Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B757_LEIMU

TriTrypDb:

LmxM.34.5310

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B757

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B757

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.240
CLV_NRD_NRD_1	59	61	PF00675	0.473
CLV_NRD_NRD_1	6	8	PF00675	0.420
CLV_PCSK_KEX2_1	316	318	PF00082	0.238
CLV_PCSK_KEX2_1	326	328	PF00082	0.238
CLV_PCSK_KEX2_1	6	8	PF00082	0.421
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.238
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.238
CLV_PCSK_SKI1_1	210	214	PF00082	0.238
CLV_PCSK_SKI1_1	337	341	PF00082	0.249
CLV_PCSK_SKI1_1	66	70	PF00082	0.238
DOC_MAPK_gen_1	182	191	PF00069	0.576
DOC_MAPK_gen_1	242	250	PF00069	0.438
DOC_MAPK_gen_1	264	274	PF00069	0.438
DOC_MAPK_MEF2A_6	140	149	PF00069	0.438
DOC_MAPK_MEF2A_6	242	250	PF00069	0.438
DOC_MAPK_MEF2A_6	267	276	PF00069	0.438
DOC_MAPK_RevD_3	168	183	PF00069	0.381
DOC_PP2B_LxvP_1	116	119	PF13499	0.429
DOC_PP4_FxxP_1	309	312	PF00568	0.438
DOC_USP7_MATH_1	156	160	PF00917	0.464
DOC_USP7_UBL2_3	105	109	PF12436	0.463
DOC_USP7_UBL2_3	210	214	PF12436	0.438
DOC_USP7_UBL2_3	326	330	PF12436	0.463
LIG_14-3-3_CanoR_1	202	209	PF00244	0.516
LIG_14-3-3_CanoR_1	267	273	PF00244	0.467
LIG_APCC_ABBA_1	274	279	PF00400	0.447
LIG_Dynein_DLC8_1	81	87	PF01221	0.513
LIG_FHA_1	199	205	PF00498	0.456
LIG_FHA_2	256	262	PF00498	0.449
LIG_FHA_2	83	89	PF00498	0.442
LIG_GBD_Chelix_1	272	280	PF00786	0.238
LIG_LIR_Apic_2	308	312	PF02991	0.438
LIG_LIR_Gen_1	232	238	PF02991	0.449
LIG_LIR_Gen_1	287	298	PF02991	0.438
LIG_LIR_Gen_1	95	103	PF02991	0.439
LIG_LIR_Nem_3	215	219	PF02991	0.505
LIG_LIR_Nem_3	232	237	PF02991	0.347
LIG_LIR_Nem_3	287	293	PF02991	0.438
LIG_LIR_Nem_3	95	99	PF02991	0.439
LIG_Pex14_2	309	313	PF04695	0.440
LIG_PTB_Apo_2	175	182	PF02174	0.425
LIG_SH2_NCK_1	251	255	PF00017	0.438
LIG_SH2_STAP1	194	198	PF00017	0.499
LIG_SH2_STAP1	338	342	PF00017	0.438
LIG_SH2_STAT5	249	252	PF00017	0.428
LIG_SH2_STAT5	299	302	PF00017	0.438
LIG_SH3_3	67	73	PF00018	0.438
LIG_SUMO_SIM_anti_2	143	150	PF11976	0.451
LIG_SUMO_SIM_par_1	145	150	PF11976	0.437
LIG_TRAF2_1	258	261	PF00917	0.438
LIG_TRAF2_1	9	12	PF00917	0.394
LIG_UBA3_1	144	153	PF00899	0.306
LIG_UBA3_1	295	302	PF00899	0.306
MOD_CK1_1	193	199	PF00069	0.330
MOD_CK1_1	79	85	PF00069	0.306
MOD_CK2_1	156	162	PF00069	0.338
MOD_CK2_1	255	261	PF00069	0.306
MOD_CK2_1	368	374	PF00069	0.457
MOD_CK2_1	82	88	PF00069	0.296
MOD_GlcNHglycan	344	347	PF01048	0.325
MOD_GlcNHglycan	61	64	PF01048	0.423
MOD_GSK3_1	190	197	PF00069	0.295
MOD_GSK3_1	198	205	PF00069	0.288
MOD_GSK3_1	268	275	PF00069	0.346
