60S ribosomal protein L37

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L37

Species:

Leishmania mexicana

UniProt:

E9B736_LEIMU

TriTrypDb:

LmxM.34.5100

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	9
GO:0044391	ribosomal subunit	3	2
GO:1990904	ribonucleoprotein complex	2	9
GO:0005730	nucleolus	5	1

Expansion

Sequence features

E9B736

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B736

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	13
GO:0019843	rRNA binding	5	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.268
CLV_NRD_NRD_1	38	40	PF00675	0.268
CLV_NRD_NRD_1	50	52	PF00675	0.384
CLV_NRD_NRD_1	65	67	PF00675	0.248
CLV_PCSK_KEX2_1	13	15	PF00082	0.268
CLV_PCSK_KEX2_1	37	39	PF00082	0.268
CLV_PCSK_KEX2_1	48	50	PF00082	0.381
CLV_PCSK_KEX2_1	65	67	PF00082	0.389
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.381
CLV_PCSK_PC7_1	34	40	PF00082	0.268
CLV_PCSK_SKI1_1	45	49	PF00082	0.384
CLV_PCSK_SKI1_1	58	62	PF00082	0.432
DOC_CKS1_1	71	76	PF01111	0.554
DOC_PP4_FxxP_1	71	74	PF00568	0.540
DOC_USP7_MATH_1	33	37	PF00917	0.303
DOC_WW_Pin1_4	70	75	PF00397	0.542
LIG_14-3-3_CanoR_1	17	21	PF00244	0.349
LIG_14-3-3_CanoR_1	39	45	PF00244	0.268
LIG_FHA_1	6	12	PF00498	0.268
LIG_SH2_STAT3	20	23	PF00017	0.303
LIG_SH2_STAT5	59	62	PF00017	0.413
MOD_CDK_SPK_2	70	75	PF00069	0.542
MOD_N-GLC_1	40	45	PF02516	0.268
MOD_NEK2_2	40	45	PF00069	0.303
MOD_NMyristoyl	1	7	PF02799	0.200
MOD_PKA_1	49	55	PF00069	0.391
MOD_PKA_2	16	22	PF00069	0.349
MOD_PKA_2	33	39	PF00069	0.295
MOD_PKA_2	49	55	PF00069	0.327
MOD_PKB_1	49	57	PF00069	0.422
MOD_Plk_1	40	46	PF00069	0.269
MOD_ProDKin_1	70	76	PF00069	0.551
TRG_ENDOCYTIC_2	59	62	PF00928	0.420
TRG_ER_diArg_1	37	39	PF00400	0.268
TRG_ER_diArg_1	49	51	PF00400	0.381
TRG_ER_diArg_1	56	59	PF00400	0.377
TRG_ER_diArg_1	65	67	PF00400	0.423
TRG_NLS_Bipartite_1	37	52	PF00514	0.268
TRG_NLS_MonoCore_2	47	52	PF00514	0.417
TRG_NLS_MonoExtN_4	45	52	PF00514	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q8	Leptomonas seymouri	99%	92%
A0A0S4IIV4	Bodo saltans	88%	90%
A0A1D8PF45	Candida albicans (strain SC5314 / ATCC MYA-2876)	55%	84%
A0A3Q8IHK7	Leishmania donovani	100%	92%
A0A3S7XA17	Leishmania donovani	97%	92%
A3DN33	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	50%	100%
A4HNH2	Leishmania braziliensis	97%	100%
A4IC63	Leishmania infantum	100%	100%
B8D688	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	53%	100%
C9ZYE0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	93%	90%
E9AEH2	Leishmania major	100%	100%
E9AFY3	Leishmania major	100%	100%
E9AHN8	Leishmania infantum	100%	92%
E9B433	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O44125	Schistosoma mansoni	53%	86%
P05733	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	84%
P0DJ24	Tetrahymena thermophila (strain SB210)	53%	81%
P49166	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	55%	86%
P49622	Caenorhabditis elegans	52%	84%
P51402	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	86%
P54011	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	49%	100%
P59289	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	85%
P61927	Homo sapiens	51%	78%
P61928	Rattus norvegicus	51%	78%
P62885	Leishmania donovani	100%	92%
P62886	Leishmania infantum	100%	92%
P79244	Bos taurus	51%	78%
Q43292	Arabidopsis thaliana	58%	80%
Q54MG6	Dictyostelium discoideum	56%	84%
Q6BPF6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	55%	86%
Q8LEM8	Arabidopsis thaliana	58%	80%
Q8LFH7	Arabidopsis thaliana	58%	80%
Q8SRH5	Encephalitozoon cuniculi (strain GB-M1)	48%	84%
Q90YT1	Ictalurus punctatus	53%	78%
Q962S7	Spodoptera frugiperda	58%	83%
Q9C0T1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	55%	83%
Q9D823	Mus musculus	51%	78%
Q9P836	Candida albicans	55%	86%
Q9VXX8	Drosophila melanogaster	61%	82%
Q9W1U6	Drosophila melanogaster	50%	85%
Q9YEQ4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	54%	100%