ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynein heavy chain and region D6 of dynein motor/Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B760_LEIMU

TriTrypDb:

LmxM.34.5340

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0005875	microtubule associated complex	2	3
GO:0030286	dynein complex	3	3
GO:0032991	protein-containing complex	1	3
GO:1902494	catalytic complex	2	3

Expansion

Sequence features

E9B760

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B760

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0008569	minus-end-directed microtubule motor activity	3	3
GO:0140657	ATP-dependent activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.409
CLV_NRD_NRD_1	182	184	PF00675	0.519
CLV_NRD_NRD_1	241	243	PF00675	0.452
CLV_NRD_NRD_1	252	254	PF00675	0.351
CLV_NRD_NRD_1	342	344	PF00675	0.431
CLV_PCSK_KEX2_1	116	118	PF00082	0.437
CLV_PCSK_KEX2_1	182	184	PF00082	0.486
CLV_PCSK_KEX2_1	241	243	PF00082	0.411
CLV_PCSK_KEX2_1	51	53	PF00082	0.395
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.395
CLV_PCSK_SKI1_1	117	121	PF00082	0.434
CLV_PCSK_SKI1_1	169	173	PF00082	0.691
CLV_PCSK_SKI1_1	253	257	PF00082	0.313
CLV_PCSK_SKI1_1	268	272	PF00082	0.259
CLV_PCSK_SKI1_1	275	279	PF00082	0.279
DOC_CYCLIN_RxL_1	163	173	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.502
DOC_MAPK_MEF2A_6	121	130	PF00069	0.347
DOC_PP2B_PxIxI_1	30	36	PF00149	0.491
DOC_USP7_MATH_1	287	291	PF00917	0.259
DOC_WW_Pin1_4	11	16	PF00397	0.560
DOC_WW_Pin1_4	131	136	PF00397	0.434
DOC_WW_Pin1_4	257	262	PF00397	0.266
DOC_WW_Pin1_4	27	32	PF00397	0.377
DOC_WW_Pin1_4	329	334	PF00397	0.328
LIG_14-3-3_CanoR_1	24	32	PF00244	0.288
LIG_14-3-3_CanoR_1	241	251	PF00244	0.414
LIG_14-3-3_CanoR_1	275	281	PF00244	0.351
LIG_AP2alpha_2	40	42	PF02296	0.351
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_FHA_1	218	224	PF00498	0.579
LIG_FHA_1	269	275	PF00498	0.299
LIG_FHA_1	28	34	PF00498	0.374
LIG_FHA_2	325	331	PF00498	0.451
LIG_FHA_2	85	91	PF00498	0.348
LIG_GBD_Chelix_1	100	108	PF00786	0.531
LIG_LIR_Gen_1	159	167	PF02991	0.638
LIG_LIR_Gen_1	315	325	PF02991	0.318
LIG_LIR_Gen_1	40	49	PF02991	0.370
LIG_LIR_Gen_1	72	78	PF02991	0.389
LIG_LIR_Gen_1	82	91	PF02991	0.272
LIG_LIR_Nem_3	10	16	PF02991	0.465
LIG_LIR_Nem_3	103	108	PF02991	0.521
LIG_LIR_Nem_3	118	123	PF02991	0.295
LIG_LIR_Nem_3	159	164	PF02991	0.593
LIG_LIR_Nem_3	315	320	PF02991	0.357
LIG_LIR_Nem_3	40	45	PF02991	0.374
LIG_LIR_Nem_3	72	76	PF02991	0.366
LIG_LIR_Nem_3	82	86	PF02991	0.299
LIG_LIR_Nem_3	94	100	PF02991	0.364
LIG_MYND_1	111	115	PF01753	0.452
LIG_Pex14_2	120	124	PF04695	0.330
LIG_Pex14_2	140	144	PF04695	0.555
