WASH-7_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B738_LEIMU

TriTrypDb:

LmxM.34.5120

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B738

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B738

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.557
CLV_C14_Caspase3-7	388	392	PF00656	0.419
CLV_C14_Caspase3-7	399	403	PF00656	0.426
CLV_C14_Caspase3-7	516	520	PF00656	0.564
CLV_NRD_NRD_1	211	213	PF00675	0.553
CLV_NRD_NRD_1	215	217	PF00675	0.500
CLV_NRD_NRD_1	314	316	PF00675	0.519
CLV_NRD_NRD_1	548	550	PF00675	0.427
CLV_NRD_NRD_1	633	635	PF00675	0.495
CLV_NRD_NRD_1	646	648	PF00675	0.286
CLV_PCSK_KEX2_1	314	316	PF00082	0.519
CLV_PCSK_KEX2_1	511	513	PF00082	0.612
CLV_PCSK_KEX2_1	548	550	PF00082	0.466
CLV_PCSK_KEX2_1	646	648	PF00082	0.448
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.630
CLV_PCSK_SKI1_1	136	140	PF00082	0.443
CLV_PCSK_SKI1_1	216	220	PF00082	0.409
CLV_PCSK_SKI1_1	285	289	PF00082	0.449
CLV_PCSK_SKI1_1	315	319	PF00082	0.473
CLV_PCSK_SKI1_1	398	402	PF00082	0.385
CLV_PCSK_SKI1_1	408	412	PF00082	0.412
CLV_PCSK_SKI1_1	44	48	PF00082	0.596
CLV_PCSK_SKI1_1	448	452	PF00082	0.360
CLV_PCSK_SKI1_1	459	463	PF00082	0.357
CLV_PCSK_SKI1_1	689	693	PF00082	0.411
CLV_PCSK_SKI1_1	703	707	PF00082	0.262
DEG_APCC_DBOX_1	247	255	PF00400	0.607
DEG_APCC_DBOX_1	284	292	PF00400	0.469
DEG_APCC_DBOX_1	669	677	PF00400	0.514
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DEG_SPOP_SBC_1	29	33	PF00917	0.628
DEG_SPOP_SBC_1	627	631	PF00917	0.404
DOC_ANK_TNKS_1	337	344	PF00023	0.440
DOC_CKS1_1	287	292	PF01111	0.433
DOC_CKS1_1	345	350	PF01111	0.555
DOC_CKS1_1	706	711	PF01111	0.411
DOC_CYCLIN_RxL_1	395	402	PF00134	0.420
DOC_CYCLIN_yClb1_LxF_4	537	543	PF00134	0.463
DOC_MAPK_gen_1	314	322	PF00069	0.469
DOC_MAPK_gen_1	349	359	PF00069	0.408
DOC_MAPK_gen_1	634	641	PF00069	0.513
DOC_MAPK_MEF2A_6	352	361	PF00069	0.376
DOC_MAPK_MEF2A_6	529	536	PF00069	0.451
DOC_PP4_FxxP_1	327	330	PF00568	0.487
DOC_PP4_FxxP_1	345	348	PF00568	0.507
DOC_USP7_MATH_1	155	159	PF00917	0.689
DOC_USP7_MATH_1	161	165	PF00917	0.636
DOC_USP7_MATH_1	24	28	PF00917	0.521
DOC_USP7_MATH_1	29	33	PF00917	0.475
DOC_USP7_MATH_1	564	568	PF00917	0.723
DOC_USP7_UBL2_3	213	217	PF12436	0.462
DOC_USP7_UBL2_3	369	373	PF12436	0.501
DOC_USP7_UBL2_3	413	417	PF12436	0.478
