Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B729_LEIMU

TriTrypDb:

LmxM.34.5030

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B729

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B729

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.597
CLV_C14_Caspase3-7	505	509	PF00656	0.342
CLV_NRD_NRD_1	135	137	PF00675	0.514
CLV_NRD_NRD_1	149	151	PF00675	0.481
CLV_NRD_NRD_1	159	161	PF00675	0.431
CLV_NRD_NRD_1	229	231	PF00675	0.387
CLV_NRD_NRD_1	267	269	PF00675	0.390
CLV_NRD_NRD_1	305	307	PF00675	0.447
CLV_NRD_NRD_1	42	44	PF00675	0.513
CLV_NRD_NRD_1	457	459	PF00675	0.561
CLV_NRD_NRD_1	63	65	PF00675	0.555
CLV_NRD_NRD_1	73	75	PF00675	0.479
CLV_PCSK_FUR_1	303	307	PF00082	0.427
CLV_PCSK_KEX2_1	135	137	PF00082	0.522
CLV_PCSK_KEX2_1	149	151	PF00082	0.481
CLV_PCSK_KEX2_1	158	160	PF00082	0.445
CLV_PCSK_KEX2_1	266	268	PF00082	0.396
CLV_PCSK_KEX2_1	305	307	PF00082	0.447
CLV_PCSK_KEX2_1	457	459	PF00082	0.573
CLV_PCSK_KEX2_1	73	75	PF00082	0.473
CLV_PCSK_PC7_1	154	160	PF00082	0.488
CLV_PCSK_SKI1_1	202	206	PF00082	0.481
CLV_PCSK_SKI1_1	267	271	PF00082	0.440
CLV_PCSK_SKI1_1	278	282	PF00082	0.528
CLV_PCSK_SKI1_1	338	342	PF00082	0.520
CLV_PCSK_SKI1_1	476	480	PF00082	0.485
CLV_PCSK_SKI1_1	97	101	PF00082	0.468
DEG_APCC_DBOX_1	7	15	PF00400	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DOC_CKS1_1	363	368	PF01111	0.713
DOC_CKS1_1	374	379	PF01111	0.574
DOC_CKS1_1	50	55	PF01111	0.594
DOC_CKS1_1	526	531	PF01111	0.342
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.550
DOC_MAPK_MEF2A_6	164	172	PF00069	0.692
DOC_PP1_RVXF_1	328	334	PF00149	0.655
DOC_PP1_RVXF_1	42	49	PF00149	0.706
DOC_PP4_FxxP_1	205	208	PF00568	0.608
DOC_PP4_FxxP_1	383	386	PF00568	0.613
DOC_USP7_MATH_1	128	132	PF00917	0.768
DOC_USP7_MATH_1	162	166	PF00917	0.667
DOC_USP7_MATH_1	273	277	PF00917	0.601
DOC_USP7_MATH_1	386	390	PF00917	0.691
DOC_USP7_MATH_1	406	410	PF00917	0.553
DOC_USP7_MATH_1	489	493	PF00917	0.395
DOC_USP7_MATH_1	509	513	PF00917	0.336
DOC_USP7_MATH_1	514	518	PF00917	0.304
DOC_USP7_UBL2_3	177	181	PF12436	0.677
DOC_WW_Pin1_4	122	127	PF00397	0.745
DOC_WW_Pin1_4	164	169	PF00397	0.683
DOC_WW_Pin1_4	283	288	PF00397	0.652
DOC_WW_Pin1_4	355	360	PF00397	0.742
DOC_WW_Pin1_4	362	367	PF00397	0.699
DOC_WW_Pin1_4	373	378	PF00397	0.535
DOC_WW_Pin1_4	396	401	PF00397	0.671
DOC_WW_Pin1_4	49	54	PF00397	0.595
DOC_WW_Pin1_4	525	530	PF00397	0.359
LIG_14-3-3_CanoR_1	135	141	PF00244	0.752
LIG_14-3-3_CanoR_1	164	168	PF00244	0.691
