Putative biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

biopterin transporter, putative

Species:

Leishmania mexicana

UniProt:

E9B741_LEIMU

TriTrypDb:

LmxM.34.5150

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9B741

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B741

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.487
CLV_C14_Caspase3-7	302	306	PF00656	0.394
CLV_NRD_NRD_1	181	183	PF00675	0.231
CLV_NRD_NRD_1	603	605	PF00675	0.279
CLV_NRD_NRD_1	628	630	PF00675	0.494
CLV_PCSK_KEX2_1	122	124	PF00082	0.292
CLV_PCSK_KEX2_1	180	182	PF00082	0.251
CLV_PCSK_KEX2_1	478	480	PF00082	0.521
CLV_PCSK_KEX2_1	628	630	PF00082	0.527
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.292
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.521
CLV_PCSK_SKI1_1	334	338	PF00082	0.278
DEG_APCC_DBOX_1	333	341	PF00400	0.398
DEG_ODPH_VHL_1	518	530	PF01847	0.520
DOC_AGCK_PIF_1	450	455	PF00069	0.381
DOC_CDC14_PxL_1	30	38	PF14671	0.532
DOC_CDC14_PxL_1	564	572	PF14671	0.331
DOC_CKS1_1	410	415	PF01111	0.191
DOC_CKS1_1	576	581	PF01111	0.432
DOC_CYCLIN_yClb5_NLxxxL_5	396	405	PF00134	0.264
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.206
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.397
DOC_MAPK_FxFP_2	581	584	PF00069	0.181
DOC_MAPK_gen_1	478	486	PF00069	0.323
DOC_MAPK_gen_1	604	611	PF00069	0.563
DOC_MAPK_MEF2A_6	47	55	PF00069	0.549
DOC_MAPK_MEF2A_6	478	486	PF00069	0.357
DOC_MAPK_MEF2A_6	604	611	PF00069	0.395
DOC_PP1_RVXF_1	384	391	PF00149	0.477
DOC_PP2B_LxvP_1	399	402	PF13499	0.374
DOC_PP2B_LxvP_1	507	510	PF13499	0.337
DOC_PP4_FxxP_1	309	312	PF00568	0.458
DOC_PP4_FxxP_1	378	381	PF00568	0.316
DOC_PP4_FxxP_1	581	584	PF00568	0.257
DOC_USP7_MATH_1	188	192	PF00917	0.323
DOC_USP7_MATH_1	274	278	PF00917	0.575
DOC_USP7_MATH_1	411	415	PF00917	0.296
DOC_USP7_MATH_1	45	49	PF00917	0.563
DOC_USP7_MATH_1	467	471	PF00917	0.322
DOC_USP7_MATH_1	520	524	PF00917	0.486
DOC_WW_Pin1_4	10	15	PF00397	0.764
DOC_WW_Pin1_4	269	274	PF00397	0.499
DOC_WW_Pin1_4	409	414	PF00397	0.249
DOC_WW_Pin1_4	575	580	PF00397	0.414
LIG_14-3-3_CanoR_1	93	98	PF00244	0.491
LIG_14-3-3_CterR_2	628	631	PF00244	0.624
LIG_Actin_WH2_2	15	33	PF00022	0.492
LIG_APCC_ABBA_1	172	177	PF00400	0.520
LIG_APCC_ABBA_1	237	242	PF00400	0.406
LIG_APCC_ABBA_1	491	496	PF00400	0.246
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BIR_III_4	305	309	PF00653	0.545
LIG_BRCT_BRCA1_1	374	378	PF00533	0.257
LIG_BRCT_BRCA1_1	422	426	PF00533	0.317
LIG_BRCT_BRCA1_1	524	528	PF00533	0.492
LIG_EH1_1	499	507	PF00400	0.369
LIG_FHA_1	112	118	PF00498	0.548
LIG_FHA_1	222	228	PF00498	0.433
LIG_FHA_1	341	347	PF00498	0.349
LIG_FHA_1	377	383	PF00498	0.354
LIG_FHA_1	405	411	PF00498	0.378
LIG_FHA_1	571	577	PF00498	0.416
LIG_FHA_2	300	306	PF00498	0.529
LIG_FHA_2	355	361	PF00498	0.208
LIG_GBD_Chelix_1	347	355	PF00786	0.315
