Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B739_LEIMU

TriTrypDb:

LmxM.34.5130

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B739

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B739

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.451
CLV_NRD_NRD_1	245	247	PF00675	0.560
CLV_NRD_NRD_1	46	48	PF00675	0.583
CLV_PCSK_FUR_1	243	247	PF00082	0.489
CLV_PCSK_KEX2_1	170	172	PF00082	0.457
CLV_PCSK_KEX2_1	245	247	PF00082	0.603
CLV_PCSK_KEX2_1	46	48	PF00082	0.583
CLV_PCSK_SKI1_1	170	174	PF00082	0.452
CLV_PCSK_SKI1_1	20	24	PF00082	0.616
DEG_Nend_UBRbox_2	1	3	PF02207	0.622
DEG_SPOP_SBC_1	129	133	PF00917	0.452
DEG_SPOP_SBC_1	205	209	PF00917	0.544
DEG_SPOP_SBC_1	339	343	PF00917	0.512
DOC_CYCLIN_RxL_1	308	319	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.583
DOC_MAPK_gen_1	185	193	PF00069	0.439
DOC_MAPK_MEF2A_6	188	195	PF00069	0.419
DOC_PP1_RVXF_1	171	177	PF00149	0.512
DOC_PP1_RVXF_1	18	25	PF00149	0.537
DOC_PP1_RVXF_1	309	316	PF00149	0.443
DOC_PP2B_LxvP_1	102	105	PF13499	0.482
DOC_USP7_MATH_1	222	226	PF00917	0.628
DOC_USP7_MATH_1	241	245	PF00917	0.419
DOC_USP7_MATH_1	328	332	PF00917	0.555
DOC_WW_Pin1_4	348	353	PF00397	0.623
LIG_14-3-3_CanoR_1	206	211	PF00244	0.666
LIG_14-3-3_CanoR_1	223	227	PF00244	0.480
LIG_BIR_III_2	110	114	PF00653	0.455
LIG_BRCT_BRCA1_1	267	271	PF00533	0.613
LIG_CaM_IQ_9	232	248	PF13499	0.415
LIG_FHA_1	10	16	PF00498	0.632
LIG_FHA_1	107	113	PF00498	0.618
LIG_FHA_1	135	141	PF00498	0.622
LIG_FHA_1	216	222	PF00498	0.462
LIG_FHA_1	226	232	PF00498	0.382
LIG_FHA_1	270	276	PF00498	0.616
LIG_FHA_1	341	347	PF00498	0.536
LIG_FHA_2	79	85	PF00498	0.538
LIG_Integrin_RGD_1	355	357	PF01839	0.510
LIG_LIR_Gen_1	21	31	PF02991	0.572
LIG_LIR_Nem_3	21	27	PF02991	0.575
LIG_MYND_1	257	261	PF01753	0.561
LIG_PCNA_yPIPBox_3	295	309	PF02747	0.519
LIG_Pex14_2	194	198	PF04695	0.516
LIG_Pex14_2	238	242	PF04695	0.515
LIG_SH2_NCK_1	276	280	PF00017	0.585
LIG_SH2_STAP1	56	60	PF00017	0.608
LIG_SH2_STAT5	291	294	PF00017	0.614
LIG_SH2_STAT5	301	304	PF00017	0.616
LIG_SH2_STAT5	314	317	PF00017	0.399
LIG_SH3_3	2	8	PF00018	0.788
LIG_SH3_3	251	257	PF00018	0.638
LIG_SH3_3	346	352	PF00018	0.593
LIG_SxIP_EBH_1	127	138	PF03271	0.501
LIG_TRAF2_1	264	267	PF00917	0.549
LIG_WRC_WIRS_1	195	200	PF05994	0.528
MOD_CDK_SPxxK_3	348	355	PF00069	0.592
MOD_CK1_1	133	139	PF00069	0.640
MOD_CK1_1	225	231	PF00069	0.525
MOD_CK1_1	274	280	PF00069	0.578
MOD_CK1_1	290	296	PF00069	0.592