LIG_14-3-3_CanoR_1	235	243	PF00244	0.735
LIG_14-3-3_CanoR_1	64	69	PF00244	0.745
LIG_14-3-3_CanoR_1	73	82	PF00244	0.673
LIG_APCC_ABBA_1	472	477	PF00400	0.314
LIG_BIR_III_2	508	512	PF00653	0.338
LIG_BRCT_BRCA1_1	16	20	PF00533	0.582
LIG_CSL_BTD_1	363	366	PF09270	0.618
LIG_CSL_BTD_1	459	462	PF09270	0.368
LIG_FHA_1	165	171	PF00498	0.637
LIG_FHA_1	374	380	PF00498	0.633
LIG_FHA_1	489	495	PF00498	0.506
LIG_FHA_1	75	81	PF00498	0.707
LIG_FHA_2	100	106	PF00498	0.686
LIG_FHA_2	33	39	PF00498	0.702
LIG_GBD_Chelix_1	427	435	PF00786	0.208
LIG_LIR_Apic_2	203	208	PF02991	0.575
LIG_LIR_Apic_2	381	386	PF02991	0.604
LIG_LIR_Gen_1	118	128	PF02991	0.658
LIG_LIR_Gen_1	477	487	PF02991	0.348
LIG_LIR_Nem_3	118	123	PF02991	0.650
LIG_LIR_Nem_3	276	280	PF02991	0.628
LIG_LIR_Nem_3	40	45	PF02991	0.665
LIG_LIR_Nem_3	477	482	PF02991	0.348
LIG_LIR_Nem_3	515	521	PF02991	0.331
LIG_NRBOX	426	432	PF00104	0.315
LIG_SH2_CRK	277	281	PF00017	0.669
LIG_SH2_CRK	42	46	PF00017	0.698
LIG_SH2_STAP1	521	525	PF00017	0.322
LIG_SH2_STAT5	106	109	PF00017	0.732
LIG_SH3_3	145	151	PF00018	0.694
LIG_SH3_3	240	246	PF00018	0.709
LIG_SH3_3	281	287	PF00018	0.702
LIG_SH3_3	360	366	PF00018	0.678
LIG_SH3_3	394	400	PF00018	0.706
LIG_SH3_3	456	462	PF00018	0.365
LIG_SUMO_SIM_par_1	502	508	PF11976	0.448
LIG_TRAF2_1	182	185	PF00917	0.594
LIG_TRAF2_1	447	450	PF00917	0.320
LIG_TRFH_1	293	297	PF08558	0.582
LIG_WRC_WIRS_1	431	436	PF05994	0.395
MOD_CDC14_SPxK_1	286	289	PF00782	0.676
MOD_CDK_SPxK_1	283	289	PF00069	0.673
MOD_CK1_1	122	128	PF00069	0.749
MOD_CK1_1	221	227	PF00069	0.617
MOD_CK1_1	238	244	PF00069	0.698
MOD_CK1_1	358	364	PF00069	0.689
MOD_CK1_1	409	415	PF00069	0.715
MOD_CK2_1	342	348	PF00069	0.540
MOD_CK2_1	509	515	PF00069	0.327
MOD_Cter_Amidation	156	159	PF01082	0.489
MOD_DYRK1A_RPxSP_1	164	168	PF00069	0.658
MOD_GlcNHglycan	136	139	PF01048	0.504
MOD_GlcNHglycan	155	158	PF01048	0.586
MOD_GlcNHglycan	194	197	PF01048	0.396
MOD_GlcNHglycan	237	240	PF01048	0.549
MOD_GlcNHglycan	300	303	PF01048	0.499
MOD_GlcNHglycan	338	341	PF01048	0.438
MOD_GlcNHglycan	345	348	PF01048	0.414
MOD_GlcNHglycan	388	391	PF01048	0.459
MOD_GlcNHglycan	438	441	PF01048	0.491
MOD_GlcNHglycan	491	494	PF01048	0.572
MOD_GSK3_1	134	141	PF00069	0.648
MOD_GSK3_1	162	169	PF00069	0.823
MOD_GSK3_1	358	365	PF00069	0.755
MOD_GSK3_1	369	376	PF00069	0.603
MOD_GSK3_1	386	393	PF00069	0.621
MOD_GSK3_1	430	437	PF00069	0.454
MOD_GSK3_1	60	67	PF00069	0.718
MOD_GSK3_1	74	81	PF00069	0.746