LIG_SH2_CRK	105	109	PF00017	0.560
LIG_SH2_PTP2	73	76	PF00017	0.361
LIG_SH2_SRC	73	76	PF00017	0.361
LIG_SH2_STAP1	9	13	PF00017	0.317
LIG_SH2_STAT5	18	21	PF00017	0.504
LIG_SH2_STAT5	338	341	PF00017	0.428
LIG_SH2_STAT5	47	50	PF00017	0.474
LIG_SH2_STAT5	73	76	PF00017	0.372
LIG_SH2_STAT5	85	88	PF00017	0.304
LIG_SH2_STAT5	9	12	PF00017	0.376
LIG_SH2_STAT5	96	99	PF00017	0.506
LIG_SH3_3	123	129	PF00018	0.467
LIG_SH3_3	133	139	PF00018	0.446
LIG_SH3_3	147	153	PF00018	0.457
LIG_TYR_ITIM	205	210	PF00017	0.501
LIG_WRC_WIRS_1	56	61	PF05994	0.457
MOD_CDC14_SPxK_1	14	17	PF00782	0.403
MOD_CDK_SPxK_1	11	17	PF00069	0.417
MOD_CK1_1	219	225	PF00069	0.492
MOD_CK1_1	273	279	PF00069	0.331
MOD_CK1_1	7	13	PF00069	0.335
MOD_CK2_1	186	192	PF00069	0.520
MOD_CK2_1	242	248	PF00069	0.432
MOD_CK2_1	315	321	PF00069	0.469
MOD_GlcNHglycan	172	175	PF01048	0.692
MOD_GlcNHglycan	201	204	PF01048	0.494
MOD_GlcNHglycan	245	248	PF01048	0.300
MOD_GlcNHglycan	53	56	PF01048	0.391
MOD_GSK3_1	186	193	PF00069	0.520
MOD_GSK3_1	23	30	PF00069	0.537
MOD_GSK3_1	324	331	PF00069	0.455
MOD_GSK3_1	51	58	PF00069	0.480
MOD_GSK3_1	7	14	PF00069	0.536
MOD_N-GLC_1	7	12	PF02516	0.451
MOD_NEK2_1	124	129	PF00069	0.490
MOD_NEK2_1	144	149	PF00069	0.452
MOD_NEK2_1	270	275	PF00069	0.411
MOD_NEK2_2	167	172	PF00069	0.604
MOD_PKA_1	51	57	PF00069	0.358
MOD_PKA_2	151	157	PF00069	0.610
MOD_PKA_2	186	192	PF00069	0.520
MOD_PKA_2	199	205	PF00069	0.474
MOD_PKA_2	23	29	PF00069	0.294
MOD_PKA_2	287	293	PF00069	0.259
MOD_PKA_2	51	57	PF00069	0.472
MOD_Plk_1	167	173	PF00069	0.510
MOD_Plk_1	216	222	PF00069	0.511
MOD_Plk_2-3	188	194	PF00069	0.517
MOD_Plk_4	145	151	PF00069	0.386
MOD_Plk_4	167	173	PF00069	0.510
MOD_Plk_4	92	98	PF00069	0.473
MOD_ProDKin_1	11	17	PF00069	0.565
MOD_ProDKin_1	131	137	PF00069	0.435
MOD_ProDKin_1	257	263	PF00069	0.266
MOD_ProDKin_1	27	33	PF00069	0.370
MOD_ProDKin_1	329	335	PF00069	0.318
MOD_SUMO_for_1	224	227	PF00179	0.539
MOD_SUMO_rev_2	340	346	PF00179	0.446
TRG_AP2beta_CARGO_1	315	324	PF09066	0.305
TRG_ENDOCYTIC_2	105	108	PF00928	0.565
TRG_ENDOCYTIC_2	207	210	PF00928	0.611
TRG_ENDOCYTIC_2	73	76	PF00928	0.372
TRG_ER_diArg_1	115	117	PF00400	0.399
TRG_ER_diArg_1	240	242	PF00400	0.331
TRG_NES_CRM1_1	269	283	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG4	Leptomonas seymouri	72%	100%
A0A0S4JP67	Bodo saltans	45%	93%
A0A1X0P5J8	Trypanosomatidae	49%	100%
A0A3Q8IIK7	Leishmania donovani	94%	100%
A0A3R7N649	Trypanosoma rangeli	47%	100%
A4HNJ5	Leishmania braziliensis	83%	100%
A4IC52	Leishmania infantum	94%	100%
C9ZYC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AG07	Leishmania major	93%	100%
V5BYP5	Trypanosoma cruzi	46%	92%