DOC_WW_Pin1_4	286	291	PF00397	0.416
DOC_WW_Pin1_4	344	349	PF00397	0.551
DOC_WW_Pin1_4	576	581	PF00397	0.619
DOC_WW_Pin1_4	705	710	PF00397	0.465
LIG_14-3-3_CanoR_1	129	135	PF00244	0.511
LIG_14-3-3_CanoR_1	248	252	PF00244	0.607
LIG_14-3-3_CanoR_1	267	276	PF00244	0.451
LIG_14-3-3_CanoR_1	529	533	PF00244	0.491
LIG_14-3-3_CanoR_1	634	641	PF00244	0.493
LIG_14-3-3_CanoR_1	695	701	PF00244	0.446
LIG_Actin_WH2_2	443	461	PF00022	0.478
LIG_Actin_WH2_2	618	636	PF00022	0.509
LIG_BIR_III_4	603	607	PF00653	0.379
LIG_BRCT_BRCA1_1	130	134	PF00533	0.531
LIG_BRCT_BRCA1_1	587	591	PF00533	0.550
LIG_BRCT_BRCA1_2	130	136	PF00533	0.529
LIG_Clathr_ClatBox_1	622	626	PF01394	0.577
LIG_deltaCOP1_diTrp_1	363	368	PF00928	0.367
LIG_EH1_1	191	199	PF00400	0.263
LIG_EH1_1	394	402	PF00400	0.403
LIG_eIF4E_1	395	401	PF01652	0.492
LIG_eIF4E_1	445	451	PF01652	0.386
LIG_FHA_1	135	141	PF00498	0.429
LIG_FHA_1	206	212	PF00498	0.452
LIG_FHA_1	247	253	PF00498	0.560
LIG_FHA_1	438	444	PF00498	0.443
LIG_FHA_1	447	453	PF00498	0.261
LIG_FHA_1	482	488	PF00498	0.502
LIG_FHA_1	523	529	PF00498	0.538
LIG_FHA_1	55	61	PF00498	0.588
LIG_FHA_1	552	558	PF00498	0.515
LIG_FHA_1	628	634	PF00498	0.589
LIG_FHA_2	112	118	PF00498	0.524
LIG_FHA_2	168	174	PF00498	0.707
LIG_FHA_2	238	244	PF00498	0.612
LIG_FHA_2	287	293	PF00498	0.501
LIG_FHA_2	433	439	PF00498	0.473
LIG_FHA_2	514	520	PF00498	0.664
LIG_FHA_2	57	63	PF00498	0.497
LIG_FHA_2	706	712	PF00498	0.561
LIG_Integrin_isoDGR_2	693	695	PF01839	0.492
LIG_LIR_Apic_2	324	330	PF02991	0.504
LIG_LIR_Gen_1	306	317	PF02991	0.434
LIG_LIR_Gen_1	353	362	PF02991	0.435
LIG_LIR_Gen_1	588	597	PF02991	0.530
LIG_LIR_Gen_1	683	692	PF02991	0.408
LIG_LIR_Gen_1	84	94	PF02991	0.466
LIG_LIR_Nem_3	306	312	PF02991	0.428
LIG_LIR_Nem_3	353	359	PF02991	0.362
LIG_LIR_Nem_3	426	432	PF02991	0.467
LIG_LIR_Nem_3	588	594	PF02991	0.539
LIG_LIR_Nem_3	84	90	PF02991	0.474
LIG_LIR_Nem_3	93	99	PF02991	0.362
LIG_Pex14_1	609	613	PF04695	0.383
LIG_Pex14_2	605	609	PF04695	0.389
LIG_PTB_Apo_2	389	396	PF02174	0.492
LIG_PTB_Apo_2	536	543	PF02174	0.357
LIG_PTB_Phospho_1	389	395	PF10480	0.488
LIG_SH2_CRK	455	459	PF00017	0.444
LIG_SH2_CRK	463	467	PF00017	0.522
LIG_SH2_CRK	70	74	PF00017	0.460
LIG_SH2_GRB2like	404	407	PF00017	0.480
LIG_SH2_NCK_1	295	299	PF00017	0.514
LIG_SH2_PTP2	354	357	PF00017	0.463
