Ecotin-like protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ecotin-like protein

Species:

Leishmania major

UniProt:

ECOT1_LEIMA

TriTrypDb:

LmjF.15.0300 , LMJLV39_150008900 , LMJSD75_150008800

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFF0

Function

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Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0042783	evasion of host immune response	6	1
GO:0042784	evasion of host immune response via modulation of host complement system	7	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0050896	response to stimulus	1	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1

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Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	14
GO:0004866	endopeptidase inhibitor activity	5	14
GO:0004867	serine-type endopeptidase inhibitor activity	6	14
GO:0030234	enzyme regulator activity	2	14
GO:0030414	peptidase inhibitor activity	4	14
GO:0061134	peptidase regulator activity	3	14
GO:0061135	endopeptidase regulator activity	4	14
GO:0098772	molecular function regulator activity	1	14
GO:0140678	molecular function inhibitor activity	2	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.306
CLV_NRD_NRD_1	100	102	PF00675	0.404
CLV_PCSK_KEX2_1	18	20	PF00082	0.313
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.310
CLV_PCSK_SKI1_1	19	23	PF00082	0.278
CLV_PCSK_SKI1_1	79	83	PF00082	0.260
DOC_MAPK_gen_1	115	124	PF00069	0.355
DOC_MAPK_MEF2A_6	115	124	PF00069	0.326
DOC_PP1_RVXF_1	16	23	PF00149	0.310
DOC_USP7_MATH_1	113	117	PF00917	0.277

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL0	Leptomonas seymouri	55%	99%
A0A0N1PE50	Leptomonas seymouri	40%	98%
A0A1X0NTQ2	Trypanosomatidae	42%	92%
A0A1X0NV40	Trypanosomatidae	38%	96%
A0A3Q8I919	Leishmania donovani	91%	100%
A0A3R7KH31	Trypanosoma rangeli	33%	99%
A0A422N3M7	Trypanosoma rangeli	38%	100%
A1JL79	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	32%	87%
A4H804	Leishmania braziliensis	79%	100%
A4H823	Leishmania braziliensis	40%	95%

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