LIG_GBD_Chelix_1	457	465	PF00786	0.449
LIG_LIR_Apic_2	2	8	PF02991	0.599
LIG_LIR_Apic_2	375	381	PF02991	0.401
LIG_LIR_Apic_2	578	584	PF02991	0.344
LIG_LIR_Gen_1	113	120	PF02991	0.522
LIG_LIR_Gen_1	134	144	PF02991	0.359
LIG_LIR_Gen_1	357	367	PF02991	0.295
LIG_LIR_Gen_1	395	405	PF02991	0.341
LIG_LIR_Gen_1	425	434	PF02991	0.324
LIG_LIR_Gen_1	443	453	PF02991	0.383
LIG_LIR_Gen_1	470	477	PF02991	0.334
LIG_LIR_Gen_1	525	535	PF02991	0.511
LIG_LIR_Nem_3	113	118	PF02991	0.497
LIG_LIR_Nem_3	121	127	PF02991	0.501
LIG_LIR_Nem_3	134	139	PF02991	0.338
LIG_LIR_Nem_3	217	222	PF02991	0.305
LIG_LIR_Nem_3	360	366	PF02991	0.286
LIG_LIR_Nem_3	375	380	PF02991	0.367
LIG_LIR_Nem_3	395	401	PF02991	0.339
LIG_LIR_Nem_3	423	427	PF02991	0.296
LIG_LIR_Nem_3	443	449	PF02991	0.257
LIG_LIR_Nem_3	454	458	PF02991	0.466
LIG_LIR_Nem_3	470	475	PF02991	0.335
LIG_LIR_Nem_3	525	531	PF02991	0.472
LIG_LIR_Nem_3	551	557	PF02991	0.291
LIG_MLH1_MIPbox_1	374	378	PF16413	0.399
LIG_NRBOX	229	235	PF00104	0.378
LIG_PCNA_TLS_4	311	318	PF02747	0.392
LIG_Pex14_1	359	363	PF04695	0.285
LIG_Pex14_2	422	426	PF04695	0.306
LIG_Pex14_2	446	450	PF04695	0.365
LIG_PTAP_UEV_1	7	12	PF05743	0.589
LIG_PTB_Apo_2	403	410	PF02174	0.391
LIG_PTB_Apo_2	449	456	PF02174	0.553
LIG_PTB_Phospho_1	403	409	PF10480	0.402
LIG_PTB_Phospho_1	449	455	PF10480	0.454
LIG_SH2_CRK	125	129	PF00017	0.367
LIG_SH2_CRK	140	144	PF00017	0.321
LIG_SH2_CRK	363	367	PF00017	0.355
LIG_SH2_CRK	427	431	PF00017	0.298
LIG_SH2_CRK	455	459	PF00017	0.495
LIG_SH2_CRK	5	9	PF00017	0.607
LIG_SH2_CRK	91	95	PF00017	0.512
LIG_SH2_GRB2like	392	395	PF00017	0.381
LIG_SH2_GRB2like	398	401	PF00017	0.405
LIG_SH2_GRB2like	564	567	PF00017	0.351
LIG_SH2_NCK_1	427	431	PF00017	0.300
LIG_SH2_NCK_1	564	568	PF00017	0.295
LIG_SH2_PTP2	21	24	PF00017	0.624
LIG_SH2_PTP2	38	41	PF00017	0.645
LIG_SH2_PTP2	587	590	PF00017	0.206
LIG_SH2_SRC	21	24	PF00017	0.630
LIG_SH2_SRC	38	41	PF00017	0.568
LIG_SH2_SRC	598	601	PF00017	0.380
LIG_SH2_STAP1	120	124	PF00017	0.501
LIG_SH2_STAP1	175	179	PF00017	0.487
LIG_SH2_STAP1	363	367	PF00017	0.284
LIG_SH2_STAP1	453	457	PF00017	0.505
LIG_SH2_STAT3	175	178	PF00017	0.495
LIG_SH2_STAT5	120	123	PF00017	0.498
LIG_SH2_STAT5	125	128	PF00017	0.340
LIG_SH2_STAT5	21	24	PF00017	0.621
LIG_SH2_STAT5	222	225	PF00017	0.350
LIG_SH2_STAT5	317	320	PF00017	0.548
LIG_SH2_STAT5	38	41	PF00017	0.604
LIG_SH2_STAT5	392	395	PF00017	0.353
LIG_SH2_STAT5	398	401	PF00017	0.342
LIG_SH2_STAT5	409	412	PF00017	0.281
LIG_SH2_STAT5	424	427	PF00017	0.261
LIG_SH2_STAT5	492	495	PF00017	0.294
LIG_SH2_STAT5	547	550	PF00017	0.256
LIG_SH2_STAT5	587	590	PF00017	0.505
LIG_SH2_STAT5	598	601	PF00017	0.395
LIG_SH2_STAT5	98	101	PF00017	0.545
LIG_SH3_1	5	11	PF00018	0.597
LIG_SH3_2	273	278	PF14604	0.394
LIG_SH3_3	270	276	PF00018	0.544
LIG_SH3_3	407	413	PF00018	0.333
LIG_SH3_3	414	420	PF00018	0.280
LIG_SH3_3	461	467	PF00018	0.206
