G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B743_LEIMU

TriTrypDb:

LmxM.34.5170

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B743

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B743

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.543
CLV_NRD_NRD_1	130	132	PF00675	0.687
CLV_PCSK_KEX2_1	130	132	PF00082	0.687
CLV_PCSK_SKI1_1	10	14	PF00082	0.552
CLV_PCSK_SKI1_1	178	182	PF00082	0.371
CLV_PCSK_SKI1_1	377	381	PF00082	0.497
DOC_CKS1_1	137	142	PF01111	0.741
DOC_CKS1_1	226	231	PF01111	0.381
DOC_CKS1_1	66	71	PF01111	0.618
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.482
DOC_MAPK_gen_1	253	262	PF00069	0.581
DOC_MAPK_MEF2A_6	162	170	PF00069	0.597
DOC_MAPK_MEF2A_6	398	407	PF00069	0.388
DOC_PP1_RVXF_1	365	371	PF00149	0.347
DOC_PP4_FxxP_1	62	65	PF00568	0.626
DOC_USP7_MATH_1	331	335	PF00917	0.307
DOC_USP7_MATH_1	346	350	PF00917	0.442
DOC_USP7_UBL2_3	251	255	PF12436	0.490
DOC_WW_Pin1_4	106	111	PF00397	0.723
DOC_WW_Pin1_4	136	141	PF00397	0.620
DOC_WW_Pin1_4	225	230	PF00397	0.384
DOC_WW_Pin1_4	266	271	PF00397	0.412
DOC_WW_Pin1_4	329	334	PF00397	0.526
DOC_WW_Pin1_4	56	61	PF00397	0.563
DOC_WW_Pin1_4	65	70	PF00397	0.587
LIG_14-3-3_CanoR_1	120	129	PF00244	0.750
LIG_14-3-3_CanoR_1	141	146	PF00244	0.640
LIG_14-3-3_CanoR_1	44	49	PF00244	0.629
LIG_Actin_WH2_2	310	327	PF00022	0.273
LIG_APCC_ABBA_1	397	402	PF00400	0.391
LIG_BIR_III_2	330	334	PF00653	0.518
LIG_BRCT_BRCA1_1	151	155	PF00533	0.564
LIG_BRCT_BRCA1_1	58	62	PF00533	0.588
LIG_deltaCOP1_diTrp_1	290	300	PF00928	0.415
LIG_FHA_1	11	17	PF00498	0.566
LIG_FHA_1	163	169	PF00498	0.430
LIG_FHA_1	206	212	PF00498	0.443
LIG_FHA_1	284	290	PF00498	0.377
LIG_FHA_1	369	375	PF00498	0.527
LIG_FHA_1	383	389	PF00498	0.527
LIG_FHA_2	207	213	PF00498	0.398
LIG_FHA_2	336	342	PF00498	0.478
LIG_FHA_2	66	72	PF00498	0.596
LIG_LIR_Apic_2	59	65	PF02991	0.602
LIG_LIR_Gen_1	161	171	PF02991	0.516
LIG_LIR_Gen_1	179	189	PF02991	0.248
LIG_LIR_Gen_1	222	229	PF02991	0.399
LIG_LIR_Nem_3	179	184	PF02991	0.255
LIG_LIR_Nem_3	222	226	PF02991	0.408
LIG_LIR_Nem_3	45	51	PF02991	0.692
LIG_Pex14_1	300	304	PF04695	0.438
LIG_Pex14_2	62	66	PF04695	0.604
LIG_SH2_STAT5	233	236	PF00017	0.439
LIG_SH2_STAT5	316	319	PF00017	0.384
LIG_SH2_STAT5	369	372	PF00017	0.359
LIG_SH2_STAT5	51	54	PF00017	0.565
LIG_SH3_3	104	110	PF00018	0.530
LIG_SH3_3	134	140	PF00018	0.624
LIG_SH3_3	193	199	PF00018	0.494
LIG_SH3_3	54	60	PF00018	0.564
