DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B742_LEIMU

TriTrypDb:

LmxM.34.5160

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B742

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B742

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.462
CLV_NRD_NRD_1	301	303	PF00675	0.505
CLV_PCSK_KEX2_1	293	295	PF00082	0.387
CLV_PCSK_KEX2_1	301	303	PF00082	0.410
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.387
CLV_PCSK_SKI1_1	24	28	PF00082	0.344
CLV_Separin_Metazoa	131	135	PF03568	0.456
DEG_APCC_DBOX_1	23	31	PF00400	0.328
DEG_Nend_UBRbox_4	1	3	PF02207	0.337
DOC_CYCLIN_RxL_1	18	28	PF00134	0.457
DOC_MAPK_DCC_7	261	271	PF00069	0.482
DOC_MAPK_gen_1	177	187	PF00069	0.467
DOC_MAPK_gen_1	261	271	PF00069	0.366
DOC_MAPK_MEF2A_6	264	271	PF00069	0.428
DOC_MAPK_MEF2A_6	4	12	PF00069	0.380
DOC_MAPK_MEF2A_6	96	103	PF00069	0.336
DOC_MAPK_RevD_3	281	294	PF00069	0.352
DOC_PP1_RVXF_1	27	34	PF00149	0.329
DOC_PP2B_PxIxI_1	266	272	PF00149	0.239
DOC_PP4_FxxP_1	200	203	PF00568	0.474
DOC_USP7_MATH_1	204	208	PF00917	0.260
DOC_WW_Pin1_4	150	155	PF00397	0.612
LIG_14-3-3_CanoR_1	108	118	PF00244	0.468
LIG_14-3-3_CanoR_1	248	252	PF00244	0.426
LIG_14-3-3_CanoR_1	273	278	PF00244	0.541
LIG_14-3-3_CanoR_1	43	47	PF00244	0.474
LIG_14-3-3_CanoR_1	57	65	PF00244	0.543
LIG_14-3-3_CanoR_1	70	74	PF00244	0.287
LIG_FHA_1	207	213	PF00498	0.416
LIG_FHA_1	244	250	PF00498	0.483
LIG_FHA_1	266	272	PF00498	0.467
LIG_FHA_2	274	280	PF00498	0.479
LIG_FHA_2	59	65	PF00498	0.471
LIG_GBD_Chelix_1	291	299	PF00786	0.396
LIG_LIR_Gen_1	195	205	PF02991	0.401
LIG_LIR_Gen_1	3	12	PF02991	0.353
LIG_LIR_Nem_3	16	22	PF02991	0.361
LIG_LIR_Nem_3	193	197	PF02991	0.456
LIG_LIR_Nem_3	3	8	PF02991	0.369
LIG_MYND_1	238	242	PF01753	0.440
LIG_NRBOX	113	119	PF00104	0.432
LIG_PCNA_yPIPBox_3	57	69	PF02747	0.426
LIG_SH2_CRK	5	9	PF00017	0.368
LIG_SH2_STAT5	20	23	PF00017	0.376
LIG_SH2_STAT5	233	236	PF00017	0.578
LIG_SH2_STAT5	270	273	PF00017	0.475
LIG_SH2_STAT5	68	71	PF00017	0.474
LIG_TYR_ITIM	17	22	PF00017	0.426
LIG_WRC_WIRS_1	144	149	PF05994	0.499
MOD_CK1_1	143	149	PF00069	0.635
MOD_CK1_1	87	93	PF00069	0.523
MOD_CK2_1	136	142	PF00069	0.379
MOD_CK2_1	58	64	PF00069	0.390
MOD_GlcNHglycan	135	139	PF01048	0.545
MOD_GlcNHglycan	166	170	PF01048	0.461
MOD_GSK3_1	136	143	PF00069	0.593
MOD_GSK3_1	150	157	PF00069	0.532
MOD_GSK3_1	243	250	PF00069	0.429
MOD_GSK3_1	52	59	PF00069	0.557
MOD_N-GLC_1	122	127	PF02516	0.458
MOD_N-GLC_1	190	195	PF02516	0.473
MOD_N-GLC_2	280	282	PF02516	0.379
MOD_NEK2_1	192	197	PF00069	0.300
MOD_NEK2_1	205	210	PF00069	0.461
MOD_NEK2_1	25	30	PF00069	0.347
MOD_PIKK_1	58	64	PF00454	0.390
MOD_PIKK_1	87	93	PF00454	0.445
MOD_PKA_2	247	253	PF00069	0.435
MOD_PKA_2	272	278	PF00069	0.509
MOD_PKA_2	42	48	PF00069	0.452
MOD_PKA_2	56	62	PF00069	0.488
MOD_PKA_2	69	75	PF00069	0.284
MOD_Plk_1	122	128	PF00069	0.456
MOD_Plk_1	140	146	PF00069	0.597
MOD_Plk_1	190	196	PF00069	0.528
MOD_Plk_1	37	43	PF00069	0.425
MOD_Plk_1	55	61	PF00069	0.250
MOD_Plk_4	123	129	PF00069	0.419
MOD_Plk_4	247	253	PF00069	0.557
MOD_Plk_4	265	271	PF00069	0.474
MOD_Plk_4	281	287	PF00069	0.449
MOD_Plk_4	69	75	PF00069	0.419
MOD_ProDKin_1	150	156	PF00069	0.611
TRG_DiLeu_LyEn_5	95	100	PF01217	0.375
TRG_ENDOCYTIC_2	19	22	PF00928	0.339
TRG_ENDOCYTIC_2	5	8	PF00928	0.392
TRG_ER_diArg_1	301	304	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P619	Leptomonas seymouri	54%	94%
A0A3S7XA31	Leishmania donovani	91%	100%
A0A422P2U5	Trypanosoma rangeli	38%	77%
A4HNH8	Leishmania braziliensis	76%	100%
A4IC34	Leishmania infantum	91%	100%
C9ZZ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	74%
E9AFY9	Leishmania major	89%	100%
V5BTH5	Trypanosoma cruzi	37%	76%