Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B731_LEIMU

TriTrypDb:

LmxM.34.5050

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B731

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B731

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.629
CLV_C14_Caspase3-7	107	111	PF00656	0.520
CLV_C14_Caspase3-7	133	137	PF00656	0.632
CLV_NRD_NRD_1	19	21	PF00675	0.791
CLV_NRD_NRD_1	329	331	PF00675	0.567
CLV_NRD_NRD_1	373	375	PF00675	0.682
CLV_NRD_NRD_1	377	379	PF00675	0.647
CLV_NRD_NRD_1	412	414	PF00675	0.646
CLV_NRD_NRD_1	520	522	PF00675	0.707
CLV_NRD_NRD_1	545	547	PF00675	0.696
CLV_NRD_NRD_1	583	585	PF00675	0.714
CLV_NRD_NRD_1	590	592	PF00675	0.646
CLV_PCSK_FUR_1	374	378	PF00082	0.637
CLV_PCSK_FUR_1	517	521	PF00082	0.676
CLV_PCSK_FUR_1	588	592	PF00082	0.713
CLV_PCSK_KEX2_1	19	21	PF00082	0.701
CLV_PCSK_KEX2_1	329	331	PF00082	0.567
CLV_PCSK_KEX2_1	373	375	PF00082	0.682
CLV_PCSK_KEX2_1	376	378	PF00082	0.658
CLV_PCSK_KEX2_1	412	414	PF00082	0.646
CLV_PCSK_KEX2_1	519	521	PF00082	0.716
CLV_PCSK_KEX2_1	545	547	PF00082	0.696
CLV_PCSK_KEX2_1	583	585	PF00082	0.714
CLV_PCSK_KEX2_1	590	592	PF00082	0.646
CLV_PCSK_PC7_1	373	379	PF00082	0.636
CLV_PCSK_SKI1_1	190	194	PF00082	0.658
CLV_PCSK_SKI1_1	243	247	PF00082	0.640
CLV_PCSK_SKI1_1	36	40	PF00082	0.632
CLV_PCSK_SKI1_1	558	562	PF00082	0.650
CLV_PCSK_SKI1_1	72	76	PF00082	0.594
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DEG_SPOP_SBC_1	214	218	PF00917	0.668
DEG_SPOP_SBC_1	40	44	PF00917	0.662
DEG_SPOP_SBC_1	417	421	PF00917	0.597
DOC_ANK_TNKS_1	460	467	PF00023	0.620
DOC_CKS1_1	83	88	PF01111	0.724
DOC_CYCLIN_RxL_1	69	78	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	180	183	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	564	570	PF00134	0.641
DOC_MAPK_MEF2A_6	558	566	PF00069	0.649
DOC_MAPK_RevD_3	359	374	PF00069	0.659
DOC_PP2B_LxvP_1	180	183	PF13499	0.644
DOC_PP2B_LxvP_1	224	227	PF13499	0.715
DOC_PP2B_LxvP_1	265	268	PF13499	0.687
DOC_PP2B_LxvP_1	288	291	PF13499	0.514
DOC_PP2B_LxvP_1	564	567	PF13499	0.644
DOC_SPAK_OSR1_1	357	361	PF12202	0.676
DOC_USP7_MATH_1	152	156	PF00917	0.650
DOC_USP7_MATH_1	192	196	PF00917	0.684
DOC_USP7_MATH_1	214	218	PF00917	0.590
DOC_USP7_MATH_1	227	231	PF00917	0.561
DOC_USP7_MATH_1	275	279	PF00917	0.736
DOC_USP7_MATH_1	313	317	PF00917	0.562
DOC_USP7_MATH_1	393	397	PF00917	0.655
