Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B748_LEIMU

TriTrypDb:

LmxM.34.5220

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B748

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B748

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.337
CLV_MEL_PAP_1	289	295	PF00089	0.307
CLV_NRD_NRD_1	13	15	PF00675	0.429
CLV_NRD_NRD_1	276	278	PF00675	0.510
CLV_NRD_NRD_1	38	40	PF00675	0.511
CLV_PCSK_KEX2_1	13	15	PF00082	0.429
CLV_PCSK_KEX2_1	38	40	PF00082	0.496
CLV_PCSK_SKI1_1	33	37	PF00082	0.453
CLV_PCSK_SKI1_1	98	102	PF00082	0.460
DEG_APCC_DBOX_1	97	105	PF00400	0.554
DOC_CKS1_1	119	124	PF01111	0.591
DOC_USP7_MATH_1	2	6	PF00917	0.590
DOC_USP7_MATH_1	210	214	PF00917	0.618
DOC_WW_Pin1_4	118	123	PF00397	0.748
DOC_WW_Pin1_4	134	139	PF00397	0.533
DOC_WW_Pin1_4	206	211	PF00397	0.562
DOC_WW_Pin1_4	219	224	PF00397	0.563
DOC_WW_Pin1_4	81	86	PF00397	0.485
LIG_14-3-3_CanoR_1	13	20	PF00244	0.412
LIG_14-3-3_CanoR_1	174	184	PF00244	0.461
LIG_14-3-3_CanoR_1	292	296	PF00244	0.422
LIG_14-3-3_CanoR_1	63	69	PF00244	0.581
LIG_14-3-3_CanoR_1	94	98	PF00244	0.336
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_FHA_1	165	171	PF00498	0.582
LIG_FHA_1	193	199	PF00498	0.611
LIG_FHA_1	260	266	PF00498	0.464
LIG_FHA_2	65	71	PF00498	0.474
LIG_GBD_Chelix_1	50	58	PF00786	0.433
LIG_LIR_Gen_1	252	260	PF02991	0.443
LIG_LIR_Gen_1	53	61	PF02991	0.389
LIG_LIR_Nem_3	252	257	PF02991	0.393
LIG_LIR_Nem_3	53	58	PF02991	0.391
LIG_PTB_Apo_2	49	56	PF02174	0.369
LIG_SH2_CRK	254	258	PF00017	0.442
LIG_SH2_STAP1	236	240	PF00017	0.479
LIG_SH2_STAP1	64	68	PF00017	0.445
LIG_SH2_STAT5	18	21	PF00017	0.484
LIG_SH2_STAT5	64	67	PF00017	0.390
LIG_SH3_3	113	119	PF00018	0.518
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.417
LIG_SUMO_SIM_par_1	18	25	PF11976	0.513
LIG_UBA3_1	101	106	PF00899	0.380
LIG_UBA3_1	159	165	PF00899	0.402
MOD_CDK_SPK_2	118	123	PF00069	0.586
MOD_CK1_1	200	206	PF00069	0.641
MOD_CK1_1	222	228	PF00069	0.538
MOD_CK2_1	39	45	PF00069	0.474
MOD_CK2_1	63	69	PF00069	0.436
MOD_GlcNHglycan	125	128	PF01048	0.749
MOD_GlcNHglycan	199	202	PF01048	0.597
MOD_GlcNHglycan	211	215	PF01048	0.681
MOD_GlcNHglycan	4	7	PF01048	0.548
MOD_GSK3_1	121	128	PF00069	0.574
MOD_GSK3_1	2	9	PF00069	0.529
MOD_GSK3_1	206	213	PF00069	0.645
MOD_GSK3_1	255	262	PF00069	0.447
MOD_GSK3_1	72	79	PF00069	0.471
MOD_N-GLC_1	2	7	PF02516	0.699
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	12	17	PF00069	0.468
MOD_NEK2_1	76	81	PF00069	0.520
MOD_NEK2_1	93	98	PF00069	0.457
MOD_PIKK_1	12	18	PF00454	0.508
MOD_PIKK_1	39	45	PF00454	0.487
MOD_PK_1	112	118	PF00069	0.555
MOD_PKA_1	38	44	PF00069	0.511
MOD_PKA_2	12	18	PF00069	0.420
MOD_PKA_2	291	297	PF00069	0.406
MOD_PKA_2	38	44	PF00069	0.492
MOD_PKA_2	62	68	PF00069	0.553
MOD_PKA_2	93	99	PF00069	0.368
MOD_PKB_1	31	39	PF00069	0.409
MOD_Plk_1	112	118	PF00069	0.604
MOD_Plk_1	192	198	PF00069	0.469
MOD_Plk_4	112	118	PF00069	0.513
MOD_Plk_4	46	52	PF00069	0.559
MOD_Plk_4	72	78	PF00069	0.431
MOD_ProDKin_1	118	124	PF00069	0.750
MOD_ProDKin_1	134	140	PF00069	0.530
MOD_ProDKin_1	206	212	PF00069	0.561
MOD_ProDKin_1	219	225	PF00069	0.556
MOD_ProDKin_1	81	87	PF00069	0.480
TRG_DiLeu_BaEn_1	113	118	PF01217	0.569
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.452
TRG_ENDOCYTIC_2	254	257	PF00928	0.390
TRG_ER_diArg_1	12	14	PF00400	0.436
TRG_ER_diArg_1	187	190	PF00400	0.516
TRG_ER_diArg_1	38	40	PF00400	0.496
TRG_NES_CRM1_1	17	30	PF08389	0.392
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE8	Leptomonas seymouri	49%	96%
A0A3S7XA65	Leishmania donovani	86%	100%
A4HNI4	Leishmania braziliensis	63%	100%
A4IC40	Leishmania infantum	86%	100%
E9AFZ5	Leishmania major	84%	100%
V5DQG3	Trypanosoma cruzi	29%	84%