LIG_SH2_SRC	258	261	PF00017	0.556
LIG_SH2_SRC	404	407	PF00017	0.487
LIG_SH2_SRC	601	604	PF00017	0.439
LIG_SH2_STAP1	419	423	PF00017	0.428
LIG_SH2_STAP1	657	661	PF00017	0.403
LIG_SH2_STAP1	99	103	PF00017	0.464
LIG_SH2_STAT5	103	106	PF00017	0.418
LIG_SH2_STAT5	286	289	PF00017	0.381
LIG_SH2_STAT5	350	353	PF00017	0.482
LIG_SH2_STAT5	354	357	PF00017	0.463
LIG_SH2_STAT5	404	407	PF00017	0.436
LIG_SH2_STAT5	445	448	PF00017	0.390
LIG_SH2_STAT5	482	485	PF00017	0.491
LIG_SH2_STAT5	601	604	PF00017	0.403
LIG_SH2_STAT5	96	99	PF00017	0.382
LIG_SH3_1	556	562	PF00018	0.368
LIG_SH3_3	173	179	PF00018	0.467
LIG_SH3_3	284	290	PF00018	0.379
LIG_SH3_3	556	562	PF00018	0.528
LIG_SH3_3	579	585	PF00018	0.547
LIG_SH3_3	71	77	PF00018	0.534
LIG_SUMO_SIM_anti_2	677	684	PF11976	0.241
LIG_SUMO_SIM_par_1	56	62	PF11976	0.618
LIG_SUMO_SIM_par_1	620	626	PF11976	0.487
LIG_TRAF2_1	475	478	PF00917	0.405
LIG_TRAF2_1	59	62	PF00917	0.504
LIG_TRFH_1	286	290	PF08558	0.381
LIG_TYR_ITIM	461	466	PF00017	0.535
LIG_UBA3_1	251	256	PF00899	0.584
LIG_UBA3_1	265	270	PF00899	0.395
LIG_UBA3_1	652	660	PF00899	0.452
LIG_WRC_WIRS_1	25	30	PF05994	0.539
LIG_WW_3	580	584	PF00397	0.398
MOD_CDK_SPK_2	344	349	PF00069	0.551
MOD_CDK_SPxxK_3	576	583	PF00069	0.429
MOD_CK1_1	146	152	PF00069	0.687
MOD_CK1_1	164	170	PF00069	0.705
MOD_CK1_1	247	253	PF00069	0.651
MOD_CK1_1	33	39	PF00069	0.602
MOD_CK1_1	615	621	PF00069	0.463
MOD_CK2_1	111	117	PF00069	0.500
MOD_CK2_1	268	274	PF00069	0.487
MOD_CK2_1	286	292	PF00069	0.484
MOD_CK2_1	412	418	PF00069	0.548
MOD_CK2_1	432	438	PF00069	0.380
MOD_CK2_1	472	478	PF00069	0.426
MOD_CK2_1	56	62	PF00069	0.491
MOD_CK2_1	593	599	PF00069	0.542
MOD_CK2_1	615	621	PF00069	0.527
MOD_CK2_1	626	632	PF00069	0.548
MOD_CK2_1	705	711	PF00069	0.543
MOD_GlcNHglycan	150	153	PF01048	0.604
MOD_GlcNHglycan	157	160	PF01048	0.648
MOD_GlcNHglycan	173	176	PF01048	0.709
MOD_GlcNHglycan	20	23	PF01048	0.553
MOD_GlcNHglycan	270	273	PF01048	0.407
MOD_GlcNHglycan	32	35	PF01048	0.527
MOD_GSK3_1	167	174	PF00069	0.723
MOD_GSK3_1	24	31	PF00069	0.520
MOD_GSK3_1	243	250	PF00069	0.699
MOD_GSK3_1	299	306	PF00069	0.475
MOD_GSK3_1	419	426	PF00069	0.454
MOD_GSK3_1	428	435	PF00069	0.374
MOD_GSK3_1	513	520	PF00069	0.606
MOD_GSK3_1	617	624	PF00069	0.572
MOD_LATS_1	515	521	PF00433	0.649