DOC_USP7_MATH_1	418	422	PF00917	0.657
DOC_USP7_MATH_1	439	443	PF00917	0.541
DOC_USP7_MATH_1	511	515	PF00917	0.723
DOC_USP7_MATH_1	560	564	PF00917	0.572
DOC_USP7_MATH_1	634	638	PF00917	0.628
DOC_USP7_MATH_1	91	95	PF00917	0.604
DOC_WW_Pin1_4	202	207	PF00397	0.716
DOC_WW_Pin1_4	219	224	PF00397	0.549
DOC_WW_Pin1_4	309	314	PF00397	0.622
DOC_WW_Pin1_4	335	340	PF00397	0.786
DOC_WW_Pin1_4	388	393	PF00397	0.642
DOC_WW_Pin1_4	424	429	PF00397	0.564
DOC_WW_Pin1_4	441	446	PF00397	0.670
DOC_WW_Pin1_4	454	459	PF00397	0.608
DOC_WW_Pin1_4	502	507	PF00397	0.599
DOC_WW_Pin1_4	509	514	PF00397	0.656
DOC_WW_Pin1_4	536	541	PF00397	0.613
DOC_WW_Pin1_4	558	563	PF00397	0.678
DOC_WW_Pin1_4	578	583	PF00397	0.527
DOC_WW_Pin1_4	58	63	PF00397	0.685
DOC_WW_Pin1_4	592	597	PF00397	0.555
DOC_WW_Pin1_4	621	626	PF00397	0.775
DOC_WW_Pin1_4	82	87	PF00397	0.820
LIG_14-3-3_CanoR_1	103	107	PF00244	0.679
LIG_14-3-3_CanoR_1	173	182	PF00244	0.574
LIG_14-3-3_CanoR_1	407	414	PF00244	0.659
LIG_14-3-3_CanoR_1	441	445	PF00244	0.622
LIG_14-3-3_CanoR_1	90	96	PF00244	0.701
LIG_Actin_WH2_2	615	633	PF00022	0.533
LIG_BRCT_BRCA1_1	154	158	PF00533	0.503
LIG_CtBP_PxDLS_1	206	210	PF00389	0.675
LIG_EVH1_1	265	269	PF00568	0.688
LIG_FHA_1	26	32	PF00498	0.692
LIG_FHA_1	503	509	PF00498	0.635
LIG_FHA_1	559	565	PF00498	0.649
LIG_FHA_2	398	404	PF00498	0.630
LIG_FHA_2	432	438	PF00498	0.595
LIG_LIR_Apic_2	595	601	PF02991	0.678
LIG_LIR_Gen_1	355	364	PF02991	0.667
LIG_LIR_Gen_1	55	65	PF02991	0.617
LIG_LIR_Nem_3	218	224	PF02991	0.779
LIG_LIR_Nem_3	355	361	PF02991	0.672
LIG_LIR_Nem_3	55	60	PF02991	0.665
LIG_MYND_1	96	100	PF01753	0.698
LIG_RPA_C_Fungi	541	553	PF08784	0.701
LIG_SH2_CRK	57	61	PF00017	0.669
LIG_SH2_CRK	598	602	PF00017	0.680
LIG_SH2_NCK_1	598	602	PF00017	0.680
LIG_SH3_1	19	25	PF00018	0.681
LIG_SH3_1	263	269	PF00018	0.688
LIG_SH3_3	19	25	PF00018	0.681
LIG_SH3_3	263	269	PF00018	0.754
LIG_SH3_3	28	34	PF00018	0.616
LIG_SH3_3	328	334	PF00018	0.708
LIG_SH3_3	347	353	PF00018	0.802
LIG_SH3_3	361	367	PF00018	0.654
LIG_SH3_3	619	625	PF00018	0.677
LIG_SH3_3	77	83	PF00018	0.707
LIG_SH3_3	94	100	PF00018	0.600
LIG_SUMO_SIM_par_1	200	205	PF11976	0.529
MOD_CDC14_SPxK_1	581	584	PF00782	0.702
MOD_CDC14_SPxK_1	624	627	PF00782	0.667
MOD_CDC14_SPxK_1	628	631	PF00782	0.695
MOD_CDK_SPK_2	578	583	PF00069	0.701
MOD_CDK_SPxK_1	578	584	PF00069	0.703
MOD_CDK_SPxK_1	621	627	PF00069	0.671
MOD_CDK_SPxxK_3	454	461	PF00069	0.567
MOD_CK1_1	105	111	PF00069	0.616
MOD_CK1_1	127	133	PF00069	0.686
MOD_CK1_1	167	173	PF00069	0.699
MOD_CK1_1	175	181	PF00069	0.608
MOD_CK1_1	205	211	PF00069	0.782
MOD_CK1_1	217	223	PF00069	0.643
MOD_CK1_1	231	237	PF00069	0.561
MOD_CK1_1	256	262	PF00069	0.683
MOD_CK1_1	454	460	PF00069	0.615
MOD_CK1_1	498	504	PF00069	0.633
MOD_CK1_1	548	554	PF00069	0.665
MOD_CK1_1	594	600	PF00069	0.683
MOD_CK1_1	604	610	PF00069	0.584
MOD_CK2_1	294	300	PF00069	0.622
MOD_CK2_1	322	328	PF00069	0.627
MOD_CK2_1	397	403	PF00069	0.629
MOD_CK2_1	459	465	PF00069	0.572
MOD_DYRK1A_RPxSP_1	441	445	PF00069	0.731
MOD_DYRK1A_RPxSP_1	558	562	PF00069	0.650
MOD_DYRK1A_RPxSP_1	621	625	PF00069	0.640
MOD_DYRK1A_RPxSP_1	82	86	PF00069	0.720
MOD_GlcNHglycan	133	136	PF01048	0.591
MOD_GlcNHglycan	161	164	PF01048	0.679
MOD_GlcNHglycan	175	178	PF01048	0.566
MOD_GlcNHglycan	277	280	PF01048	0.740
MOD_GlcNHglycan	296	299	PF01048	0.603
MOD_GlcNHglycan	367	370	PF01048	0.731
MOD_GlcNHglycan	420	423	PF01048	0.658
MOD_GlcNHglycan	424	427	PF01048	0.634
MOD_GlcNHglycan	48	51	PF01048	0.604
MOD_GlcNHglycan	497	500	PF01048	0.765
MOD_GlcNHglycan	513	516	PF01048	0.599
MOD_GlcNHglycan	521	524	PF01048	0.667
MOD_GlcNHglycan	548	551	PF01048	0.660
MOD_GlcNHglycan	572	576	PF01048	0.639
MOD_GlcNHglycan	585	588	PF01048	0.568
MOD_GlcNHglycan	611	615	PF01048	0.676
MOD_GlcNHglycan	632	635	PF01048	0.544
MOD_GSK3_1	102	109	PF00069	0.754
MOD_GSK3_1	124	131	PF00069	0.713
MOD_GSK3_1	169	176	PF00069	0.534
MOD_GSK3_1	188	195	PF00069	0.720
MOD_GSK3_1	213	220	PF00069	0.581
MOD_GSK3_1	227	234	PF00069	0.561
MOD_GSK3_1	289	296	PF00069	0.647
MOD_GSK3_1	309	316	PF00069	0.528
MOD_GSK3_1	32	39	PF00069	0.783
MOD_GSK3_1	393	400	PF00069	0.625
MOD_GSK3_1	40	47	PF00069	0.630
MOD_GSK3_1	416	423	PF00069	0.687
MOD_GSK3_1	452	459	PF00069	0.697
MOD_GSK3_1	498	505	PF00069	0.576
MOD_GSK3_1	52	59	PF00069	0.503
MOD_GSK3_1	617	624	PF00069	0.702
MOD_GSK3_1	630	637	PF00069	0.586
MOD_GSK3_1	78	85	PF00069	0.717
MOD_N-GLC_1	128	133	PF02516	0.661
MOD_N-GLC_1	159	164	PF02516	0.512
MOD_N-GLC_1	36	41	PF02516	0.640
MOD_N-GLC_1	578	583	PF02516	0.532
MOD_N-GLC_2	446	448	PF02516	0.562
MOD_NEK2_1	164	169	PF00069	0.683
MOD_NEK2_1	253	258	PF00069	0.646
MOD_NEK2_1	27	32	PF00069	0.702
MOD_NEK2_1	293	298	PF00069	0.558
MOD_NEK2_1	314	319	PF00069	0.650
MOD_NEK2_1	38	43	PF00069	0.540
MOD_NEK2_1	397	402	PF00069	0.611
MOD_NEK2_1	630	635	PF00069	0.542
MOD_NEK2_2	152	157	PF00069	0.501
MOD_NEK2_2	393	398	PF00069	0.637
MOD_PIKK_1	253	259	PF00454	0.498
MOD_PIKK_1	322	328	PF00454	0.554
MOD_PIKK_1	456	462	PF00454	0.663
MOD_PIKK_1	551	557	PF00454	0.711
MOD_PKA_1	519	525	PF00069	0.672
MOD_PKA_1	545	551	PF00069	0.702
MOD_PKA_1	583	589	PF00069	0.663
MOD_PKA_2	102	108	PF00069	0.737
MOD_PKA_2	167	173	PF00069	0.685
MOD_PKA_2	32	38	PF00069	0.758
MOD_PKA_2	406	412	PF00069	0.651
MOD_PKA_2	440	446	PF00069	0.621
MOD_PKA_2	519	525	PF00069	0.672
MOD_PKA_2	545	551	PF00069	0.702
MOD_PKA_2	583	589	PF00069	0.663
MOD_PKB_1	517	525	PF00069	0.669
MOD_Plk_1	159	165	PF00069	0.585
MOD_Plk_1	253	259	PF00069	0.571
MOD_Plk_1	304	310	PF00069	0.679
MOD_Plk_1	353	359	PF00069	0.739
MOD_Plk_2-3	102	108	PF00069	0.520
MOD_Plk_4	27	33	PF00069	0.647
MOD_Plk_4	289	295	PF00069	0.552
MOD_Plk_4	393	399	PF00069	0.686
MOD_Plk_4	474	480	PF00069	0.637
MOD_Plk_4	538	544	PF00069	0.639
MOD_Plk_4	601	607	PF00069	0.681
MOD_ProDKin_1	202	208	PF00069	0.716
MOD_ProDKin_1	219	225	PF00069	0.549
MOD_ProDKin_1	309	315	PF00069	0.617
MOD_ProDKin_1	335	341	PF00069	0.786
MOD_ProDKin_1	388	394	PF00069	0.638
MOD_ProDKin_1	424	430	PF00069	0.565
MOD_ProDKin_1	441	447	PF00069	0.671
MOD_ProDKin_1	454	460	PF00069	0.609
MOD_ProDKin_1	502	508	PF00069	0.600
MOD_ProDKin_1	509	515	PF00069	0.656
MOD_ProDKin_1	536	542	PF00069	0.614
MOD_ProDKin_1	558	564	PF00069	0.679
MOD_ProDKin_1	578	584	PF00069	0.529
MOD_ProDKin_1	58	64	PF00069	0.686
MOD_ProDKin_1	592	598	PF00069	0.556
MOD_ProDKin_1	621	627	PF00069	0.777
MOD_ProDKin_1	82	88	PF00069	0.820
TRG_DiLeu_BaEn_1	474	479	PF01217	0.587
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.582
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.705
TRG_ENDOCYTIC_2	57	60	PF00928	0.671
TRG_ER_diArg_1	112	115	PF00400	0.571
TRG_ER_diArg_1	18	20	PF00400	0.701
TRG_ER_diArg_1	329	331	PF00400	0.567
TRG_ER_diArg_1	373	376	PF00400	0.681
TRG_ER_diArg_1	412	414	PF00400	0.644
TRG_ER_diArg_1	517	520	PF00400	0.708
TRG_ER_diArg_1	544	546	PF00400	0.576
TRG_ER_diArg_1	582	584	PF00400	0.704
TRG_ER_diArg_1	588	591	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H810	Leishmania donovani	82%	100%
A4HNG7	Leishmania braziliensis	61%	100%
A4IC58	Leishmania infantum	81%	100%
E9AFX8	Leishmania major	82%	100%