LIG_SH3_3	5	11	PF00018	0.683
LIG_SH3_3	585	591	PF00018	0.390
LIG_SH3_3	606	612	PF00018	0.655
LIG_SUMO_SIM_anti_2	473	478	PF11976	0.315
LIG_SUMO_SIM_par_1	226	231	PF11976	0.206
LIG_TRAF2_1	618	621	PF00917	0.629
LIG_TRFH_1	140	144	PF08558	0.361
LIG_TRFH_1	587	591	PF08558	0.291
LIG_TYR_ITIM	138	143	PF00017	0.377
LIG_TYR_ITIM	36	41	PF00017	0.587
LIG_TYR_ITIM	361	366	PF00017	0.374
LIG_TYR_ITIM	396	401	PF00017	0.333
LIG_TYR_ITIM	585	590	PF00017	0.505
LIG_TYR_ITSM	423	430	PF00017	0.339
LIG_UBA3_1	138	146	PF00899	0.348
LIG_WRC_WIRS_1	374	379	PF05994	0.287
LIG_WRC_WIRS_1	405	410	PF05994	0.335
LIG_WRC_WIRS_1	46	51	PF05994	0.557
MOD_CDC14_SPxK_1	275	278	PF00782	0.398
MOD_CDK_SPxK_1	272	278	PF00069	0.398
MOD_CK1_1	13	19	PF00069	0.604
MOD_CK1_1	272	278	PF00069	0.566
MOD_CK1_1	376	382	PF00069	0.206
MOD_CK1_1	540	546	PF00069	0.358
MOD_CK2_1	284	290	PF00069	0.526
MOD_CK2_1	6	12	PF00069	0.647
MOD_Cter_Amidation	602	605	PF01082	0.320
MOD_GlcNHglycan	1	4	PF01048	0.492
MOD_GlcNHglycan	128	131	PF01048	0.390
MOD_GlcNHglycan	147	151	PF01048	0.502
MOD_GlcNHglycan	230	233	PF01048	0.387
MOD_GlcNHglycan	25	28	PF01048	0.289
MOD_GlcNHglycan	461	464	PF01048	0.378
MOD_GlcNHglycan	542	545	PF01048	0.391
MOD_GlcNHglycan	8	11	PF01048	0.468
MOD_GSK3_1	265	272	PF00069	0.492
MOD_GSK3_1	372	379	PF00069	0.293
MOD_GSK3_1	440	447	PF00069	0.311
MOD_GSK3_1	536	543	PF00069	0.375
MOD_GSK3_1	558	565	PF00069	0.400
MOD_GSK3_1	589	596	PF00069	0.514
MOD_GSK3_1	6	13	PF00069	0.618
MOD_GSK3_1	620	627	PF00069	0.754
MOD_GSK3_1	92	99	PF00069	0.541
MOD_N-GLC_1	451	456	PF02516	0.254
MOD_NEK2_1	111	116	PF00069	0.495
MOD_NEK2_1	118	123	PF00069	0.453
MOD_NEK2_1	162	167	PF00069	0.351
MOD_NEK2_1	193	198	PF00069	0.335
MOD_NEK2_1	201	206	PF00069	0.331
MOD_NEK2_1	228	233	PF00069	0.286
MOD_NEK2_1	340	345	PF00069	0.357
MOD_NEK2_1	422	427	PF00069	0.309
MOD_NEK2_1	444	449	PF00069	0.376
MOD_NEK2_1	459	464	PF00069	0.363
MOD_NEK2_1	530	535	PF00069	0.346
MOD_NEK2_1	537	542	PF00069	0.353
MOD_NEK2_1	549	554	PF00069	0.301
MOD_NEK2_1	570	575	PF00069	0.457
MOD_NEK2_1	72	77	PF00069	0.479
MOD_NEK2_2	373	378	PF00069	0.462
MOD_NEK2_2	45	50	PF00069	0.424
MOD_NEK2_2	467	472	PF00069	0.369
MOD_PIKK_1	354	360	PF00454	0.194
MOD_PIKK_1	555	561	PF00454	0.410
MOD_PKA_2	520	526	PF00069	0.490
MOD_PKA_2	593	599	PF00069	0.400
MOD_PKA_2	72	78	PF00069	0.407
MOD_PKA_2	92	98	PF00069	0.519
MOD_PKB_1	311	319	PF00069	0.394
MOD_PKB_1	4	12	PF00069	0.592
MOD_Plk_1	451	457	PF00069	0.454
MOD_Plk_4	131	137	PF00069	0.283
MOD_Plk_4	188	194	PF00069	0.347
MOD_Plk_4	202	208	PF00069	0.337
MOD_Plk_4	313	319	PF00069	0.502
MOD_Plk_4	373	379	PF00069	0.391
MOD_Plk_4	392	398	PF00069	0.371
MOD_Plk_4	404	410	PF00069	0.338
MOD_Plk_4	422	428	PF00069	0.363
MOD_Plk_4	440	446	PF00069	0.231
MOD_Plk_4	467	473	PF00069	0.320
MOD_Plk_4	522	528	PF00069	0.516
MOD_Plk_4	530	536	PF00069	0.358
MOD_Plk_4	549	555	PF00069	0.299
MOD_Plk_4	93	99	PF00069	0.444
MOD_ProDKin_1	10	16	PF00069	0.761
MOD_ProDKin_1	269	275	PF00069	0.499
MOD_ProDKin_1	409	415	PF00069	0.249
MOD_ProDKin_1	575	581	PF00069	0.414
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.445
TRG_ENDOCYTIC_2	125	128	PF00928	0.346
TRG_ENDOCYTIC_2	140	143	PF00928	0.336
TRG_ENDOCYTIC_2	363	366	PF00928	0.358
TRG_ENDOCYTIC_2	38	41	PF00928	0.596
TRG_ENDOCYTIC_2	398	401	PF00928	0.352
TRG_ENDOCYTIC_2	427	430	PF00928	0.301
TRG_ENDOCYTIC_2	455	458	PF00928	0.495
TRG_ENDOCYTIC_2	547	550	PF00928	0.323
TRG_ENDOCYTIC_2	587	590	PF00928	0.495
TRG_ENDOCYTIC_2	91	94	PF00928	0.480
TRG_ER_diArg_1	179	182	PF00400	0.437
TRG_ER_diArg_1	310	313	PF00400	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	43%	90%
A0A0N1HY49	Leptomonas seymouri	40%	94%
A0A0N1HZ06	Leptomonas seymouri	59%	100%
A0A0N1IHL1	Leptomonas seymouri	37%	88%
A0A0N1PAY4	Leptomonas seymouri	39%	72%
A0A0N1PB77	Leptomonas seymouri	69%	97%
A0A0N1PBZ2	Leptomonas seymouri	38%	94%
A0A0N1PCC1	Leptomonas seymouri	37%	94%
A0A0S4INN8	Bodo saltans	28%	97%
A0A381MBI0	Leishmania infantum	40%	96%
A0A3Q8I8X7	Leishmania donovani	40%	96%
A0A3Q8IAZ0	Leishmania donovani	37%	90%
A0A3Q8IH50	Leishmania donovani	39%	87%
A0A3Q8IVN0	Leishmania donovani	89%	100%
A0A3R7M4J1	Trypanosoma rangeli	38%	99%
A0A3S5H5P4	Leishmania donovani	39%	93%
A0A3S5H5V2	Leishmania donovani	42%	97%
A0A3S5H6F6	Leishmania donovani	37%	90%
A0A3S5H763	Leishmania donovani	42%	94%
A0A3S7WR10	Leishmania donovani	39%	85%
A0A3S7WR14	Leishmania donovani	37%	92%
A0A3S7WR15	Leishmania donovani	36%	74%
A0A3S7WR24	Leishmania donovani	37%	90%
A4H4T8	Leishmania braziliensis	44%	100%
A4H5Y4	Leishmania braziliensis	39%	100%
A4H617	Leishmania braziliensis	37%	100%
A4H618	Leishmania braziliensis	37%	100%
A4H619	Leishmania braziliensis	37%	100%
A4H620	Leishmania braziliensis	40%	100%
A4H6C3	Leishmania braziliensis	39%	100%
A4HNH7	Leishmania braziliensis	82%	100%
A4HSS2	Leishmania infantum	39%	93%
A4HUE4	Leishmania infantum	39%	85%
A4HUE5	Leishmania infantum	36%	91%
A4HUE6	Leishmania infantum	37%	92%
A4HUE7	Leishmania infantum	37%	90%
A4HUE8	Leishmania infantum	38%	90%
A4HUF4	Leishmania infantum	36%	90%
A4HUF5	Leishmania infantum	39%	96%
A4HYA9	Leishmania infantum	42%	94%
A4IC33	Leishmania infantum	88%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AG72	Leishmania infantum	42%	97%
E9AI40	Leishmania braziliensis	38%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
Q4QDC4	Leishmania major	41%	100%
Q4QH81	Leishmania major	39%	100%
Q4QHH7	Leishmania major	39%	100%
Q4QHH8	Leishmania major	37%	100%
Q4QHH9	Leishmania major	38%	100%
Q4QHI0	Leishmania major	37%	100%
Q4QHI1	Leishmania major	37%	100%
Q4QHI2	Leishmania major	37%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	40%	100%
Q7KIP2	Leishmania major	88%	100%