Putative NIMA-related kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NIMA-related kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B745_LEIMU

TriTrypDb:

LmxM.34.5190

Length:

478

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 81
NetGPI	no	yes: 0, no: 81

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B745

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B745

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	82
GO:0006793	phosphorus metabolic process	3	82
GO:0006796	phosphate-containing compound metabolic process	4	82
GO:0006807	nitrogen compound metabolic process	2	82
GO:0008152	metabolic process	1	82
GO:0009987	cellular process	1	82
GO:0016310	phosphorylation	5	82
GO:0019538	protein metabolic process	3	82
GO:0036211	protein modification process	4	82
GO:0043170	macromolecule metabolic process	3	82
GO:0043412	macromolecule modification	4	82
GO:0044237	cellular metabolic process	2	82
GO:0044238	primary metabolic process	2	82
GO:0071704	organic substance metabolic process	2	82
GO:1901564	organonitrogen compound metabolic process	3	82
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	82
GO:0003824	catalytic activity	1	82
GO:0004672	protein kinase activity	3	82
GO:0005488	binding	1	82
GO:0005524	ATP binding	5	82
GO:0016301	kinase activity	4	82
GO:0016740	transferase activity	2	82
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	82
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	82
GO:0017076	purine nucleotide binding	4	82
GO:0030554	adenyl nucleotide binding	5	82
GO:0032553	ribonucleotide binding	3	82
GO:0032555	purine ribonucleotide binding	4	82
GO:0032559	adenyl ribonucleotide binding	5	82
GO:0035639	purine ribonucleoside triphosphate binding	4	82
GO:0036094	small molecule binding	2	82
GO:0043167	ion binding	2	82
GO:0043168	anion binding	3	82
GO:0097159	organic cyclic compound binding	2	82
GO:0097367	carbohydrate derivative binding	2	82
GO:0140096	catalytic activity, acting on a protein	2	82
GO:1901265	nucleoside phosphate binding	3	82
GO:1901363	heterocyclic compound binding	2	82
GO:0004674	protein serine/threonine kinase activity	4	49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	244	246	PF00675	0.277
CLV_PCSK_KEX2_1	246	248	PF00082	0.271
CLV_PCSK_KEX2_1	394	396	PF00082	0.304
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.324
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.306
CLV_PCSK_SKI1_1	139	143	PF00082	0.315
CLV_PCSK_SKI1_1	154	158	PF00082	0.264
CLV_PCSK_SKI1_1	193	197	PF00082	0.303
CLV_PCSK_SKI1_1	269	273	PF00082	0.314
DEG_APCC_DBOX_1	112	120	PF00400	0.418
DEG_APCC_KENBOX_2	160	164	PF00400	0.135
DEG_COP1_1	425	436	PF00400	0.342
DEG_SPOP_SBC_1	294	298	PF00917	0.160
DOC_CDC14_PxL_1	236	244	PF14671	0.299
DOC_MAPK_gen_1	157	166	PF00069	0.348
DOC_MAPK_gen_1	193	202	PF00069	0.308
DOC_MAPK_gen_1	62	70	PF00069	0.503
DOC_MAPK_MEF2A_6	135	144	PF00069	0.258
DOC_MAPK_MEF2A_6	21	28	PF00069	0.577
DOC_MAPK_MEF2A_6	440	449	PF00069	0.380
DOC_PP4_FxxP_1	201	204	PF00568	0.305
DOC_PP4_FxxP_1	271	274	PF00568	0.305
DOC_PP4_FxxP_1	291	294	PF00568	0.328
DOC_PP4_FxxP_1	431	434	PF00568	0.264
DOC_USP7_MATH_1	294	298	PF00917	0.386
DOC_USP7_MATH_1	363	367	PF00917	0.615
DOC_USP7_UBL2_3	135	139	PF12436	0.282
DOC_USP7_UBL2_3	157	161	PF12436	0.284
DOC_USP7_UBL2_3	246	250	PF12436	0.243
DOC_USP7_UBL2_3	95	99	PF12436	0.425
DOC_WW_Pin1_4	231	236	PF00397	0.305
