SH2_STAT5 30 33 PF00017 0.295
LIG_SH2_STAT5 80 83 PF00017 0.153
LIG_SH3_3 124 130 PF00018 0.266
LIG_SUMO_SIM_par_1 123 129 PF11976 0.227
LIG_SUMO_SIM_par_1 83 89 PF11976 0.290
LIG_TRAF2_1 69 72 PF00917 0.153
MOD_CDK_SPK_2 126 131 PF00069 0.227
MOD_CK1_1 144 150 PF00069 0.488
MOD_CK2_1 66 72 PF00069 0.153
MOD_GlcNHglycan 146 149 PF01048 0.444
MOD_GlcNHglycan 5 8 PF01048 0.532
MOD_GlcNHglycan 90 93 PF01048 0.229
MOD_GSK3_1 138 145 PF00069 0.416
MOD_GSK3_1 86 93 PF00069 0.245
MOD_NEK2_1 90 95 PF00069 0.255
MOD_PIKK_1 118 124 PF00454 0.227
MOD_PIKK_1 22 28 PF00454 0.229
MOD_PKB_1 136 144 PF00069 0.344
MOD_Plk_1 71 77 PF00069 0.344
MOD_Plk_2-3 71 77 PF00069 0.290
MOD_Plk_4 78 84 PF00069 0.227
MOD_Plk_4 90 96 PF00069 0.344
MOD_ProDKin_1 126 132 PF00069 0.227
MOD_SUMO_rev_2 42 48 PF00179 0.292
TRG_ENDOCYTIC_2 30 33 PF00928 0.251
TRG_ENDOCYTIC_2 82 85 PF00928 0.227
TRG_ER_diArg_1 105 108 PF00400 0.229
TRG_ER_diArg_1 28 30 PF00400 0.298
TRG_NLS_MonoCore_2 103 108 PF00514 0.229

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIL0 Leptomonas seymouri 31% 100%
A0A0N1PE50 Leptomonas seymouri 61% 100%
A0A1X0NTQ2 Trypanosomatidae 53% 100%
A0A1X0NV40 Trypanosomatidae 37% 100%
A0A3Q8I919 Leishmania donovani 40% 100%
A0A3R7KH31 Trypanosoma rangeli 50% 100%
A0A422N3M7 Trypanosoma rangeli 37% 100%
A1JL79 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 40% 94%
A4H804 Leishmania braziliensis 41% 100%
A4H823 Leishmania braziliensis 73% 100%
A4HWD2 Leishmania infantum 40% 100%
A4HWE9 Leishmania infantum 100% 100%
A4TNJ2 Yersinia pestis (strain Pestoides F) 39% 93%
A5W3S6 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 39% 99%
A7FKF8 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 39% 93%
A7ZP31 Escherichia coli O139:H28 (strain E24377A / ETEC) 40% 98%
A8A271 Escherichia coli O9:H4 (strain HS) 40% 98%
A8GCA1 Serratia proteamaculans (strain 568) 42% 93%
A9MJZ3 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 42% 98%
A9R289 Yersinia pestis bv. Antiqua (strain Angola) 39% 93%
B0KU25 Pseudomonas putida (strain GB-1) 41% 99%
B1IY63 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 40% 98%
B1J8K6 Pseudomonas putida (strain W619) 36% 99%
B1JSA0 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 39% 93%
B1LKV6 Escherichia coli (strain SMS-3-5 / SECEC) 40% 98%
B1X8A5 Escherichia coli (strain K12 / DH10B) 40% 98%
B2K9A0 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 39% 93%
B2TV26 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 40% 98%
B5BDZ1 Salmonella paratyphi A (strain AKU_12601) 42% 96%
B5R236 Salmonella enteritidis PT4 (strain P125109) 42% 96%
B5RC88 Salmonella gallinarum (strain 287/91 / NCTC 13346) 42% 96%
B5YX01 Escherichia coli O157:H7 (strain EC4115 / EHEC) 40% 98%
B6I1A7 Escherichia coli (strain SE11) 40% 98%
B7LAN3 Escherichia coli (strain 55989 / EAEC) 40% 98%
B7LJV0 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 42% 98%
B7M5Q0 Escherichia coli O8 (strain IAI1) 40% 98%
B7MFC2 Escherichia coli O45:K1 (strain S88 / ExPEC) 41% 98%
B7MXP0 Escherichia coli O81 (strain ED1a) 40% 98%
B7N5H1 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 40% 98%
B7NN20 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 41% 98%
B7UFM3 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 40% 98%
B7UZW2 Pseudomonas aeruginosa (strain LESB58) 43% 100%
C4ZU52 Escherichia coli (strain K12 / MC4100 / BW2952) 40% 98%
C9ZNX6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 96%
C9ZNZ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AQ32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
P23827 Escherichia coli (strain K12) 40% 98%
Q02NQ8 Pseudomonas aeruginosa (strain UCBPP-PA14) 43% 100%
Q0T2R6 Shigella flexneri serotype 5b (strain 8401) 41% 98%
Q0TFN2 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 40% 98%
Q1C9H9 Yersinia pestis bv. Antiqua (strain Antiqua) 39% 93%
Q1CFY7 Yersinia pestis bv. Antiqua (strain Nepal516) 39% 93%
Q1H1S3 Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) 39% 98%
Q1R9K8 Escherichia coli (strain UTI89 / UPEC) 40% 98%
Q31Z32 Shigella boydii serotype 4 (strain Sb227) 40% 98%
Q3KCZ4 Pseudomonas fluorescens (strain Pf0-1) 37% 98%
Q3YZZ8 Shigella sonnei (strain Ss046) 41% 98%
Q4D4Y5 Trypanosoma cruzi (strain CL Brener) 53% 100%
Q4KC31 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 39% 100%
Q4QFD4 Leishmania major 91% 100%
Q4QFF0 Leishmania major 40% 100%
Q4UMT9 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 41% 98%
Q57M90 Salmonella choleraesuis (strain SC-B67) 42% 98%
Q57ZP2 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 38% 96%
Q57ZQ7 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 48% 100%
Q5PI36 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 42% 96%
Q66CZ8 Yersinia pseudotuberculosis serotype I (strain IP32953) 39% 93%
Q821B1 Shigella flexneri 41% 98%
Q88IC7 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 38% 99%
Q8CVW3 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 40% 98%
Q8EEQ7 Shewanella oneidensis (strain MR-1) 35% 86%
Q8XE46 Escherichia coli O157:H7 40% 98%
Q8Z568 Salmonella typhi 42% 96%
Q8ZGS0 Yersinia pestis 39% 93%
Q8ZNH4 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 42% 96%
Q9I088 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS