LeishMANIAdb
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C-myc binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C-myc binding protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B752_LEIMU
TriTrypDb:
LmxM.34.5260
Length:
85

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9
GO:0005815 microtubule organizing center 2 1
GO:0005930 axoneme 2 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

E9B752
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B752

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 9
GO:0003713 transcription coactivator activity 3 9
GO:0140110 transcription regulator activity 1 9
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 13 15 PF00675 0.390
CLV_PCSK_KEX2_1 48 50 PF00082 0.504
CLV_PCSK_PC1ET2_1 48 50 PF00082 0.504
CLV_PCSK_SKI1_1 48 52 PF00082 0.414
LIG_APCC_ABBA_1 31 36 PF00400 0.385
LIG_BIR_II_1 1 5 PF00653 0.485
LIG_FHA_1 18 24 PF00498 0.402
LIG_FHA_1 25 31 PF00498 0.348
LIG_GBD_Chelix_1 22 30 PF00786 0.463
LIG_LIR_Gen_1 56 67 PF02991 0.418
LIG_LIR_Nem_3 11 16 PF02991 0.429
LIG_LIR_Nem_3 56 62 PF02991 0.434
LIG_SH2_SRC 16 19 PF00017 0.409
LIG_SH2_STAT5 16 19 PF00017 0.392
LIG_SH2_STAT5 46 49 PF00017 0.501
LIG_SH3_3 37 43 PF00018 0.472
MOD_CK1_1 2 8 PF00069 0.443
MOD_GlcNHglycan 55 58 PF01048 0.524
MOD_GlcNHglycan 80 83 PF01048 0.512
MOD_NEK2_1 17 22 PF00069 0.409
MOD_PIKK_1 17 23 PF00454 0.493
MOD_PKA_2 3 9 PF00069 0.522
MOD_Plk_1 17 23 PF00069 0.467
MOD_SUMO_for_1 8 11 PF00179 0.371
MOD_SUMO_rev_2 35 40 PF00179 0.497
TRG_ENDOCYTIC_2 59 62 PF00928 0.458

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P616 Leptomonas seymouri 95% 100%
A0A0S4JQH9 Bodo saltans 71% 97%
A0A3S5H811 Leishmania donovani 99% 100%
A4HNI7 Leishmania braziliensis 95% 100%
A4IC44 Leishmania infantum 99% 100%
C9ZYD0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 79% 100%
E9AFZ9 Leishmania major 98% 100%
Q2TBP7 Bos taurus 36% 83%
Q54I57 Dictyostelium discoideum 57% 94%
Q5R7A8 Pongo abelii 38% 83%
Q99417 Homo sapiens 38% 83%
Q9EQS3 Mus musculus 38% 83%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS