Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B750_LEIMU

TriTrypDb:

LmxM.34.5240

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B750

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B750

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.453
CLV_PCSK_SKI1_1	135	139	PF00082	0.579
CLV_PCSK_SKI1_1	242	246	PF00082	0.688
DEG_APCC_DBOX_1	144	152	PF00400	0.392
DOC_CKS1_1	167	172	PF01111	0.479
DOC_CYCLIN_yCln2_LP_2	117	120	PF00134	0.483
DOC_MAPK_HePTP_8	197	209	PF00069	0.438
DOC_MAPK_MEF2A_6	200	209	PF00069	0.437
DOC_MAPK_MEF2A_6	255	264	PF00069	0.314
DOC_PP2B_LxvP_1	117	120	PF13499	0.483
DOC_PP2B_LxvP_1	17	20	PF13499	0.611
DOC_PP2B_LxvP_1	192	195	PF13499	0.422
DOC_PP2B_LxvP_1	92	95	PF13499	0.367
DOC_PP4_FxxP_1	179	182	PF00568	0.474
DOC_USP7_MATH_1	182	186	PF00917	0.483
DOC_WW_Pin1_4	166	171	PF00397	0.433
DOC_WW_Pin1_4	178	183	PF00397	0.452
DOC_WW_Pin1_4	199	204	PF00397	0.443
DOC_WW_Pin1_4	234	239	PF00397	0.384
LIG_14-3-3_CanoR_1	132	138	PF00244	0.348
LIG_14-3-3_CanoR_1	255	260	PF00244	0.377
LIG_14-3-3_CanoR_1	80	86	PF00244	0.377
LIG_BRCT_BRCA1_1	195	199	PF00533	0.432
LIG_BRCT_BRCA1_1	24	28	PF00533	0.362
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.349
LIG_FHA_1	120	126	PF00498	0.473
LIG_FHA_1	128	134	PF00498	0.323
LIG_FHA_1	212	218	PF00498	0.445
LIG_FHA_1	243	249	PF00498	0.325
LIG_LIR_Apic_2	178	182	PF02991	0.479
LIG_LIR_Gen_1	219	225	PF02991	0.421
LIG_LIR_Gen_1	62	69	PF02991	0.530
LIG_LIR_Nem_3	219	223	PF02991	0.431
LIG_LIR_Nem_3	252	257	PF02991	0.244
LIG_LIR_Nem_3	62	67	PF02991	0.535
LIG_NRBOX	261	267	PF00104	0.404
LIG_PDZ_Class_2	263	268	PF00595	0.398
LIG_SH2_CRK	64	68	PF00017	0.421
LIG_SH2_CRK	82	86	PF00017	0.420
LIG_SH2_STAP1	64	68	PF00017	0.418
LIG_SH2_STAP1	82	86	PF00017	0.413
LIG_SH2_STAT5	82	85	PF00017	0.447
LIG_SH2_STAT5	91	94	PF00017	0.350
LIG_SH3_3	31	37	PF00018	0.365
LIG_SH3_3	92	98	PF00018	0.326
LIG_SH3_5	230	234	PF00018	0.435
LIG_SUMO_SIM_par_1	221	229	PF11976	0.411
LIG_SUMO_SIM_par_1	5	10	PF11976	0.497
MOD_CK1_1	10	16	PF00069	0.454
MOD_CK1_1	121	127	PF00069	0.465
MOD_CK1_1	165	171	PF00069	0.495
MOD_CK1_1	178	184	PF00069	0.426
MOD_CK1_1	211	217	PF00069	0.465
MOD_CK2_1	213	219	PF00069	0.341
MOD_GlcNHglycan	249	252	PF01048	0.439
MOD_GlcNHglycan	64	67	PF01048	0.649
MOD_GSK3_1	161	168	PF00069	0.416
MOD_GSK3_1	178	185	PF00069	0.394
MOD_GSK3_1	195	202	PF00069	0.350
MOD_N-GLC_1	172	177	PF02516	0.674
MOD_N-GLC_1	225	230	PF02516	0.618
MOD_N-GLC_2	49	51	PF02516	0.582
MOD_NEK2_1	172	177	PF00069	0.488
MOD_NEK2_2	195	200	PF00069	0.506
MOD_OFUCOSY	159	166	PF10250	0.615
MOD_PIKK_1	211	217	PF00454	0.431
MOD_PIKK_1	75	81	PF00454	0.454
MOD_PK_1	104	110	PF00069	0.410
MOD_PK_1	255	261	PF00069	0.244
MOD_Plk_1	127	133	PF00069	0.354
MOD_Plk_4	208	214	PF00069	0.429
MOD_Plk_4	249	255	PF00069	0.286
MOD_Plk_4	7	13	PF00069	0.641
MOD_Plk_4	81	87	PF00069	0.421
MOD_ProDKin_1	166	172	PF00069	0.433
MOD_ProDKin_1	178	184	PF00069	0.456
MOD_ProDKin_1	199	205	PF00069	0.439
MOD_ProDKin_1	234	240	PF00069	0.379
TRG_ENDOCYTIC_2	64	67	PF00928	0.424
TRG_ENDOCYTIC_2	82	85	PF00928	0.390
TRG_ENDOCYTIC_2	91	94	PF00928	0.301
TRG_NES_CRM1_1	215	229	PF08389	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL7	Leptomonas seymouri	72%	100%
A0A0S4JP52	Bodo saltans	42%	96%
A0A3S7XA33	Leishmania donovani	93%	100%
A4IC42	Leishmania infantum	93%	99%
E9AFZ7	Leishmania major	91%	100%