Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B764_LEIMU

TriTrypDb:

LmxM.34.5380

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B764

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B764

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.511
CLV_NRD_NRD_1	165	167	PF00675	0.354
CLV_PCSK_KEX2_1	27	29	PF00082	0.459
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.407
CLV_PCSK_SKI1_1	105	109	PF00082	0.481
CLV_PCSK_SKI1_1	15	19	PF00082	0.436
CLV_PCSK_SKI1_1	167	171	PF00082	0.610
CLV_PCSK_SKI1_1	209	213	PF00082	0.524
CLV_PCSK_SKI1_1	224	228	PF00082	0.460
CLV_PCSK_SKI1_1	28	32	PF00082	0.371
DEG_APCC_KENBOX_2	43	47	PF00400	0.364
DEG_Nend_UBRbox_1	1	4	PF02207	0.643
DEG_SPOP_SBC_1	172	176	PF00917	0.471
DEG_SPOP_SBC_1	202	206	PF00917	0.282
DOC_CKS1_1	49	54	PF01111	0.233
DOC_CYCLIN_RxL_1	12	19	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	75	78	PF00134	0.478
DOC_MAPK_MEF2A_6	7	14	PF00069	0.470
DOC_PP2B_LxvP_1	54	57	PF13499	0.516
DOC_PP2B_LxvP_1	75	78	PF13499	0.433
DOC_PP4_FxxP_1	165	168	PF00568	0.464
DOC_PP4_FxxP_1	49	52	PF00568	0.247
DOC_USP7_MATH_1	132	136	PF00917	0.451
DOC_USP7_MATH_1	172	176	PF00917	0.471
DOC_USP7_MATH_1	192	196	PF00917	0.520
DOC_USP7_MATH_1	198	202	PF00917	0.463
DOC_USP7_MATH_1	246	250	PF00917	0.396
DOC_WW_Pin1_4	16	21	PF00397	0.464
DOC_WW_Pin1_4	48	53	PF00397	0.390
LIG_FHA_1	49	55	PF00498	0.307
LIG_FHA_1	88	94	PF00498	0.438
LIG_FHA_2	106	112	PF00498	0.499
LIG_FHA_2	125	131	PF00498	0.408
LIG_FHA_2	168	174	PF00498	0.532
LIG_HCF-1_HBM_1	94	97	PF13415	0.362
LIG_LIR_Apic_2	162	168	PF02991	0.450
LIG_LIR_Gen_1	135	146	PF02991	0.504
LIG_LIR_Nem_3	135	141	PF02991	0.484
LIG_LIR_Nem_3	94	100	PF02991	0.350
LIG_MYND_1	16	20	PF01753	0.273
LIG_PDZ_Class_1	254	259	PF00595	0.505
LIG_Pex14_1	161	165	PF04695	0.396
LIG_RPA_C_Fungi	191	203	PF08784	0.337
LIG_SH2_SRC	215	218	PF00017	0.376
LIG_SH2_STAT5	101	104	PF00017	0.336
LIG_SH2_STAT5	145	148	PF00017	0.435
LIG_SH2_STAT5	159	162	PF00017	0.336
LIG_SH2_STAT5	215	218	PF00017	0.481
LIG_SH2_STAT5	234	237	PF00017	0.362
LIG_SH2_STAT5	97	100	PF00017	0.332
LIG_SH3_3	143	149	PF00018	0.525
LIG_SH3_3	73	79	PF00018	0.589
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.498
LIG_TRAF2_1	127	130	PF00917	0.541
LIG_UBA3_1	82	87	PF00899	0.526
MOD_CK1_1	201	207	PF00069	0.524
MOD_CK1_1	249	255	PF00069	0.459
MOD_CK1_1	34	40	PF00069	0.393
MOD_CK2_1	105	111	PF00069	0.388
MOD_CK2_1	124	130	PF00069	0.423
MOD_GlcNHglycan	114	117	PF01048	0.415
MOD_GlcNHglycan	175	178	PF01048	0.520
MOD_GlcNHglycan	2	5	PF01048	0.616
MOD_GlcNHglycan	200	203	PF01048	0.545
MOD_GlcNHglycan	256	259	PF01048	0.489
MOD_GlcNHglycan	33	36	PF01048	0.587
MOD_GSK3_1	167	174	PF00069	0.519
MOD_GSK3_1	198	205	PF00069	0.406
MOD_NEK2_1	203	208	PF00069	0.407
MOD_NEK2_1	211	216	PF00069	0.412
MOD_NEK2_1	31	36	PF00069	0.461
MOD_NEK2_2	100	105	PF00069	0.426
MOD_PIKK_1	125	131	PF00454	0.557
MOD_PIKK_1	252	258	PF00454	0.329
MOD_PKA_2	123	129	PF00069	0.507
MOD_Plk_1	249	255	PF00069	0.558
MOD_Plk_4	211	217	PF00069	0.519
MOD_ProDKin_1	16	22	PF00069	0.462
MOD_ProDKin_1	48	54	PF00069	0.384
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.401
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.449
TRG_ENDOCYTIC_2	101	104	PF00928	0.345
TRG_ENDOCYTIC_2	236	239	PF00928	0.400
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE1	Leptomonas seymouri	49%	96%
A0A1X0NWL1	Trypanosomatidae	27%	92%
A0A3S7XA73	Leishmania donovani	91%	100%
A0A422N815	Trypanosoma rangeli	21%	97%
A4HNJ9	Leishmania braziliensis	80%	100%
A4IC68	Leishmania infantum	91%	100%
E9AG11	Leishmania major	89%	100%
V5DS95	Trypanosoma cruzi	23%	97%