LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B744_LEIMU
TriTrypDb:
LmxM.34.5180
Length:
604

Annotations

LeishMANIAdb annotations

Putative transporter, with little homology outside Kinetoplastida

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9B744
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B744

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 235 239 PF00656 0.592
CLV_MEL_PAP_1 215 221 PF00089 0.379
CLV_NRD_NRD_1 159 161 PF00675 0.268
CLV_NRD_NRD_1 27 29 PF00675 0.392
CLV_NRD_NRD_1 33 35 PF00675 0.375
CLV_NRD_NRD_1 406 408 PF00675 0.332
CLV_NRD_NRD_1 473 475 PF00675 0.374
CLV_NRD_NRD_1 557 559 PF00675 0.295
CLV_NRD_NRD_1 65 67 PF00675 0.447
CLV_PCSK_FUR_1 63 67 PF00082 0.323
CLV_PCSK_KEX2_1 35 37 PF00082 0.398
CLV_PCSK_KEX2_1 406 408 PF00082 0.419
CLV_PCSK_KEX2_1 473 475 PF00082 0.409
CLV_PCSK_KEX2_1 557 559 PF00082 0.295
CLV_PCSK_KEX2_1 65 67 PF00082 0.457
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.398
CLV_PCSK_SKI1_1 53 57 PF00082 0.410
DEG_COP1_1 500 510 PF00400 0.394
DOC_CKS1_1 100 105 PF01111 0.634
DOC_CYCLIN_yCln2_LP_2 466 472 PF00134 0.620
DOC_CYCLIN_yCln2_LP_2 481 487 PF00134 0.198
DOC_MAPK_DCC_7 333 342 PF00069 0.606
DOC_MAPK_MEF2A_6 130 138 PF00069 0.599
DOC_MAPK_MEF2A_6 333 342 PF00069 0.606
DOC_PP1_RVXF_1 291 297 PF00149 0.547
DOC_PP4_FxxP_1 505 508 PF00568 0.428
DOC_USP7_MATH_1 227 231 PF00917 0.482
DOC_USP7_MATH_1 308 312 PF00917 0.599
DOC_USP7_MATH_1 315 319 PF00917 0.444
DOC_USP7_MATH_1 321 325 PF00917 0.549
DOC_USP7_MATH_1 73 77 PF00917 0.551
DOC_WW_Pin1_4 114 119 PF00397 0.534
DOC_WW_Pin1_4 178 183 PF00397 0.605
DOC_WW_Pin1_4 38 43 PF00397 0.542
DOC_WW_Pin1_4 448 453 PF00397 0.502
DOC_WW_Pin1_4 480 485 PF00397 0.486
DOC_WW_Pin1_4 566 571 PF00397 0.456
DOC_WW_Pin1_4 99 104 PF00397 0.635
LIG_14-3-3_CanoR_1 163 169 PF00244 0.525
LIG_14-3-3_CanoR_1 218 224 PF00244 0.562
LIG_14-3-3_CanoR_1 343 351 PF00244 0.426
LIG_14-3-3_CanoR_1 53 58 PF00244 0.556
LIG_14-3-3_CanoR_1 557 566 PF00244 0.542
LIG_14-3-3_CanoR_1 63 72 PF00244 0.528
LIG_Actin_WH2_2 438 456 PF00022 0.556
LIG_BRCT_BRCA1_1 170 174 PF00533 0.583
LIG_BRCT_BRCA1_1 458 462 PF00533 0.561
LIG_BRCT_BRCA1_1 568 572 PF00533 0.552
LIG_CtBP_PxDLS_1 469 473 PF00389 0.618
LIG_DLG_GKlike_1 568 576 PF00625 0.589
LIG_eIF4E_1 439 445 PF01652 0.561
LIG_eIF4E_1 529 535 PF01652 0.356
LIG_FHA_1 131 137 PF00498 0.603
LIG_FHA_1 181 187 PF00498 0.595
LIG_FHA_1 381 387 PF00498 0.292
LIG_FHA_1 43 49 PF00498 0.538
LIG_FHA_1 433 439 PF00498 0.546
LIG_FHA_1 542 548 PF00498 0.305
LIG_FHA_1 593 599 PF00498 0.316
LIG_FHA_2 100 106 PF00498 0.543
LIG_FHA_2 330 336 PF00498 0.601
LIG_GBD_Chelix_1 539 547 PF00786 0.396
