Mediator of RNA polymerase II transcription subunit 21

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B734_LEIMU

TriTrypDb:

LmxM.34.5080

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B734

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B734

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.284
CLV_PCSK_SKI1_1	130	134	PF00082	0.480
CLV_PCSK_SKI1_1	85	89	PF00082	0.527
CLV_PCSK_SKI1_1	96	100	PF00082	0.552
CLV_Separin_Metazoa	41	45	PF03568	0.465
DEG_APCC_DBOX_1	100	108	PF00400	0.500
DEG_APCC_DBOX_1	38	46	PF00400	0.454
DOC_CYCLIN_RxL_1	82	92	PF00134	0.542
DOC_MAPK_gen_1	130	139	PF00069	0.534
DOC_MAPK_gen_1	37	45	PF00069	0.467
DOC_PP1_RVXF_1	165	171	PF00149	0.447
DOC_PP4_FxxP_1	4	7	PF00568	0.432
LIG_14-3-3_CanoR_1	167	171	PF00244	0.507
LIG_14-3-3_CanoR_1	72	78	PF00244	0.505
LIG_14-3-3_CanoR_1	9	14	PF00244	0.532
LIG_Actin_WH2_2	10	28	PF00022	0.546
LIG_APCC_ABBA_1	43	48	PF00400	0.527
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_Clathr_ClatBox_1	50	54	PF01394	0.320
LIG_FHA_1	72	78	PF00498	0.507
LIG_FHA_1	89	95	PF00498	0.336
LIG_FHA_2	22	28	PF00498	0.548
LIG_LIR_Apic_2	2	7	PF02991	0.471
LIG_LIR_Gen_1	75	86	PF02991	0.432
LIG_LIR_Nem_3	75	81	PF02991	0.424
LIG_PDZ_Class_1	166	171	PF00595	0.501
LIG_SH2_CRK	84	88	PF00017	0.569
LIG_SH2_STAP1	31	35	PF00017	0.523
LIG_SH2_STAT3	46	49	PF00017	0.561
LIG_UBA3_1	77	85	PF00899	0.504
MOD_CK1_1	110	116	PF00069	0.625
MOD_CK1_1	12	18	PF00069	0.493
MOD_CK1_1	151	157	PF00069	0.272
MOD_CK1_1	56	62	PF00069	0.563
MOD_CK1_1	71	77	PF00069	0.385
MOD_CK1_1	90	96	PF00069	0.306
MOD_CK2_1	21	27	PF00069	0.561
MOD_GlcNHglycan	109	112	PF01048	0.584
MOD_GSK3_1	128	135	PF00069	0.330
MOD_GSK3_1	151	158	PF00069	0.520
MOD_GSK3_1	67	74	PF00069	0.463
MOD_NEK2_1	107	112	PF00069	0.604
MOD_NEK2_1	11	16	PF00069	0.488
MOD_PIKK_1	110	116	PF00454	0.600
MOD_PIKK_1	151	157	PF00454	0.523
MOD_PK_1	9	15	PF00069	0.597
MOD_PKA_2	71	77	PF00069	0.470
MOD_Plk_1	56	62	PF00069	0.539
MOD_Plk_2-3	128	134	PF00069	0.526
MOD_Plk_4	12	18	PF00069	0.500
MOD_Plk_4	132	138	PF00069	0.481
MOD_SUMO_for_1	20	23	PF00179	0.547
TRG_DiLeu_BaEn_1	103	108	PF01217	0.540
TRG_ENDOCYTIC_2	84	87	PF00928	0.534
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHH3	Leptomonas seymouri	52%	100%
A0A0S4JTH6	Bodo saltans	23%	97%
A0A1X0P528	Trypanosomatidae	27%	100%
A0A422NCM8	Trypanosoma rangeli	27%	100%
A4HNH0	Leishmania braziliensis	68%	100%
C9ZYE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AFY1	Leishmania major	90%	100%
Q25302	Leishmania infantum	89%	100%