DOC_WW_Pin1_4	55	60	PF00397	0.672
LIG_14-3-3_CanoR_1	314	321	PF00244	0.285
LIG_14-3-3_CanoR_1	405	409	PF00244	0.296
LIG_14-3-3_CanoR_1	77	85	PF00244	0.444
LIG_AP2alpha_2	289	291	PF02296	0.272
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.313
LIG_Clathr_ClatBox_1	141	145	PF01394	0.256
LIG_deltaCOP1_diTrp_1	389	397	PF00928	0.280
LIG_deltaCOP1_diTrp_1	466	472	PF00928	0.366
LIG_eIF4E_1	169	175	PF01652	0.341
LIG_eIF4E_1	22	28	PF01652	0.463
LIG_eIF4E_1	69	75	PF01652	0.383
LIG_FHA_1	11	17	PF00498	0.542
LIG_FHA_1	203	209	PF00498	0.276
LIG_FHA_1	315	321	PF00498	0.308
LIG_FHA_1	347	353	PF00498	0.511
LIG_FHA_1	372	378	PF00498	0.527
LIG_FHA_1	70	76	PF00498	0.434
LIG_FHA_2	27	33	PF00498	0.419
LIG_FHA_2	424	430	PF00498	0.337
LIG_FHA_2	459	465	PF00498	0.293
LIG_HCF-1_HBM_1	66	69	PF13415	0.529
LIG_LIR_Apic_2	234	240	PF02991	0.305
LIG_LIR_Apic_2	289	294	PF02991	0.320
LIG_LIR_Apic_2	429	434	PF02991	0.290
LIG_LIR_Nem_3	323	328	PF02991	0.383
LIG_NRBOX	260	266	PF00104	0.249
LIG_Pex14_1	392	396	PF04695	0.281
LIG_Pex14_1	468	472	PF04695	0.340
LIG_SH2_CRK	176	180	PF00017	0.342
LIG_SH2_GRB2like	458	461	PF00017	0.155
LIG_SH2_GRB2like	46	49	PF00017	0.418
LIG_SH2_SRC	176	179	PF00017	0.299
LIG_SH2_STAP1	19	23	PF00017	0.411
LIG_SH2_STAP1	219	223	PF00017	0.278
LIG_SH2_STAP1	248	252	PF00017	0.331
LIG_SH2_STAP1	458	462	PF00017	0.328
LIG_SH2_STAT5	22	25	PF00017	0.443
LIG_SH2_STAT5	237	240	PF00017	0.309
LIG_SH2_STAT5	328	331	PF00017	0.375
LIG_SH2_STAT5	382	385	PF00017	0.321
LIG_SH2_STAT5	396	399	PF00017	0.286
LIG_SH2_STAT5	69	72	PF00017	0.371
LIG_SH3_3	47	53	PF00018	0.599
LIG_SUMO_SIM_anti_2	136	145	PF11976	0.255
LIG_SUMO_SIM_par_1	136	145	PF11976	0.292
LIG_SUMO_SIM_par_1	178	184	PF11976	0.237
LIG_TRAF2_1	165	168	PF00917	0.380
LIG_TRAF2_1	33	36	PF00917	0.558
LIG_TRFH_1	236	240	PF08558	0.275
LIG_TYR_ITIM	174	179	PF00017	0.310
LIG_TYR_ITIM	260	265	PF00017	0.320
LIG_UBA3_1	264	272	PF00899	0.297
LIG_UBA3_1	302	309	PF00899	0.304
MOD_CDK_SPxxK_3	55	62	PF00069	0.558
MOD_CK1_1	10	16	PF00069	0.478
MOD_CK1_1	375	381	PF00069	0.354
MOD_CK1_1	58	64	PF00069	0.610
MOD_CK1_1	90	96	PF00069	0.306
MOD_CK2_1	26	32	PF00069	0.437
MOD_CK2_1	272	278	PF00069	0.388
MOD_CK2_1	404	410	PF00069	0.289
MOD_GlcNHglycan	147	150	PF01048	0.265
MOD_GlcNHglycan	196	199	PF01048	0.317
MOD_GlcNHglycan	357	360	PF01048	0.583
MOD_GlcNHglycan	9	12	PF01048	0.605
MOD_GSK3_1	213	220	PF00069	0.270
MOD_GSK3_1	227	234	PF00069	0.304
MOD_GSK3_1	305	312	PF00069	0.319
MOD_GSK3_1	337	344	PF00069	0.427
MOD_GSK3_1	371	378	PF00069	0.557
MOD_N-GLC_1	37	42	PF02516	0.564
MOD_NEK2_1	213	218	PF00069	0.294
MOD_NEK2_1	404	409	PF00069	0.281
MOD_NEK2_1	84	89	PF00069	0.434
MOD_PIKK_1	272	278	PF00454	0.349
MOD_PIKK_1	314	320	PF00454	0.249
MOD_PIKK_1	372	378	PF00454	0.541
MOD_PIKK_1	435	441	PF00454	0.389
MOD_PKA_1	246	252	PF00069	0.314
MOD_PKA_2	246	252	PF00069	0.309
MOD_PKA_2	313	319	PF00069	0.299
MOD_PKA_2	337	343	PF00069	0.396
MOD_PKA_2	404	410	PF00069	0.339
MOD_PKA_2	87	93	PF00069	0.416
MOD_Plk_1	37	43	PF00069	0.603
MOD_Plk_2-3	133	139	PF00069	0.282
MOD_Plk_2-3	221	227	PF00069	0.307
MOD_Plk_4	70	76	PF00069	0.437
MOD_ProDKin_1	231	237	PF00069	0.305
MOD_ProDKin_1	55	61	PF00069	0.673
MOD_SUMO_rev_2	132	141	PF00179	0.383
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.400
TRG_ENDOCYTIC_2	176	179	PF00928	0.318
TRG_ENDOCYTIC_2	262	265	PF00928	0.306
TRG_ENDOCYTIC_2	288	291	PF00928	0.246