LIG_IRF3_LxIS_1 16 23 PF10401 0.547
LIG_LIR_Apic_2 504 508 PF02991 0.399
LIG_LIR_Apic_2 97 103 PF02991 0.609
LIG_LIR_Gen_1 10 20 PF02991 0.524
LIG_LIR_Gen_1 107 115 PF02991 0.588
LIG_LIR_Gen_1 240 248 PF02991 0.564
LIG_LIR_Gen_1 392 401 PF02991 0.450
LIG_LIR_Gen_1 586 596 PF02991 0.178
LIG_LIR_Nem_3 10 16 PF02991 0.528
LIG_LIR_Nem_3 107 112 PF02991 0.593
LIG_LIR_Nem_3 153 158 PF02991 0.620
LIG_LIR_Nem_3 171 177 PF02991 0.413
LIG_LIR_Nem_3 240 245 PF02991 0.577
LIG_LIR_Nem_3 260 266 PF02991 0.634
LIG_LIR_Nem_3 392 396 PF02991 0.450
LIG_LIR_Nem_3 459 465 PF02991 0.559
LIG_LIR_Nem_3 525 529 PF02991 0.353
LIG_LIR_Nem_3 545 551 PF02991 0.356
LIG_LIR_Nem_3 575 580 PF02991 0.552
LIG_LIR_Nem_3 586 591 PF02991 0.338
LIG_LIR_Nem_3 71 77 PF02991 0.455
LIG_MLH1_MIPbox_1 170 174 PF16413 0.583
LIG_Pex14_1 341 345 PF04695 0.555
LIG_Pex14_1 495 499 PF04695 0.369
LIG_Pex14_2 491 495 PF04695 0.370
LIG_Pex14_2 588 592 PF04695 0.297
LIG_PTB_Apo_2 103 110 PF02174 0.568
LIG_PTB_Apo_2 236 243 PF02174 0.610
LIG_PTB_Apo_2 295 302 PF02174 0.539
LIG_PTB_Apo_2 336 343 PF02174 0.601
LIG_SH2_CRK 100 104 PF00017 0.605
LIG_SH2_CRK 155 159 PF00017 0.585
LIG_SH2_CRK 433 437 PF00017 0.597
LIG_SH2_CRK 582 586 PF00017 0.507
LIG_SH2_GRB2like 104 107 PF00017 0.545
LIG_SH2_NCK_1 100 104 PF00017 0.605
LIG_SH2_NCK_1 297 301 PF00017 0.531
LIG_SH2_NCK_1 433 437 PF00017 0.475
LIG_SH2_NCK_1 499 503 PF00017 0.341
LIG_SH2_SRC 225 228 PF00017 0.538
LIG_SH2_SRC 597 600 PF00017 0.402
LIG_SH2_STAP1 104 108 PF00017 0.569
LIG_SH2_STAP1 263 267 PF00017 0.613
LIG_SH2_STAP1 433 437 PF00017 0.498
LIG_SH2_STAT3 564 567 PF00017 0.578
LIG_SH2_STAT5 173 176 PF00017 0.511
LIG_SH2_STAT5 225 228 PF00017 0.538
LIG_SH2_STAT5 46 49 PF00017 0.498
LIG_SH2_STAT5 538 541 PF00017 0.314
LIG_SH2_STAT5 597 600 PF00017 0.374
LIG_SH3_3 354 360 PF00018 0.335
LIG_SH3_3 461 467 PF00018 0.516
LIG_SH3_3 484 490 PF00018 0.420
LIG_SH3_3 510 516 PF00018 0.391
LIG_SH3_3 521 527 PF00018 0.420
LIG_TRFH_1 109 113 PF08558 0.561
LIG_TRFH_1 480 484 PF08558 0.249
MOD_CDK_SPxK_1 448 454 PF00069 0.557
MOD_CDK_SPxxK_3 114 121 PF00069 0.547
MOD_CK1_1 114 120 PF00069 0.541
MOD_CK1_1 246 252 PF00069 0.658
MOD_CK1_1 378 384 PF00069 0.333
MOD_CK1_1 98 104 PF00069 0.615
MOD_CK2_1 20 26 PF00069 0.494
MOD_CK2_1 244 250 PF00069 0.440
MOD_CK2_1 4 10 PF00069 0.601
MOD_CK2_1 408 414 PF00069 0.634
MOD_CK2_1 494 500 PF00069 0.389
MOD_CK2_1 65 71 PF00069 0.627
MOD_CK2_1 99 105 PF00069 0.647
MOD_CMANNOS 495 498 PF00535 0.370
MOD_GlcNHglycan 201 204 PF01048 0.243
MOD_GlcNHglycan 246 249 PF01048 0.425
MOD_GlcNHglycan 303 306 PF01048 0.394
MOD_GlcNHglycan 346 349 PF01048 0.426
MOD_GlcNHglycan 410 413 PF01048 0.441
