LeishMANIAdb
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Ecotin-like protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ecotin-like protein 2
Gene product:
ecotin, putative
Species:
Leishmania braziliensis
UniProt:
ECOT2_LEIBR
TriTrypDb:
LbrM.15.0540 , LBRM2903_150011200
Length:
154

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H823
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H823

Function

Biological processes
Term Name Level Count
GO:0009605 response to external stimulus 2 1
GO:0009607 response to biotic stimulus 2 1
GO:0042783 evasion of host immune response 6 1
GO:0042784 evasion of host immune response via modulation of host complement system 7 1
GO:0043207 response to external biotic stimulus 3 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0050896 response to stimulus 1 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0051707 response to other organism 2 1
GO:0052173 response to defenses of other organism 3 1
GO:0052200 response to host defenses 4 1
GO:0052572 response to host immune response 5 1
GO:0075136 response to host 3 1
Molecular functions
Term Name Level Count
GO:0004857 enzyme inhibitor activity 3 8
GO:0004866 endopeptidase inhibitor activity 5 8
GO:0004867 serine-type endopeptidase inhibitor activity 6 8
GO:0030234 enzyme regulator activity 2 8
GO:0030414 peptidase inhibitor activity 4 8
GO:0061134 peptidase regulator activity 3 8
GO:0061135 endopeptidase regulator activity 4 8
GO:0098772 molecular function regulator activity 1 8
GO:0140678 molecular function inhibitor activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 24 26 PF00675 0.262
CLV_PCSK_FUR_1 22 26 PF00082 0.177
CLV_PCSK_KEX2_1 24 26 PF00082 0.262
CLV_PCSK_SKI1_1 147 151 PF00082 0.297
DOC_MAPK_gen_1 100 107 PF00069 0.177
DOC_MAPK_gen_1 22 30 PF00069 0.265
DOC_MAPK_MEF2A_6 114 123 PF00069 0.237
DOC_PP1_RVXF_1 98 105 PF00149 0.177
DOC_USP7_UBL2_3 65 69 PF12436 0.177
LIG_BIR_II_1 1 5 PF00653 0.474
LIG_FHA_1 107 113 PF00498 0.290
LIG_FHA_1 135 141 PF00498 0.306
LIG_FHA_1 87 93 PF00498 0.247
LIG_FHA_2 6 12 PF00498 0.446
LIG_FHA_2 80 86 PF00498 0.287
LIG_LIR_Apic_2 11 15 PF02991 0.290
LIG_LIR_Apic_2 72 77 PF02991 0.272
LIG_Pex14_1 74 78 PF04695 0.237
LIG_SH2_CRK 12 16 PF00017 0.206
LIG_SH2_PTP2 26 29 PF00017 0.177
LIG_SH2_STAT5 124 127 PF00017 0.213
LIG_SH2_STAT5 26 29 PF00017 0.262
LIG_SH2_STAT5 60 63 PF00017 0.410
LIG_SH2_STAT5 79 82 PF00017 0.226
LIG_SH3_3 120 126 PF00018 0.259
LIG_SUMO_SIM_par_1 26 31 PF11976 0.262
LIG_SUMO_SIM_par_1 79 85 PF11976 0.317
MOD_CK2_1 79 85 PF00069 0.296
MOD_GlcNHglycan 1 4 PF01048 0.610
MOD_GlcNHglycan 140 143 PF01048 0.468
MOD_GSK3_1 134 141 PF00069 0.317
MOD_NEK2_1 107 112 PF00069 0.177
MOD_NEK2_1 86 91 PF00069 0.262
MOD_PK_1 145 151 PF00069 0.299
MOD_PKB_1 132 140 PF00069 0.353
MOD_Plk_1 67 73 PF00069 0.353
MOD_Plk_2-3 67 73 PF00069 0.317
MOD_Plk_4 108 114 PF00069 0.177
MOD_SUMO_rev_2 35 44 PF00179 0.295
TRG_ENDOCYTIC_2 26 29 PF00928 0.262
TRG_ENDOCYTIC_2 78 81 PF00928 0.237
TRG_ER_diArg_1 22 25 PF00400 0.265
TRG_ER_diLys_1 150 154 PF00400 0.313

