Diacylglycerol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol kinase-like protein

Species:

Leishmania mexicana

UniProt:

E9B763_LEIMU

TriTrypDb:

LmxM.34.5370

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9B763

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B763

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0007165	signal transduction	2	9
GO:0007186	G protein-coupled receptor signaling pathway	3	9
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0044237	cellular metabolic process	2	9
GO:0050789	regulation of biological process	2	9

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004143	diacylglycerol kinase activity	5	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.175
CLV_NRD_NRD_1	28	30	PF00675	0.334
CLV_NRD_NRD_1	67	69	PF00675	0.279
CLV_PCSK_FUR_1	196	200	PF00082	0.154
CLV_PCSK_KEX2_1	137	139	PF00082	0.279
CLV_PCSK_KEX2_1	198	200	PF00082	0.279
CLV_PCSK_KEX2_1	28	30	PF00082	0.377
CLV_PCSK_KEX2_1	92	94	PF00082	0.306
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.291
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.306

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR4	Leptomonas seymouri	69%	100%
A0A0S4KIS7	Bodo saltans	24%	87%
A0A1X0NZZ0	Trypanosomatidae	35%	100%
A0A3Q8IIW3	Leishmania donovani	94%	100%
A4HNJ8	Leishmania braziliensis	79%	100%
A4IC67	Leishmania infantum	94%	100%
C9ZVX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	67%
E9AG10	Leishmania major	91%	100%
F4JKI3	Arabidopsis thaliana	26%	83%
P52429	Homo sapiens	32%	68%

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