MOD_N-GLC_1	205	210	PF02516	0.485
MOD_N-GLC_1	54	59	PF02516	0.624
MOD_N-GLC_2	539	541	PF02516	0.457
MOD_NEK2_1	134	139	PF00069	0.446
MOD_NEK2_1	266	271	PF00069	0.353
MOD_NEK2_1	28	33	PF00069	0.518
MOD_NEK2_1	322	327	PF00069	0.480
MOD_NEK2_1	334	339	PF00069	0.339
MOD_NEK2_1	371	376	PF00069	0.480
MOD_NEK2_1	446	451	PF00069	0.414
MOD_NEK2_1	454	459	PF00069	0.375
MOD_NEK2_1	462	467	PF00069	0.282
MOD_NEK2_1	605	610	PF00069	0.432
MOD_NEK2_1	633	638	PF00069	0.478
MOD_NEK2_1	674	679	PF00069	0.425
MOD_NEK2_2	419	424	PF00069	0.507
MOD_PIKK_1	146	152	PF00454	0.598
MOD_PIKK_1	585	591	PF00454	0.564
MOD_PIKK_1	633	639	PF00454	0.496
MOD_PIKK_1	668	674	PF00454	0.403
MOD_PIKK_1	696	702	PF00454	0.541
MOD_PKA_2	128	134	PF00069	0.515
MOD_PKA_2	247	253	PF00069	0.634
MOD_PKA_2	266	272	PF00069	0.476
MOD_PKA_2	528	534	PF00069	0.493
MOD_PKA_2	633	639	PF00069	0.484
MOD_Plk_1	322	328	PF00069	0.489
MOD_Plk_1	386	392	PF00069	0.513
MOD_Plk_1	432	438	PF00069	0.479
MOD_Plk_1	54	60	PF00069	0.614
MOD_Plk_1	674	680	PF00069	0.400
MOD_Plk_1	83	89	PF00069	0.570
MOD_Plk_2-3	412	418	PF00069	0.429
MOD_Plk_2-3	621	627	PF00069	0.557
MOD_Plk_4	247	253	PF00069	0.670
MOD_Plk_4	303	309	PF00069	0.407
MOD_Plk_4	322	328	PF00069	0.339
MOD_Plk_4	446	452	PF00069	0.442
MOD_Plk_4	462	468	PF00069	0.278
MOD_ProDKin_1	286	292	PF00069	0.429
MOD_ProDKin_1	344	350	PF00069	0.548
MOD_ProDKin_1	576	582	PF00069	0.618
MOD_ProDKin_1	705	711	PF00069	0.464
MOD_SUMO_rev_2	214	224	PF00179	0.498
MOD_SUMO_rev_2	41	48	PF00179	0.645
TRG_DiLeu_BaEn_2	377	383	PF01217	0.469
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.471
TRG_ENDOCYTIC_2	354	357	PF00928	0.433
TRG_ENDOCYTIC_2	455	458	PF00928	0.416
TRG_ENDOCYTIC_2	463	466	PF00928	0.476
TRG_ER_diArg_1	313	315	PF00400	0.521
TRG_ER_diArg_1	395	398	PF00400	0.526
TRG_ER_diArg_1	547	549	PF00400	0.464
TRG_ER_diArg_1	646	648	PF00400	0.484
TRG_NES_CRM1_1	519	533	PF08389	0.373
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N5	Leptomonas seymouri	68%	100%
A0A0S4JQA4	Bodo saltans	34%	98%
A0A1X0P526	Trypanosomatidae	44%	100%
A0A3Q8IIV4	Leishmania donovani	91%	100%
A0A422NCN3	Trypanosoma rangeli	43%	100%
A4HNH4	Leishmania braziliensis	80%	100%
C9ZYD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AFY5	Leishmania major	91%	100%
V5BYQ9	Trypanosoma cruzi	42%	100%