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIL0 Leptomonas seymouri 34% 100%
A0A0N1PE50 Leptomonas seymouri 58% 100%
A0A1X0NTQ2 Trypanosomatidae 53% 97%
A0A1X0NV40 Trypanosomatidae 39% 100%
A0A3Q8I919 Leishmania donovani 42% 100%
A0A3R7KH31 Trypanosoma rangeli 49% 100%
A0A422N3M7 Trypanosoma rangeli 41% 100%
A1JL79 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 40% 92%
A4H804 Leishmania braziliensis 44% 100%
A4H823 Leishmania braziliensis 100% 100%
A4HWD2 Leishmania infantum 42% 100%
A4HWE9 Leishmania infantum 73% 97%
A4TNJ2 Yersinia pestis (strain Pestoides F) 38% 91%
A5W3S6 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 43% 97%
A7FKF8 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 38% 91%
A7ZP31 Escherichia coli O139:H28 (strain E24377A / ETEC) 41% 95%
A8A271 Escherichia coli O9:H4 (strain HS) 41% 95%
A8GCA1 Serratia proteamaculans (strain 568) 44% 91%
A9MJZ3 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 42% 95%
A9R289 Yersinia pestis bv. Antiqua (strain Angola) 38% 91%
B0KU25 Pseudomonas putida (strain GB-1) 43% 97%
B1IY63 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 41% 95%
B1J8K6 Pseudomonas putida (strain W619) 41% 97%
B1JSA0 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 38% 91%
B1LKV6 Escherichia coli (strain SMS-3-5 / SECEC) 41% 95%
B1X8A5 Escherichia coli (strain K12 / DH10B) 41% 95%
B2K9A0 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 38% 91%
B2TV26 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 41% 95%
B5BDZ1 Salmonella paratyphi A (strain AKU_12601) 42% 94%
B5R236 Salmonella enteritidis PT4 (strain P125109) 42% 94%
B5RC88 Salmonella gallinarum (strain 287/91 / NCTC 13346) 42% 94%
B5YX01 Escherichia coli O157:H7 (strain EC4115 / EHEC) 41% 95%
B6I1A7 Escherichia coli (strain SE11) 41% 95%
B7LAN3 Escherichia coli (strain 55989 / EAEC) 41% 95%
B7LJV0 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 42% 95%
B7M5Q0 Escherichia coli O8 (strain IAI1) 41% 95%
B7MFC2 Escherichia coli O45:K1 (strain S88 / ExPEC) 42% 95%
B7MXP0 Escherichia coli O81 (strain ED1a) 41% 95%
B7N5H1 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 41% 95%
B7NN20 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 42% 95%
B7UFM3 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 41% 95%
B7UZW2 Pseudomonas aeruginosa (strain LESB58) 44% 99%
C4ZU52 Escherichia coli (strain K12 / MC4100 / BW2952) 41% 95%
C9ZNX6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 93%
C9ZNZ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AQ32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
P23827 Escherichia coli (strain K12) 41% 95%
Q02NQ8 Pseudomonas aeruginosa (strain UCBPP-PA14) 44% 99%
Q0T2R6 Shigella flexneri serotype 5b (strain 8401) 41% 95%
Q0TFN2 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 41% 95%
Q1C9H9 Yersinia pestis bv. Antiqua (strain Antiqua) 38% 91%
Q1CFY7 Yersinia pestis bv. Antiqua (strain Nepal516) 38% 91%
Q1H1S3 Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) 41% 96%
Q1R9K8 Escherichia coli (strain UTI89 / UPEC) 41% 95%
Q31Z32 Shigella boydii serotype 4 (strain Sb227) 41% 95%
Q3KCZ4 Pseudomonas fluorescens (strain Pf0-1) 40% 96%
Q3YZZ8 Shigella sonnei (strain Ss046) 41% 95%
Q4D4Y5 Trypanosoma cruzi (strain CL Brener) 51% 100%
Q4KC31 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 41% 97%
Q4QFD4 Leishmania major 73% 100%
Q4QFF0 Leishmania major 40% 100%
Q4UMT9 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 45% 95%
Q57M90 Salmonella choleraesuis (strain SC-B67) 42% 95%
Q57ZP2 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 35% 93%
Q57ZQ7 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 48% 100%
Q5PI36 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 42% 94%
Q66CZ8 Yersinia pseudotuberculosis serotype I (strain IP32953) 38% 91%
Q821B1 Shigella flexneri 41% 95%
Q88IC7 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 43% 97%
Q8CVW3 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 41% 95%
Q8EEQ7 Shewanella oneidensis (strain MR-1) 36% 84%
Q8XE46 Escherichia coli O157:H7 41% 95%
Q8Z568 Salmonella typhi 42% 94%
Q8ZGS0 Yersinia pestis 38% 91%
Q8ZNH4 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 42% 94%
Q9I088 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 44% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS