bVLRF1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B732_LEIMU

TriTrypDb:

LmxM.34.5060

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B732

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B732

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.675
CLV_NRD_NRD_1	114	116	PF00675	0.643
CLV_NRD_NRD_1	383	385	PF00675	0.260
CLV_NRD_NRD_1	494	496	PF00675	0.323
CLV_PCSK_KEX2_1	114	116	PF00082	0.690
CLV_PCSK_KEX2_1	138	140	PF00082	0.668
CLV_PCSK_KEX2_1	494	496	PF00082	0.323
CLV_PCSK_KEX2_1	70	72	PF00082	0.510
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.668
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.510
CLV_PCSK_SKI1_1	209	213	PF00082	0.467
CLV_PCSK_SKI1_1	345	349	PF00082	0.329
CLV_PCSK_SKI1_1	42	46	PF00082	0.519
CLV_PCSK_SKI1_1	421	425	PF00082	0.240
CLV_PCSK_SKI1_1	447	451	PF00082	0.240
DEG_APCC_DBOX_1	41	49	PF00400	0.523
DEG_APCC_DBOX_1	501	509	PF00400	0.555
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DEG_SCF_FBW7_1	17	24	PF00400	0.461
DEG_SPOP_SBC_1	190	194	PF00917	0.575
DEG_SPOP_SBC_1	284	288	PF00917	0.739
DOC_MAPK_gen_1	474	483	PF00069	0.508
DOC_PP1_RVXF_1	207	213	PF00149	0.361
DOC_PP2B_LxvP_1	330	333	PF13499	0.569
DOC_PP4_FxxP_1	271	274	PF00568	0.435
DOC_USP7_MATH_1	110	114	PF00917	0.740
DOC_USP7_MATH_1	116	120	PF00917	0.786
DOC_USP7_MATH_1	165	169	PF00917	0.634
DOC_USP7_MATH_1	203	207	PF00917	0.327
DOC_USP7_MATH_1	258	262	PF00917	0.571
DOC_USP7_MATH_1	284	288	PF00917	0.738
DOC_USP7_MATH_1	458	462	PF00917	0.504
DOC_USP7_MATH_1	46	50	PF00917	0.536
DOC_USP7_MATH_1	476	480	PF00917	0.546
DOC_USP7_UBL2_3	118	122	PF12436	0.651
DOC_USP7_UBL2_3	124	128	PF12436	0.658
DOC_USP7_UBL2_3	386	390	PF12436	0.440
DOC_WW_Pin1_4	17	22	PF00397	0.520
DOC_WW_Pin1_4	280	285	PF00397	0.680
DOC_WW_Pin1_4	466	471	PF00397	0.466
LIG_14-3-3_CanoR_1	209	218	PF00244	0.558
LIG_14-3-3_CanoR_1	22	26	PF00244	0.509
LIG_14-3-3_CanoR_1	345	354	PF00244	0.292
LIG_14-3-3_CanoR_1	447	457	PF00244	0.440
LIG_14-3-3_CanoR_1	480	490	PF00244	0.494
LIG_14-3-3_CanoR_1	502	506	PF00244	0.575
LIG_BRCT_BRCA1_1	336	340	PF00533	0.548
LIG_BRCT_BRCA1_1	85	89	PF00533	0.647
LIG_FHA_1	169	175	PF00498	0.577
LIG_FHA_1	211	217	PF00498	0.420
LIG_FHA_1	22	28	PF00498	0.553
LIG_FHA_1	327	333	PF00498	0.499
LIG_FHA_1	346	352	PF00498	0.516
LIG_FHA_1	9	15	PF00498	0.520
LIG_FHA_2	138	144	PF00498	0.780
LIG_FHA_2	21	27	PF00498	0.493
LIG_FHA_2	236	242	PF00498	0.446
LIG_FHA_2	284	290	PF00498	0.646
LIG_FHA_2	293	299	PF00498	0.805
LIG_FHA_2	305	311	PF00498	0.549
LIG_FHA_2	487	493	PF00498	0.471
LIG_LIR_Apic_2	238	242	PF02991	0.327
LIG_LIR_Apic_2	268	274	PF02991	0.434
LIG_LIR_Gen_1	170	180	PF02991	0.494
LIG_LIR_Gen_1	349	356	PF02991	0.346
LIG_LIR_Gen_1	398	408	PF02991	0.536
LIG_LIR_Gen_1	451	460	PF02991	0.472
LIG_LIR_Gen_1	489	497	PF02991	0.453
LIG_LIR_Nem_3	170	176	PF02991	0.511
LIG_LIR_Nem_3	228	233	PF02991	0.367
LIG_LIR_Nem_3	349	355	PF02991	0.363
LIG_LIR_Nem_3	398	404	PF02991	0.440
LIG_LIR_Nem_3	426	430	PF02991	0.471
LIG_LIR_Nem_3	435	439	PF02991	0.458
LIG_LIR_Nem_3	451	456	PF02991	0.377
LIG_LIR_Nem_3	489	493	PF02991	0.453
LIG_PCNA_yPIPBox_3	198	211	PF02747	0.503
LIG_PDZ_Class_3	508	513	PF00595	0.325
LIG_Pex14_2	85	89	PF04695	0.647
LIG_SH2_CRK	230	234	PF00017	0.367
LIG_SH2_CRK	401	405	PF00017	0.440
LIG_SH2_CRK	439	443	PF00017	0.535
LIG_SH2_NCK_1	316	320	PF00017	0.502
LIG_SH2_NCK_1	401	405	PF00017	0.535
LIG_SH2_NCK_1	439	443	PF00017	0.535
LIG_SH2_STAT3	507	510	PF00017	0.464
LIG_SH2_STAT3	52	55	PF00017	0.521
LIG_SH2_STAT5	361	364	PF00017	0.440
LIG_SH2_STAT5	381	384	PF00017	0.440
LIG_SH2_STAT5	430	433	PF00017	0.440
LIG_SH2_STAT5	507	510	PF00017	0.364
LIG_SH2_STAT5	52	55	PF00017	0.404
LIG_SH3_3	143	149	PF00018	0.672
LIG_TRAF2_1	322	325	PF00917	0.605
LIG_TRAF2_1	410	413	PF00917	0.535
LIG_TRAF2_1	489	492	PF00917	0.453
LIG_TRAF2_1	90	93	PF00917	0.603
LIG_TRAF2_2	470	475	PF00917	0.492
LIG_TRFH_1	453	457	PF08558	0.535
MOD_CDK_SPK_2	17	22	PF00069	0.559
MOD_CDK_SPK_2	280	285	PF00069	0.605
MOD_CK1_1	167	173	PF00069	0.706
MOD_CK1_1	283	289	PF00069	0.746
MOD_CK1_1	400	406	PF00069	0.443
MOD_CK1_1	501	507	PF00069	0.489
MOD_CK2_1	1	7	PF00069	0.471
MOD_CK2_1	117	123	PF00069	0.758
MOD_CK2_1	20	26	PF00069	0.377
MOD_CK2_1	235	241	PF00069	0.503
MOD_CK2_1	242	248	PF00069	0.393
MOD_CK2_1	298	304	PF00069	0.713
MOD_CK2_1	486	492	PF00069	0.453
MOD_GlcNHglycan	103	106	PF01048	0.749
MOD_GlcNHglycan	119	122	PF01048	0.565
MOD_GlcNHglycan	193	196	PF01048	0.515
MOD_GlcNHglycan	296	301	PF01048	0.783
MOD_GlcNHglycan	47	51	PF01048	0.445
MOD_GSK3_1	13	20	PF00069	0.537
MOD_GSK3_1	163	170	PF00069	0.680
MOD_GSK3_1	210	217	PF00069	0.414
MOD_GSK3_1	280	287	PF00069	0.713
MOD_GSK3_1	292	299	PF00069	0.684
MOD_GSK3_1	458	465	PF00069	0.458
MOD_GSK3_1	482	489	PF00069	0.453
MOD_N-GLC_1	203	208	PF02516	0.331
MOD_N-GLC_1	334	339	PF02516	0.311
MOD_NEK2_1	191	196	PF00069	0.544
MOD_PIKK_1	165	171	PF00454	0.630
MOD_PIKK_1	252	258	PF00454	0.397
MOD_PIKK_1	403	409	PF00454	0.452
MOD_PKA_1	117	123	PF00069	0.706
MOD_PKA_2	21	27	PF00069	0.499
MOD_PKA_2	368	374	PF00069	0.538
MOD_PKA_2	476	482	PF00069	0.552
MOD_PKA_2	486	492	PF00069	0.375
MOD_PKA_2	501	507	PF00069	0.551
MOD_PKB_1	343	351	PF00069	0.437
MOD_Plk_1	203	209	PF00069	0.330
MOD_Plk_1	214	220	PF00069	0.315
MOD_Plk_1	304	310	PF00069	0.558
MOD_Plk_1	451	457	PF00069	0.479
MOD_Plk_2-3	137	143	PF00069	0.560
MOD_Plk_2-3	214	220	PF00069	0.340
MOD_Plk_2-3	298	304	PF00069	0.632
MOD_Plk_4	298	304	PF00069	0.679
MOD_Plk_4	432	438	PF00069	0.497
MOD_Plk_4	501	507	PF00069	0.567
MOD_ProDKin_1	17	23	PF00069	0.518
MOD_ProDKin_1	280	286	PF00069	0.683
MOD_ProDKin_1	466	472	PF00069	0.466
MOD_SUMO_for_1	266	269	PF00179	0.440
MOD_SUMO_rev_2	4	11	PF00179	0.437
TRG_DiLeu_BaEn_4	325	331	PF01217	0.389
TRG_ENDOCYTIC_2	230	233	PF00928	0.391
TRG_ENDOCYTIC_2	401	404	PF00928	0.440
TRG_ER_diArg_1	114	116	PF00400	0.671
TRG_ER_diArg_1	493	495	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGL8	Leptomonas seymouri	62%	99%
A0A1X0P4S2	Trypanosomatidae	40%	100%
A0A3Q8IQ93	Leishmania donovani	91%	100%
A0A3S5IQY8	Trypanosoma rangeli	38%	99%
A4HNG8	Leishmania braziliensis	74%	100%
A4IC59	Leishmania infantum	91%	100%
C9ZYE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AFX9	Leishmania major	90%	100%
V5DQH4	Trypanosoma cruzi	43%	100%