TRG_ENDOCYTIC_2	370	373	PF00928	0.533
TRG_ENDOCYTIC_2	396	399	PF00928	0.310
TRG_ER_diArg_1	245	248	PF00400	0.276
TRG_NLS_MonoExtN_4	391	397	PF00514	0.306
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	39%	100%
A0A0N0P953	Leptomonas seymouri	87%	100%
A0A0N1I9A0	Leptomonas seymouri	27%	74%
A0A0N1PD05	Leptomonas seymouri	36%	100%
A0A0S4IMB7	Bodo saltans	37%	100%
A0A0S4IQ75	Bodo saltans	29%	95%
A0A0S4IRZ7	Bodo saltans	35%	97%
A0A0S4IVW1	Bodo saltans	28%	76%
A0A0S4IX86	Bodo saltans	38%	100%
A0A0S4J575	Bodo saltans	27%	77%
A0A0S4J804	Bodo saltans	64%	91%
A0A0S4JIJ6	Bodo saltans	31%	85%
A0A0S4JPZ1	Bodo saltans	34%	100%
A0A0S4JQN5	Bodo saltans	29%	68%
A0A1X0NIA0	Trypanosomatidae	39%	100%
A0A1X0NIX2	Trypanosomatidae	34%	100%
A0A1X0NUB2	Trypanosomatidae	32%	82%
A0A1X0P527	Trypanosomatidae	37%	100%
A0A1X0P549	Trypanosomatidae	74%	100%
A0A1X0P863	Trypanosomatidae	37%	96%
A0A1X0P994	Trypanosomatidae	35%	96%
A0A3Q8IAQ1	Leishmania donovani	35%	100%
A0A3Q8IC87	Leishmania donovani	30%	100%
A0A3Q8IFW0	Leishmania donovani	38%	100%
A0A3Q8IIG1	Leishmania donovani	31%	100%
A0A3Q8IJM9	Leishmania donovani	96%	100%
A0A3R7KCZ4	Trypanosoma rangeli	40%	100%
A0A3R7MKG5	Trypanosoma rangeli	36%	100%
A0A3S7X2W9	Leishmania donovani	25%	100%
A0A3S7X5M4	Leishmania donovani	30%	73%
A0A3S7X6T8	Leishmania donovani	35%	100%
A0A3S7XAL3	Leishmania donovani	35%	96%
A0A3S7XAT9	Leishmania donovani	36%	95%
A0A422NCP0	Trypanosoma rangeli	36%	96%
A0A422NH41	Trypanosoma rangeli	33%	83%
A4H4S9	Leishmania braziliensis	26%	100%
A4HED7	Leishmania braziliensis	30%	100%
A4HH03	Leishmania braziliensis	28%	100%
A4HJT5	Leishmania braziliensis	35%	100%
A4HJW2	Leishmania braziliensis	37%	100%
A4HKG9	Leishmania braziliensis	29%	100%
A4HLR0	Leishmania braziliensis	35%	100%
A4HNI1	Leishmania braziliensis	90%	100%
A4HP12	Leishmania braziliensis	34%	100%
A4HP13	Leishmania braziliensis	36%	100%
A4HZV1	Leishmania infantum	30%	100%
A4HZW8	Leishmania infantum	35%	100%
A4I435	Leishmania infantum	31%	100%
A4I4Y0	Leishmania infantum	25%	100%
A4I7C4	Leishmania infantum	38%	100%
A4I7Z6	Leishmania infantum	30%	73%
A4I960	Leishmania infantum	35%	100%
A4IC37	Leishmania infantum	96%	100%
A4IDC1	Leishmania infantum	34%	94%
A4IDC2	Leishmania infantum	36%	95%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A2Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
D0A2Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
D0AA64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	83%
E9AED4	Leishmania major	25%	100%
E9AFZ2	Leishmania major	96%	100%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ASS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B2V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	73%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q03428	Trypanosoma brucei brucei	38%	100%
Q08942	Trypanosoma brucei brucei	39%	100%
Q12469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	73%
Q4Q1S3	Leishmania major	38%	100%
Q4Q1S4	Leishmania major	34%	100%
Q4Q3Y9	Leishmania major	35%	100%
Q4Q598	Leishmania major	29%	100%
Q4Q5T9	Leishmania major	38%	100%
Q4Q5W2	Leishmania major	35%	100%
Q4Q7W2	Leishmania major	31%	100%
Q4QBQ2	Leishmania major	40%	100%
Q4QBR6	Leishmania major	30%	100%
Q4QCK0	Leishmania major	23%	100%
Q4QIV8	Leishmania major	25%	100%
V5BC28	Trypanosoma cruzi	38%	95%
V5BPJ0	Trypanosoma cruzi	36%	97%
V5D579	Trypanosoma cruzi	39%	100%
V5DFW9	Trypanosoma cruzi	31%	82%