C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B746_LEIMU

TriTrypDb:

LmxM.34.5200

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B746

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B746

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.590
CLV_PCSK_KEX2_1	11	13	PF00082	0.590
CLV_PCSK_SKI1_1	27	31	PF00082	0.492
CLV_Separin_Metazoa	17	21	PF03568	0.536
DOC_CKS1_1	125	130	PF01111	0.663
DOC_CKS1_1	233	238	PF01111	0.723
DOC_CKS1_1	5	10	PF01111	0.587
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.510
DOC_MAPK_MEF2A_6	94	103	PF00069	0.513
DOC_USP7_MATH_1	111	115	PF00917	0.593
DOC_USP7_MATH_1	136	140	PF00917	0.675
DOC_USP7_MATH_1	143	147	PF00917	0.688
DOC_USP7_MATH_1	174	178	PF00917	0.648
DOC_USP7_MATH_1	186	190	PF00917	0.658
DOC_USP7_MATH_1	192	196	PF00917	0.564
DOC_USP7_MATH_1	245	249	PF00917	0.718
DOC_WW_Pin1_4	124	129	PF00397	0.645
DOC_WW_Pin1_4	158	163	PF00397	0.554
DOC_WW_Pin1_4	172	177	PF00397	0.759
DOC_WW_Pin1_4	232	237	PF00397	0.697
DOC_WW_Pin1_4	35	40	PF00397	0.411
DOC_WW_Pin1_4	4	9	PF00397	0.597
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_FHA_1	104	110	PF00498	0.394
LIG_FHA_1	125	131	PF00498	0.649
LIG_FHA_1	214	220	PF00498	0.472
LIG_FHA_1	49	55	PF00498	0.589
LIG_LIR_Apic_2	106	111	PF02991	0.567
LIG_LIR_Gen_1	40	47	PF02991	0.389
LIG_LIR_Gen_1	97	105	PF02991	0.533
LIG_LIR_Nem_3	146	150	PF02991	0.579
LIG_LIR_Nem_3	177	182	PF02991	0.694
LIG_LIR_Nem_3	248	254	PF02991	0.745
LIG_LIR_Nem_3	40	46	PF02991	0.389
LIG_LIR_Nem_3	97	101	PF02991	0.507
LIG_SH2_CRK	98	102	PF00017	0.509
LIG_SH2_GRB2like	108	111	PF00017	0.587
LIG_SH2_GRB2like	182	185	PF00017	0.768
LIG_SH2_NCK_1	182	186	PF00017	0.684
LIG_SH2_SRC	108	111	PF00017	0.587
LIG_SH2_SRC	182	185	PF00017	0.690
LIG_SH2_STAT3	93	96	PF00017	0.482
LIG_SH2_STAT5	108	111	PF00017	0.528
LIG_SH2_STAT5	251	254	PF00017	0.574
LIG_SH3_3	122	128	PF00018	0.706
LIG_SH3_3	130	136	PF00018	0.654
LIG_SH3_3	196	202	PF00018	0.779
LIG_SH3_3	36	42	PF00018	0.424
LIG_SH3_3	89	95	PF00018	0.508
LIG_SH3_3	98	104	PF00018	0.526
LIG_WRC_WIRS_1	144	149	PF05994	0.581
LIG_WRC_WIRS_1	58	63	PF05994	0.482
MOD_CDK_SPxxK_3	4	11	PF00069	0.593
MOD_CK1_1	114	120	PF00069	0.614
MOD_CK1_1	195	201	PF00069	0.721
MOD_CK1_1	57	63	PF00069	0.483
MOD_GlcNHglycan	194	197	PF01048	0.695
MOD_GlcNHglycan	87	90	PF01048	0.604
MOD_GSK3_1	154	161	PF00069	0.583
MOD_GSK3_1	164	171	PF00069	0.675
MOD_GSK3_1	186	193	PF00069	0.728
MOD_GSK3_1	228	235	PF00069	0.510
MOD_GSK3_1	29	36	PF00069	0.513
MOD_NEK2_1	164	169	PF00069	0.674
MOD_NEK2_1	29	34	PF00069	0.411
MOD_NEK2_1	75	80	PF00069	0.475
MOD_NEK2_1	85	90	PF00069	0.540
MOD_OFUCOSY	35	41	PF10250	0.389
MOD_PIKK_1	154	160	PF00454	0.752
MOD_PIKK_1	164	170	PF00454	0.683
MOD_PIKK_1	186	192	PF00454	0.695
MOD_PIKK_1	228	234	PF00454	0.766
MOD_PIKK_1	239	245	PF00454	0.701
MOD_PIKK_1	60	66	PF00454	0.498
MOD_PIKK_1	75	81	PF00454	0.486
MOD_PKA_2	33	39	PF00069	0.513
MOD_Plk_4	160	166	PF00069	0.672
MOD_Plk_4	195	201	PF00069	0.670
MOD_Plk_4	57	63	PF00069	0.483
MOD_Plk_4	70	76	PF00069	0.485
MOD_ProDKin_1	124	130	PF00069	0.647
MOD_ProDKin_1	158	164	PF00069	0.557
MOD_ProDKin_1	172	178	PF00069	0.760
MOD_ProDKin_1	232	238	PF00069	0.696
MOD_ProDKin_1	35	41	PF00069	0.411
MOD_ProDKin_1	4	10	PF00069	0.594
TRG_ENDOCYTIC_2	251	254	PF00928	0.574
TRG_ENDOCYTIC_2	43	46	PF00928	0.411
TRG_ENDOCYTIC_2	98	101	PF00928	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL43	Leptomonas seymouri	56%	90%
A0A3S7XA28	Leishmania donovani	92%	100%
A4HNI2	Leishmania braziliensis	80%	100%
A4IC38	Leishmania infantum	93%	100%
E9AFZ3	Leishmania major	92%	100%