MOD_CK1_1	324	330	PF00069	0.581
MOD_CK1_1	333	339	PF00069	0.450
MOD_CK1_1	341	347	PF00069	0.671
MOD_CK1_1	351	357	PF00069	0.559
MOD_CK1_1	359	365	PF00069	0.538
MOD_CK1_1	40	46	PF00069	0.643
MOD_CK1_1	78	84	PF00069	0.515
MOD_CK2_1	283	289	PF00069	0.656
MOD_CK2_1	38	44	PF00069	0.748
MOD_CK2_1	78	84	PF00069	0.638
MOD_DYRK1A_RPxSP_1	348	352	PF00069	0.578
MOD_GlcNHglycan	155	158	PF01048	0.518
MOD_GlcNHglycan	210	213	PF01048	0.636
MOD_GlcNHglycan	254	257	PF01048	0.549
MOD_GlcNHglycan	277	280	PF01048	0.657
MOD_GlcNHglycan	326	329	PF01048	0.650
MOD_GlcNHglycan	330	333	PF01048	0.631
MOD_GSK3_1	129	136	PF00069	0.707
MOD_GSK3_1	153	160	PF00069	0.561
MOD_GSK3_1	200	207	PF00069	0.662
MOD_GSK3_1	227	234	PF00069	0.430
MOD_GSK3_1	265	272	PF00069	0.570
MOD_GSK3_1	283	290	PF00069	0.560
MOD_GSK3_1	324	331	PF00069	0.541
MOD_GSK3_1	338	345	PF00069	0.642
MOD_GSK3_1	347	354	PF00069	0.600
MOD_GSK3_1	359	366	PF00069	0.579
MOD_GSK3_1	60	67	PF00069	0.745
MOD_N-GLC_1	287	292	PF02516	0.583
MOD_N-GLC_1	294	299	PF02516	0.475
MOD_NEK2_1	194	199	PF00069	0.539
MOD_NEK2_1	215	220	PF00069	0.545
MOD_NEK2_1	231	236	PF00069	0.350
MOD_NEK2_1	271	276	PF00069	0.658
MOD_NEK2_1	338	343	PF00069	0.554
MOD_NEK2_1	55	60	PF00069	0.532
MOD_NEK2_1	75	80	PF00069	0.593
MOD_NEK2_1	9	14	PF00069	0.742
MOD_PK_1	206	212	PF00069	0.544
MOD_PKA_2	200	206	PF00069	0.658
MOD_PKA_2	222	228	PF00069	0.628
MOD_PKA_2	347	353	PF00069	0.638
MOD_PKB_1	62	70	PF00069	0.650
MOD_Plk_1	20	26	PF00069	0.641
MOD_Plk_1	282	288	PF00069	0.663
MOD_Plk_1	294	300	PF00069	0.676
MOD_Plk_1	305	311	PF00069	0.503
MOD_Plk_1	333	339	PF00069	0.663
MOD_Plk_1	356	362	PF00069	0.653
MOD_Plk_2-3	283	289	PF00069	0.454
MOD_Plk_4	143	149	PF00069	0.680
MOD_Plk_4	194	200	PF00069	0.533
MOD_Plk_4	222	228	PF00069	0.473
MOD_Plk_4	271	277	PF00069	0.628
MOD_Plk_4	287	293	PF00069	0.658
MOD_Plk_4	333	339	PF00069	0.706
MOD_ProDKin_1	348	354	PF00069	0.623
MOD_SUMO_for_1	172	175	PF00179	0.414
MOD_SUMO_rev_2	84	92	PF00179	0.641
TRG_ER_diArg_1	170	172	PF00400	0.458
TRG_ER_diArg_1	242	245	PF00400	0.544
TRG_ER_diArg_1	96	99	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I004	Leptomonas seymouri	41%	96%
A0A1X0P4S3	Trypanosomatidae	32%	100%
A0A3S7XA50	Leishmania donovani	91%	100%
A4HNH5	Leishmania braziliensis	61%	100%
A4IC31	Leishmania infantum	91%	100%
C9ZYD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFY6	Leishmania major	91%	100%
V5BTY5	Trypanosoma cruzi	26%	100%