LIG_SH3_3	66	72	PF00018	0.581
LIG_SUMO_SIM_par_1	12	19	PF11976	0.564
LIG_SUMO_SIM_par_1	384	392	PF11976	0.387
LIG_TRAF2_1	68	71	PF00917	0.551
MOD_CDK_SPK_2	136	141	PF00069	0.738
MOD_CDK_SPK_2	56	61	PF00069	0.597
MOD_CK1_1	144	150	PF00069	0.751
MOD_CK1_1	231	237	PF00069	0.548
MOD_CK1_1	25	31	PF00069	0.563
MOD_CK1_1	42	48	PF00069	0.622
MOD_CK2_1	120	126	PF00069	0.786
MOD_CK2_1	15	21	PF00069	0.631
MOD_CK2_1	206	212	PF00069	0.414
MOD_CK2_1	65	71	PF00069	0.557
MOD_DYRK1A_RPxSP_1	106	110	PF00069	0.656
MOD_GlcNHglycan	122	125	PF01048	0.758
MOD_GlcNHglycan	134	137	PF01048	0.630
MOD_GlcNHglycan	202	205	PF01048	0.545
MOD_GlcNHglycan	30	33	PF01048	0.635
MOD_GlcNHglycan	348	351	PF01048	0.489
MOD_GlcNHglycan	37	40	PF01048	0.663
MOD_GSK3_1	106	113	PF00069	0.730
MOD_GSK3_1	132	139	PF00069	0.667
MOD_GSK3_1	141	148	PF00069	0.531
MOD_GSK3_1	21	28	PF00069	0.542
MOD_GSK3_1	331	338	PF00069	0.326
MOD_GSK3_1	35	42	PF00069	0.585
MOD_GSK3_1	6	13	PF00069	0.738
MOD_GSK3_1	84	91	PF00069	0.562
MOD_LATS_1	118	124	PF00433	0.762
MOD_LATS_1	217	223	PF00433	0.449
MOD_N-GLC_1	190	195	PF02516	0.493
MOD_NEK2_1	205	210	PF00069	0.491
MOD_NEK2_1	260	265	PF00069	0.357
MOD_NEK2_1	320	325	PF00069	0.386
MOD_NEK2_1	379	384	PF00069	0.550
MOD_NEK2_1	388	393	PF00069	0.383
MOD_NEK2_1	6	11	PF00069	0.569
MOD_PIKK_1	242	248	PF00454	0.277
MOD_PIKK_1	260	266	PF00454	0.352
MOD_PIKK_1	88	94	PF00454	0.590
MOD_PK_1	141	147	PF00069	0.669
MOD_PKA_2	145	151	PF00069	0.602
MOD_PKA_2	26	32	PF00069	0.624
MOD_Plk_1	190	196	PF00069	0.500
MOD_Plk_1	77	83	PF00069	0.604
MOD_Plk_2-3	15	21	PF00069	0.569
MOD_Plk_4	176	182	PF00069	0.380
MOD_Plk_4	219	225	PF00069	0.432
MOD_Plk_4	228	234	PF00069	0.410
MOD_Plk_4	294	300	PF00069	0.579
MOD_Plk_4	331	337	PF00069	0.277
MOD_ProDKin_1	106	112	PF00069	0.727
MOD_ProDKin_1	136	142	PF00069	0.619
MOD_ProDKin_1	225	231	PF00069	0.385
MOD_ProDKin_1	266	272	PF00069	0.415
MOD_ProDKin_1	329	335	PF00069	0.521
MOD_ProDKin_1	56	62	PF00069	0.566
MOD_ProDKin_1	65	71	PF00069	0.587
MOD_SUMO_rev_2	53	57	PF00179	0.512
TRG_DiLeu_BaEn_1	375	380	PF01217	0.466
TRG_ENDOCYTIC_2	163	166	PF00928	0.503
TRG_ER_diArg_1	129	131	PF00400	0.755
TRG_ER_diArg_1	300	303	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M5	Leptomonas seymouri	59%	100%
A0A3Q8IFN6	Leishmania donovani	88%	100%
A4HNH9	Leishmania braziliensis	78%	100%
A4IC35	Leishmania infantum	92%	100%
E9AFZ0	Leishmania major	91%	100%