MOD_GSK3_1	93	100	PF00069	0.655
MOD_LATS_1	134	140	PF00433	0.723
MOD_N-GLC_2	115	117	PF02516	0.436
MOD_N-GLC_2	335	337	PF02516	0.452
MOD_NEK2_1	14	19	PF00069	0.620
MOD_NEK2_1	163	168	PF00069	0.698
MOD_NEK2_1	170	175	PF00069	0.667
MOD_NEK2_1	2	7	PF00069	0.690
MOD_NEK2_1	20	25	PF00069	0.555
MOD_NEK2_1	200	205	PF00069	0.687
MOD_NEK2_1	229	234	PF00069	0.688
MOD_NEK2_1	298	303	PF00069	0.609
MOD_NEK2_1	32	37	PF00069	0.670
MOD_NEK2_1	342	347	PF00069	0.537
MOD_NEK2_1	430	435	PF00069	0.395
MOD_NEK2_1	59	64	PF00069	0.681
MOD_NEK2_2	370	375	PF00069	0.591
MOD_NEK2_2	497	502	PF00069	0.426
MOD_PIKK_1	2	8	PF00454	0.579
MOD_PIKK_1	409	415	PF00454	0.602
MOD_PIKK_1	509	515	PF00454	0.384
MOD_PIKK_1	80	86	PF00454	0.701
MOD_PKA_1	64	70	PF00069	0.724
MOD_PKA_1	73	79	PF00069	0.659
MOD_PKA_2	134	140	PF00069	0.665
MOD_PKA_2	153	159	PF00069	0.693
MOD_PKA_2	163	169	PF00069	0.712
MOD_PKA_2	229	235	PF00069	0.647
MOD_PKA_2	342	348	PF00069	0.541
MOD_PKA_2	73	79	PF00069	0.686
MOD_PKB_1	334	342	PF00069	0.654
MOD_PKB_1	95	103	PF00069	0.742
MOD_Plk_1	514	520	PF00069	0.366
MOD_Plk_4	171	177	PF00069	0.654
MOD_Plk_4	200	206	PF00069	0.719
MOD_Plk_4	406	412	PF00069	0.651
MOD_Plk_4	430	436	PF00069	0.384
MOD_ProDKin_1	122	128	PF00069	0.744
MOD_ProDKin_1	164	170	PF00069	0.680
MOD_ProDKin_1	283	289	PF00069	0.654
MOD_ProDKin_1	355	361	PF00069	0.743
MOD_ProDKin_1	362	368	PF00069	0.695
MOD_ProDKin_1	373	379	PF00069	0.535
MOD_ProDKin_1	396	402	PF00069	0.670
MOD_ProDKin_1	49	55	PF00069	0.595
MOD_ProDKin_1	525	531	PF00069	0.374
MOD_SUMO_rev_2	178	188	PF00179	0.679
MOD_SUMO_rev_2	326	331	PF00179	0.655
TRG_AP2beta_CARGO_1	477	486	PF09066	0.329
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.640
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.649
TRG_ENDOCYTIC_2	277	280	PF00928	0.632
TRG_ENDOCYTIC_2	42	45	PF00928	0.699
TRG_ENDOCYTIC_2	523	526	PF00928	0.348
TRG_ER_diArg_1	148	150	PF00400	0.740
TRG_ER_diArg_1	158	160	PF00400	0.645
TRG_ER_diArg_1	265	268	PF00400	0.642
TRG_ER_diArg_1	303	306	PF00400	0.640
TRG_ER_diArg_1	333	336	PF00400	0.701
TRG_ER_diArg_1	456	458	PF00400	0.373
TRG_ER_diArg_1	72	74	PF00400	0.655
TRG_ER_diArg_1	92	95	PF00400	0.764
TRG_NLS_MonoExtN_4	228	234	PF00514	0.588
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3L4	Leptomonas seymouri	34%	92%
A0A3S7XA13	Leishmania donovani	81%	100%
A4HNG5	Leishmania braziliensis	56%	100%
A4IC56	Leishmania infantum	81%	100%
E9AFX6	Leishmania major	80%	100%