MOD_GSK3_1	71	78	PF00069	0.290
MOD_GSK3_1	82	89	PF00069	0.290
MOD_N-GLC_1	177	182	PF02516	0.400
MOD_NEK2_1	368	373	PF00069	0.432
MOD_NEK2_2	177	182	PF00069	0.380
MOD_PIKK_1	14	20	PF00454	0.452
MOD_PIKK_1	82	88	PF00454	0.379
MOD_PK_1	317	323	PF00069	0.348
MOD_PKA_1	182	188	PF00069	0.455
MOD_PKA_2	263	269	PF00069	0.297
MOD_PKA_2	59	65	PF00069	0.435
MOD_PKA_2	82	88	PF00069	0.276
MOD_Plk_1	177	183	PF00069	0.391
MOD_Plk_1	227	233	PF00069	0.290
MOD_Plk_1	317	323	PF00069	0.348
MOD_Plk_1	94	100	PF00069	0.278
MOD_Plk_2-3	227	233	PF00069	0.290
MOD_Plk_2-3	255	261	PF00069	0.306
MOD_Plk_4	268	274	PF00069	0.339
MOD_Plk_4	76	82	PF00069	0.290
MOD_SUMO_for_1	152	155	PF00179	0.318
MOD_SUMO_for_1	37	40	PF00179	0.426
TRG_DiLeu_BaEn_4	260	266	PF01217	0.290
TRG_ENDOCYTIC_2	216	219	PF00928	0.411
TRG_ENDOCYTIC_2	251	254	PF00928	0.290
TRG_ENDOCYTIC_2	338	341	PF00928	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B2	Leptomonas seymouri	49%	100%
A0A0N1I7A1	Leptomonas seymouri	95%	100%
A0A0S4JLR9	Bodo saltans	83%	100%
A0A0S4JSR7	Bodo saltans	50%	100%
A0A1X0P4R4	Trypanosomatidae	89%	100%
A0A1X0P8M9	Trypanosomatidae	50%	100%
A0A3Q8IK74	Leishmania donovani	50%	100%
A0A3S7XAC8	Leishmania donovani	99%	100%
A0A422N5U7	Trypanosoma rangeli	87%	100%
A0A422NIT8	Trypanosoma rangeli	50%	100%
A4HNJ2	Leishmania braziliensis	95%	100%
A4HP94	Leishmania braziliensis	49%	99%
A4IC49	Leishmania infantum	99%	100%
A4IDJ9	Leishmania infantum	50%	100%
C9ZYC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
D0A397	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AG04	Leishmania major	99%	100%
E9AT02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	99%
P17103	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	38%	100%
P32233	Mus musculus	51%	100%
P32234	Drosophila melanogaster	50%	100%
P32235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
P34280	Caenorhabditis elegans	56%	100%
P39729	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P43690	Xenopus laevis	51%	100%
P53295	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	100%
P55039	Homo sapiens	61%	100%
Q3MHP5	Bos taurus	51%	100%
Q4Q1J6	Leishmania major	49%	99%
Q54HP3	Dictyostelium discoideum	52%	100%
Q54WT4	Dictyostelium discoideum	55%	100%
Q58722	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	45%	96%
Q58D56	Bos taurus	60%	100%
Q9CAI1	Arabidopsis thaliana	51%	94%
Q9LQK0	Arabidopsis thaliana	52%	94%
Q9QXB9	Mus musculus	60%	100%
Q9SVA6	Arabidopsis thaliana	52%	100%
Q9UT21	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
Q9Y295	Homo sapiens	51%	100%
V5BKY5	Trypanosoma cruzi	50%	76%
V5DQF8	Trypanosoma cruzi	87%	100%