EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B733_LEIMU

TriTrypDb:

LmxM.34.5070

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B733

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B733

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	108	112	PF00082	0.404
CLV_PCSK_SKI1_1	55	59	PF00082	0.442
CLV_PCSK_SKI1_1	67	71	PF00082	0.402
DOC_MAPK_MEF2A_6	124	132	PF00069	0.469
DOC_PP1_RVXF_1	65	71	PF00149	0.473
DOC_USP7_MATH_1	100	104	PF00917	0.450
DOC_USP7_MATH_2	100	106	PF00917	0.407
DOC_USP7_UBL2_3	108	112	PF12436	0.446
DOC_WW_Pin1_4	117	122	PF00397	0.369
LIG_14-3-3_CanoR_1	78	84	PF00244	0.480
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_BRCT_BRCA1_1	76	80	PF00533	0.524
LIG_Clathr_ClatBox_1	131	135	PF01394	0.474
LIG_deltaCOP1_diTrp_1	85	89	PF00928	0.467
LIG_FHA_1	162	168	PF00498	0.493
LIG_FHA_2	47	53	PF00498	0.577
LIG_FHA_2	80	86	PF00498	0.331
LIG_LIR_Gen_1	85	92	PF02991	0.370
LIG_LIR_Nem_3	135	141	PF02991	0.392
LIG_LIR_Nem_3	155	161	PF02991	0.277
LIG_LIR_Nem_3	51	57	PF02991	0.474
LIG_LIR_Nem_3	77	83	PF02991	0.470
LIG_LIR_Nem_3	85	89	PF02991	0.349
LIG_REV1ctd_RIR_1	108	116	PF16727	0.403
LIG_SH2_CRK	158	162	PF00017	0.545
LIG_SH2_NCK_1	143	147	PF00017	0.487
LIG_SH2_STAP1	115	119	PF00017	0.395
LIG_SH2_STAT5	141	144	PF00017	0.529
LIG_SH2_STAT5	38	41	PF00017	0.439
LIG_SUMO_SIM_anti_2	5	15	PF11976	0.509
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.413
LIG_SUMO_SIM_par_1	127	133	PF11976	0.480
LIG_TRAF2_1	88	91	PF00917	0.446
MOD_CDK_SPxxK_3	117	124	PF00069	0.286
MOD_CK1_1	2	8	PF00069	0.664
MOD_CK2_1	3	9	PF00069	0.640
MOD_CK2_1	46	52	PF00069	0.554
MOD_CK2_1	79	85	PF00069	0.469
MOD_GlcNHglycan	104	107	PF01048	0.448
MOD_GSK3_1	90	97	PF00069	0.518
MOD_NEK2_1	161	166	PF00069	0.508
MOD_PIKK_1	32	38	PF00454	0.358
MOD_PKA_2	94	100	PF00069	0.628
MOD_Plk_1	61	67	PF00069	0.259
MOD_Plk_2-3	152	158	PF00069	0.440
MOD_Plk_2-3	3	9	PF00069	0.665
MOD_Plk_2-3	94	100	PF00069	0.540
MOD_Plk_4	61	67	PF00069	0.341
MOD_ProDKin_1	117	123	PF00069	0.375
MOD_SUMO_for_1	111	114	PF00179	0.405
TRG_DiLeu_BaEn_1	157	162	PF01217	0.542
TRG_ENDOCYTIC_2	143	146	PF00928	0.482
TRG_ENDOCYTIC_2	158	161	PF00928	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC25	Leptomonas seymouri	76%	100%
A0A0S4JSV4	Bodo saltans	49%	99%
A0A1X0P4T8	Trypanosomatidae	55%	93%
A0A3S7XA39	Leishmania donovani	97%	100%
A0A422ND44	Trypanosoma rangeli	51%	100%
A0A6L0Y1J4	Leishmania infantum	97%	100%
A4HNG9	Leishmania braziliensis	92%	100%
C9ZYE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AFY0	Leishmania major	96%	100%