MOD_GlcNHglycan 42 45 PF01048 0.342
MOD_GlcNHglycan 441 444 PF01048 0.357
MOD_GlcNHglycan 67 70 PF01048 0.338
MOD_GSK3_1 164 171 PF00069 0.619
MOD_GSK3_1 176 183 PF00069 0.494
MOD_GSK3_1 327 334 PF00069 0.582
MOD_GSK3_1 38 45 PF00069 0.555
MOD_GSK3_1 416 423 PF00069 0.689
MOD_GSK3_1 494 501 PF00069 0.382
MOD_GSK3_1 568 575 PF00069 0.651
MOD_GSK3_1 95 102 PF00069 0.640
MOD_N-GLC_1 188 193 PF02516 0.409
MOD_N-GLC_1 389 394 PF02516 0.388
MOD_N-GLC_1 408 413 PF02516 0.273
MOD_N-GLC_1 456 461 PF02516 0.363
MOD_NEK2_1 144 149 PF00069 0.671
MOD_NEK2_1 168 173 PF00069 0.534
MOD_NEK2_1 177 182 PF00069 0.575
MOD_NEK2_1 244 249 PF00069 0.464
MOD_NEK2_1 301 306 PF00069 0.554
MOD_NEK2_1 327 332 PF00069 0.445
MOD_NEK2_1 375 380 PF00069 0.333
MOD_NEK2_1 425 430 PF00069 0.543
MOD_NEK2_1 543 548 PF00069 0.314
MOD_NEK2_1 572 577 PF00069 0.574
MOD_NEK2_1 591 596 PF00069 0.166
MOD_NEK2_2 227 232 PF00069 0.498
MOD_NEK2_2 308 313 PF00069 0.603
MOD_PIKK_1 85 91 PF00454 0.539
MOD_PKA_1 65 71 PF00069 0.529
MOD_PKA_2 257 263 PF00069 0.561
MOD_PKA_2 375 381 PF00069 0.336
MOD_PKA_2 64 70 PF00069 0.568
MOD_PKB_1 581 589 PF00069 0.543
MOD_PKB_1 63 71 PF00069 0.525
MOD_Plk_1 389 395 PF00069 0.388
MOD_Plk_1 456 462 PF00069 0.552
MOD_Plk_4 164 170 PF00069 0.539
MOD_Plk_4 375 381 PF00069 0.355
MOD_Plk_4 42 48 PF00069 0.532
MOD_Plk_4 494 500 PF00069 0.511
MOD_Plk_4 501 507 PF00069 0.362
MOD_Plk_4 509 515 PF00069 0.262
MOD_Plk_4 538 544 PF00069 0.344
MOD_Plk_4 95 101 PF00069 0.610
MOD_ProDKin_1 114 120 PF00069 0.531
MOD_ProDKin_1 178 184 PF00069 0.605
MOD_ProDKin_1 38 44 PF00069 0.537
MOD_ProDKin_1 448 454 PF00069 0.501
MOD_ProDKin_1 480 486 PF00069 0.486
MOD_ProDKin_1 566 572 PF00069 0.449
MOD_ProDKin_1 99 105 PF00069 0.632
TRG_DiLeu_BaEn_1 107 112 PF01217 0.568
TRG_DiLeu_BaEn_2 239 245 PF01217 0.585
TRG_ENDOCYTIC_2 155 158 PF00928 0.585
TRG_ENDOCYTIC_2 297 300 PF00928 0.545
TRG_ENDOCYTIC_2 433 436 PF00928 0.534
TRG_ENDOCYTIC_2 582 585 PF00928 0.546
TRG_ER_diArg_1 34 37 PF00400 0.585
TRG_ER_diArg_1 472 474 PF00400 0.649
TRG_ER_diArg_1 514 517 PF00400 0.342
TRG_ER_diArg_1 557 559 PF00400 0.519
TRG_ER_diArg_1 63 66 PF00400 0.530
TRG_Pf-PMV_PEXEL_1 325 329 PF00026 0.239

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7A6 Leptomonas seymouri 66% 94%
A0A0S4JQH1 Bodo saltans 27% 93%
A0A1X0P4Y6 Trypanosomatidae 38% 93%
A0A3Q8IK04 Leishmania donovani 91% 100%
A0A3R7MCC1 Trypanosoma rangeli 42% 95%
A4HNI0 Leishmania braziliensis 79% 100%
A4IC36 Leishmania infantum 91% 100%
C9ZYD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 98%
E9AFZ1 Leishmania major 91% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS