PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B756_LEIMU

TriTrypDb:

LmxM.34.5300

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B756

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B756

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.492
CLV_NRD_NRD_1	232	234	PF00675	0.452
CLV_NRD_NRD_1	253	255	PF00675	0.426
CLV_PCSK_FUR_1	251	255	PF00082	0.467
CLV_PCSK_KEX2_1	114	116	PF00082	0.504
CLV_PCSK_KEX2_1	251	253	PF00082	0.363
CLV_PCSK_KEX2_1	264	266	PF00082	0.344
CLV_PCSK_KEX2_1	63	65	PF00082	0.461
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.529
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.509
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.554
CLV_PCSK_SKI1_1	2	6	PF00082	0.460
CLV_PCSK_SKI1_1	79	83	PF00082	0.330
DEG_Nend_UBRbox_1	1	4	PF02207	0.473
DOC_CKS1_1	109	114	PF01111	0.394
DOC_PP2B_LxvP_1	55	58	PF13499	0.333
DOC_USP7_MATH_1	116	120	PF00917	0.531
DOC_USP7_MATH_1	147	151	PF00917	0.547
DOC_USP7_MATH_1	176	180	PF00917	0.536
DOC_USP7_UBL2_3	287	291	PF12436	0.397
DOC_WW_Pin1_4	108	113	PF00397	0.374
DOC_WW_Pin1_4	202	207	PF00397	0.630
DOC_WW_Pin1_4	245	250	PF00397	0.333
DOC_WW_Pin1_4	297	302	PF00397	0.434
DOC_WW_Pin1_4	311	316	PF00397	0.756
LIG_14-3-3_CanoR_1	115	125	PF00244	0.564
LIG_14-3-3_CanoR_1	238	245	PF00244	0.453
LIG_14-3-3_CanoR_1	251	257	PF00244	0.417
LIG_14-3-3_CanoR_1	66	76	PF00244	0.302
LIG_BRCT_BRCA1_1	25	29	PF00533	0.355
LIG_CSL_BTD_1	246	249	PF09270	0.316
LIG_deltaCOP1_diTrp_1	156	160	PF00928	0.448
LIG_eIF4E_1	220	226	PF01652	0.350
LIG_FHA_1	134	140	PF00498	0.304
LIG_FHA_1	237	243	PF00498	0.560
LIG_FHA_2	191	197	PF00498	0.650
LIG_FHA_2	225	231	PF00498	0.480
LIG_FHA_2	257	263	PF00498	0.343
LIG_FHA_2	66	72	PF00498	0.312
LIG_IRF3_LxIS_1	42	49	PF10401	0.301
LIG_LIR_Gen_1	15	24	PF02991	0.270
LIG_LIR_Gen_1	223	231	PF02991	0.482
LIG_LIR_Gen_1	26	33	PF02991	0.318
LIG_LIR_Gen_1	89	99	PF02991	0.341
LIG_LIR_Nem_3	15	19	PF02991	0.269
LIG_LIR_Nem_3	156	161	PF02991	0.348
LIG_LIR_Nem_3	223	229	PF02991	0.472
LIG_LIR_Nem_3	246	250	PF02991	0.316
LIG_LIR_Nem_3	289	293	PF02991	0.438
LIG_LIR_Nem_3	294	299	PF02991	0.437
LIG_LIR_Nem_3	41	47	PF02991	0.302
LIG_LIR_Nem_3	89	94	PF02991	0.343
LIG_NRBOX	224	230	PF00104	0.326
LIG_PDZ_Class_1	311	316	PF00595	0.547
LIG_Pex14_2	91	95	PF04695	0.343
LIG_SH2_CRK	126	130	PF00017	0.442
LIG_SH2_PTP2	128	131	PF00017	0.431
LIG_SH2_SRC	128	131	PF00017	0.285
LIG_SH2_STAP1	135	139	PF00017	0.281
LIG_SH2_STAT3	258	261	PF00017	0.493
LIG_SH2_STAT5	128	131	PF00017	0.311
LIG_SH2_STAT5	135	138	PF00017	0.281
LIG_SH2_STAT5	161	164	PF00017	0.349
LIG_SH2_STAT5	220	223	PF00017	0.360
LIG_SH2_STAT5	258	261	PF00017	0.439
LIG_SH2_STAT5	44	47	PF00017	0.283
LIG_SH2_STAT5	77	80	PF00017	0.370
LIG_SH3_2	58	63	PF14604	0.397
LIG_SH3_3	55	61	PF00018	0.330
LIG_SUMO_SIM_par_1	134	141	PF11976	0.355
LIG_TRAF2_1	259	262	PF00917	0.362
LIG_UBA3_1	105	114	PF00899	0.502
LIG_UBA3_1	225	234	PF00899	0.446
MOD_CDK_SPK_2	108	113	PF00069	0.374
MOD_CDK_SPxK_1	108	114	PF00069	0.390
MOD_CDK_SPxK_1	245	251	PF00069	0.333
MOD_CDK_SPxxK_3	108	115	PF00069	0.403
MOD_CDK_SPxxK_3	245	252	PF00069	0.318
MOD_CK1_1	138	144	PF00069	0.317
MOD_CK1_1	165	171	PF00069	0.362
MOD_CK1_1	17	23	PF00069	0.416
MOD_CK1_1	179	185	PF00069	0.355
MOD_CK1_1	200	206	PF00069	0.648
MOD_CK1_1	300	306	PF00069	0.563
MOD_CK1_1	38	44	PF00069	0.380
MOD_CK2_1	190	196	PF00069	0.521
MOD_CK2_1	224	230	PF00069	0.473
MOD_CK2_1	256	262	PF00069	0.357
MOD_GlcNHglycan	131	134	PF01048	0.337
MOD_GlcNHglycan	178	181	PF01048	0.453
MOD_GlcNHglycan	19	22	PF01048	0.360
MOD_GlcNHglycan	207	210	PF01048	0.505
MOD_GlcNHglycan	310	313	PF01048	0.613
MOD_GlcNHglycan	48	51	PF01048	0.298
MOD_GSK3_1	129	136	PF00069	0.308
MOD_GSK3_1	165	172	PF00069	0.450
MOD_GSK3_1	200	207	PF00069	0.641
MOD_GSK3_1	220	227	PF00069	0.419
MOD_GSK3_1	252	259	PF00069	0.551
MOD_GSK3_1	297	304	PF00069	0.495
MOD_GSK3_1	31	38	PF00069	0.420
MOD_N-GLC_1	200	205	PF02516	0.680
MOD_N-GLC_2	73	75	PF02516	0.343
MOD_NEK2_1	23	28	PF00069	0.313
MOD_NEK2_1	256	261	PF00069	0.451
MOD_NEK2_1	46	51	PF00069	0.328
MOD_NEK2_2	135	140	PF00069	0.282
MOD_PIKK_1	165	171	PF00454	0.376
MOD_PIKK_1	237	243	PF00454	0.553
MOD_PKA_1	252	258	PF00069	0.526
MOD_PKA_1	286	292	PF00069	0.442
MOD_PKA_2	116	122	PF00069	0.526
MOD_PKA_2	237	243	PF00069	0.512
MOD_PKA_2	252	258	PF00069	0.350
MOD_PKA_2	65	71	PF00069	0.329
MOD_PKB_1	113	121	PF00069	0.595
MOD_Plk_1	133	139	PF00069	0.335
MOD_Plk_1	210	216	PF00069	0.404
MOD_Plk_4	135	141	PF00069	0.305
MOD_Plk_4	220	226	PF00069	0.461
MOD_ProDKin_1	108	114	PF00069	0.390
MOD_ProDKin_1	202	208	PF00069	0.628
MOD_ProDKin_1	245	251	PF00069	0.337
MOD_ProDKin_1	297	303	PF00069	0.445
MOD_SUMO_rev_2	172	177	PF00179	0.529
MOD_SUMO_rev_2	187	195	PF00179	0.623
TRG_ENDOCYTIC_2	126	129	PF00928	0.398
TRG_ER_diArg_1	112	115	PF00400	0.470
TRG_ER_diArg_1	151	154	PF00400	0.378
TRG_ER_diArg_1	250	253	PF00400	0.351
TRG_ER_diArg_1	64	67	PF00400	0.378
TRG_NLS_MonoExtC_3	112	117	PF00514	0.548
TRG_NLS_MonoExtC_3	62	67	PF00514	0.455
TRG_NLS_MonoExtN_4	112	118	PF00514	0.542
TRG_NLS_MonoExtN_4	61	67	PF00514	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L9	Leptomonas seymouri	82%	79%
A0A0S4JQD1	Bodo saltans	43%	72%
A0A1X0P4Q6	Trypanosomatidae	56%	78%
A0A3S7XA38	Leishmania donovani	95%	100%
A0A422N5V3	Trypanosoma rangeli	53%	79%
A4HNJ1	Leishmania braziliensis	87%	100%
A4IC48	Leishmania infantum	95%	100%
C9ZYC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	78%
E9AG03	Leishmania major	96%	100%
V5BTX9	Trypanosoma cruzi	53%	71%